Article
Medicine, Research & Experimental
Shanzeh M. Ahmed, Nina L. Fransen, Hanane Touil, Iliana Michailidou, Inge Huitinga, Jennifer L. Gommerman, Amit Bar-Or, Valeria Ramaglia
Summary: Meningeal inflammation may play a significant role in subpial cortical injury in multiple sclerosis, and it is related to white matter lesion activity.
Article
Multidisciplinary Sciences
Bonnie Yin Ka Lam, Brian Yiu, Encarnita Ampil, Christopher Li-Hsian Chen, Yustiani Dikot, Jacqueline C. Dominguez, Patel Vishal Ganeshbhai, Saima Hilal, Nagaendran Kandiah, SangYun Kim, Jun-Young Lee, Anam Paulus Ong, Vorapun Senanarong, Kam Tat Leung, Huali Wang, Yuan-Han Yang, Tingting Yong, Faheem Arshad, Suvarna Alladi, Samuel Wong, Ho Ko, Alexander Yuk Lun Lau, Vincent Chung Tong Mok
Summary: This study aimed to investigate the burden of WML and its associated risk factors in different Asian societies. The prevalence of moderate-to-severe WML was highest in stroke/TIA patients, with Bandung Indonesia showing the highest prevalence. Hypertension and hyperlipidemia were significant risk factors for WML, which was negatively associated with cognitive performance in all groups.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Andrei Irimia, Van Ngo, Nikhil N. Chaudhari, Fan Zhang, Shantanu H. Joshi, Anita N. Penkova, Lauren J. O'Donnell, Nasim Sheikh-Bahaei, Xiaoyu Zheng, Helena C. Chui
Summary: This study found that cerebral microbleeds in mTBI patients are associated with white matter degradation and cognitive decline, with male sex and older age as significant risk factors for larger reductions. The findings indicate a significant positive correlation between CMBs and changes in cognitive functions, suggesting the need for long-term cognitive assessment in mTBI patients.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Jingqin Luo, Yinjiao Ma, Folasade Jane Agboola, Elizabeth C. Grant, John Morris, Eric M. McDade, Anne Fagan, Tammie L. S. Benzinger, Jason J. Hassenstab, Randall J. Bateman, Richard A. Perrin, Brian Gordon, Manu F. Goyal, Jeremy Strain, Igor S. Yakushev, Gregory Day, Chengjie Xiong
Summary: White matter hyperintensities (WMH) are correlated with Alzheimer disease (AD) biomarkers and modulate AD pathogenesis. This study analyzed the longitudinal data of WMH volume and established AD biomarkers in cognitively normal individuals. The results showed that longitudinal increases in WMH volume were associated with changes in PET amyloid uptake, MRI structural outcomes, and cognition. The inflection point of baseline age in WMH volume was identified at 60.46 years.
Article
Multidisciplinary Sciences
Mohammed Y. Ezzeldin, Doaa M. Mahmoud, Shady M. Safwat, Radwa Kamel Soliman, Tarek Desoky, Eman M. Khedr
Summary: Fatigue is a common symptom in RRMS, and gray matter atrophy has been linked to fatigue in previous studies. However, the relationship between fatigue and white matter lesion load (WM-LL) has received less attention. This study aims to assess this relationship.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Jianqiao Tian, Sheelakumari Raghavan, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Robel K. Gebre, Jonathan Graff-Radford, Christopher G. Schwarz, Val J. Lowe, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri
Summary: This study used neurite orientation dispersion and density imaging (NODDI) to investigate the association between white matter (WM) changes and Alzheimer disease (AD), and evaluated its relationship with cognitive performance. The results showed that the neurodegeneration of WM is spatially dependent and correlated with regional tau deposition in different stages of AD. Additionally, the WM changes explained a similar amount of cognitive performance variation as regional tau deposition and provided complementary information about disease staging and progression.
Review
Clinical Neurology
Angela C. C. Jochems, Carmen Arteaga, Francesca Chappell, Tuula Ritakari, Monique Hooley, Fergus Doubal, Susana Munoz Maniega, Joanna M. Wardlaw
Summary: This study aims to assess the longitudinal intraindividual changes in white matter hyperintensities (WMH) volume in sporadic small vessel disease (SVD). The study found that WMH regression is a possible phenomenon in SVD patients.
Article
Geriatrics & Gerontology
Sen Zhang, Yaya Hu, Huilin Yang, Qianqian Li, Jing Chen, Hongying Bai
Summary: This study investigated the correlations of white matter hyperintensities (WMH) volume and white matter (WM) volume with cognitive dysfunction in patients with cerebral small-vessel disease (CSVD). It was found that both WMH volume and WM volume were independent risk factors for cognitive dysfunction. WMH volume primarily affected cognitive dysfunction involving visual space and delayed recall, while WM volume was not strongly associated with different types of cognitive dysfunction. The ratio of WMH to WM volume can be used for more accurate evaluation of cognitive dysfunction in older adults with CSVD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Hyun Song, Pradyumna K. Bharadwaj, David A. Raichlen, Christian G. Habeck, Matthew J. Huentelman, Georg A. Hishaw, Theodore P. Trouard, Gene E. Alexander
Summary: In this study, a network pattern was identified, using multivariate scaled subprofile model analysis, that reflected the association of plasma Hcy with subcortical gray matter volumes. This pattern was related to other health risk factors and cognition in healthy older adults.
NEUROBIOLOGY OF AGING
(2023)
Article
Medicine, General & Internal
Batool Rizvi, Patrick J. Lao, Anthony G. Chesebro, Jordan D. Dworkin, Erica Amarante, Juliet M. Beato, Jose Gutierrez, Laura B. Zahodne, Nicole Schupf, Jennifer J. Manly, Richard Mayeux, Adam M. Brickman
Summary: This study found that white matter hyperintensity volume is associated with cortical thinning and subsequent memory functioning, with variations in the association among different racial and ethnic groups. Particularly, the impact of small vessel cerebrovascular disease on cortical thinning is stronger among non-Hispanic Black participants, which may influence the risk and progression of Alzheimer's disease.
Article
Clinical Neurology
Nathan R. DeJong, Jacobus F. A. Jansen, Martin P. J. van Boxtel, Miranda T. Schram, Coen D. A. Stehouwer, Pieter C. Dagnelie, Carla J. H. van der Kallen, Abraham A. Kroon, Anke Wesselius, Annemarie Koster, Walter H. Backes, Sebastian Koehler
Summary: This study examined the associations between white matter connectivity, brain damage markers, and cognition in middle-aged individuals. The results showed that increasing connectivity moderated the negative association between brain damage and cognition, supporting the reserve hypothesis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Paolo Preziosa, Elisabetta Pagani, Alessandro Meani, Olga Marchesi, Lorenzo Conti, Andrea Falini, Maria A. Rocca, Massimo Filippi
Summary: Using diffusion tensor and neurite orientation dispersion and density imaging (NODDI), this study found that neuro-axonal damage and loss of microarchitecture integrity in focal WM lesions, NAWM, and GM contribute to cognitive impairment in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Keun-Hwa Jung, Kimberly A. Stephens, Kathryn M. Yochim, Joost M. Riphagen, Chan Mi Kim, Randy L. Buckner, David H. Salat
Summary: The study successfully differentiated different classes of cerebral white matter signal abnormalities (WMSA) using automated procedures and found that different classes of WMSA are associated with different clinical risk factors.
Article
Clinical Neurology
Raffaello Bonacchi, Alessandro Meani, Elisabetta Pagani, Olga Marchesi, Andrea Falini, Massimo Filippi, Maria A. Rocca
Summary: In patients with multiple sclerosis, younger individuals are initially more resilient to brain damage, but compensatory mechanisms eventually fail, leading to loss of white matter integrity, followed by gray matter atrophy and ultimately disability.
Article
Neuroimaging
Michelle R. Caunca, Lily Wang, Ying Kuen Cheung, Noam Alperin, Sang H. Lee, Mitchell S. Elkind, Ralph L. Sacco, Clinton B. Wright, Tatjana Rundek
Summary: High dimensional neuroimaging datasets and machine learning were used to estimate and predict domain-specific cognition. The study found that the combination of basic model and MRI markers did not improve estimation, but elastic net models with only MRI markers performed significantly better than random MRI markers. Structural brain MRI markers may be more useful for etiological modeling.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neuroimaging
Yaakov Stern
BRAIN IMAGING AND BEHAVIOR
(2017)
Article
Neurosciences
C. Habeck, Q. Razlighi, Y. Gazes, D. Barulli, J. Steffener, Y. Stern
Article
Geriatrics & Gerontology
Briana S. Last, Maria-Jose Garcia Rubio, Carolyn W. Zhu, Stephanie Cosentino, Jennifer J. Manly, Charles DeCarli, Yaakov Stern, Adam M. Brickman
EXPERIMENTAL AGING RESEARCH
(2017)
Article
Neurosciences
Jack Grinband, Jason Steffener, Qolamreza R. Razlighi, Yaakov Stern
HUMAN BRAIN MAPPING
(2017)
Article
Neurosciences
Carolyn W. Zhu, Stephanie Cosentino, Katherine A. Ornstein, Yian Gu, Howard Andrews, Yaakov Stern
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Neurosciences
Martin J. Lan, R. Todd Ogden, Dileep Kumar, Yaakov Stern, Ramin V. Parsey, Gregory H. Pelton, Harry Rubin-Falcone, Gnanavalli Pradhaban, Francesca Zanderigo, Jeffrey M. Miller, J. John Mann, D. P. Devanand
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Neurosciences
Bruce P. Dore, Chelsea Boccagno, Daisy Burr, Alexa Hubbard, Kan Long, Jochen Weber, Yaakov Stern, Kevin N. Ochsner
JOURNAL OF COGNITIVE NEUROSCIENCE
(2017)
Article
Geriatrics & Gerontology
Justin S. Golub, Jose A. Luchsinger, Jennifer J. Manly, Yaakov Stern, Richard Mayeux, Nicole Schupf
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2017)
Article
Geriatrics & Gerontology
Nicolai Franzmeier, Katharina Buerger, Stefan Teipel, Yaakov Stern, Martin Dichgans, Michael Ewers
NEUROBIOLOGY OF AGING
(2017)
Article
Behavioral Sciences
A. Tsapanou, Y. Gu, D. M. O'Shea, M. Yannakoulia, M. Kosmidis, E. Dardiotis, G. Hadjigeorgiou, P. Sakka, Y. Stern, N. Scarmeas
NEUROBIOLOGY OF LEARNING AND MEMORY
(2017)
Article
Neurosciences
Qolamreza R. Razlighi, Christian Habeck, Daniel Barulli, Yaakov Stern
Article
Medicine, General & Internal
Yaakov Stern, Seonjoo Lee, David Predovan, Richard P. Sloan
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Genetics & Heredity
Angeliki Tsapanou, Niki Mourtzi, Sokratis Charisis, Alex Hatzimanolis, Eva Ntanasi, Mary H. Kosmidis, Mary Yannakoulia, Georgios Hadjigeorgiou, Efthimios Dardiotis, Paraskevi Sakka, Yaakov Stern, Nikolaos Scarmeas
Summary: Sleep problems are associated with cognition, and specific genes are associated with sleep regulation and cognition. This study validates the association between Sleep Polygenic Risk Score (Sleep PRS) and self-reported sleep duration, and finds an association between Sleep PRS and cognitive changes related to visuo-spatial ability in older non-demented adults.
Article
Genetics & Heredity
Angeliki Tsapanou, Margaret Gacheru, Seonjoo Lee, Niki Mourtzi, Yunglin Gazes, Christian Habeck, Daniel W. Belsky, Yaakov Stern
Summary: This study analyzed the relationship between genetics and cognitive performance, and found that genetics play a moderating role in cognitive aging. The results suggest that genetics have a stronger association with cognitive performance in young and midlife older adults.
Article
Clinical Neurology
Yaakov Stern, Yian Gu, Stephanie Cosentino, Martina Azar, Siobhan Lawless, Oksana Tatarina
ALZHEIMERS & DEMENTIA
(2017)