Review
Pharmacology & Pharmacy
Nathalia Grave, Thamiris Becker Scheffel, Fernanda Fernandes Cruz, Liliana Rockenbach, Marcia Ines Goettert, Stefan Laufer, Fernanda Bueno Morrone
Summary: Gliomas are debilitating malignant brain tumors with limited response to therapies, driven by molecular abnormalities like mutations in regulatory networks. The MAPK pathway, particularly p38 MAPK activation, plays a crucial role in glioma cell invasion and metastasis, and is associated with tumor grade and chemotherapy resistance, underlining its potential as a therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Felix Marius Blaesius, Johannes Greven, Weijun Guo, Eftychios Bolierakis, Zhizhen He, Cavan Luebke, Tim-Philipp Simon, Frank Hildebrand, Klemens Horst
Summary: This study provides the first evidence that multiple trauma and traumatic hemorrhage can alter protein concentrations in bone, indicating the need for further research on the impact of these injuries on the hypoxia transcriptome.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Review
Chemistry, Medicinal
Corrado Pelaia, Alessandro Vatrella, Luca Gallelli, Nicola Lombardo, Angela Sciacqua, Rocco Savino, Girolamo Pelaia
Summary: The p38 MAPK subgroup plays a crucial role in the pathogenesis of asthma and COPD by regulating the expression of various inflammatory mediators and fibrogenic factors. Studies suggest that p38 MAPK may be a potential therapeutic target, with research evaluating its effects in both asthma and COPD treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Shumei Kato, Robert Porter, Ryosuke Okamura, Suzanna Lee, Ori Zelichov, Gabi Tarcic, Michael Vidne, Razelle Kurzrock
Summary: The study found that patients with tumors harboring RAS alterations with high MAPK activity had significantly longer median progression-free survival (PFS) and overall survival when treated with MEK inhibitors. This correlation between RAS-mutant cancers with greater MAPK signaling and PFS suggests potential clinical benefit of MEK inhibitor treatment.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Olive S. Eckstein, Carl E. Allen, P. Mickey Williams, Sinchita Roy-Chowdhuri, David R. Patton, Brent Coffey, Joel M. Reid, Jin Piao, Lauren Saguilig, Todd A. Alonzo, Stacey L. Berg, Nilsa C. Ramirez, Alok Jaju, Joyce Mhlanga, Elizabeth Fox, Douglas S. Hawkins, Margaret M. Mooney, Naoko Takebe, James Tricoli, Katherine A. Janeway, Nita L. Seibel, D. Williams Parsons
Summary: In the NCI-COG Pediatric MATCH trial, the MEK inhibitor selumetinib showed limited efficacy in treating pediatric patients with treatment-refractory tumors harboring MAPK alterations. The study highlights the importance of individualized treatments for pediatric cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Fisheries
Yuanlan Wu, Xuelin Zhao, Yangxi Xiang, Ming Guo, Chenghua Li
Summary: In this study, the echinoderm MAPK family was identified and analyzed, revealing insights into its evolutionary history and immune function.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Allergy
Johanna Theodorou, Elisabeth Nowak, Andreas Boeck, Michael Salvermoser, Claudia Beerweiler, Kathrin Zeber, Paulina Kulig, Miranda S. Tsang, Chun-Kwok Wong, Gary W. K. Wong, Marjut Roponen, Joerg Kumbrink, Fahd Alhamdan, Florian Michel, Holger Garn, Vinko Tosevski, Bianca Schaub, Omer Kalayci
Summary: The study found that children with asthma have lower levels of DUSP1, but after exposure to farm dust stimulation, their DUSP1 expression is upregulated, and inflammatory MAPK is downregulated at the gene and protein level. The farm environment regulates inflammatory MAPK in various immune cell types, contributing to anti-inflammatory characteristics.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Tomoki Katome, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study demonstrated that methylglyoxal may enhance uridine diphosphate-induced contraction in rat carotid arteries, potentially through the activation of p38 MAPK and protein kinase C, and increased oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Ester Diaz-Mora, Diego Gonzalez-Romero, Marta Meireles-da-Silva, Juan Jose Sanz-Ezquerro, Ana Cuenda
Summary: Mitogen- and Stress-activated Kinase (MSK) 1 is a nuclear protein that modulates the production of certain cytokines in macrophages, and it is activated by p38 alpha Mitogen-Activated Kinase (MAPK) and extracellular signal-regulated kinase (ERK1/2). Our study shows that p38 delta, another p38MAPK, is also involved in the phosphorylation and activation of MSK in LPS-stimulated macrophages. The activation of MSK by p38 delta is crucial for the expression of various inflammatory molecules involved in immune innate response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Plant Sciences
Ye Chen, Lin Chen, Xiaomeng Sun, Shuang Kou, Tiantian Liu, Jianke Dong, Wei Tu, Yiling Zhang, Botao Song
Summary: The study identified key genes in the MAPK pathway of both S. acaule and S. tuberosum through comparative genomics analysis, showing increased expression of SaMKK2 and SaMAPK16 in cold-tolerant S. acaule. The interaction between SaMKK2 and SaMAPK4/7 may positively promote cold resistance in potato.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Critical Care Medicine
Archana Hinduja, Yevgeniya Gokun, Elochukwu Ibekwe, Blake Senay, Jonathan Elmer
Summary: Cerebral edema following cardiac arrest is a well-known complication of resuscitation and indicates a poor outcome. By retrospectively reviewing patient charts, we identified several predictors of post-cardiac arrest cerebral edema and examined its association with discharge outcome.
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Biochemistry & Molecular Biology
Nana Liu, Ge Liu, Haihong Jiang, Jing Yu, Yunqin Jin, Hong Wang
Summary: The role of ferroptosis in human acute lymphoblastic leukemia and its molecular mechanisms of action were investigated in this study. Erastin was used to inhibit the growth of Molt-4 cells, and the effects were partially reversed by ferroptosis inhibitor Ferrostatin-1 and p38 MAPK inhibitor. Erastin treatment caused mitochondrial alterations, increased reactive oxygen species and malondialdehyde levels, decreased glutathione levels, decreased SLC7A11 and GPX4 mRNA levels, and increased p38 MAPK, ERK, and c-Jun N-terminal kinase expression levels in Molt-4 cells. These findings suggest that erastin-induced ferroptosis in Molt-4 cells is associated with inhibition of the cystine/glutamate antiporter system and GPX4, as well as activation of p38 MAPK and ERK1/2.
DNA AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deri Morgan, Kiersten L. Berggren, Colby D. Spiess, Hannah M. Smith, Ajay Tejwani, Scott J. Weir, Christopher E. Lominska, Sufi M. Thomas, Gregory N. Gan
Summary: Cancer and the immune system have a close relationship, with inflammation increasing cancer risk and promoting tumor growth. The activation of the p38 MAPK pathway by various factors has led to unsuccessful attempts to develop drugs targeting p38. MK2 has multiple functions within cells, including stress protection, promoting immune response, and aiding wound healing.
MOLECULAR CARCINOGENESIS
(2022)
Article
Endocrinology & Metabolism
Mengyang Xu, Binshi Bo, Mengchao Pei, Yuyan Chen, Christina Y. Shu, Qikai Qin, Lydiane Hirschler, Jan M. Warnking, Emmanuel L. Barbier, Zhiliang Wei, Hanzhang Lu, Peter Herman, Fahmeed Hyder, Zhi-jie Liu, Zhifeng Liang, Garth J. Thompson
Summary: Research utilized a relaxometry-based calibrated fMRI method in mice to map cerebral oxygen metabolism without the need for gas challenges, revealing CMRO2 1.5-2 times higher in awake state compared to anesthetized state. This study confirms the potential of calibrated fMRI in preclinical research.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Thomas Mistral, Pauline Roca, Christophe Maggia, Alan Tucholka, Florence Forbes, Senan Doyle, Alexandre Krainik, Damien Galanaud, Emmanuelle Schmitt, Stephane Kremer, Adrian Kastler, Irene Tropres, Emmanuel L. Barbier, Jean-Francois Payen, Michel Dojat
Summary: The study aimed to evaluate the feasibility of an automated atlas-based quantification procedure for determining the volume of brain lesions after trauma. Results showed comparable performance between the automated procedure and manual delineation, suggesting its potential use in large cohorts of patients. The approach will be further tested in the OxyTC trial.
FRONTIERS IN NEUROLOGY
(2022)
Article
Oncology
Ilyass Moummad, Cyril Jaudet, Alexis Lechervy, Samuel Valable, Charlotte Raboutet, Zamila Soilihi, Juliette Thariat, Nadia Falzone, Joelle Lacroix, Alain Batalla, Aurelien Corroyer-Dulmont
Summary: Due to long waiting times for MRI, algorithms such as resampling and denoising models are developed to speed up image acquisition time. However, the impact of these algorithms on radiomics has been poorly studied. This study aimed to develop resampling and denoising DL models and evaluate their impact on radiomics. The findings showed that DL models were able to reconstruct low resolution and noised MRI images quickly into high quality images, restoring radiomic features.
Article
Neurosciences
Micaela Roque, Diego Alves Rodrigues de Souza, Martha M. Rangel-Sosa, Mike Altounian, Melanie Hocine, Jean-Christophe Deloulme, Emmanuel L. Barbier, Fanny Mann, Sophie Chauvet
Summary: VPS35 is an important component involved in neurodegenerative diseases, and its deficiency leads to abnormal brain development, including microcephaly, decreased cortical thickness, and misrouting of axonal projections. It also affects the survival of neural progenitor cells and postmitotic neurons. Overall, VPS35 plays a greater role in mammalian embryonic brain development than previously believed.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
David Mallet, Raphael Goutaudier, Emmanuel L. Barbier, Sebastien Carnicella, Jerry R. Colca, Florence Fauvelle, Sabrina Boulet
Summary: The growing evidence suggests that mitochondrial dysfunction is a key feature of Parkinson's disease. Recent studies have shown the neuroprotective effect of targeting mitochondrial pyruvate carrier (MPC) through the use of insulin sensitizer MSDC-0160. This study provides insights into the mechanisms underlying the neuroprotective effect of MSDC-0160, demonstrating its impact on energy metabolism and its ability to modify multiple pathways connected to energy metabolism.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biophysics
Samuel Valable, Jerome Toutain, Didier Divoux, Laurent Chazalviel, Aurelien Corroyer-Dulmont, Ararat Chakhoyan, Stephane Guillouet, Myriam Bernaudin, Emmanuel L. Barbier, Omar Touzani
Summary: The purpose of this study is to validate the accuracy of brain oxygen saturation magnetic resonance imaging (StO2-MRI) for hypoxia imaging and analyze its application ability in acute ischemic stroke. The results show that StO2-MRI is sensitive for the detection of hypoxia and prediction of the final lesion.
NMR IN BIOMEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wafae Labriji, Julien Clauzel, Jean-Louis Mestas, Maxime Lafond, Cyril Lafon, Anne-Sophie Salabert, Lydiane Hirschler, Jan M. Warnking, Emmanuel L. Barbier, Isabelle Loubinoux, Franck Desmoulin
Summary: The purpose of this study was to investigate the effect of Blood Brain Barrier (BBB) opening using ultrasound combined with microbubbles injection on cerebral blood flow in rats. The results showed that BBB opening induced by microbubble intravenous injection led to transient hypoperfusion, which shared some similarities with cortical spreading depression phenomenon.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barriere, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Celestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvorakova, Claudia Falfan-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibanez, Clement Garin, Eveline Gelderman, Carla E. M. Golden, Chao C. G. Guo, Marloes J. A. G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra Lopez-Castro, Xavier Lopez-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M. P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickael Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Perez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-Garcia, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T. B. van Hout, Roberta Vertullo, Benjamin Vidal, Roel M. Vrooman, Victora X. Wang, Isabel Wank, David J. G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Juergen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J. P. C. Becq, Erwin L. A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jeremie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Grohn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean-Baptiste Langlois, Jason P. Lerch, Monica A. Lopez-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Munoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldan, Wen-Ju Pan, Roberto A. Prado-Alcala, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W. J. Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie van der Linden, Annette van der Toorn, Geralda A. F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess
Summary: Task-free functional connectivity in animal models is an important tool for studying connectivity phenomena. However, the lack of standardized protocols and analysis methods hampers result comparison and integration. In this study, the authors developed a standardized protocol, called StandardRat, for rat functional magnetic resonance imaging (fMRI) acquisition and analysis, which enhances the detection of functional connectivity patterns and promotes cooperation in neuroscience research.
NATURE NEUROSCIENCE
(2023)
Correction
Neurosciences
Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barriere, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Celestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvorakova, Claudia Falfan-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibanez, Clement M. Garin, Eveline Gelderman, Carla E. M. Golden, Chao C. G. Guo, Marloes J. A. G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra Lopez-Castro, Xavier Lopez-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M. P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickael Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Perez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A. B. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-Garcia, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T. B. van Hout, Roberta Vertullo, Benjamin Vidal, Roel M. Vrooman, Victora X. Wang, Isabel Wank, David J. G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Juergen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J. P. C. Becq, Erwin L. A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jeremie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Groehn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean-Baptiste Langlois, Jason P. Lerch, Monica A. Lopez-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Munoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldan, Wen-Ju Pan, Roberto A. Prado-Alcala, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W. J. Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie van der Linden, Annette van der Toorn, Geralda A. F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Diego Alves Rodrigues de Souza, Herve Mathieu, Jean-Christophe Deloulme, Emmanuel L. Barbier
Summary: Compressed sensing (CS) is used in clinical diffusion MRI to accelerate acquisitions, but its use in preclinical settings is limited. This study optimized and compared CS reconstruction methods for diffusion imaging, finding that the kernel low-rank (KLR)-CS approach outperformed the conventional CS approach in terms of error and structural similarity index measure (SSIM). The KLR-CS method showed promising results in accelerating preclinical diffusion MRI and mitigating the effect of frequency drift.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Stenzel Cackowski, Emmanuel L. Barbier, Michel Dojat, Thomas Christen
Summary: ImUnity is an innovative 2.5D deep-learning model designed for efficient and flexible MR image harmonization. It uses multiple 2D slices from different anatomical locations and image contrast transformations for training, generating 'corrected' MR images for various multi-center population studies.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Neurosciences
Valentin Garcia, Marine Blaquiere, Alicia Janvier, Noemie Cresto, Carla Lana, Athenais Genin, Helene Hirbec, Etienne Audinat, Adele Faucherre, Emmanuel L. Barbier, Sophie Hamelin, Philippe Kahane, Chris Jopling, Nicola Marchi
Summary: This study reveals the association between mechanosensitive channel PIEZO1 and inflammatory responses in the central nervous system, particularly in the context of epilepsy. The expression of PIEZO1 is increased in epileptogenic regions of the brain and correlates with pro-inflammatory biomarkers. Additionally, TNF alpha is identified as a direct regulator of PIEZO1 expression. These findings highlight the potential significance of PIEZO1 in neuro-inflammatory processes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ulysse Gimenez, Jean Christophe Deloulme, Hana Lahrech
Summary: The study demonstrates the use of super resolution reconstruction method to generate high spatial resolution 3D-DTI of mouse brains. The findings show that the white-matter defects quantified from two different scanning methods are very similar.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
Mylene Fournie, Thomas Ador, Colleen Guillard, Vasile Stupar, Emmanuel Barbier, Arnaud Menuet, Chantal Pichon, Anthony Delalande
Article
Medicine, Research & Experimental
David Mallet, Thibault Dufourd, Melina Decourt, Carole Carcenac, Paola Bossu, Laure Verlin, Pierre-Olivier Fernagut, Marianne Benoit-Marand, Gianfranco Spalletta, Emmanuel L. Barbier, Sebastien Carnicella, Veronique Sgambato, Florence Fauvelle, Sabrina Boulet
Summary: By studying metabolic markers in animal models and PD patients, we identified a promising composite biomarker that can accurately diagnose early-stage PD and predict its development before motor symptoms appear.
JOURNAL OF CLINICAL INVESTIGATION
(2022)