期刊
JOURNAL OF CHILD NEUROLOGY
卷 26, 期 9, 页码 1131-1136出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073811408093
关键词
gene expression profiling; blood; RNA; stroke; ischemia; hypoxia; hypoglycemia; kainic acid
资金
- US National Institutes of Health [5R13NS040925-09, NS056302]
- National Institutes of Health Office of Rare Diseases Research
- Child Neurology Society
- Children's Hemiplegia and Stroke Association
- American Heart Association Bugher Foundation
- National Center for Medical Research [UL1 RR024146]
A blood test to detect stroke and its causes would be particularly useful in babies, young children, and patients in intensive care units and for emergencies when imaging is difficult to obtain or is unavailable. Whole genome microarrays were used to show specific gene expression profiles in rats 24 hours after ischemic and hemorrhagic stroke, hypoxia, and hypoglycemia. These proof-of-principle studies revealed that groups of genes (called gene profiles) can distinguish ischemic stroke patients from controls within 3 to 24 hours after the strokes. In addition, gene expression profiles have been developed that distinguish stroke due to large-vessel atherosclerosis from cardioembolic stroke. These profiles will be useful for predicting the causes of cryptogenic stroke. The results in adults suggest that similar diagnostic tools could be developed for children.
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