Article
Medicine, Research & Experimental
Nanees F. El-Malkey, Amira E. Alsemeh, Wesam M. R. Ashour, Nancy H. Hassan, Husam M. Edrees
Summary: Fetuin-A supplementation has a protective effect against intestinal ischemia/reperfusion injury in rats, reducing inflammation and oxidative stress, improving mucosal injury, and regulating autophagy protein expression levels to improve structural and functional damage.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Endeshaw Chekol Abebe, Zelalem Tilahun Muche, Awigchew Behaile T. Mariam, TeklieMengie Ayele, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Tadesse Asmamaw Dejenie, Misganaw Asmamaw Mengstie
Summary: Fetuin-A is a plasma glycoprotein with diverse physiological and pathological functions, involved in calcium metabolism, osteogenesis, and insulin signaling pathway. It also functions as a calcification inhibitor, protease inhibitor, and inflammatory regulator, and plays a crucial role in the pathogenesis of various disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Franziska Vollmy, Henk van den Toorn, Riccardo Zenezini Chiozzi, Ottavio Zucchetti, Alberto Papi, Carlo Alberto Volta, Luisa Marracino, Francesco Vieceli Dalla Sega, Francesca Fortini, Vadim Demichev, Pinkus Tober-Lau, Gianluca Campo, Marco Contoli, Markus Ralser, Florian Kurth, Savino Spadaro, Paola Rizzo, Albert J. R. Heck
Summary: The study recorded serum proteome profiles of 33 severe COVID-19 patients and identified a panel of about a dozen proteins that showed significantly different abundance between survivors and non-survivors. Nine proteins were defined for mortality risk assessment, and the predictive power of this panel was found to perform well in predicting mortality in independent cohorts measured in other countries. Some proteins in the panel have been previously annotated as mortality markers in aging and other diseases caused by different pathogens.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Fardin Moradi, Fateme Kooshki, Forough Nokhostin, Manouchehr Khoshbaten, Hadi Bazyar, Bahram Pourghassem Gargari
Summary: This study evaluated the impact of chromium picolinate supplementation on patients with non-alcoholic fatty liver disease (NAFLD), and found that chromium significantly improved lipid profiles, inflammatory markers, and insulin sensitivity without affecting blood glucose and cholesterol levels. Further studies are needed to explore different doses of chromium and its mechanisms of action.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Review
Physiology
Stefan Rudloff, Willi Jahnen-Dechent, Uyen Huynh-Do
Summary: Traditionally, fetuin-A is known as an anti-calcification protein that prevents cardiovascular calcification. Recent evidence suggests that it also plays a crucial role in moderating tissue inflammation and fibrosis, as well as serving as a systemic indicator of acute inflammatory disease. In this context, unbalanced depletion of fetuin-A may trigger a vicious cycle of progressive calcification, inflammation, and tissue injury.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Teoman Dogru, Ali Kirik, Hasan Gurel, Ali A. Rizvi, Manfredi Rizzo, Alper Sonmez
Summary: Nonalcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. The main cause of mortality in people with NAFLD is atherosclerotic cardiovascular disease (CVD). The prevalence of NAFLD is increasing due to its close association with obesity and type 2 diabetes (T2D).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Junliang Qian, Huiyin Tu, Dongze Zhang, Aaron N. Barksdale, Kaushik P. Patel, Michael C. Wadman, Yu-Long Li
Summary: The use of masitinib can improve nerve damage and abnormal mechanoreception caused by tourniquet-induced ischemia-reperfusion injury, reduce inflammation, and significantly ameliorate sensory deficits and allodynia in mouse hind paw tourniquet-induced ischemia-reperfusion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Christopher T. Turner, Megan Pawluk, Juliana Bolsoni, Matthew R. Zeglinski, Yue Shen, Hongyan Zhao, Tatjana Ponomarev, Katlyn C. Richardson, Christopher R. West, Anthony Papp, David J. Granville
Summary: This study investigated the therapeutic effect of sulfaphenazole (SP) in pressure injuries. The results showed that SP could alleviate the severity of pressure injuries, promote wound closure, and improve wound tensile strength. Additionally, SP rapidly restored tissue perfusion, reduced tissue hypoxia, inflammation, and fibrosis. Moreover, SP demonstrated bactericidal activity through enhanced macrophage activity. The effectiveness of SP in reducing thermal injury severity was also demonstrated. Therefore, SP has the potential to be a therapeutic option for pressure injuries and other ischemic skin injuries.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
G. G. H. van den Akker, J. S. J. J. Steijns, R. H. M. J. Stassen, G. B. Wasilewski, L. C. M. Peeters, K. A. P. Wijnands, L. J. Schurgers, M. M. J. Caron, L. W. van Rhijn, T. J. M. Welting
Summary: Peptides derived from AHSG/Fetuin A were found to effectively counteract calcification and inhibit calcium phosphate precipitation. The peptides showed therapeutic potential in treating osteoarthritis, as demonstrated in cellular and animal models.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Immunology
Yun-Hai Luo, Zuo-Tian Huang, Ke-Zhen Zong, Zhen-Rui Cao, Da-Di Peng, Bao-Yong Zhou, Ai Shen, Ping Yan, Zhong-Jun Wu
Summary: The study identified miR-194- suppressed PHLDA1 as a critical intersection of dual inflammatory signals in hepatic IRI, showing that PHLDA1 upregulation could lead to liver pathological injury, apoptosis, and cytokine release. Overexpression of miR-194 decreased PHLDA1, alleviating the damage, and further enrichment of PHLDA1 reversed this effect.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ting Li, Jin Zhao, Wenguang Xie, Wanru Yuan, Jing Guo, Shengru Pang, Wen-Biao Gan, Diego Gomez-Nicola, Shengxiang Zhang
Summary: The specific depletion of microglia in the early stage of ischemic stroke can significantly reduce the infarct volume and improve motor ability. Depleting microglia also leads to a decrease in degenerating neurons and inducible nitric oxide synthase positive (iNOS(+)) cells. Moreover, the depletion of microglia results in an increase in anti-inflammatory factors and a decrease in pro-inflammatory factors 3 days after stroke. These findings suggest that modulation of the inflammatory response through the elimination of microglia may be a promising therapeutic approach for the treatment of cerebral ischemia.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Wenjing Lv, Junqi Jiang, Yi Xu, Zhiyuan Chen, Zixuan Wang, Ang Xing, Xueping Zheng, Tingting Qu, Qi Wan
Summary: By using a comprehensive analysis approach, including DEG analysis, WGCNA, and pathway analysis, the genetic transcription profile of brain ischemic and reperfusion injury was studied. It was found that there were 58 upregulated DEGs and some validated core genes associated with stroke in mouse and rat models. Factors such as ischemic treatment and reperfusion time were important confounding factors in gene profile changes. Additionally, modules related to reperfusion time, inflammation, and thrombo-inflammation were identified, and core hub genes within these modules were identified as well. Overall, these findings expand our understanding of the genetic profile involved in brain ischemia and reperfusion, emphasizing the crucial role of inflammatory disequilibrium.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biology
Bo Peng, Chengping Xu, Shuaiwei Wang, Yijie Zhang, Wei Li
Summary: This article provides an updated view of the role of connexin hemichannels in inflammatory diseases, as well as the progress in developing selective blockers for these channels. Opening of connexin hemichannels promotes inflammation, while blockade of these channels leads to reduced inflammation, tissue injury and improved organ function.
Article
Cell Biology
Runliu Wu, Jiao Liu, Nian Wang, Ling Zeng, Chunhua Yu, Feng Chen, Haichao Wang, Timothy R. Billiar, Jianxin Jiang, Daolin Tang, Rui Kang
Summary: This study identifies an unexpected role of aconitate decarboxylase 1 (ACOD1) in sepsis, showing that its accumulation in monocytes and macrophages leads to a robust proinflammation response through tumor necrosis factor signaling pathway. Additionally, the CDK2-ACOD1 axis is correlated with disease severity in sepsis patients.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Kensuke Murata, Atsushi Murao, Monowar Aziz, Ping Wang
Summary: Neutrophil heterogeneity in sepsis is a significant factor, and the extracellular cold-inducible RNA-binding protein (eCIRP) regulates neutrophil phenotype and function through TLR4. This study found that eCIRP can induce CD112 expression in neutrophils, promoting Th1 differentiation in sepsis.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Cassie Shu Zhu, Xiaoling Qiang, Weiqiang Chen, Jianhua Li, Xiqian Lan, Huan Yang, Jonathan Gong, Lance Becker, Ping Wang, Kevin J. Tracey, Haichao Wang
Summary: The expression and secretion of procathepsin-L (pCTS-L) induced by serum amyloid A (SAA) contributes to its late and systemic accumulation in sepsis. Inhibition of pCTS-L interaction may be a potential antibody-based strategy to prevent dysregulated immune responses mediated by late-acting cytokines.
Editorial Material
Cell Biology
Haichao Wang
Article
Engineering, Biomedical
Christina Polan, Christina Brenner, Monika Herten, Gero Hilken, Florian Grabellus, Heinz-Lothar Meyer, Manuel Burggraf, Marcel Dudda, Willi Jahnen-Dechent, Christian Wedemeyer, Max Daniel Kauther
Summary: Particle-induced osteolysis is a major cause of prosthetic loosening. In this study, the influence of fetuin-A on particle-induced osteolysis was investigated using fetuin-A-deficient mice. The results showed that fetuin-A deficiency led to increased bone resorption, eroded surface areas, and osteoclast numbers. Fetuin-A deficiency also caused changes in bone metabolism parameters. These findings suggest that fetuin-A deficiency may be a risk factor for particle-induced osteolysis.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Weiqiang Chen, Cassie Shu Zhu, Xiaoling Qiang, Shujin Chen, Jianhua Li, Ping Wang, Kevin J. Tracey, Haichao Wang
Summary: A lipophilic sterol, lanosterol (LAN), has been identified as a selective inhibitor of procathepsin L (pCTS-L)-induced production of cytokines and chemokines. LAN-containing liposomes effectively rescued mice from lethal sepsis, even when administered 24 hours after the onset of the disease, by attenuating tissue injury and reducing systemic accumulation of inflammatory biomarkers. These findings suggest that liposome nanoparticles carrying anti-inflammatory sterols may have potential as therapies for sepsis and other inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Archna Sharma, Ezgi Sari, Yongchan Lee, Shivani Patel, Max Brenner, Philippe Marambaud, Ping Wang
Summary: Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have been implicated in neurogenerative diseases. The current study investigates how eCIRP regulates the signaling pathways involved in calcium and calpain, and uncovers a novel mechanism involving Ca2+ release from ER stores in an IL-6R alpha/PLC/IP3-dependent manner.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jianhua Li, Cassie Shu Zhu, Li He, Xiaoling Qiang, Weiqiang Chen, Haichao Wang
Summary: Microbial infections and resulting sepsis are a major cause of hospital deaths, accounting for about 20% of total deaths worldwide. Despite the challenges in translating experimental insights into effective therapies for heterogeneous patient populations, a better understanding of the pathogenic mechanisms underlying experimental sepsis is still urgently needed. This article reviews recent progress in searching for late-acting mediators of experimental sepsis and proposes HMGB1 and pCTS-L as potential therapeutic targets for improving outcomes of lethal sepsis and other infectious diseases.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Surgery
Molly Kobritz, Colleen Nofi, Maria Sfakianos, Gene Coppa, Monowar Aziz, Ping Wang
Summary: H151 has the potential to therapeutically reduce acute intestinal injury in sepsis.
Article
Medicine, Research & Experimental
Hui Jin, Monowar Aziz, Atsushi Murao, Molly Kobritz, Andrew J. Shih, Robert P. Adelson, Max Brenner, Ping Wang
Summary: Extracellular cold-inducible RNA-binding protein (eCIRP) is a key factor in the severity and mortality of sepsis, which induces the formation of antigen-presenting aged neutrophils (APANs) through CD4+ T cell activation, Th1 polarization, and IFN-gamma-mediated hyper-NETosis. APANs exacerbate acute lung injury (ALI) and worsen the survival of septic animals. These findings highlight the role of eCIRP and APANs in sepsis pathogenesis and potential therapeutic targets.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Physiology
Zhijian Hu, Fangming Zhang, Max Brenner, Asha Jacob, Ping Wang
Summary: Renal ischemia-reperfusion (RIR)-induced acute kidney injury (AKI) is a common renal disorder with high morbidity and mortality. STING is a signaling pathway that mediates inflammation and injury through cytosolic DNA activation. eCIRP, a damage-associated molecular pattern, activates STING and worsens hemorrhagic shock. H151, a small molecule, inhibits eCIRP-induced STING activation in vitro and protects against RIR-induced AKI.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Timothy Borjas, Asha Jacob, Molly Kobritz, Gaifeng Ma, Chuyi Tan, Vihas Patel, Gene F. F. Coppa, Monowar Aziz, Ping Wang
Summary: This study investigates the potential of a synthetic miRNA called PS-OMe miR130 in inhibiting eCIRP-mediated inflammation and acute lung injury in sepsis. The results show that PS-OMe miR130 has a strong binding affinity to eCIRP, decreases inflammatory proteins, and improves survival in a murine model of sepsis. This synthetic miRNA, with enhanced stability and protection from nuclease activity, holds promise as a novel therapeutic approach.
MOLECULAR MEDICINE
(2023)
Article
Immunology
Mian Zhou, Monowar Aziz, Hao-Ting Yen, Gaifeng Ma, Atsushi Murao, Ping Wang
Summary: In this study, we identified a novel mechanism by which eCIRP impairs macrophage bacterial phagocytosis in sepsis. Increased eCIRP levels were associated with decreased bacterial clearance in infected mice. eCIRP inhibited actin remodeling in macrophages through the formation of a STAT3-beta PIX complex, resulting in phagocytic dysfunction. Inhibition of STAT3 rescued the macrophage phagocytic dysfunction induced by eCIRP.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)