期刊
JOURNAL OF CHEMICAL PHYSICS
卷 130, 期 15, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3109902
关键词
biomembranes; cellular biophysics; DNA; genetics; molecular biophysics
资金
- U. S. Department of Energy Office of Biological and Environmental Research [SCFY081004]
We present molecular-level simulations of dendrimer/DNA complexes in the presence of a model cell membrane. We determine the required conditions for the complex to arrive intact at the membrane, and the lifetime of the complex as it resides attached to the membrane. Our simulations directly pertain to critical issues arising in emerging gene delivery therapeutic applications, where a molecular carrier is required to deliver DNA segments to the interior of living cells.
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