Article
Clinical Neurology
Stefanie Bartha, Annet Bluschke, Tina Rawish, Kim E. R. Naumann, Paul Wendiggensen, Tobias Baeumer, Veit Roessner, Alexander Muenchau, Christian Beste
Summary: The occurrence of motor/vocal tics is the leading diagnostic criterion for tic disorders. However, extra movements are also common in healthy controls, questioning the usefulness of diagnostic criteria in clinical practice. It is not solely a surplus of movements that defines tic disorders, but rather movement characteristics and patterns.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Emily J. Ricketts, Sara Beth Wolicki, Joseph R. Holbrook, Michelle Rozenman, Joseph F. McGuire, Sana N. Charania, John Piacentini, Jonathan W. Mink, John T. Walkup, Douglas W. Woods, Angelika H. Claussen
Summary: This study examined sleep problems in children with Tourette Syndrome (TS). It found that children with sleep disorder were more likely to come from households with lower parental education and poverty, and had more other diagnoses and severe symptoms. These findings highlight the importance of monitoring and intervention for children with TS, as well as considering the socioeconomic context in sleep disorder management and prevention.
PEDIATRIC NEUROLOGY
(2023)
Article
Psychiatry
Raymond A. Clarke, Teri M. Furlong, Valsamma Eapen
Summary: Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by motor and vocal tics, with high rates of inheritance and involvement of mitochondrial pathways. Mutations in genes related to mitochondrial dynamics and function may contribute to the pathogenesis of GTS.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Tracy Bhikram, Rana Elmaghraby, Elia Abi-Jaoude, Paul Sandor
Summary: This study investigated health service delivery and care practices for TS patients in different geographic settings, revealing a scarcity of specialized TS clinics, variations in service accessibility, and differences in pharmacotherapeutic preferences among clinicians in different regions. The results highlight the need for interprofessional care and holistic management to improve healthcare delivery to TS patients.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Justin L. Blaty, Lourdes M. DelRosso
Summary: Healthy sleep is crucial for growth, development, and overall health. Patients, especially children, with Tourette Disorder (TD), experience negative effects on sleep. Common sleep abnormalities in TD include decreased total sleep time, lower sleep efficiency, and higher arousal index. TD is often associated with Attention Deficit Hyperactivity Disorder (ADHD), which further worsens sleep quality. Treatment of TD is essential for improving sleep in these patients.
BIOMEDICAL JOURNAL
(2022)
Article
Psychiatry
I-Jun Chou, Po-Cheng Hung, Jainn-Jim Lin, Meng-Ying Hsieh, Yi-Shan Wang, Cheng-Yen Kuo, Chang-Fu Kuo, Kuang-Lin Lin, Huei-Shyong Wang
Summary: Based on data from the National Taiwan Insurance Research Database, the incidence rates of Tourette syndrome and chronic tic disorders showed an increasing trend in children and adolescents from 2007 to 2015, but a decreasing trend in adults. The prevalence rates also increased over the same period.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Elena Zaklyazminskaya, Anna Shestak, Dmitry Podolyak, Vera Komoliatova, Leonid Makarov, Anna Novitskaya, Amiran Revishvili
Summary: This study aimed to evaluate the diagnostic yield and pathogenicity assessment of rare genetic variants in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome. The study found that PR interval was longer in SCN5A (+) probands compared to normal individuals, and depression was the only recurring non-cardiac symptom.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Psychiatry
Eu Gene Park, Young-Hoon Kim
Summary: This study investigated the clinical characteristics and comorbid neuropsychiatric conditions in 119 pediatric patients diagnosed with tic disorders. Findings revealed issues such as early onset of tics, diagnosis lag, and an association between tic severity, functional impairment, and tic noticeability. Comprehensive assessment during the disease course is crucial for prioritizing treatment goals.
Article
Clinical Neurology
Josefine Lund, Liv Borch-Johnsen, Camilla Groth, Liselotte Skov, Nanette Mol Debes
Summary: This study investigated the association between the severity of tics and comorbidities and educational outcomes in Tourette syndrome (TS) patients. It was found that children with TS had a lower passing rate at lower secondary school and high school compared to healthy controls. The severity of comorbidities was more likely to drive this difference than tic severity. Therefore, it is important to provide the right support for children with TS in order to optimize their educational opportunities.
Article
Multidisciplinary Sciences
Eman M. Khedr, Islam El Malky, Hussein B. Hussein, Doaa M. Mahmoud, Ayman Gamea
Summary: The earlier the diagnosis of multiple sclerosis (MS), the sooner disease-modifying treatments can be initiated. However, significant delays still occur in developing countries. Factors leading to delayed diagnosis of MS in Upper Egypt were identified in this study, including initial non-neurological consultation and previous misdiagnoses. These factors contribute to a higher relapse rate and delayed MRI acquisition, leading to a delay in diagnosis in Upper Egypt.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Hematology
Michael Nagler, Henning Nilius
Summary: Gallo et al. examined the impact of implementing a clinical decision support tool across multiple hospitals. This study highlights three crucial steps to unleash the potential of next-generation diagnostic instruments: (a) integrating diagnostic information from various sources, (b) ensuring accurate development and validation through well-designed clinical studies, and (c) seamlessly integrating them into clinical practice.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Clinical Neurology
Antigony Rigas, Tina Mainka, Tamara Pringsheim, Alexander Muenchau, Irene Malaty, Yulia Worbe, Andrea E. Cavanna, Andrew John Lees, Anthony E. Lang, Davide Martino, Christos Ganos
Summary: This study revealed that the diagnostic distinction between primary and functional tics is often difficult, even for expert clinicians, in the absence of clinical information.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Wei-De Lin, Fuu-Jen Tsai, I-Ching Chou
Summary: Gilles de la Tourette syndrome (TS) is a common childhood-onset psychiatric disorder characterized by persistent motor and vocal tics. Genetic factors and environmental factors play a role in the etiology of TS, and several genes and loci have been associated with the disorder. Copy number variations are considered significant sources of mutations in TS. Further research is needed to understand the underlying mechanisms and improve prognosis and treatment options for TS.
BIOMEDICAL JOURNAL
(2022)
Article
Neurosciences
Joseph Jurgiel, Makoto Miyakoshi, Andrea Dillon, John Piacentini, Sandra K. Loo
Summary: This study examined the neural connectivity of pediatric attention-deficit/hyperactivity disorder (ADHD) and persistent tic disorder (PTD) and tested three models of pathophysiology for the two disorders. The results showed that ADHD had a primary impact on cognitive and behavioral deficits, while deficits associated with PTD were primarily related to thought problems and internalizing problems. Co-occurring ADHD and PTD had additive effects on behavioral problems and cognitive functions. Weaker ADHD-related connectivity was associated with more severe behavioral problems, including internalizing behaviors, thought problems, and working memory deficits. These findings highlight the importance of targeting ADHD in the treatment of comorbid cases.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Review
Biochemistry & Molecular Biology
Chia-Jui Hsu, Lee-Chin Wong, Wang-Tso Lee
Summary: This review examines the clinical characteristics, clinical evidence, and genetic studies in vitro as well as animal studies regarding immune dysfunction in Tourette syndrome, suggesting that autoimmune dysfunction may play a significant role in the pathogenesis of Tourette syndrome and related neuropsychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychology, Developmental
Per Andren, Ewgeni Jakubovski, Tara L. Murphy, Katrin Woitecki, Zsanett Tarnok, Sharon Zimmerman-Brenner, Jolande van de Griendt, Nanette Mol Debes, Paula Viefhaus, Sally Robinson, Veit Roessner, Christos Ganos, Natalia Szejko, Kirsten R. Mueller-Vahl, Danielle Cath, Andreas Hartmann, Cara Verdellen
Summary: Part II of the European clinical guidelines for Tourette syndrome and other tic disorders provides updated information and recommendations for psychological interventions, recommending Habit Reversal Training (HRT) and Exposure and Response Prevention (ERP) as first-line interventions for tic disorders. Cognitive interventions and third-wave interventions are currently not recommended as stand-alone treatments for tic disorders.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Review
Psychology, Developmental
Veit Roessner, Heike Eichele, Jeremy S. Stern, Liselotte Skov, Renata Rizzo, Nanette Mol Debes, Peter Nagy, Andrea E. Cavanna, Cristiano Termine, Christos Ganos, Alexander Muenchau, Natalia Szejko, Danielle Cath, Kirsten R. Mueller-Vahl, Cara Verdellen, Andreas Hartmann, Aribert Rothenberger, Pieter J. Hoekstra, Kerstin J. Plessen
Summary: The first European guidelines for Tourette Syndrome (TS) were published in 2011 by the European Society for the Study of Tourette Syndrome (ESSTS). The updated part on pharmacological treatment emphasizes the importance of psychoeducation and behavioral approaches as first-line treatments. Pharmacological treatment, particularly with dopamine blocking agents like aripiprazole, is indicated in some patients, especially when behavioral approaches are not effective or feasible. Treatment should be individualized based on the patient's needs, preferences, and co-existing conditions.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Review
Psychology, Developmental
Natalia Szejko, Sally Robinson, Andreas Hartmann, Christos Ganos, Nanette M. Debes, Liselotte Skov, Martina Haas, Renata Rizzo, Jeremy Stern, Alexander Munchau, Virginie Czernecki, Andrea Dietrich, Tara L. Murphy, Davide Martino, Zsanett Tarnok, Tammy Hedderly, Kirsten R. Muller-Vahl, Danielle C. Cath
Summary: This article presents an updated version 2.0 of European clinical guidelines for Tourette syndrome and other tic disorders, focusing on assessment. The guidelines were developed through thorough literature screening, national guidelines supplementation, and expert discussions within ESSTS. Diagnostic changes between DSM-IV and DSM-5 classifications, recommendations for rating scales, and new information on differential diagnoses are highlighted. Additionally, a recent survey among ESSTS members on assessment in TS is discussed.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Psychiatry
Julie Holst Pedersen, Axel Skytthe, Jonas Bybjerg-Grauholm, Asli Sena Kucukyildiz, Liselotte Skov, Nanette Mol Debes, Zeynep Tumer
Summary: Gilles de la Tourette Syndrome (GTS) is a multifactorial neurodevelopmental disorder characterized by tics and multiple comorbidities. Twin studies indicate that both genetic and environmental risk factors are involved. The study found high concordance of GTS and chronic tic disorders in monozygotic twins, suggesting common genetic risk factors. The findings also showed higher comorbidity rates in twins with GTS or CTD compared to the general population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Josefine Lund, Amalie Berring-Uldum, Merve Colak, Nanette Marinette Monique Debes
Summary: The study showed an association between screen time and headache frequency in children and adolescents, especially in those with migraine with aura. However, there was no statistically significant difference in total screen time across the five headache groups. Future prospective studies are needed to determine causality in this association.
Review
Clinical Neurology
Astrid Forland-Schill, Amalie Berring-Uldum, Nanette Mol Debes
Summary: This review aims to describe the pathophysiological characteristics of migraine in pediatric patients and discuss the possible differences with adult migraine, as well as the need for further research on pediatric patients with migraine.
JOURNAL OF CHILD NEUROLOGY
(2022)
Article
Clinical Neurology
Josefine Lund, Liv Borch-Johnsen, Camilla Groth, Liselotte Skov, Nanette Mol Debes
Summary: This study investigated the association between the severity of tics and comorbidities and educational outcomes in Tourette syndrome (TS) patients. It was found that children with TS had a lower passing rate at lower secondary school and high school compared to healthy controls. The severity of comorbidities was more likely to drive this difference than tic severity. Therefore, it is important to provide the right support for children with TS in order to optimize their educational opportunities.
Article
Clinical Neurology
Camilla Birgitte Soerensen, Theis Lange, Sidsel Normann Jensen, Judy Grejsen, Lone Aaslet, Liselotte Skov, Nanette Mol Debes
Summary: Tourette syndrome and chronic tic disorders are characterized by tics. Although different behavioral therapies have been effective in treating tics in children and adolescents, Exposure and Response Prevention (ERP) has not been extensively studied. This study evaluated the long-term effects of ERP on tic severity and found that it had a significant and lasting effect, particularly for those who completed the program or discontinued due to positive results.
Article
Clinical Neurology
Camilla Birgitte Soerensen, Theis Lange, Sidsel Normann Jensen, Judy Grejsen, Lone Aaslet, Liselotte Skov, Nanette Mol Debes
Summary: Chronic tic disorders, such as Tourette syndrome, can be effectively treated using a behavioral therapy called exposure and response prevention (ERP). However, limited treatment sites hinder access to this therapy. Web-based videoconferences offer a solution by connecting patients at home with therapists in hospitals, providing treatment over a wide geographic area. In this study, ERP delivered via web-based videoconferences was found to be as effective as the traditional face-to-face method.
Article
Clinical Neurology
Kirstine Birkebaek Okkels, Liselotte Skov, Susanne Klanso, Lone Aaslet, Judy Grejsen, Annika Reenberg, Camilla Birgitte Sorensen, Nanette Marinette Monique Mol Debes
Summary: The study investigates the possible triggers for the development of functional tics in adolescents and discusses the role of the COVID-19 pandemic and social media exposure in these cases. The treatment for functional tics includes psychoeducation, cognitive behavioral therapy, and focusing on psychiatric symptoms, with positive responses from all patients.
Article
Health Care Sciences & Services
Kaja Andersen, Ida Jensen, Kirstine Birkebaek Okkels, Liselotte Skov, Nanette Mol Debes
Summary: Due to an increase in the number of patients with Functional Tic-Like Behaviors (FTLB), it is important to find differences between this patient group and patients with organic tics (OTs) for accurate diagnosis. This retrospective study examined established and suggested differences between the groups, replicating some findings from literature and revealing new differences. The study highlighted that FTLB patients have more complex tics, older symptom onset age, higher female representation, and fewer family members with tics compared to OT patients. Additionally, FTLB patients have more family members with psychiatric disorders, are more likely to experience adverse psychosocial events before symptom onset, and have fewer simple tics.
Article
Clinical Neurology
Laura Bogut, Kaja Andersen, Judy Grejsen, Maria Jose Miranda Gimenez-Rico, Nanette Monique Mol Debes
Summary: The cognitive function of healthy Danish children and Danish children diagnosed with epilepsy was examined using EpiTrack Junior. The patient group showed significantly lower test scores compared to the control group, confirming the relationship between impaired cognitive function and childhood epilepsy. Furthermore, there was a correlation between a higher EpiTrack Junior score and the presence of generalized tonic-clonic seizures (GTCS), while focal seizures and antiepileptic drug treatment were not associated with the EpiTrack Junior score.
Article
Clinical Neurology
Kaja Andersen, Camilla Groth, Liselotte Skov, Nanette Mol Debes
Summary: This study examines the longitudinal impact of Tourette Syndrome (TS) severity, Attention-Deficit/Hyperactivity Disorder (ADHD) and Obsessive-Compulsive Disorder (OCD) diagnosis and severity, and guardian socioeconomic status on substance use in pediatric patients with TS. The results indicate that greater severity of ADHD and lower guardian socioeconomic status significantly increase the likelihood of higher cigarette consumption in the future. Additionally, the presence and increased severity of ADHD at baseline increase the odds of illegal substance consumption later on, while increased severity of OCD at baseline decreases cigarette and illegal substance consumption, and presence and increased severity of OCD decrease alcohol consumption. Preventative conversations about substance use are crucial for pediatric patients with TS and high ADHD severity.
PEDIATRIC NEUROLOGY
(2023)
Article
Psychiatry
Marie Louise Boeg Tygesen, Katrine Maigaard, Julie Hagstrom, Liselotte Skov, Kerstin Jessica Plessen, Nanette Marinette Monique Debes
Summary: This study compared fine motor skill performance on the Purdue Pegboard Task (PPT) in 18 children with TS, 24 unaffected first-degree siblings and 20 controls. The results showed no significant differences in fine motor skills between children with TS, their siblings, and controls. However, there was an inverse correlation between performance on the PPT and the severity of ADHD symptoms, indicating that fine motor skill impairment in children with TS may be more strongly correlated with comorbid ADHD than to TS and tics. Evaluation: 8 out of 10.
SCANDINAVIAN JOURNAL OF CHILD AND ADOLESCENT PSYCHIATRY AND PSYCHOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Amanda M. Levy, Mathis Hildonen, Christina Dahl, Victoria A. Bjerregaard, Lisbeth Birk Moller, Per Guldberg, Nanette M. Debes, Zeynep Tumer
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)