期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 31, 期 1, 页码 41-46出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2010.186
关键词
basal ganglia; deep brain stimulation; default-mode network; Huntington's disease; positron emission tomography
资金
- FRS-FNRS (Belgium)
- PHRC (France) [2004/R1905]
- Adrinord (Association pour le Developpement de la Recherche et de l'Innovation dans le NORD PAS DE CALAIS)
Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 41-46; doi:10.1038/jcbfm.2010.186; published online 20 October 2010
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