期刊
JOURNAL OF CHILD NEUROLOGY
卷 24, 期 11, 页码 1375-1386出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0883073809339213
关键词
medulloblastoma; pilocytic astrocytoma; ependymoma; molecular genetics; translational oncology
资金
- Deutsche Kindetkrebsstiftung
- Landesstiftung Baden-Wurttemberg
- Dr Hella-Buhler-Preis 2007
In recent years, brain tumors have become the single most frequent cause of cancer-related mortality in children, although their frequency is approximately 50% less than leukemia. According to the classification of the World Health Organization, histopathological diagnosis is of paramount importance for clinicians to choose the most appropriate treatment option and tailor treatment intensity to disease risk. However, histopathological assessment is often difficult, and adding molecular information to classic neuropathological analyses may help ensure diagnostic accuracy, improve risk stratification of patients within a given tumor entity and help in identifying novel therapeutic targets for an individualized treatment approach. Therefore, this review focuses both on established histopathology as well as on molecular features in the most important brain tumors in children.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据