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Plant Sciences
Jikai Xu, Jingyu Liu, Qing Li, Guoxun Li, Guijie Zhang, Yan Mi, Ting Zhao, Danyang Mu, Dequan Wang, Kewu Zeng, Yue Hou
Summary: This study found that pterostilbene, a compound isolated from Chinese dragon's blood, can reduce inflammation in Alzheimer's disease (AD). The study demonstrated that pterostilbene can improve learning and memory abilities in AD transgenic mice and reduce microglial activation and A beta aggregation in their hippocampus. This is achieved by blocking the interaction of TLR4 and MD2 to suppress TLR4-mediated inflammation.
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Neurosciences
Xiaohui Xia, Shuai Wang, Lirong Wu, Guoxing Li, Kaiwen Hou, Anyong Yu, Zhao Yang
Summary: This study found that TIPE2 levels were significantly decreased in microglia treated with erythrocyte lysate. Upregulation of TIPE2 reduced inflammation and accelerated brain damage in ICH mice. TIPE2 may serve as a novel target for ICH therapy.
BRAIN RESEARCH BULLETIN
(2022)
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Food Science & Technology
Yanjun Liu, Panpan Li, Yuanfa Liu, Tianyu Jiang, Jie Xu, Changhu Xue
Summary: The study demonstrates that plasmenylethanolamine (PlsEtn) attenuates neuroinflammation and neuronal loss by promoting microglial autophagy. This finding may contribute to the prevention and treatment of Alzheimer's disease.
Article
Neurosciences
Dongzhu Zhang, Xue Shen, Ke Pang, Zhao Yang, Anyong Yu
Summary: This study found that levels of VSIG4 in macrophages decreased after intracerebral hemorrhage, leading to macrophage M1 polarization. Up-regulation of VSIG4 inhibited macrophage M1 polarization, pro-inflammatory cytokine production, BBB disruption, and neurological deficits following ICH. Additionally, the anti-inflammatory effect of VSIG4 was mainly through blocking TLR4/NF-kappa beta signaling.
BRAIN RESEARCH BULLETIN
(2021)
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Pharmacology & Pharmacy
Ji Xu, Sahar Mashayekhi Firouz, Mina Farrokhian, Shadi Ghoreishizadeh, Talar Ahmad Merza Mohamad, Amirabbas Rostami, Rozita Tamjididfar, Morteza Akbari, Navid Shomali, Reza Eghdam Zamiri, Siamak Sandoghchian Shotorbani, Ali Sadeghian Shahi
Summary: The study found that anti-HMGB1 treatment had better anti-inflammatory effects on intracerebral hemorrhage (ICH), which could reduce TLR4-related signaling pathways, suppress the production of pro-inflammatory cytokines, and increase the production of anti-inflammatory cytokines.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
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Plant Sciences
Yuanyuan Li, Chao Tian, Yufei Wei, Haoqi Liu, Na An, Ke Song, Yikun Sun, Yonghong Gao, Ying Gao
Summary: This study explored the pharmacological mechanism of Naoxueshu oral liquid in the treatment of intracerebral hemorrhage (ICH). It was found that Naoxueshu oral liquid suppressed the inflammatory response and accelerated hematoma absorption, possibly through the regulation of Nrf2/CD163/HO-1 pathway. The study suggests that Naoxueshu oral liquid could be a potential drug for ICH treatment.
Review
Immunology
Kunli Zhang, Qiuyan Huang, Shoulong Deng, Yecheng Yang, Jianhao Li, Sutian Wang
Summary: Pathogenic infections have a significant impact on public health and the breeding industry, with immune cells generating reactive oxygen and nitrogen species to clear pathogens. Autophagy and nitroxidative stress are intertwined, with Toll-like receptor 4 playing a key role in regulating inflammation, autophagy, and nitroxidative stress during infectious diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jia Lu, Wei Zhou, Fangfang Dou, Chenfei Wang, Zhihua Yu
Summary: Microglia energy metabolism is suppressed during chronic A beta-tolerant processes, but pharmacological activation of TRPV1 can rescue microglial dysfunction and restore immune responses, leading to reduced amyloid pathology and reversed memory deficits in AD mice. This study suggests that TRPV1 is an important target for regulating metabolic reprogramming in microglial functions for AD treatment.
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Pharmacology & Pharmacy
Sung Hee Park, Young-Sun Lee, Hyun-Jeong Yang, Gyun Jee Song
Summary: Fluoxetine has regulatory effects on microglial function, reducing the production of proinflammatory cytokines and oxidative stress, while enhancing phagocytosis and autophagy in microglia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chenfei Wang, Wei Huang, Jia Lu, Hongzhuan Chen, Zhihua Yu
Summary: Autophagy plays a crucial role in regulating the ageing process and neurodegeneration. Dysfunction of autophagy is implicated in Alzheimer's disease pathogenesis. The activation of TRPV1 using capsaicin induces autophagy, which could potentially be a therapeutic target for Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhongqiu Zhou, Qingqing Ye, Hui Ren, Yuan Zhang, Bing Han, Honghong Yao, Ying Bai
Summary: This study found that circDYM inhibits microglial apoptosis induced by LPS via the CEBPB/ZC3H4 axis. CircDYM prevents CEBPB from translocating into the nucleus by binding with it. In addition, LPS-induced CEBPB nuclear entry downregulates the expression of ZC3H4, which promotes autophagy and apoptosis in microglia. These findings provide new insights into the relationship between circDYM and microglial apoptosis, as well as shed new light on the complex changes in the brain associated with depression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Environmental Sciences
Chunyan Yao, Xiaoling Liu, Yan Tang, Chunmei Wang, Chenggang Duan, Xiaoyan Liu, Mingliang Chen, Yumeng Zhou, Enjie Tang, Ying Xiang, Yafei Li, Ailing Ji, Tongjian Cai
Summary: Microglia-mediated neuroinflammation is crucial in the pathophysiology of neurodegenerative diseases. Lipopolysaccharide (LPS) can activate microglia and induce inflammation. Matrix metalloproteinases (MMPs) and CD147 are key factors involved in microglial activation and inflammation. This study found that CD147 expression was induced in LPS-induced microglial activation, and inhibiting CD147 expression could suppress microglial activation. Furthermore, MMPs and autophagy were involved in the inflammatory activation of microglia, and inhibiting MMPs or autophagy could attenuate this activation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Yangchun Hu, Chao Li, Xiaojian Wang, Weiwei Chen, Yu Qian, Xingliang Dai
Summary: Increasing evidence suggests that TREM2 plays an important role in the pathophysiology of neuroinflammation. Knockdown of TREM2 aggravated pro-inflammatory responses and microglial activities after SAH, leading to worsened neurological dysfunction. TLR4 knockout increased TREM2 expression, resulting in improved neuroinflammation and neurological function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yangchun Hu, Chao Li, Xiaojian Wang, Weiwei Chen, Yu Qian, Xingliang Dai
Summary: Increasing evidence implicates TREM2 in neuroinflammation, particularly in the context of SAH. Knockdown of TREM2 exacerbates inflammation and microglial dysfunction after SAH, while TLR4 knockout increases TREM2 expression and improves neuroinflammation and function. These findings suggest that targeting TREM2 pharmacologically may be a promising therapeutic approach for SAH.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Deqiang Fu, Xingyue Liang, Yuxuan Jiang, Jieping Liu, Xiaosi Lin, Quan Yang, Xue Chen, Ping Huang, Wei Wang, Wenlin Wu
Summary: Iron accumulation in the brain has been implicated in the pathogenesis of various neurodegenerative diseases. Autophagy induction has been proposed as a potential therapeutic strategy, but the relationship between autophagy and iron is not well understood. This study found that iron induces autophagosome accumulation and disrupts the autophagic flux in microglia, which may contribute to iron neurotoxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)