Review
Clinical Neurology
Jeffrey J. Rakofsky, Michael J. Lucido, Boadie W. Dunlop
Summary: The efficacy of lithium in the treatment of acute bipolar depression needs further investigation. It showed poorer performance compared to antidepressants and slightly better performance than placebo. The current research does not support lithium as a first-line treatment, but it may still be a viable option.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Gregory Jones, Carola Rong, Courtney M. Vecera, Christopher Gurguis, Roshan Chudal, Rushaniya Khairova, Edison Leung, Ana C. Ruiz, Lokesh Shahani, Marcus Zanetti, Rafael T. de Sousa, Geraldo Busatto, Jair Soares, Wagner F. Gattaz, Rodrigo Machado-Vieira
Summary: Lithium may play an important role in treating comorbid anxiety in bipolar disorder, both as adjunct and monotherapy. Lower doses of lithium may provide equivalent efficacy and enhance tolerability and compliance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Juan R. Bustillo, Elizabeth G. Mayer, Joel Upston, Thomas Jones, Crystal Garcia, Sulaiman Sheriff, Andrew Maudsley, Mauricio Tohen, Charles Gasparovic, Rhoshel Lenroot
Summary: Research has shown that patients with schizophrenia have higher Glx levels in the right cingulate gyrus compared to patients with bipolar-I disorder. Additionally, patients with schizophrenia also showed higher levels of various metabolites compared to bipolar-I patients.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Huang, Miao Zhang, Yibo Zhao, Yudu Li, Wen Jin, Rong Guo, Wei Liu, Bingyang Cai, Jiwei Li, Siyu Yuan, Xinyun Huang, Xiaozhu Lin, Zhi-Pei Liang, Biao Li, Jie Luo
Summary: The purpose of this study was to investigate the synergy of fast, high-resolution, whole-brain MRSI in conjunction with simultaneous [F-18]FDG PET for the lateralization of drug-resistant mesial temporal lobe epilepsy (mTLE). The results showed that the combination of MRSI and FDG PET had a higher accuracy rate in lateralizing mTLE compared to routine MRI scans, especially in MRI-negative cases.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Rachel Shvartsur, Galila Agam, Sarit Uzzan, Abed N. Azab
Summary: Mounting evidence suggests that immune-system dysfunction and inflammation play a role in the pathophysiology and treatment of mood disorders. This study found that chronic combined treatment attenuated LPS-induced hypothermia and reduced cytokine levels, suggesting a potential approach for treating inflammation-related mental illness. The treatment also showed antidepressant-like effects.
Article
Psychology, Clinical
Dimitrios Andreou, Nils Eiel Steen, Kjetil Nordbo Jorgensen, Runar Elle Smelror, Kirsten Wedervang-Resell, Stener Nerland, Lars T. Westlye, Terje Naerland, Anne Margrethe Myhre, Inge Joa, Solveig Merete Klaebo Reitan, Arne Vaaler, Gunnar Morken, Erlend Boen, Torbjorn Elvsashagen, Birgitte Boye, Ulrik Fredrik Malt, Pal Aukrust, Silje Skrede, Rune Andreas Kroken, Erik Johnsen, Srdjan Djurovic, Ole A. Andreassen, Thor Ueland, Ingrid Agartz
Summary: The study found lower levels of NSE in adult and adolescent patients with SMI compared to healthy controls. Among adults, both patients with schizophrenia spectrum disorders and bipolar spectrum disorders had lower NSE levels, which were associated with increased symptom severity. Females also had lower NSE concentrations than males, suggesting a potential role of gender in the pathogenesis of SMI.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Danielle Soares Bio, Ricardo Alberto Moreno, Maria Concepcion Garcia-Otaduy, Fabiano Nery, Beny Lafer, Marcio Gerhardt Soeiro-de-Souza
Summary: The study found that patients with bipolar disorder (BD) had higher scores on the Childhood Trauma Questionnaire (CTQ) and higher rates of severity of sexual and physical abuse compared to healthy control (HC) subjects. The severity of physical and sexual abuse was associated with changes in anterior cingulate cortex (ACC) metabolites in BD patients only, suggesting a potential link between childhood abuse and creatine metabolism in the ACC. Further research is needed to explore the mechanism underlying the association between childhood abuse and worse clinical outcomes in BD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Orestes Forlenza, Tomas Hajek, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Farren B. S. Briggs, Vanessa J. R. De-Paula, Annemiek Dols, Lisa T. Eyler, Brent P. Forester, Ariel Gildengers, Esther Jimenez, Nicole C. M. Korten, Beny Lafer, Sean R. McWhinney, Benoit Mulsant, Soham Rej, Kaylee Sarna, Sigfried Schouws, Ashley Sutherland, Shangying Tsai, Eduard Vieta, Joy Yala, Martha Sajatovic
Summary: This study aimed to describe the demographic and clinical characteristics of older adults with bipolar disorder receiving lithium therapy. Results showed that patients treated with lithium had better performance in terms of depression scores, cognitive state, functionality, frequency of antipsychotics use, and cardiovascular comorbidities.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Biochemistry & Molecular Biology
Alonso Gonzalez, Mario Grageda, Adrian Quispe, Svetlana Ushak, Philippe Sistat, Marc Cretin
Summary: This study aimed to evaluate the feasibility of obtaining LiOH directly from brines with high LiCl concentrations using bipolar membrane electrodialysis. Experimental tests were conducted to determine the efficiency and energy consumption of LiOH production under different concentration conditions. The results demonstrate the potential of this technology for large-scale LiOH production.
Article
Psychiatry
Joshua T. Kantrowitz, Zhengchao Dong, Matthew S. Milak, Rain Rashid, Lawrence S. Kegeles, Daniel C. Javitt, Jeffrey A. Lieberman, J. John Mann
Summary: The study found that levels of Glx and Glu are elevated in MDD patients, while GABA levels are lower. Higher Glx levels are associated with more severe depression and lower GABA levels. The severity and diagnosis of MDD are both linked to higher Glx levels in the vmPFC/ACC.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Environmental Sciences
Erika Noren, Christian Lindh, Anders Glynn, Lars Rylander, Daniela Pineda, Christel Nielsen
Summary: The study assessed temporal trends of PFAAs concentrations in serum of Swedish adolescents and found that some compounds decreased annually, while others increased up to 2009 and decreased thereafter. Sensitivity analysis showed consistent trends. Furthermore, the results indicated that PFAAs remain stable in serum samples after long-term storage.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Clinical Neurology
Nicole R. Wong, Kayla E. Carta, Marc J. Weintraub, David J. Miklowitz
Summary: Family-focused therapy (FFT) is associated with longer intervals between mood episodes and reductions in suicidal ideation among adolescents at risk for bipolar disorders. Therapeutic alliance between adolescents/parents and their therapists is correlated with symptomatic outcomes of adolescents over 18 weeks. Enhancing adolescents' engagement in therapy may strengthen the long-term effects of family interventions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Ole Kohler-Forsberg, Louisa G. Sylvia, Michael Thase, Joseph R. Calabrese, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, Dan Iosifescu, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Vicki Fung, Michael J. Ostacher, Andrew A. Nierenberg
Summary: This study found that patients with bipolar disorder who used lithium in combination with antipsychotics or anticonvulsants showed worse response compared to those who only used lithium. However, compared to lithium and anticonvulsants, the combined use of lithium and antipsychotics showed slight improvement in general and manic symptoms, but worse development in glucose, triglycerides, and metabolic syndrome.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Ching-Fang Sun, Zeeshan Mansuri, Chintan Trivedi, Ramu Vadukapuram, Abhishek Reddy
Summary: The study aimed to evaluate the prevalence of demographic characteristics and psychiatric disorders in adolescents with and without homicidal ideation (HI). The results showed a higher prevalence of psychiatric illnesses such as depression, anxiety, and bipolar disorder in adolescents with HI in the inpatient setting. White and black races were more prevalent in patients with homicidal ideation.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Rebecca B. Price, Nicholas Kissel, Andrew Baumeister, Rebecca Rohac, Mary L. Woody, Elizabeth D. Ballard, Carlos A. Zarate, William Deakin, Chadi G. Abdallah, Adriana Feder, Dennis S. Charney, Michael F. Grunebaum, J. John Mann, Sanjay J. Mathew, Bronagh Gallagher, Declan M. McLoughlin, James W. Murrough, Suresh Muthukumaraswamy, Rebecca McMillan, Rachael Sumner, George Papakostas, Maurizio Fava, Rebecca Hock, Jennifer L. Phillips, Pierre Blier, Paulo Shiroma, Peter Sos, Tung-Ping Su, Mu-Hong Chen, Mikael Tiger, Johan Lundberg, Samuel T. Wilkinson, Meredith L. Wallace
Summary: Ketamine has rapid antidepressant effects and can reduce depressive symptoms in a variety of patients. It is particularly effective in patients who have been resistant to previous medications. However, there are currently no specific clinical or demographic characteristics that can guide treatment decisions for ketamine.
MOLECULAR PSYCHIATRY
(2022)
Article
Endocrinology & Metabolism
Joseph M. Braun, Melissa Eliot, George D. Papandonatos, Jessie P. Buckley, Kim M. Cecil, Heidi J. Kalkwarf, Aimin Chen, Charles B. Eaton, Karl Kelsey, Bruce P. Lanphear, Kimberly Yolton
Summary: Gestational exposure to PFAS may be associated with BMI trajectories related to adult obesity and cardiometabolic disease, while exposure to PFOS and PFHxS is associated with lower BMI in the first 12 years of life.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Clinical Neurology
Eric T. Dobson, Paul E. Croarkin, Heidi K. Schroeder, Sara T. Varney, Sarah A. Mossman, Kim Cecil, Jeffrey R. Strawn
Summary: This study found that in adolescents with GAD, certain symptoms not directly related to anxiety can bridge anxiety and depression, while patients with a heavier burden of depressive symptoms showed alterations in cortical thickness, indicating a unique neurostructural fingerprint. Additionally, youth with high depressive symptoms in GAD had reduced age-cortical thickness correlations, suggesting bidirectional neurobiological relationships between early GAD and cortical development.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Environmental Sciences
Yun Liu, Melissa N. Eliot, George D. Papandonatos, Karl T. Kelsey, Ruby Fore, Scott Langevin, Jessie Buckley, Aimin Chen, Bruce P. Lanphear, Kim M. Cecil, Kimberly Yolton, Marie-France Hivert, Sharon K. Sagiv, Andrea A. Baccarelli, Emily Oken, Joseph M. Braun
Summary: In this study, we examined the associations between gestational PFAS exposure and DNA methylation levels at birth and in adolescence using longitudinal data. The results showed that gestational PFAS exposure was associated with differences in several CpG sites at birth and at 12 years of age, which were linked to genes associated with PFAS-related health outcomes.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Review
Medicine, General & Internal
Kim M. Cecil
Summary: Studies using MRI have examined the effects of exposure to heavy metals, air pollution, pesticides, environmental tobacco smoke, and flame retardants on pediatric populations. These studies have found morphological changes, abnormal metabolic concentrations, white matter disorganization, and atypical patterns of activation as a result of these exposures. Some studies track pregnant women and their offspring throughout their lives to collect exposure biomarkers, while others use public databases to obtain relevant biomarkers and monitor developmental features in large imaging cohorts.
Article
Endocrinology & Metabolism
Nat Nasomyont, Andrea R. Meisman, Kirsten Ecklund, Sridhar Vajapeyam, Kim M. Cecil, Jean A. Tkach, Mekibib Altaye, Sarah D. Corathers, Lee Ann Conard, Heidi J. Kalkwarf, Lawrence M. Dolan, Catherine M. Gordon
Summary: Pubertal suppression with GnRH agonists may negatively affect BMAT and bone mass acquisition in TGNC youth.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Article
Environmental Sciences
Joseph M. Braun, George D. Papandonatos, Nan Li, Clara G. Sears, Jessie P. Buckley, Kim M. Cecil, Aimin Chen, Charles B. Eaton, Heidi J. Kalkwarf, Karl T. Kelsey, Bruce P. Lanphear, Kimberly Yolton
Summary: In this cohort, physical activity during adolescence modified the association between prenatal serum PFOA concentrations and cardiometabolic risk in children, suggesting that lifestyle interventions may alleviate the adverse effects of PFOA exposure. However, diet did not modify any associations.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Taylor M. Etzel, Joseph M. Braun, Jordan R. Kuiper, Antonia M. Calafat, Kim M. Cecil, Aimin Chen, Bruce P. Lanphear, Kimberly Yolton, Heidi J. Kalkwarf, Jessie P. Buckley
Summary: This study suggests that early life exposure to certain phthalates may be associated with body composition, particularly lean mass, during adolescence.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Zana Percy, Aimin Chen, Weili Yang, Joseph M. Braun, Bruce Lanphear, Maria Ospina, Antonia M. Calafat, Changchung Xie, Kim M. Cecil, Ann M. Vuong, Yingying Xu, Kimberly Yolton
Summary: The use of organophosphate esters as flame retardants may have adverse effects on cognitive abilities in children, with socioeconomic status influencing the relationship.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Nerea Mourino, Monica Perez-Rios, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen, Jessie P. Buckley, Heidi J. Kalkwarf, Kim M. Cecil, Joseph M. Braun
Summary: This study found that postnatal serum cotinine concentrations had a greater influence on adolescent's cardiometabolic risk compared to the prenatal period, and these associations may be sex-specific.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Nidhi Iyanna, Kimberly Yolton, Grace LeMasters, Bruce P. Lanphear, Kim M. Cecil, Joel Schwartz, Cole Brokamp, Erika Rasnick, Yingying Xu, Melinda C. MacDougall, Patrick H. Ryan
Summary: Exposure to air pollutants NO2 and PM2.5 during pregnancy and the first year of life may increase the risk of Autism Spectrum Disorder (ASD) in children, but this association is no longer significant after controlling for confounding factors.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Jordan R. Kuiper, Shudi Pan, Bruce P. Lanphear, Antonia M. Calafat, Aimin Chen, Kim M. Cecil, Yingying Xu, Kimberly Yolton, Heidi J. Kalkwarf, Joseph M. Braun, Jessie P. Buckley
Summary: Background: Early life environmental exposures may affect bone mass accrual in childhood, but only limited research has been done on the role of environmental phenols in child bone health. This study found weak associations between the concentrations of environmental phenols and bone mineral content and density, suggesting the need for further research on the mechanisms of this effect.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Zana Percy, Aimin Chen, Heidi Sucharew, Weili Yang, Ann M. Vuong, Joseph M. Braun, Bruce Lanphear, Maria Ospina, Antonia M. Calafat, Kim M. Cecil, Yingying Xu, Kimberly Yolton
Summary: This study aimed to assess the impact of early-life exposure to an OPE mixture on child behavior. It was found that higher urinary concentrations of OPE metabolites during pregnancy and postnatal period were associated with child behavioral problems at 3 and 8 years, including internalizing, externalizing, and overall negative behaviors. However, there was no consistent pattern in terms of the direction of the effects or a particularly sensitive time point.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Taylor M. Etzel, Jordan R. Kuiper, Xiaobin Wang, Noel T. Mueller, Antonia M. Calafat, Kim M. Cecil, Aimin Chen, Bruce P. Lanphear, Kimberly Yolton, Heidi J. Kalkwarf, Joseph M. Braun, Jessie P. Buckley
Summary: A prospective study found that early-life phthalate exposures may affect cardiometabolic outcomes during adolescence. The concentrations of nine phthalate metabolites in urine samples collected during pregnancy and childhood were associated with cardiometabolic biomarkers at age 12, with differences observed between males and females.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Harry Sultan, Jessie P. Buckley, Heidi J. Kalkwarf, Kim M. Cecil, Aimin Chen, Bruce P. Lanphear, Kimberly Yolton, Joseph M. Braun
Summary: This study investigated the relationship between dietary quality and macronutrient intake with serum PFAS concentrations in US adolescents, and found that higher dietary quality and dietary fiber intake were associated with lower PFAS concentrations. These findings can inform future policies in reducing human exposure to PFAS.
ENVIRONMENTAL RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Junqi Wang, Hailong Li, Gang Qu, Kim M. Cecil, Jonathan R. Dillman, Nehal A. Parikh, Lili He
Summary: A dynamic weighted hypergraph convolutional network (dwHGCN) framework is proposed in this study to learn features from dynamic hypergraphs. The model improves the learning capability of brain functional connectome by assigning larger weights to hyperedges with higher discriminative power and enhances the interpretability of the model by identifying highly active interactions among ROIs shared by a common hyperedge. Experimental results demonstrate the superiority of this model in classification tasks using functional magnetic resonance imaging (fMRI) data.
MEDICAL IMAGE ANALYSIS
(2023)
