期刊
JOURNAL OF CHEMICAL INFORMATION AND MODELING
卷 49, 期 4, 页码 1025-1032出版社
AMER CHEMICAL SOC
DOI: 10.1021/ci800429e
关键词
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From an analysis of calculated physicochemical properties for 81 currently marketed respiratory drugs, compounds administered via the inhaled/intranasal routes have a higher polar surface area, a higher molecular weight, and a trend toward lower lipophilicity, when compared with their orally administered counterparts. Ranges of physicochemical space are described for the 29 drugs administered by the inhaled or intranasal routes.
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