期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 33, 期 6, 页码 826-833出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2013.24
关键词
Alzheimer's disease; amyloid; arterial spin-labeling MRI; blood flow; brain injury; statin
资金
- NIH [P50 NS30318]
- National Institutes of Health [P41-EB001977]
Traumatic brain injury (TBI) is an environmental risk factor for Alzheimer's disease (AD). Increased brain concentrations of amyloid-beta (A beta) peptides and impaired cerebral blood flow (CBF) are shared pathologic features of TBI and AD and promising therapeutic targets. We used arterial spin-labeling magnetic resonance imaging to examine if CBF changes after TBI are influenced by human A beta and amenable to simvastatin therapy. CBF was measured 3 days and 3 weeks after controlled cortical impact (CCI) injury in transgenic human A beta-expressing APP(NLh/NLh) mice compared to murine A beta-expressing C57Bl/6J wild types. Compared to uninjured littermates, CBF was reduced in the cortex of the injured hemisphere in both A beta transgenics and wild types; deficits were more pronounced in the transgenic group, which exhibited injury-induced increased concentrations of human A beta. In the hemisphere contralateral to CCI, CBF levels were stable in A beta transgenic mice but increased in wild-type mice, both relative to uninjured littermates. Post-injury treatment of A beta transgenic mice with simvastatin lowered brain A beta concentrations, attenuated deficits in CBF ipsilateral to injury, restored hyperemia contralateral to injury, and reduced brain tissue loss. Future studies examining long-term effects of simvastatin therapy on CBF and chronic neurodegenerative changes after TBI are warranted.
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