Article
Biotechnology & Applied Microbiology
Bowen Weng, Mei Li, Weilai Zhu, Jing Peng, Xufeng Mao, Yanan Zheng, Chi Zhang, Senhao Pan, Haijiao Mao, Jiyuan Zhao
Summary: Breast cancer is a common malignant tumor in women, with bone being the most common site of distant metastasis. Early detection of bone metastasis is crucial for improving prognosis. A biomimetic decellularized extracellular matrix (dECM) system was developed to mimic bone niches and capture metastatic breast cancer cells both in vitro and in vivo.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Indira Sigdel, Niraj Gupta, Fairuz Faizee, Vishwa M. Khare, Amit K. Tiwari, Yuan Tang
Summary: The article highlights the high mortality rate of breast cancer due to metastasis, emphasizing the urgent need for better models to understand and prevent this process. Microfluidic approaches offer the ability to mimic cellular microenvironments and monitor interactions in real-time, showing great potential in advancing our mechanistic understanding of breast cancer metastasis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Aaron E. Chiou, Chuang Liu, Ines Moreno-Jimenez, Tengteng Tang, Wolfgang Wagermaier, Mason N. Dean, Claudia Fischbach, Peter Fratzl
Summary: Factors secreted by breast cancer may promote disturbed bone growth before metastasis, potentially affecting the initial seeding of tumor cells.
Article
Engineering, Biomedical
Xiao Zheng, Yawei Zhao, Yong Jia, Dan Shao, Fan Zhang, Madi Sun, Jianati Dawulieti, Hanze Hu, Lianzhi Cui, Yue Pan, Chao Yang, Wen Sun, Shuang Zhang, Kan He, Jing Li, Jinzhi Du, Ming Zhang, Li Chen
Summary: Chemotherapy is a double-edged sword in treating breast cancer, as it can induce cancer progression; Berberine has shown potential as a regulator for Dox-exacerbated breast cancer metastasis by targeting the HMGB1-TLR4 axis; The combination of Dox and Ber in a self-assembled nanodrug can effectively inhibit tumor growth and metastasis.
Review
Pharmacology & Pharmacy
Claire L. Ihle, Sabrina J. Wright-Hobart, Philip Owens
Summary: The survival rate of breast cancer patients has improved, but metastatic breast cancer still causes high mortality. Metastasis mainly occurs in the bone, and current treatment methods focus on palliative care and slowing down the progression. Recent advances in molecularly targeted agents have made breakthroughs in the treatment of metastatic breast cancer, but immunotherapies have not been fully applied in estrogen receptor-positive tumors. Therapeutic approaches targeting the bone microenvironment of metastatic breast cancer have potential applications in other bone-resident cancers.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Alessandro Fulgenzi, Anita Ferraretto
Summary: Bone metastasis is a severe complication of common cancers like breast and prostate cancer, reducing survival rates and quality of life. Following a Mediterranean diet can prevent cancer and improve patient health, potentially impacting the spread of cancer to the bones.
Review
Genetics & Heredity
Jingyao Cui, Haoran Chen, Kaiwen Zhang, Xin Li
Summary: Wnt pathway plays a crucial role in cancer bone metastasis and targeted therapeutic strategies have shown promise. Current progress includes research on pharmacological Wnt modulators against breast cancer bone metastasis and exploration of emerging therapeutic strategies based on Wnt pathway-related targets, providing new ideas for the development of Wnt-based intervention strategies in the future.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Chemistry, Multidisciplinary
Hai-jun Liu, Junfeng Wang, Mingming Wang, Yuzhen Wang, Shanshan Shi, Xiangxiang Hu, Quanguang Zhang, Daping Fan, Peisheng Xu
Summary: A targeted cerium oxide nanoparticle system has been developed to effectively inhibit cancer-associated fibroblast transdifferentiation and reduce the size of primary tumors while preventing metastasis in breast cancer models through homologous targeting of cancer cell membrane-coated nanoparticles.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Anita Ferraretto, Giovanni Lombardi
Summary: Bone metastases are a major issue in the progression of breast cancer, posing a significant treatment challenge. Interleukin-11 plays a key role in bone metastasis and could be a candidate for anti-metastatic therapy. Further research is needed to understand the contribution of different cytokines in breast cancer progression and develop effective therapeutic strategies.
Review
Oncology
Marie-Therese Haider, Daniel J. Smit, Hanna Taipaleenmaeki
Summary: This article summarizes the recent research progress on miRNAs in breast cancer bone metastasis. MiRNAs not only affect the function of cancer cells, but also play an important role in key cells of the bone microenvironment. In addition, the article discusses the potential application of miRNAs as therapeutic targets and elaborates on the advantages and challenges of miRNA treatment.
Article
Engineering, Biomedical
Xuan Zhang, Yan Zhang, Haiping Zheng, Yufeng He, Honglin Jia, Liyuan Zhang, Chunjie Lin, Shuang Chen, Junfeng Zheng, Qunfang Yang, Tao Liu, Xichun Pan, Haigang Zhang, Chenhui Wang, Lei Ren, Wenjun Shan
Summary: The study identified a biomimetic nanoformulation that effectively activated lung immune cells, enhanced anti-tumor immune responses, significantly increased specific CD8+ T cell responses, and cross-presented tumor antigens. The nanoformulation exhibited remarkable immunotherapeutic efficacy, improved survival in mice, and initiated immune memory to prevent tumor recurrence.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Feiyang Jin, Jing Qi, Di Liu, Yuchan You, Gaofeng Shu, Yan Du, Jun Wang, Xiaoling Xu, Xiaoying Ying, Jiansong Ji, Yongzhong Du
Summary: The combined application of anti-CD73 antibody and chemo-PDT can enhance the anti-metastatic effects of T cell-mediated antitumor immunity synergistically. This strategy not only prevents abscopal tumor metastasis but also induces a series of immunogenic cell death, leading to tumor-specific immunity.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Ana Luisa Correia, Joao C. Guimaraes, Priska Auf Der Maur, Duvini De Silva, Marcel P. Trefny, Ryoko Okamoto, Sandro Bruno, Alexander Schmidt, Kirsten Mertz, Katrin Volkmann, Luigi Terracciano, Alfred Zippelius, Marcus Vetter, Christian Kurzeder, Walter Paul Weber, Mohamed Bentires-Alj
Summary: The study investigates how different tissue-specific microenvironments can either inhibit or support the progression of breast cancer in the liver. It identifies the interplay between natural killer (NK) cells and activated hepatic stellate cells (aHSCs) as a master switch of cancer dormancy, suggesting that therapies aimed at normalizing the NK cell pool may be successful in preventing metastatic outgrowth.
Review
Health Care Sciences & Services
Lei Yi, Kai Ai, Xurui Li, Zhihong Li, Yuan Li
Summary: Bladder cancer is a common and deadly malignancy worldwide. Metastasis to the bone is a major concern for patients, with a one-year survival rate of only 21%. The mechanism of bladder cancer metastasis to the bone is not fully understood, and further research is required. Different imaging mechanisms have limitations in diagnosing bone metastasis, and treatment options include chemotherapy, immunotherapy, targeted therapy, and surgery, with the goal of improving survival and quality of life.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Lina Marie, Dina Braik, Nayef Abdel-Razeq, Hala Abu-Fares, Ahmad Al-Thunaibat, Hikmat Abdel-Razeq
Summary: Breast cancer with de novo bone-only metastasis has distinct clinical features and prognosis compared to subsequent bone-only metastasis. Patients with de novo bone-only metastasis have shorter overall survival.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Acoustics
Amit Katiyar, Jenna Osborn, Malaya DasBanerjee, Lijie Grace Zhang, Kausik Sarkar, Krishna Pada Sarker
JOURNAL OF ULTRASOUND IN MEDICINE
(2020)
Article
Nanoscience & Nanotechnology
Xuan Zhou, Sara Tenaglio, Timothy Esworthy, Sung Yun Hann, Haitao Cui, Thomas J. Webster, Hicham Fenniri, Lijie Grace Zhang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Materials Science, Biomaterials
Se-jun Lee, Dayun Yan, Xuan Zhou, Haitao Cui, Timothy Esworthy, Sung Yun Hann, Michael Keidar, Lijie Grace Zhang
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Multidisciplinary Sciences
Haitao Cui, Chengyu Liu, Timothy Esworthy, Yimin Huang, Zu-xi Yu, Xuan Zhou, Hong San, Se-jun Lee, Sung Yun Hann, Manfred Boehm, Muhammad Mohiuddin, John P. Fisher, Lijie Grace Zhang
Article
Nanoscience & Nanotechnology
Xuan Zhou, Margaret Nowicki, Hao Sun, Sung Yun Hann, Haitao Cui, Timothy Esworthy, James D. Lee, Michael Plesniak, Lijie Grace Zhang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Nanoscience & Nanotechnology
Yue Wang, Haitao Cui, Yancheng Wang, Chengyao Xu, Timothy J. Esworthy, Sung Yun Hann, Manfred Boehm, Yin-Lin Shen, Deqing Mei, Lijie Grace Zhang
Summary: 4D printing enables the creation of pre-designed structures with time-dependent, dynamic shape changes to promote uniform cellular growth and distribution. The development of near-infrared light-sensitive cardiac constructs allows on-demand shape changes to mimic the curved topology of myocardial tissue.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Sung Yun Hann, Haitao Cui, Timothy Esworthy, Xuan Zhou, Se-jun Lee, Michael W. Plesniak, Lijie Grace Zhang
Summary: The development of vascular networks is crucial for tissue fabrication in regenerative medicine. 3D printing vascularized bone has gained attention due to bone disorders, but challenges persist due to the need for nanoscale precision. A novel 3D printing approach was combined with biocompatible materials to enhance vascular growth and tissue bioactivity.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Biomaterials
Alejandro Herreros-Pomares, Xuan Zhou, Silvia Calabuig-Farinas, Se-Jun Lee, Susana Torres, Timothy Esworthy, Sung Yun Hann, Eloisa Jantus-Lewintre, Carlos Camps, Lijie Grace Zhang
Summary: Traditional two-dimensional (2D) in vitro cell cultures and animal models are limited in simulating the native environment for cancer stem cell (CSC) studies, but novel three-dimensional (3D) cell cultures show promise in enriching CSCs from lung cancer patients. Different 3D printing platforms were used to produce rigid and hydrogel-based scaffolds, with gene expression analysis confirming overexpression of stemness and invasion promoters in cells grown on hydrogel scaffolds and tumor spheres. The 3D printed models, especially those using GelMA-PEGDA hydrogels, outperform 2D culture models in mimicking tumor complexity and regulating cancer cell behavior.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Materials Science, Biomaterials
Tarun Agarwal, Dishary Banerjee, Rocktotpal Konwarh, Timothy Esworthy, Jyoti Kumari, Valentina Onesto, Prativa Das, Bae Hoon Lee, Frank A. D. T. G. Wagener, Pooyan Makvandi, Virgilio Mattoli, Sudip Kumar Ghosh, Tapas Kumar Maiti, Lijie Grace Zhang, Ibrahim T. Ozbolat
Summary: This review focuses on the significance of using 3D bioprinting technology in liver tissue engineering, as well as the opportunities for stem cells and differentiation strategies for different types of liver cells.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Materials Science, Biomaterials
Tarun Agarwal, Gabriele Maria Fortunato, Sung Yun Hann, Bugra Ayan, Kiran Yellappa Vajanthri, Dario Presutti, Haitao Cui, Alex H. P. Chan, Marco Costantini, Valentina Onesto, Concetta Di Natale, Ngan F. Huang, Pooyan Makvandi, Majid Shabani, Tapas Kumar Maiti, Lijie Grace Zhang, Carmelo De Maria
Summary: Bioprinting technologies have made significant advancements in the fabrication of engineered cardiac tissue, offering possibilities for functional cardiac tissue models for regenerative and diagnostic applications, while also discussing the related challenges and prospects.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Biotechnology & Applied Microbiology
Nathan J. Castro, Greta Babakhanova, Jerry Hu, K. A. Athanasiou
Summary: Traditional destructive tests are limited in their applicability to biomanufacturing, making nondestructive testing methods, such as photo- and acoustic-based techniques, more important. These methods allow for quantitative measurements of structural, compositional, and functional variances in soft tissues.
TRENDS IN BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yue Wang, Haitao Cui, Timothy Esworthy, Deqing Mei, Yancheng Wang, Lijie Grace Zhang
Summary: The rapid development of 3D printing has had a significant impact on the field of biomedical engineering, particularly 4D printing. While there has been progress made in the development of 4D printing for tissue scaffolds and medical devices, there are limitations in printable smart materials and achievable responses with current stimulation sources. This review highlights recent progress in 4D printing, focusing on printing mechanisms, smart ink mechanisms, structural design, and printing technologies. It also summarizes recent studies on tissue/organ regeneration and medical device applications, and discusses current challenges and future perspectives of 4D printing.
ADVANCED MATERIALS
(2022)
Article
Acoustics
Jenna Osborn, Megan S. Anderson, Morgan Beddingfield, Lijie Grace Zhang, Kausik Sarkar
Summary: Scientists are facing challenges in creating effective biomimetic constructs in tissue engineering with sustained and controlled delivery of growth factors. They have explored acoustic droplet vaporization (ADV) in GelMA hydrogels and discovered the performance of different perfluorocarbon droplets. The results provide a potential application of ADV in hydrogel scaffolds for tissue engineering.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Sung Yun Hann, Haitao Cui, Timothy Esworthy, Lijie Grace Zhang
Summary: In this study, a two-in-one 4D smart cardiac construct that integrates the functions of minimally invasive cell vehicles and in situ tissue patches was developed for repairing damaged myocardial tissue.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Materials Science, Biomaterials
Tarun Agarwal, Sung Yun Hann, Irene Chiesa, Haitao Cui, Nehar Celikkin, Simone Micalizzi, Andrea Barbetta, Marco Costantini, Timothy Esworthy, Lijie Grace Zhang, Carmelo De Maria, Tapas Kumar Maiti
Summary: The article discusses the combination of 3D printing technology and smart materials in additive manufacturing to create biomimetic structures that can dynamically reshape in response to external stimuli. This approach shows promise in various biomedical areas.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)