Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ana Gamez-Valero, Jaume Campdelacreu, Dolores Vilas, Lourdes Ispierto, Jordi Gascon-Bayarri, Ramon Rene, Ramiro Alvarez, Maria P. Armengol, Francesc E. Borras, Katrin Beyer
Summary: This study identified a seven-miRNA biosignature that can distinguish DLB from AD, and identified three disease-specific clusters of pathways as a result of platelet-miRNA deregulation.
Article
Clinical Neurology
Simon Kang Seng Ting, Seyed Ehsan Saffari, Shahul Hameed, Hui Jin Chiew, Kok Pin Ng, Adeline S. L. Ng
Summary: In clinical practice, it is important to note that memory symptoms, although associated with a higher risk of AD diagnosis, are prominent in prodromal DLB. Psychosis is infrequent, and non-amnestic MCI is not necessarily associated with a higher risk of DLB diagnosis. A careful clinical approach is key to improve the diagnosis of prodromal DLB.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Review
Clinical Neurology
Rotem Iris Orad, Tamara Shiner
Summary: Dementia with Lewy bodies presents a diagnostic challenge due to clinical overlap with other neurodegenerative conditions, such as Parkinson's disease dementia and Alzheimer's disease. Neuroimaging plays a central role in improving diagnostic accuracy and management of this disorder.
JOURNAL OF NEUROLOGY
(2022)
Article
Cell Biology
Antonio Longobardi, Luisa Benussi, Roland Nicsanu, Sonia Bellini, Clarissa Ferrari, Claudia Saraceno, Roberta Zanardini, Marcella Catania, Giuseppe Di Fede, Rosanna Squitti, Giuliano Binetti, Roberta Ghidoni
Summary: The study suggests that alterations in extracellular vesicles (EVs) release may be a common molecular pathway underlying the three major neurodegenerative dementias (AD, DLB, and FTD). Patients with these dementias show a significant reduction in EVs concentration and larger EVs size in their plasma. Neurotrophic factors loss is a common pathogenic mechanism, and EVs size and concentration can effectively distinguish patients from controls.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Kurt A. Jellinger
Summary: PDD and DLB are two major neurocognitive disorders in the spectrum of Lewy body diseases with overlapping clinical and neuropathological features. DLB has higher Braak LB scores and neuritic Braak stages, as well as more severe neuropathological features like Thal A beta phases and neuritic Braak stages. Worse prognosis in DLB is linked to increased Braak neuritic stages and more severe cerebral amyloid angiopathy.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingjie Ge, Huamei Lin, Keliang Chen, Min Wang, Zhijie He, Jiaying Lu, Zizhao Ju, Yimin Sun, Fengtao Liu, Yihui Guan, Qianhua Zhao, Chuantao Zuo, Ping Wu
Summary: This study aimed to optimize the analysis of cingulate island sign (CIS) to improve its diagnostic accuracy in discriminating dementia with Lewy bodies (DLB) from Alzheimer disease (AD). The optimized CIS ratio calculated by dorsal posterior cingulate cortex (PCC)/lateral occipital lobe metabolism achieved the highest specificity, sensitivity, and accuracy in distinguishing DLB from AD. The metabolism of dorsal-PCC positively correlated with cognitive impairment in DLB patients and also correlated with dopaminergic impairment in the caudate.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Psychology, Clinical
Toril Marie Terum, Ingelin Testad, Arvid Rongve, Dag Aarsland, Ellen Svendsboe, John Roger Andersen
Summary: The study aimed to explore the association between carer distress and time until nursing home admission in people with mild dementia. Carer distress was found to be an important contributor to early admission, with specific factors such as feeling frustrated and limitations on social life playing significant roles in predicting time until nursing home admission. Looking beyond the total score of the Relative Stress Scale could help in developing tailored interventions to delay nursing home admission for dementia patients.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Clinical Neurology
James E. Galvin, Stephanie Chrisphonte, Iris Cohen, Keri K. Greenfield, Michael J. Kleiman, Claudia Moore, Mary Lou Riccio, Amie Rosenfeld, Niurka Shkolnik, Marcia Walker, Lun-Ching Chang, Magdalena I. Tolea
Summary: The study tested the performance of the LBD-MOD module in characterizing Lewy body dementia (DLB) and distinguishing it from Alzheimer's disease (AD). Results showed differences between DLB and AD in various symptoms, as well as differences between MCI-DLB and MCI-AD. The LBD-MOD module provided excellent characterization of core features and supportive features to differentiate DLB from AD and also characterize features of MCI-DLB.
ALZHEIMERS & DEMENTIA
(2021)
Article
Geriatrics & Gerontology
Paul C. Donaghy, Simon J. Cockell, Carmen Martin-Ruiz, Jonathan Coxhead, Joseph Kane, Daniel Erskine, David Koss, John-Paul Taylor, Christopher M. Morris, John T. O'Brien, Alan J. Thomas
Summary: This study identified multiple differentially expressed genes in MCI-LB/DLB and MCI-AD/AD. One of these differentially expressed genes, ANP32A, may be a prognostic marker in AD. Genes related to mitochondrial function were downregulated in MCI-LB/DLB.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Shannon Y. Chiu, Kathryn A. Wyman-Chick, Tanis J. Ferman, Ece Bayram, Samantha K. Holden, Parichita Choudhury, Melissa J. Armstrong
Summary: This review summarizes the current knowledge on sex differences in dementia with Lewy bodies (DLB) in terms of epidemiology, clinical features, neuropathology, biomarkers, disease progression, and caregiving. The prevalence of DLB in men is higher in many studies, but this finding is inconsistent. Women with DLB may experience more visual hallucinations, while men may have a higher frequency of REM sleep behavior disorder and parkinsonism. Women tend to be older, have greater cognitive impairment, and meet DLB criteria later than men. The impact of sex on DLB progression and the lack of research on sex differences in biomarkers and treatment are mixed. Women provide the majority of caregiving in DLB, but the effects of this on the caregiving experience are uncertain. Understanding sex differences will aid in developing sex-specific strategies in DLB.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Paul C. Donaghy, Gemma Roberts, Louise Allan, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
Summary: The study compared resting-state fMRI data of patients with mild cognitive impairment due to Lewy bodies and Alzheimer's disease, finding no significant differences between the mild cognitive impairment groups and controls. The fMRI analyses did not appear sensitive enough to detect early and subtle changes in brain function in these patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Umesh M. Venkatesan, Elena K. Festa, Brian R. Ott, William C. Heindel
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2018)
Article
Psychology, Clinical
Laura E. Korthauer, David P. Salmon, Elena K. Festa, Douglas Galasko, William C. Heindel
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2019)
Letter
Clinical Neurology
Seth A. Margolis, Elena K. Festa, George D. Papandonatos, Laura E. Korthauer, Meghan A. Gonsalves, Lindsay Oberman, William C. Heindel, Brian R. Ott
Article
Psychology, Clinical
Tatiana Karpouzian-Rogers, William C. Heindel, Brian R. Ott, Geoffrey Tremont, Elena K. Festa
Article
Psychology, Clinical
Umesh M. Venkatesan, Seth A. Margolis, Geoffrey Tremont, Elena K. Festa, William C. Heindel
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2020)
Article
Multidisciplinary Sciences
Nestor Matthews, Leslie Welch, Elena K. Festa, Anthony A. Bruno, Kendra Schafer
Article
Geriatrics & Gerontology
Leslie Y. Lai, Romy Fromer, Elena K. Festa, William C. Heindel
NEUROBIOLOGY OF AGING
(2020)
Article
Geriatrics & Gerontology
Mingjian He, William C. Heindel, Matthew R. Nassar, Elizabeth M. Siefert, Elena K. Festa
NEUROBIOLOGY OF AGING
(2020)
Article
Psychology, Clinical
Laura E. Korthauer, William C. Heindel, Leslie Y. Lai, Geoffrey Tremont, Brian R. Ott, Elena K. Festa
Article
Multidisciplinary Sciences
Nestor Matthews, Leslie Welch, Elena K. Festa, Anthony A. Bruno
Summary: Neurophysiological experiments have shown that there are both similarities and differences in the neural mechanisms and computational features underlying radial and rotational motion sensitivity. The study demonstrates a double dissociation between radial and rotational motion sensitivity, highlighting the independence of these two types of motion processing despite their shared neural and computational properties.
Article
Multidisciplinary Sciences
Tony S. L. Wang, Miles Martinez, Elena K. Festa, William C. Heindel, Joo-Hyun Song
Summary: This study investigated the interaction between age and cognitive load on motor skill acquisition. The results showed that older adults exhibited enhanced performance in the implicit learning stage, while young adults performed better in the explicit learning stage. Additionally, consistently performing a secondary task facilitated memory retrieval, regardless of age.
SCIENTIFIC REPORTS
(2022)
Meeting Abstract
Neurosciences
Brian Kavanaugh, Eric Tirrell, Nicole McLaughlin, Anna Sherman, Linda Carpenter, Elena Festa, Jennifer Grammer, Simona Temereanca Ibanescu, Lindsay Oberman, Diego Pizzagalli, Stephanie Parade, Ronald Seifer, Audrey Tyrka
BIOLOGICAL PSYCHIATRY
(2020)
Article
Psychology, Developmental
Andrew Lynn, Elena K. Festa, William C. Heindel, Dima Amso
JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY
(2020)
Article
Geriatrics & Gerontology
Jennifer D. Davis, Shuhang Wang, Elena K. Festa, Gang Luo, Mojtaba Moharrer, Justine Bernier, Brian R. Ott
Article
Neurosciences
Nestor Matthews, Leslie Welch, Elena Festa