Article
Multidisciplinary Sciences
Hongxiao Sun, Changying Liu, Xu Zhang, Panpan Liu, Zhanhui Du, Gang Luo, Silin Pan
Summary: By using bioinformatics analysis, we identified abnormal methylated differentially expressed genes in Ka-wasaki disease and established a random forest diagnostic model. We identified 6 hub genes which improved our understanding of the molecular mechanism of KD. The constructed model can be used for accurate diagnosis and provide evidence for clinical diagnosis.
Article
Biochemical Research Methods
Enfa Zhao, Hang Xie, Yushun Zhang
Summary: Idiopathic pulmonary arterial hypertension (IPAH) is a fatal cardiovascular disease with significant morbidity and mortality. In this study, differentially expressed genes (DEGs) were identified in individuals with IPAH and normal controls, revealing potential key genes and pathways involved in the pathogenesis of IPAH. Hub genes such as TLR7, JUN, and CXCR4 showed high diagnostic value in discriminating IPAH from normal individuals, suggesting they may serve as novel biomarkers for IPAH diagnosis.
JOURNAL OF COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Md. Al Mehedi Hasan, Md. Maniruzzaman, Jungpil Shin
Summary: This study used statistical and machine learning methods to identify key candidate genes for hepatocellular carcinoma (HCC), the most common lethal malignancy of the liver. By analyzing gene expression profile datasets, differentially expressed genes (DEGs) were identified and support vector machine (SVM) was used to determine differentially expressed discriminative genes (DEDGs). Enrichment analysis and protein-protein interaction (PPI) network construction were performed to select central hub genes, and six key candidate genes were determined by intersecting shared genes among central hub genes, hub module genes, and significant meta-hub genes. Validation and prognostic potential evaluation were conducted on independent test datasets.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Basdeo Kushwaha, Neha Srivastava, Murali S. Kumar, Ravindra Kumar
Summary: This study aimed to understand the interaction of the brain-gonad system in Clarias magur reproduction by analyzing differentially expressed genes (DEG). Thirteen key genes in female brain & ovary and twelve key genes in male brain & testis were identified based on network analysis. Functional annotation revealed their involvement in important reproduction-related pathways. This study provides insights into the interaction between the brain and gonads in the regulation of Clarias magur reproduction through a protein-protein interaction network.
Article
Nanoscience & Nanotechnology
Shuang Luo, Lu Gan, Yiqun Luo, Zhikun Zhang, Lan Li, Huixue Wang, Tong Li, Qiaoying Chen, Yong Huang, Jian He, Liping Zhong, Xiuli Liu, Pan Wu, Yong Wang, Yongxiang Zhao, Zhenghan Zhang
Summary: Analyzing hub genes related to tumorigenesis using big data has become a hot topic in biomedicine. In this study, a total of 603 DEGs were identified from expression profiles of HCC and normal tissue obtained from the GEO database. PPI networks were constructed and 5 hub genes were identified and used to construct a prognostic model for HCC.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rui Zhong, Xujuan Luo, Jin Xu, Xin Jiang, Yongfeng Yan, Xiaomin Shi, Yan Peng, Xiaowei Tang, Xiangsheng Fu
Summary: This study investigates differentially expressed genes in acute pancreatitis (AP) and identifies CDH1 and VCL as potential key genes regulated by MAZ in AP.
Article
Immunology
Yiqi Wang, Yahan Ju, Jiajing Wang, Na Sun, Zhimin Tang, Huiqin Gao, Ping Gu, Jing Ji
Summary: Six immune hub genes identified through bioinformatics analysis may play important roles in the occurrence and development of VKH disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Defeng Pan, Yufei Zhou, Shengjue Xiao, Yue Hu, Chunyan Huan, Qi Wu, Xiaotong Wang, Qinyuan Pan, Jie Liu, Hong Zhu
Summary: This study aimed to explore the molecular mechanisms of atrial fibrillation (AF) and identified several key genes and pathways involved in AF pathogenesis. The results indicated that macrophage migration inhibitory factor (MIF), MYC proto-oncogene, bHLH transcription factor (MYC), and inhibitor of differentiation 1 (ID1) may participate in the progression of AF through the TGF-beta and Hippo signaling pathways.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Genetics & Heredity
Weitao Hu, Taiyong Fang, Xiaoqing Chen
Summary: This study identified DEGs associated with ulcerative colitis (UC) using bioinformatics analysis, providing potential diagnostic and therapeutic targets. The DEGs, hub genes and miRNAs identified may serve as biomarkers for UC, but further research is needed to understand their biological roles in the disease.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Faisal A. Alzahrani, Mohd Faheem Khan, Varish Ahmad
Summary: In this study, differentially expressed genes associated with COVID-19 in glioblastoma (GBM) were identified using gene expression data and bioinformatics methods. Potential therapeutic drugs were also predicted. The study found that these genes are involved in pathways related to viral infection, immune system, and neuronal system, providing important clues for understanding the common mechanisms of GBM and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Min Li, Yongli Han, Shuying Wang, Yajie Yu, Mengling Liu, Yingfeng Xia, Ze'an Weng, Ling Zhou, Xiaoyan He, Jun Wang, Zhi He, Liang Yu, Yunhong Zha
Summary: This study provides insights into the clinical manifestations and genetic mutations of Becker muscular dystrophy (BMD), as well as potential therapeutic targets identified through gene ontology analysis. The involvement of TUBA1A in BMD/Duchenne muscular dystrophy (DMD) development is reported for the first time, shedding light on the progression mechanism and offering new opportunities for treatment.
NEUROLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Jian Zhou, Dazhi Zou, Rongjun Wan, Jie Liu, Qiong Zhou, Zhen Zhou, Wanchun Wang, Cheng Tao, Tang Liu
Summary: This study investigates the molecular mechanisms and hub genes associated with osteoarthritis (OA) using bioinformatics analysis. Differential gene expression analysis and GO/KEGG pathway analysis were performed on OA synovial tissue samples. Various upregulated and downregulated genes were identified, with upregulated genes involved in immune response and cell adhesion, and downregulated genes enriched in response to mechanical stimuli and the MAPK signaling pathway. Several intersection genes and hub genes were also identified. These findings provide insights into the molecular mechanisms of OA and may contribute to the development of biomarkers and drug targets.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Lin Chen, Yong Wang, Juan Huang, Binbin Hu, Wei Huang
Summary: This study identified four hub genes (SLC18A2, L1CAM, S100A12, and CXCR4) and seven immune cell types (neutrophils, T follicular helper cells, myeloid-derived suppressor cells, type 1 helper cells, immature B cells, immature dendritic cells, and CD56 bright natural killer cells) associated with the pathogenesis of PD. The combined model of the four genes showed a high accuracy in differentiating PD patients from healthy controls.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Aoqierbatu, Aqilatu Luo, Yuting Shi, Yuyan Na, Ya Tuo
Summary: This study identified genes and pathways associated with damaged knee cartilage tissues using microarray analysis, revealing hub genes and pathways strongly linked to cartilage injury. These findings offer new insights into potential pathological mechanisms and therapeutic strategies for cartilage injury.
Article
Genetics & Heredity
Cong Xiao, Tiantian Sun, Zhuliang Yang, Wenwen Xu, Juan Wang, Linghu Zeng, Jixian Deng, Xiurong Yang
Summary: The study on fat deposition in Nandan-Yao chicken using RNA sequencing identified multiple differentially expressed genes involved in regulation of fat deposition, growth development, and signaling pathways. Some genes showed differential expression in all tissues, with PCK1 potentially being a key gene in this process.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2021)
