Article
Cardiac & Cardiovascular Systems
Jiyu Li, Chun Li, Ethyn G. Loreno, Sumitra Miriyala, Manikandan Panchatcharam, Xiaohong Lu, Hong Sun
Summary: Chronic low-dose alcohol consumption promotes cerebral angiogenesis and increases vessel density and branches, while high-concentration alcohol has a mild inhibitory effect on angiogenic capability and cerebral angiogenesis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Vanessa Coelho-Santos, Andree-Anne Berthiaume, Sharon Ornelas, Heidi Stuhlmann, Andy Y. Shih
Summary: The study reveals that brain capillary networks originate exclusively from cortical ascending venules, with early, long-range sprouts connecting venules to upstream arteriolar input, establishing the backbone of the capillary bed, and short-range sprouts contributing to expansion of anastomotic connectivity within the capillary bed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Askiel Bruno, Nina Paletta, Uttam Verma, Monika E. Grabowska, Heather M. Haughey, Prem P. Batchala, Solomon Abay, Joseph Donahue, John Vender, Sankara Sethuraman, Fenwick T. Nichols
Summary: The study analyzed clinical factors and CT measurements in patients with DC for MHI and found that patient age and post-DC midline shift may be predictors of functional outcome after DC for MHI.
WORLD NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Hung Chuang, Yi-Chin Lin, Jung Yang, Shu-Ting Chan, Shu-Lan Yeh
Summary: The present study investigated the effects of quercetin on cisplatin-induced myelosuppression and found that quercetin could attenuate myelosuppression by regulating hematopoietic growth factors and inhibitory factors.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Endocrinology & Metabolism
Xavier O. Scott, Stephanie H. Chen, Roey Hadad, Dileep Yavagal, Eric C. Peterson, Robert M. Starke, W. Dalton Dietrich, Robert W. Keane, Juan Pablo de Rivero Vaccari
Summary: In this study, the differential expression of angiogenic and inflammatory factors in thrombi, cerebral plasma, and peripheral plasma of stroke patients was evaluated. The results showed that these factors varied significantly in different compartments, highlighting the importance of identifying new biomarkers for the diagnosis and treatment of stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Christina M. Termini, Amara Pang, Tiancheng Fang, Martina Roos, Vivian Y. Chang, Yurun Zhang, Nicollette J. Setiawan, Lia Signaevskaia, Michelle Li, Mindy M. Kim, Orel Tabibi, Paulina K. Lin, Joshua P. Sasine, Avradip Chatterjee, Ramachandran Murali, Heather A. Himburg, John P. Chute
Summary: Ionizing radiation and chemotherapy deplete hematopoietic stem cells and damage the vascular niche, leading to the secretion of SEMA3A from bone marrow endothelial cells. Inhibition of NRP1 promotes vascular and hematopoietic regeneration through increased expression of R spondin 2, suggesting a potential therapeutic target for improving hematopoietic recovery after myeloablation.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Esteban Ortiz-Prado, Simone Pierina Cordovez, Eduardo Vasconez, Gines Viscor, Paul Roderick
Summary: This review provides an overview of the association between long-term high-altitude exposure and ischemic stroke. Some studies suggest that living at high altitudes may increase the risk of stroke, while others suggest that altitude may act as a protective factor. The most robust studies indicate that prolonged living at higher altitudes reduces the risk of developing stroke and improves survival profiles, possibly due to increased irrigation. However, residing above 3500 m seems to be associated with an increased risk of stroke, possibly related to polycythemia and increased blood viscosity.
Article
Immunology
Justin N. Nguyen, Eric C. Mohan, Gargee Pandya, Uzma Ali, Chunfeng Tan, Julia K. Kofler, Linda Shapiro, Sean P. Marrelli, Anjali Chauhan
Summary: CD13 is involved in the migration of monocytes and neutrophils after stroke, and acutely, it leads to decreased infarct size and improved behavioral outcomes. However, loss of CD13 reduces post-stroke angiogenesis by reducing CXCL12/CXCR4 signaling.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Critical Care Medicine
Quoc Bui, Atul Kumar, Yasheng Chen, Ali Hamzehloo, Laura Heitsch, Agnieszka Slowik, Daniel Strbian, Jin-Moo Lee, Rajat Dhar
Summary: For patients with stroke, quantitative imaging biomarkers can be used to measure the severity of cerebral edema, including evaluating volumetric biomarkers such as cerebrospinal fluid displacement, which helps in early detection of cerebral edema and identification of relevant mediators.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Adnan Ghori, Vincent Prinz, Melina Nieminen-Kehla, Simon H. Bayerl, Irina Kremenetskaia, Jana Riecke, Hanna Krechel, Thomas Broggini, Lea Scherschinski, Tamar Licht, Eli Keshet, Peter Vajkoczy
Summary: The breakdown of the blood-brain barrier (BBB) is a critical event in the development of secondary brain injury after stroke. VEGF plays a vital role in repairing blood vessel integrity and stabilizing the BBB. The study suggests that VEGF-based therapy has the potential for stroke prevention and recovery.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Zhang, Weiqiang Dou, Shu Jiang, Dong Dong, Xinyi Wang
Summary: This study investigated the feasibility of using 3D isotropic high-resolution T1w-CUBE imaging to detect and measure intraluminal thrombus in stroke patients. The results showed that T1w-CUBE imaging had higher clinical efficacy in thrombus diagnosis and measurement compared to SWI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Clinical Neurology
Zhengwu Zhang, Jennifer S. Gewandter, Paul Geha
Summary: The prevalence of chronic pain has become an epidemic, and this manuscript provides evidence that the understanding of the role of the brain in chronic pain is about to change. The focus is on the concept of learning in chronic pain emergence and the latest brain imaging findings.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Wei Shang, Xin Zhao, Fan Yang, Dongyi Wang, Le Lu, Zihan Xu, Zhiming Zhao, Hui Cai, Junyi Shen
Summary: Nanomaterial drugs have advantages in improving the solubility, bioavailability, and absorption rate of insoluble drugs. Ginsenoside Rg1 composite nanoparticles can promote angiogenesis and have the potential to be used for the treatment of ischemic stroke.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
