Article
Biochemistry & Molecular Biology
Wentao Wang, Suying Hu, Jing Yang, Caijuan Zhang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang
Summary: This study identified a novel S20 R2R3-MYB regulator, SbMYB12, which positively regulates the biosynthesis of baicalin and wogonoside in Scutellaria baicalensis. These findings enhance our understanding of the transcriptional and regulatory mechanisms of baicalin biosynthesis and provide new insights for metabolic engineering in S. baicalensis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
Lin Cheng, Jingjing Yu, Lichao Zhang, Yanying Yao, Zhuo Sun, Mei Han, Yonggang Zhang, Limin Yang
Summary: In this study, the WRKY gene family in S. baicalensis was analyzed, revealing that SbWRKYs of the same subgroup have similar functions and highly conserved structural domains. The expression of SbWRKYs varies under different drought stress conditions. The expression of key enzyme genes affects the expression of SbWRKYs and has an impact on baicalin accumulation.
Article
Plant Sciences
Li Xiang, Yue Gao, Shiyu Chen, Jiayi Sun, Jiasi Wu, Xianli Meng
Summary: This review summarizes the pharmacological effects and molecular mechanisms of Scutellaria baicalensis in lung cancer therapy. Scutellaria baicalensis and its constituents exhibit multiple anti-cancer mechanisms against lung cancer and show high antitumor efficacy and safety in animal models.
Article
Integrative & Complementary Medicine
Peng Yu, Jingyang Li, Yanqing Luo, Jiayi Sun, Yingfan Hu, Bo Lin, Xianli Meng, Li Xiang
Summary: Breast cancer is a common and deadly malignancy in women. Traditional Chinese medicine, especially Scutellaria baicalensis, has shown promising activity against breast cancer through multiple mechanisms, including proliferation inhibition, apoptosis induction, and modulation of signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wentao Wang, Suying Hu, Caijuan Zhang, Jing Yang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang
Summary: R2R3-MYB transcription factors play important roles in various biological processes, particularly in the regulation of secondary metabolites. This study focused on the R2R3-MYB gene family in Scutellaria baicalensis and identified 95 genes. These genes were categorized into 34 subgroups based on their exon-intron structures and conserved motifs. The study also revealed that segmental duplications drove the evolution and expansion of the R2R3-MYB gene family. Additionally, the expression patterns of these genes varied in different tissues and under different conditions. Some genes exhibited specific expression profiles in response to hormone stimuli and abiotic stresses. Furthermore, certain genes were found to be localized in the nucleus and possessed transcriptional activation activity. This study provides a comprehensive understanding of the R2R3-MYB gene family in S. baicalensis and serves as a foundation for further investigation of their biological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Heping Hui, Weijun Gao
Summary: In this study, an arabinogalactoglucan SBP-1 was purified from Scutellaria baicalensis and its structure was characterized. SBP-1 showed antioxidant and hypoglycemic activities, indicating its potential therapeutic value.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Jun Wang, Shanshan Chen, Jizhou Zhang, Jiasi Wu
Summary: Autoimmune diseases are caused by lymphocytes self-tolerance failure. Scutellaria baicalensis Georgi and its bioactive contents have the potential to be used in the treatment of these diseases, but further research is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Xiaoqiang Chen, Yu Han, Tiefeng Zhou, Yang Liu, Ni Zhang, Jing Wang, Chunpeng Wang, Yayuan Luo, Zhengqi Wu, Yong Cheng, Yundong Shao
Summary: The O/W emulsions prepared using SBPC as an emulsifier showed smaller particle size and increased stability compared to emulsions with other emulsifiers. The emulsions exhibited tolerance to metal ions and thermal treatment, and also demonstrated antioxidant properties by inhibiting the polymerization of EGC, with an average retention rate of 88.28% on the 10th day. This research provides insights into the potential use of SBPC as an emulsifier in various applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Meng-Ying Cui, An-Rui Lu, Jian-Xu Li, Jie Liu, Yu-Min Fang, Tian-Lin Pei, Xin Zhong, Yu-Kun Wei, Yu Kong, Wen-Qing Qiu, Yong-Hong Hu, Jun Yang, Xiao-Ya Chen, Cathie Martin, Qing Zhao
Summary: The study found that methoxylated flavones have strong ability to induce apoptosis and enhance bioactivity, with methoxylation not causing side effects on healthy cells. Both type I and type II OMT enzymes are involved in the biosynthesis of methoxylated flavones in S. baicalensis.
PLANT BIOTECHNOLOGY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Guanghui Sun, Yongkang Dang, Yanke Lin, Wanying Zeng, Zongjian Wu, Xingwang Zhang, Dong Dong, Baojian Wu
Summary: The study reveals that Scutellaria baicalensis Georgi (SBG) can counteract skin aging by antagonizing REV-ERB alpha and increasing BMAL1 expression. This leads to reduced skin wrinkles, increased levels of antioxidant enzymes and collagen, and improved skin structure and function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Polymer Science
Jinshu Liu, Xiaoyan Ma, Wenzhao Shi, Jianwei Xing, Chaoqun Ma, Susong Li, Yayi Huang
Summary: The study demonstrated that PVA films incorporated with baicalin extract exhibit superior UV-blocking, optical, and antioxidant properties, while also reducing water vapor permeability and enhancing mechanical performance.
JOURNAL OF POLYMER ENGINEERING
(2021)
Article
Plant Sciences
Hyeon Ji Yeo, Chang Ha Park, Jae Kwang Kim, Ramaraj Sathasivam, Jae Cheol Jeong, Cha Young Kim, Sang Un Park
Summary: Plants adjust their nutrient balance by regulating primary and secondary metabolisms when exposed to stressful conditions; chilling stress can increase the concentrations of sugars, amino acids, salicylic acid, flavones, and phenolic acids in Scutellaria baicalensis roots.
Article
Chemistry, Analytical
Yaqian Zhou, Qianqian Xue, Miaomiao Wang, Liyan Mu, Danni Chen, Qiao Liu, Xun Liu, Wu Yin, Fangzhou Yin
Summary: This study established an integrated strategy of biosynthetic pathway - plant metabolomics - bioactivity evaluation to evaluate the quality differences between Scutellaria baicalensis (SG) and Scutellaria rehderiana (SD). The study found differences in chemical components between SG and SD, and identified chemical markers for quality analysis. Moreover, both SG and SD exhibited prominent anti-inflammatory activity, but SD was less effective.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Plant Sciences
Kajetan Grzelka, Adam Matkowski, Sylwester Slusarczyk
Summary: Scutellaria baicalensis Georgi is a valuable medicinal plant with high levels of flavones in its roots, which are responsible for its anti-inflammatory, antiviral, and antitumor activities. The variability in flavonoid content and composition can be influenced by factors such as electroporation, which can significantly impact plant growth and the content of flavonoids.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Defu Wang, Jiangran Wang, Yufen Wang, Dongzuo Yao, Yanbing Niu
Summary: This study investigated the metabolic and transcriptional profiles of Scutellaria baicalensis in response to flower coloration, providing insights into the anthocyanin synthesis pathway and differentially expressed candidate genes involved in flower color formation. The results suggested that anthocyanin accumulation in S. baicalensis flowers is closely related to the expression of key genes such as SbDFR and Sb3GT, as well as transcription factors WRKY, bHLH, and NAC.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
Sean A. Bloszies, S. Chris Reberg-Horton, Joshua L. Heitman, Alex L. Woodley, Julie M. Grossman, Shuijin Hu
Summary: Cover crops and termination methods have different effects on soil microbes, soil aggregates, and C and N pools. The quantity and quality of biomass of different cover crops dominated the effects on labile C.
Article
Ecology
Fuwei Wang, Zhen Li, Fanglong Su, Hui Guo, Peng Wang, Jiuxin Guo, Weixing Zhu, Yi Wang, Shuijin Hu
Summary: Nitrogen inputs, not warming, altered bacterial community structure. Verrucomicrobia and Chloroflexi were sensitive to warming, while Saccharibacteria, Bacteroidetes and Actinobacteria responded mainly to nitrogen input. Both warming and nitrogen input increased microbial metabolic quotients, with warming significantly impacting soil microbial CLPPs through specific carbon sources like L-cysteine, oxalic acid, oxoglutaric acid and aminobutyric acid.
Article
Environmental Sciences
Chenglong Ye, Wenjuan Huang, Steven J. Hall, Shuijin Hu
Summary: Soil pH is the primary factor controlling the abundance of Fe-associated C globally, mainly by influencing the binding of C with Fe minerals. Fe-associated C shows a significant increase when soil pH decreases from 4.2 to 3.5, while the change is small when pH > 4.2.
GLOBAL BIOGEOCHEMICAL CYCLES
(2022)
Article
Plant Sciences
Lingyan Hu, Jiuma Sai, Jin Guo, Hui Guo, Xianhui Zhou, Shuijin Hu, Peng Wang
Summary: This study investigated the effects of an actinorhizal shrub species on the nitrogen status of soil and other plants in an alpine meadow ecosystem. The results showed that the shrub had a minor facilitation effect on the soil and neighboring plants through its nitrogen-rich leaf litter, but this effect was not enough to offset the negative impact caused by competition for resources.
Article
Agronomy
Pei Zhang, Weijian Zhang, Shuijin Hu
Summary: The experimental findings suggest that the fungivorous nematode Aphelenchus avenae and collembola Hypogastrura perplexa can enhance the activity of soil microbes and reduce the incidence of damping-off disease in tomato caused by Pythium ultimum. Therefore, effective management of soil fauna is recommended for controlling root pathogens and maintaining tomato health in organic farming systems.
Article
Plant Sciences
Xuebin Yan, Mayank Kohli, Yue Wen, Xiaoyi Wang, Yuanyuan Zhang, Fei Yang, Xianhui Zhou, Guozhen Du, Shuijin Hu, Hui Guo
Summary: Foliar fungal pathogens can reduce plant biomass and their effects can be influenced by environmental conditions. We conducted a 4-year field experiment in a Tibetan alpine meadow to examine the interactive effects of nitrogen addition, warming, and foliar pathogens on plant biomass. Our results showed that nitrogen addition weakened the positive nitrogen effect on plant biomass due to the suppression of plant community biomass by foliar fungal pathogens. Furthermore, changes in plant functional traits and reduced species richness amplified the pathogen effect under nitrogen addition.
JOURNAL OF ECOLOGY
(2023)
Article
Geosciences, Multidisciplinary
Yu Wang, Yuanyuan Huang, Lian Song, Jiahui Yuan, Wei Li, Yongguan Zhu, Scott X. Chang, Yiqi Luo, Philippe Ciais, Josep Penuelas, Julie Wolf, Barbara J. Cade-Menun, Shuijin Hu, Lei Wang, Dengjun Wang, Zengwei Yuan, Yujun Wang, Jishuang Zhang, Ye Tao, Shenqiang Wang, Gang Liu, Xiaoyuan Yan, Chunwu Zhu
Summary: Long-term free air carbon dioxide enrichment experiments on rice plants show that plant-available phosphorus declines in paddy soils as atmospheric CO2 increases. The decline in phosphorus concentration is attributed to the production of soil organic phosphorus that is not readily available to plants, as well as increased loss through crop harvest. These findings suggest that future CO2 scenarios may lead to reduced rice yields, particularly in low-income countries, unless additional phosphorus fertilizers are applied.
Article
Multidisciplinary Sciences
Meifeng Deng, Shuijin Hu, Lulu Guo, Lin Jiang, Yuanyuan Huang, Bernhard Schmid, Chao Liu, Pengfei Chang, Shan Li, Xiaojuan Liu, Keping Ma, Lingli Liu
Summary: Mycorrhizae are symbiotic associations between terrestrial plants and fungi. The type of mycorrhizae critically controls the effect of diversity on productivity. AM trees increase productivity with increasing diversity, while EcM trees decrease productivity. This is because AM trees are more effective in acquiring nitrogen and phosphorus.
Article
Soil Science
Chenglong Ye, Bin Wu, Tongshuo Bai, Xianhui Zhou, Hui Guo, Guozhen Du, Shuijin Hu
Summary: Soils in alpine ecosystems store a large amount of organic carbon, with a significant portion sorbed to reactive soil minerals. This study examined the effects of air warming, nitrogen input, and precipitation changes on calcium- and iron-associated carbon dynamics in a Tibetan alpine meadow. The results showed that high rainfall significantly increased the concentrations of calcium- and iron-associated carbon, likely due to increased soil moisture and the promotion of their formation through Ca-binding to clay surfaces or increased solubility of Fe oxides.
Article
Biodiversity Conservation
Kangcheng Zhang, Yunpeng Qiu, Yunfeng Zhao, Shuhong Wang, Jun Deng, Mengfei Chen, Xinyu Xu, Hao Wang, Tongshuo Bai, Tangqing He, Yi Zhang, Huaihai Chen, Yi Wang, Shuijin Hu
Summary: The study investigated the effects of precipitation reduction on soil N2O and CO2 emissions in a semi-arid grassland. The results showed that precipitation reduction stimulated N-cycling processes and increased soil N2O and CO2 emissions, particularly after rainfall events. The findings suggest that future changes in precipitation patterns may enhance N cycling processes and soil N2O emissions in semi-arid ecosystems.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Biodiversity Conservation
Chenchao Xu, Naifang Zhang, Kaihang Zhang, Shuyao Li, Qing Xia, Jing Xiao, Maojun Liang, Weilei Lei, Junpan He, Gaiping Chen, Chengjun Ge, Xunhua Zheng, Jianguo Zhu, Shuijin Hu, Roger T. T. Koide, Mary K. K. Firestone, Lei Cheng
Summary: Continued emissions of CO2 and CH4 will significantly increase global atmospheric CO2 and CH4 concentrations and surface temperature. Paddy rice fields account for about 9% of anthropogenic CH4 sources, and elevated CO2 may enhance CH4 production in rice paddies. This study reveals that elevated CO2 promotes anaerobic oxidation of methane coupled to manganese and/or iron oxides reduction in paddy soil, as well as stimulates the growth and metabolism of Candidatus Methanoperedens nitroreducens, contributing to enhanced CH4 consumption.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Biodiversity Conservation
Tongshuo Bai, Peng Wang, Yunpeng Qiu, Yi Zhang, Shuijin Hu
Summary: Global climate warming has no significant effect on soil carbon (C) stock, but it can increase root biomass and soil respiration, depending on soil nitrogen (N) availability. The availability of soil C to N critically mediates warming effects on soil C dynamics, and incorporating this into C-climate models may improve the prediction of soil C cycling under future global warming scenarios.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Soil Science
Mu Su, Jiajie Mei, Gilberto de Oliveira Mendes, Da Tian, Limin Zhou, Shuijin Hu, Zhen Li
Summary: Red soils in subtropical regions are often deficient in available phosphorus, which is essential for plant growth. Phosphate-solubilizing microorganisms (PSMs) can release phosphorus from phosphate reservoirs, but their interactions with minerals in red soils are not fully understood. This study investigated the effects of Aspergillus niger, a phosphate-solubilizing fungus, on phosphorus dissolution in acidic and alkaline red soils. In the acidic soil, A. niger promoted phosphorus release and decreased the content of Fe/Al oxides. In the alkaline soil, phosphorus availability declined after A. niger addition due to the diminished function of PSMs and strong soil buffering.
SOIL USE AND MANAGEMENT
(2023)
Review
Multidisciplinary Sciences
Lingli Liu, Emma J. Sayer, Meifeng Deng, Ping Li, Weixing Liu, Xin Wang, Sen Yang, Junsheng Huang, Jie Luo, Yanjun Su, Jose M. Grunzweig, Lin Jiang, Shuijin Hu, Shilong Piao
Summary: Grassland, despite being one of the largest terrestrial biomes, is facing degradation and desertification due to global climate change and land-use intensification. The carbon cycle in grasslands plays a crucial role in maintaining ecosystem services, and its processes are influenced by abiotic factors such as soil inorganic C accumulation, photodegradation, thermal degradation, and wind erosion. Climate and land-use changes further affect the grassland carbon balance by modifying water budget, nutrient cycling, and plant and soil processes. It is important to prioritize research on abiotic processes, improve monitoring techniques, and select suitable plant species to develop sustainable grassland restoration strategies in a changing climate.
FUNDAMENTAL RESEARCH
(2023)
Article
Biodiversity Conservation
Huan Li, Guang-Hui Yu, Liping Hao, Yunpeng Qiu, Shuijin Hu
Summary: Soil organic carbon is crucial for sustaining terrestrial productivity and climate stability. Arbuscular mycorrhizal fungi (AMF) play a critical role in modulating soil carbon dynamics. However, it is still unknown how AMF-root associations interact with soil minerals to affect soil carbon cycling.
GLOBAL CHANGE BIOLOGY
(2023)