期刊
JOURNAL OF CHEMICAL PHYSICS
卷 138, 期 24, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4811288
关键词
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资金
- French National Research Agency ANR (T-KiNet grant)
- Labex NanoSaclay (T-DropTwo grant)
- Universite Pierre et Marie Curie (Convergence program)
Increased focus on kinetic signatures in biology, coupled with the lack of simple tools for chemical dynamics characterization, lead us to develop an efficient method for mechanism identification. A small thermal modulation is used to reveal chemical dynamics, which makes the technique compatible with in cellulo imaging. Then, the detection of concentration oscillations in an appropriate frequency range followed by a judicious analytical treatment of the data is sufficient to determine the number of chemical characteristic times, the reaction mechanism, and the full set of associated rate constants and enthalpies of reaction. To illustrate the scope of the method, dimeric protein folding is chosen as a biologically relevant example of nonlinear mechanism with one or two characteristic times. (C) 2013 AIP Publishing LLC.
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