期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 34, 期 3, 页码 380-388出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2013.214
关键词
cerebral blood flow; cerebral hemodynannics; diffuse optics; MRI; near-infrared spectroscopy; neonatal ischemia
资金
- National Institutes of Health [R21 HL088182, RO1 NS072338, K23 NS052380, R01 NS060653, P41 EB015893, T32NS007413]
- Dana Foundation
- Steve and Judy Wolfson Family Trust
Neonatal congenital heart disease (CHD) is associated with altered cerebral hemodynamics and increased risk of brain injury. Two novel noninvasive techniques, magnetic resonance imaging (MRI) and diffuse optical and correlation spectroscopies (diffuse optical spectroscopy (DOS), diffuse correlation spectroscopy (DCS)), were employed to quantify cerebral blood flow (CBF) and oxygen metabolism (CMRO2) of 32 anesthetized CHD neonates at rest and during hypercapnia. Cerebral venous oxygen saturation (SO2) and CBF were measured simultaneously with MRI in the superior sagittal sinus, yielding global oxygen extraction fraction (OEF) and global CMRO2 in physiologic units. In addition, microvascular tissue oxygenation (StO(2)) and indices of microvascular CBF (BFI) and CMRO2 (CMR021) in the frontal cortex were determined by DOS/DCS. Median resting-state MRI-measured OEF, CBF, and CMRO2 were 0.38, 9.7 mUminute per 100 g and 0.52 mL 02/minute per 100 g, respectively. These CBF and CMRO2 values are lower than literature reports for healthy term neonates (which are sparse and quantified using different methods) and resemble values reported for premature infants. Comparison of MRI measurements of global 5 +/- 02, CBF, and CMRO2 with corresponding local DOS/DCS measurements demonstrated strong linear correlations (R-2=0.69, 0.67, 0.67; P < 0.001), permitting calibration of DOS/DCS indices. The results suggest that MRI and optics offer new tools to evaluate cerebral hemodynamics and metabolism in CHD neonates.
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