期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 35, 期 1, 页码 6-10出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2014.175
关键词
brain ischemia; inflammation; microcirculation; T cells; thrombosis
资金
- Deutsche Forschungsgemeinschaft [KL2323/6-1, WI1722/8-1, SFB 688]
While the detrimental role of non-regulatory T cells in ischemic stroke is meanwhile unequivocally recognized, there are controversies about the properties of regulatory T cells (T-reg). The aim of this study was to elucidate the role of T-reg by applying superagonistic anti-CD28 antibody expansion of Treg. Stroke outcome, thrombus formation, and brain-infiltrating cells were determined on day 1 after transient middle cerebral artery occlusion. Antibody-mediated expansion of T-reg enhanced stroke size and worsened functional outcome. Mechanistically, T-reg increased thrombus formation in the cerebral microvasculature. These findings confirm that T-reg promote thrombo-inflammatory lesion growth during the acute stage of ischemic stroke.
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