☆ 4.5 Editorial Material

Commentary: Missing heritability, polygenic scores, and gene-environment correlation

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2013)

期刊

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

卷 54, 期 10, 页码 1147-1149

出版社

WILEY-BLACKWELL

DOI: 10.1111/jcpp.12128

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类别

Psychology, Developmental Psychiatry Psychology

资金

Medical Research Council [G19/2] Funding Source: researchfish
European Research Council [295366] Funding Source: Medline
Medical Research Council [G19/2(78332), G19/2] Funding Source: Medline
MRC [G19/2] Funding Source: UKRI

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摘要

This special issue amply fulfils its aim of moving the study of genexenvironment (GE) interplay forward constructively and creatively, exploiting contributions from diverse disciplines. Rather than discussing the many interesting findings and methods in this special issue, I will comment on two cross-cutting issues - one about genes and the other about the environment - that came to mind as I read these articles.

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Article Multidisciplinary Sciences

Genome-wide association study of school grades identifies genetic overlap between language ability, psychopathology and creativity

Veera M. Rajagopal, Andrea Ganna, Jonathan R. Coleman, Andrea Allegrini, Georgios Voloudakis, Jakob Grove, Thomas D. Als, Henriette T. Horsdal, Liselotte Petersen, Vivek Appadurai, Andrew Schork, Alfonso Buil, Cynthia M. Bulik, Jonas Bybjerg-Grauholm, Marie Baekvad-Hansen, David M. Hougaard, Ole Mors, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Gerome Breen, Panos Roussos, Robert Plomin, Esben Agerbo, Anders D. Borglum, Ditte Demontis

Summary: Individuals with psychiatric disorders show cognitive differences compared to the general population, which can be observed early in school performance and are genetically influenced. A genome-wide association study revealed a strong negative correlation between math performance and risk for most psychiatric disorders, while language performance correlated positively with risk for certain disorders, especially schizophrenia. Furthermore, genetic variants related to schizophrenia risk and better language performance are more common in individuals involved in creative professions compared to the general population. These findings suggest a potential genetic overlap between language ability, creativity, and psychopathology.

SCIENTIFIC REPORTS (2023)

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