Review
Pharmacology & Pharmacy
Li Zhang, Yue Liu, Haiyan Huang, Hui Xie, Baozhu Zhang, Wujiong Xia, Bing Guo
Summary: Malignant brain tumors are a group of tumors with high invasiveness and destructiveness, and near-infrared optical imaging techniques show potential in the diagnosis and treatment of brain tumors due to their noninvasiveness, high resolution, and large penetration depth.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Susmita Bhattarai, Sudha Sharma, Utsab Subedi, Hosne Ara, Alika Shum, Murov Milena, Md Shenuarin Bhuiyan, Srivatsan Kidambi, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Endothelial permeability is a major issue that needs to be addressed in stroke treatment. Understanding the mechanisms behind blood-brain barrier disruption and managing the hypoxic stress-induced permeability of the endothelium after reperfusion are crucial for stroke management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Feng Liu, Biao Huang, Tao Tang, Fanjie Wang, Ran Cui, Mingxi Zhang, Taolei Sun
Summary: Researchers developed a fluorescent nanozyme by doping Mn atoms into PbS/CdS quantum dots, which showed excellent antioxidant activity and could effectively scavenge ROS, thus providing neuroprotective effects for traumatic brain injury treatment. Additionally, the nanozyme exhibited exceptional NIR-IIb fluorescence performance, allowing for dynamic monitoring of the blood-brain barrier status to guide precise treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Sanvito, Catalina Raymond, Nicholas S. Cho, Jingwen Yao, Akifumi Hagiwara, Joey Orpilla, Linda M. Liau, Richard G. Everson, Phioanh L. Nghiemphu, Albert Lai, Robert Prins, Noriko Salamon, Timothy F. Cloughesy, Benjamin M. Ellingson
Summary: Dynamic SAGE-EPI allows for simultaneous quantification of brain tumor perfusion and permeability, as well as mapping of novel metrics related to cytoarchitecture and blood-brain barrier disruption.
EUROPEAN RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianglong Kong, Rui Zou, Ga-Lai Law, Yi Wang
Summary: In this study, a NIR PL nanoparticle TRZD was synthesized, which exhibited excellent rechargeable NIR PL in vivo and could be used for long-term autofluorescence-free imaging. TRZD could inhibit the tumor growth of glioma models and provide a promising multifunctional nanoparticle for theranostics of brain diseases.
Article
Chemistry, Multidisciplinary
Jianglong Kong, Yuting Sun, Xiaohan Ge, Meiru Mao, Hongrui Yu, Yi Wang
Summary: This study develops a dual-function near-infrared persistent luminescence nanoparticle, CUDZG, which enables long-lasting autofluorescence-free imaging of GBM and suppresses tumor growth. It offers a promising blood-brain penetrable drug carrier for precise diagnosis and therapy of central nervous system diseases.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Susmita Bhattarai, Sudha Sharma, Hosne Ara, Utsab Subedi, Grace Sun, Chun Li, Md Shenuarin Bhuiyan, Christopher Kevil, William P. Armstrong, Miles T. Minvielle, Sumitra Miriyala, Manikandan Panchatcharam
Summary: The autotaxin/LPA axis plays a crucial role in regulating blood-brain barrier integrity and mitochondrial function after ischemic stroke. Inhibitors of autotaxin or autotaxin/LPA receptor can effectively protect the blood-brain barrier and mitochondrial function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Felix C. Ng, Leonid Churilov, Nawaf Yassi, Timothy J. Kleinig, Vincent Thijs, Teddy Y. Wu, Darshan G. Shah, Helen M. Dewey, Gargan Sharma, Patricia M. Desmond, Bernard Yan, Mark W. Parsons, Geoffrey A. Donnan, Stephen M. Davis, Peter J. Mitchell, Richard Leigh, Bruce C. Campbell
Summary: This study investigates the relationship between BBB integrity, cerebral blood flow, and cerebral edema in patients who received acute reperfusion therapy. The results show that increased BBB permeability and reduced cerebral blood flow are significantly associated with cerebral edema.
Review
Radiology, Nuclear Medicine & Medical Imaging
Elles P. Elschot, Walter H. Backes, Alida A. Postma, Robert J. van Oostenbrugge, Julie Staals, Rob P. W. Rouhl, Jacobus F. A. Jansen
Summary: The blood-brain barrier (BBB) is crucial for maintaining homeostasis within the brain and is increasingly associated with various neurological diseases. MRI techniques, such as dynamic contrast-enhanced and dynamic susceptibility contrast MRI, are commonly used for noninvasive assessment of BBB integrity. Other alternative techniques targeting different aspects of the BBB, such as using endogenous markers like water and glucose, are also available. A comprehensive overview of current MRI techniques to assess BBB condition and potential applications in disease is provided, with discussions on improvements needed for clinical applicability.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom Finck, Jens Gempt, Claus Zimmer, Jan S. Kirschke, Nico Sollmann
Summary: The study suggests that CE BB imaging can significantly improve the delineation of therapy-naive HGGs compared to traditional TFE imaging, indicating a potential supplementary role for CE BB sequences in MRI protocols for brain tumors.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hye-Youn Jung, Boram Kim, Min Ho Jeon, Yoonkyung Kim
Summary: Fluorescence imaging is an indispensable tool in modern biological research, but it is limited by autofluorescence, light scattering, and limited penetration depth of light in living systems. This study prepares a water-soluble and safe fluorescence photoswitch for near-infrared imaging in living systems.
Article
Radiology, Nuclear Medicine & Medical Imaging
Heera Yoen, Roh Eul Yoo, Seung Hong Choi, Eunkyung Kim, Byung-Mo Oh, Dongjin Yang, Inpyeong Hwang, Koung Mi Kang, Tae Jin Yun, Ji Hoon Kim, Chul-Ho Sohn
Summary: Using dynamic contrast-enhanced magnetic resonance imaging and automatic whole brain segmentation, this study found increased Ktrans values and decreased vp values in mTBI patients, indicating disruption of the blood-brain barrier.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Review
Chemistry, Physical
Tao Tang, Baisong Chang, Mingxi Zhang, Taolei Sun
Summary: Gliomas are the most common primary brain tumors in adults, and the difficulty in accurately imaging and determining the malignancy grade of gliomas has significant impact on diagnostic accuracy and subsequent surgery or therapy. The rapid development of emerging nanoprobes provides a promising opportunity for the precise imaging and therapy of gliomas, enabling efficient crossing of the blood-brain barrier and targeted treatment. Challenges and future directions in nanoprobe-based diagnosis and treatment of gliomas are also discussed.
NANOSCALE HORIZONS
(2021)
Article
Immunology
Nuria Villalba, Yonggang Ma, Sarah A. Gahan, Aurelie Joly-Amado, Sam Spence, Xiaoyuan Yang, Kevin R. Nash, Sarah Y. Yuan
Summary: This study investigated the effects of lung infection on blood-brain barrier disruption and behavioral changes, and found that systemic bacterial infection may contribute to lung-brain axis inflammatory response through cytokine release.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
