Article
Plant Sciences
Xinyang Liao, Gareth I. Jenkins
Summary: This study investigates the roles of cysteine amino acids C231 and C335 in the structure and function of UVR8. The results show that the mutant UVR8(C231S,C335S) protein behaves similarly to wild-type UVR8, but has weaker interactions with specific proteins and an altered conformation.
Article
Plant Sciences
Qianwen Zhang, Li Lin, Fang Fang, Beimi Cui, Cheng Zhu, Shukun Luo, Ruohe Yin
Summary: COP1 is a critical repressor of plant photomorphogenesis in darkness. However, it plays distinct roles in the UVR8 pathway in Arabidopsis thaliana. COP1 interacts with UV-B-activated UVR8 monomers and promotes their retention and accumulation in the nucleus. Moreover, COP1 has a function in UV-B signaling, which involves its binding to UVR8 and HY5 via conserved VP motifs.
Article
Multidisciplinary Sciences
Roman Podolec, Kelvin Lau, Timothee B. Wagnon, Michael Hothorn, Roman Ulm
Summary: The study introduces a new mutant allele of the UVR8 gene, uvr8-17D, which results in weak constitutive photomorphogenesis and extreme UV-B responsiveness when overexpressed in plants. The UVR8(G101S) mutant, predominantly monomeric in vivo and inefficiently inactivated after UV-B activation, provides further insight into the mechanisms of UVR8 activation and inactivation. Additionally, the combination of G101S and W285A mutations in UVR8 leads to robust constitutive photomorphogenesis in plants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Lixia Wang, Yidong Wang, Hongfei Chang, Hui Ren, Xinquan Wu, Jia Wen, Zeyuan Guan, Ling Ma, Liang Qiu, Junjie Yan, Delin Zhang, Xi Huang, Ping Yin
Summary: The plant UVR8 undergoes monomerization and interacts with COP1/SPA to initiate UV-B signaling. RUP1 and RUP2 directly interact with UVR8 and facilitate its ground state reversion. The structure of the RUP2-UVR8 complex was reported, revealing two distinct interfaces involved in their interaction.
PLANT COMMUNICATIONS
(2023)
Article
Plant Sciences
H. Chen, Y. Yin, J. Niu, J. M. Kwak, M. Du
Summary: The Ultraviolet Resistance Locus 8 (UVR8) in plants plays a crucial role in regulating plant growth through signal transduction events triggered by ultraviolet-B (UV-B) light. This study focuses on analysing the UVR8 in monocotyledon crops, specifically Brachypodium distachyon. The results show that BdUVR8 is a photoreceptor that perceives UV-B in B. distachyon.
Review
Biochemistry & Molecular Biology
Junko Takeda
Summary: The author proposes a hypothetical model for UVB-induced photomorphogenesis mediated by UVR8, discussing two pathways affecting plant growth and the absorption spectra in the UV-B region.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Engineering, Environmental
Pengfei Wang, Kehan Li, Jianyu Yang, Jinlong Zhu, Yusheng Zhao, Ying Teng
Summary: This study investigates the dissociation properties of hydrogen-propane hydrates through experiments and simulations, revealing the characteristics of the dissociation process and the impact of different dissociation driving mechanisms on hydrogen release. The results indicate that the release rate of hydrogen from hydrates is higher than that of propane, and propose the concept of recycling hydrate clathrate structure to accelerate hydrogen storage rate.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Plant Sciences
Zhenhua Zhang, Chenjie Xu, Shiyu Zhang, Chen Shi, Hong Cheng, Hongtao Liu, Bojian Zhong
Summary: The study elucidated the origin and evolutionary paths of key components in the UVR8-mediated signaling pathway, as well as the evolutionary features and mechanisms of green plants in adapting to UV-B radiation.
Article
Multidisciplinary Sciences
Xiankun Li, Zheyun Liu, Haisheng Ren, Mainak Kundu, Frank W. Zhong, Lijuan Wang, Jiali Gao, Dongping Zhong
Summary: Researchers discovered a unique molecular mechanism of UV-induced dimer monomerization by studying the excitation energy and charge separation dynamics in photoreceptors. The process involves the release of energy, charge neutralization, and destruction of key salt bridges.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Xingyu Zhou, Xiaotong Yan, Changchun He, Xiao-Bao Yang, Yu-Jun Zhao
Summary: In this study, the adsorption and dissociation of hydrogen molecules on Mg17Al12(100), Mg17Al12(110), Mg17Al12(111), and Mg(0001) surfaces were investigated using first-principles calculations. It was found that the H adsorption on Mg17Al12 systems exhibited greater strength than that of Mg(0001) surface. Among them, the lowest adsorption energies of H atoms were observed on the Mg17Al12(110) surface, with values of -0.278 and -0.247 eV/H at H coverage of 1/11 and 2/11 ML, respectively. Additionally, the Mg17Al12(110) surface demonstrated a hydrogen dissociation energy path with a minimum barrier of 0.59 eV, which was smaller than that of the Mg(0001) surface (0.84 eV). Electronic structure analysis indicated that although H atoms obtained similar charges on the Mg17Al12(110) and Mg(0001) surfaces, the bonding between H atoms and the Mg17Al12(110) surface was enhanced. Furthermore, the reduced dissociation barriers on the three investigated Mg17Al12 surfaces were likely attributed to the stronger hybridization of H 1s and Al 3s orbitals, resulting in accelerated hydrogen adsorption kinetics on the Mg17Al12 surface compared to the pure Mg surface.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2023)
Article
Plant Sciences
Raul Carranco, Pilar Prieto-Dapena, Concepcion Almoguera, Juan Jordano
Summary: Sunflower heat shock factor A9 (A9) enhances the nuclear localization of NtUVR8 by binding to it, resulting in its activation. A9 also enhances COP1 binding to activate NtUVR8 without UV-B light. These findings reveal a UV-B-independent activation mechanism and a role for UVR8 in plant seeds.
Article
Plant Sciences
Maria Belen Fernandez, German Lukaszewicz, Lorenzo Lamattina, Raul Cassia
Summary: This study evaluated the suitability of reference genes for normalization of gene expression in tomato seedlings exposed to UV-B, recommending specific gene combinations for different tissues. The findings provide valuable insight for accurate gene expression analysis under UV-B irradiation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Chemistry, Physical
Pengwei Chang, Panwang Zhou, Jianyong Liu, Shuhui Yin
Summary: The key role of reaction intermediates in the thermal decomposition of nitromethane has been investigated. Based on Density Functional Theory calculations, it was found that the C-N bond in nitromethane is more likely to break than the monomolecular isomerization with increasing temperature. The intermediates of thermal decomposition exhibit autocatalysis, and the stable small molecules observed in initial explosive stages are products of the intermediates involved in autocatalytic reactions. The potential energy surfaces accurately describe the thermal decomposition mechanism of nitromethane.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Medicine, General & Internal
Seok-Hoon Lee, Nam-Seok Joo
Summary: This study aimed to investigate the effect of NBUVB-LED exposure on serum 25(OH)D concentrations. The results indicated that NBUVB-LED exposure might increase serum 25(OH)D levels. However, further research is needed to validate these findings.
Article
Physics, Multidisciplinary
JingYan Zheng, Kelaiti Xiao, Bumaliya Abulimiti, Mei Xiang, Huan An
Summary: This study investigated the dissociation properties of nitrogen trifluoride (NF3) under an applied electric field. The results showed that the bond length of NF3 increased and energy gap decreased as the electric field strength increased. When the electric field reached a certain threshold, NF3 started to dissociate and degrade.
Article
Chemistry, Multidisciplinary
Dong-Xing Zhu, Hui Xia, Jian-Guo Liu, Lung Wa Chung, Ming-Hua Xu
Summary: This study introduces for the first time the asymmetric insertion of an arylvinylcarbenoid into the C-H bond catalyzed by a rhodium(I)-diene complex, providing various chiral compounds with excellent enantioselectivity. Systematic DFT calculations were used to elucidate the reaction mechanism and origin of the uncommon enantioselectivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Xin Chang, Yuhong Yang, Chong Shen, Kun-Shan Xue, Zuo-Fei Wang, Hengjiang Cong, Hai-Yan Tao, Lung Wa Chung, Chun-Jiang Wang
Summary: The study successfully employed beta-substituted alkenyl heteroarenes as dipolarophiles in the Cu(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides, resulting in the synthesis of multistereogenic heterocycles with high enantioselectivity and good yields.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Zeyin Yan, Xin Li, Lung Wa Chung
Summary: The quantum refinement technique, combining crystallographic data with computational chemistry methods, can improve the accuracy of metalloprotein structures, especially those containing transition metal ions. Multiscale quantum refinement schemes have been developed to refine the local metal binding sites in metalloproteins efficiently.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2021)
Article
Chemistry, Physical
Qian Wang, Jialing Lan, Rong Liang, Yihao Xia, Lei Qin, Lung Wa Chung, Zhiping Zheng
Summary: In this study, a new application of the Grubbs catalysts in hydrogen production from aqueous-phase methanol reforming was reported, showing that the G-III catalyst achieved the best performance among those tested and can also be used for other dehydrogenation reactions. Mechanistic studies and DFT calculations revealed an unusual substrate-assisted metathesis pathway, shedding light on the reaction mechanism and suggesting new opportunities in catalyst design for clean and renewable energies.
Article
Chemistry, Multidisciplinary
Jian-Hong Fan, Jing-Jing Wang, Fangfang Li, Guannan Wang, Qiang Guo, Lung Wa Chung, Chuang-Chuang Li
Summary: This study describes the first and asymmetric total synthesis of phomarol, a rare C25 steroid, using a mild acid-promoted type I [5 + 2] cycloaddition followed by regio- and chemoselective bond cleavage and aromatization cascade. The stereoselectivity of cycloadditions was controlled using hydrogen bonding between the hydroxy group and oxidopyrylium ylide. The highly functionalized tetrahydropyran ring of phomarol was efficiently produced based on a suggested biomimetic pathway.
Review
Chemistry, Multidisciplinary
Jialing Lan, Xin Li, Yuhong Yang, Xiaoyong Zhang, Lung Wa Chung
Summary: Homogeneous catalysis and biocatalysis have found wide applications in synthetic, medicinal, and energy chemistry as well as synthetic biology. Computational chemistry has become an essential tool to understand structures and reaction mechanisms in catalysis. The synergy between computational and experimental chemistry deepens our understanding of mechanisms and promotes the design of new catalysts.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Gongyi Liu, Lini Zheng, Kui Tian, Haifeng Wang, Lung Wa Chung, Xumu Zhang, Xiu-Qin Dong
Summary: A highly efficient Ir/bisphosphine-thiourea catalytic system, ZhaoPhos, has been successfully developed for the asymmetric hydrogenation (AH) of challenging aryl substituted unprotected indoles, showing high reactivity and excellent stereoselective control. Various chiral indoline derivatives were obtained in good to high yields with excellent stereoselectivities. Anion-binding activation strategy played an important role in achieving both high reactivity and excellent stereoselectivity.
Article
Chemistry, Multidisciplinary
Tian-Yi Wang, Xiao-Xuan Chen, Dong-Xing Zhu, Lung Wa Chung, Ming-Hua Xu
Summary: A highly selective C(sp(2))-H functionalization reaction catalyzed by rhodium(I)-diene has been developed, enabling the synthesis of α,β-unsaturated esters containing heteroatoms under mild reaction conditions. Mechanistic studies show that the substrate affects the reaction rate and selectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Jialing Lan, Tonghuan Zhang, Yuhong Yang, Xin Li, Lung Wa Chung
Summary: Transition-metal-catalyzed amination of aryl halides is a useful method for synthesizing medicinal compounds, organic functional materials, and agrochemical compounds. A systematic DFT study has revealed the mechanism of Co(I)-catalyzed amination of aryl halides, with dissociative C-I activation pathway being the most favorable.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Zhifeng Ma, Zeyin Yan, Xin Li, Lung Wa Chung
Summary: In this study, the effects of external electric fields (EEFs) on three reactions involving hydrogen or carbon were extensively investigated. The study revealed that oriented EEFs can significantly reduce the barrier and increase the reaction rates. Furthermore, EEFs can modulate tunneling reactions and control the site selectivity of molecules with similar reactive sites.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Chuan Qin, Zhidao Huang, Song-Bai Wu, Zhuangxing Li, Yuhong Yang, Xin Zhang, Guixia Liu, Yun-Dong Wu, Lung Wa Chung, Zheng Huang
Summary: This study challenges a widely accepted assumption in organometallic chemistry that unactivated aliphatic C(sp3)-H bonds are less reactive than aromatic C(sp2)-H bonds within the same molecule. The researchers demonstrate that a pincer-ligated iridium complex can selectively catalyze intramolecular dehydrogenative silylation of unactivated delta-C(sp3)-H bonds, leading to the formation of 5-membered silolanes. Furthermore, chiral silolanes can be further oxidized to produce enantiopure beta-aryl-substituted 1,4-diols.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Fangrui Zheng, Yuhong Yang, Siye Wu, Shunan Zhao, Yifan Zhu, Huimin Su, Jun-Feng Dai, Zeyin Yan, Lung Wa Chung, Keith Man-Chung Wong
Summary: In contrast to the well-studied dirhodium(II) complexes and iridium(III) complexes, neutral or dicationic dinuclear iridium(II) complexes with unsupported ligands are relatively unexplored. In this study, a series of tetracationic dinuclear iridium(II) complexes with long bond distances and photoluminescent properties were synthesized and characterized. It was found that these complexes exhibit high stability due to London dispersion interactions, despite the long Ir(II)-Ir(II) bond lengths, and show potential for further photoreactivity studies involving the generation of iridium(II) radical monomers.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mingkang Zhou, Yaodong Lin, Xiao-Xuan Chen, Guangqing Xu, Lung Wa Chung, Wenjun Tang
Summary: We report the chiral diboron-templated asymmetric homocoupling of aryl alkyl ketimines, leading to the formation of chiral vicinal tetrasubstituted diamines with high enantioselectivities and good to high yields. This powerful and efficient reaction is achieved by rational design and engineering of chiral diborons, which participate in a [3,3]-sigmatropic rearrangement. DFT studies reveal that different conformational assembling strategies of chiral diborons ensure the excellent enantioselectivity in the tight concerted transition states.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Rong Liang, Qinghai Zhou, Xin Li, Ming Wah Wong, Lung Wa Chung
Summary: The macrocycle effect of [2]rotaxane on the highly trans-stereoselective cyclization reaction of N-benzylfumaramide has been extensively studied. Computational results suggest that the most favorable mechanism involves deprotonation of a N-benzyl group of the fumaramide substrate by CsOH, followed by C-C bond formation and protonation by an amide functional group of the macrocycle. The trans-selective cyclization within the rotaxane is attributed to higher distortion energy caused by the twisted cis-fumaramide conformation enforced by the rotaxane.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xin Chang, Xue-Tao Liu, Fangfang Li, Yuhong Yang, Lung Wa Chung, Chun-Jiang Wang
Summary: A series of benzofulvenes without electron-withdrawing substituents were used as 2π-type dipolarophiles in Cu(i)-catalyzed asymmetric 1,3-dipolar cycloaddition reactions. The non-benzenoid aromatic characteristic of benzofulvenes served as a key driving force for their activation. The methodology allowed for the synthesis of multi-substituted chiral spiro-pyrrolidine derivatives with exclusive chemo-/regioselectivity and high to excellent stereoselectivity.