期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 34, 期 9, 页码 1440-1443出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2014.114
关键词
aging; energy metabolism; mitochondria; neurophysiology; MR spectroscopy
资金
- NIH [K01AG040164, P30 NS-052519, R01 MH-067528, R01 AG 034953]
- American Federation for Aging Research grant [A12474]
Caloric restriction (CR) prolongs lifespan and retards many detrimental effects of aging, but its effect on brain mitochondrial function and neuronal activity-especially in healthy aging-remains unexplored. Here we measured rates of neuronal glucose oxidation and glutamate-glutamine neurotransmitter cycling in young control, old control (i.e., healthy aging), and old CR rats using in vivo nuclear magnetic resonance spectroscopy. We found that, compared with the young control, neuronal energy production and neurotransmission rates were significantly reduced in healthy aging, but were preserved in old CR rats. The results suggest that CR mitigated the age-related deceleration of brain physiology.
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