4.6 Article

A phase-contrast MRI study of physiologic cerebral venous flow

期刊

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 29, 期 6, 页码 1208-1215

出版社

SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2009.29

关键词

jugular veins; cranial sinuses; healthy; PC-MRI; pulsatility

资金

  1. MRC [G0600986] Funding Source: UKRI
  2. National Institute for Health Research [NF-SI-0508-10327] Funding Source: researchfish
  3. Medical Research Council [G9439390, G0001237, G0600986] Funding Source: Medline

向作者/读者索取更多资源

Although crucial in regulating intracranial hydrodynamics, the cerebral venous system has been rarely studied because of its structural complexity and individual variations. The purpose of our study was to evaluate the organization of cerebral venous system in healthy adults. Phase-contrast magnetic resonance imaging (PC-MRI) was performed in 18 healthy volunteers, in the supine position. Venous, arterial, and cerebrospinal fluid (CSF) flows were calculated. We found heterogeneous individual venous flows and variable side dominance in paired veins and sinuses. In some participants, the accessory epidural drainage preponderated over the habitually dominant jugular outflow. The PC-MRI enabled measurements of venous flows in superior sagittal (SSS), SRS (straight), and TS (transverse) sinuses with excellent detection rates. Pulsatility index for both intracranial (SSS) and cervical (mainly jugular) levels showed a significant increase in pulsatile blood flow in jugular veins as compared with that in SSS. Mean cervical and cerebral arterial blood flows were 714 +/- 124 and 649 +/- 178 mL/min, respectively. Cerebrospinal fluid aqueductal and cervical stroke volumes were 41 +/- 22 and 460 +/- 149 mu L, respectively. Our results emphasize the variability of venous drainage for side dominance and jugular/epidural organization. The pulsatility of venous outflow and the role it plays in the regulation of intracranial pressure require further investigation. Journal of Cerebral Blood Flow & Metabolism (2009) 29, 1208-1215; doi:10.1038/jcbfm.2009.29; published online 8 April 2009

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