期刊
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
卷 41, 期 9, 页码 1360-1364出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10870-011-0104-9
关键词
Secnidazole derivative; Single crystal structure; Anti-urease activity
资金
- National Natural Science Foundation of China [30772627]
- Province Natural Science Foundation of Jiang Su [09KJD150005]
A secnidazole derivative, 1-(2-chloropropyl)-2-methyl-5-nitro-1H-imidazole (1), was synthesized and its single crystals were successfully grown in the mixture of ethanol/chloroform (3:1) by slow evaporation at room temperature. Its structure was confirmed by (1)H NMR, (13)C NMR, mass spectra, elemental analyses and X-ray single crystal diffraction. Crystal structure analysis revealed that 1 crystallized in the triclinic, space group P (1) over bar with the following unit cell parameters: a = 6.5339(7) angstrom, b = 7.5487(8) angstrom, c = 9.7238(10) angstrom, alpha = 92.894 degrees(2), beta = 96.165(2)degrees, gamma = 102.710 degrees(2), V = 463.78(8) angstrom(3), Z = 2. Furthermore, this compound exhibited better anti-urease activity than secnidazole and acetyl-hydroxy acid when evaluated for antimicrobial activity against Helicobacter pylori.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据