Article
Medicine, Research & Experimental
Shanshan Qiao, Dexin Yang, Xiaofeng Li, Weiping Li, Yuan Zhang, Wenlan Liu
Summary: The study reveals the crucial role of PAQR3 in ischemia/reperfusion injury, showing that silencing PAQR3 protects neuronal cells and improves cell survival by inhibiting the apoptosis pathway. Knockdown of PAQR3 significantly attenuates apoptosis and increases cell viability, offering a novel therapeutic target for preventing cerebral ischemia/reperfusion injury.
Article
Critical Care Medicine
Xue Yang, Jianjiang Wu, Hu Cheng, Siyu Chen, Jiang Wang
Summary: This study aimed to investigate the mechanism and effect of Dexmedetomidine (Dex) on brain damage after myocardial ischemia/reperfusion (IR) injury. The results showed that Dex could alleviate brain damage induced by myocardial IR, including inflammatory response, blood-brain barrier disruption, neuronal edema, microglial activation, and cognitive dysfunction. Furthermore, the neuroprotective effect of Dex was found to be partially dependent on the activation of the HIF-1 pathway.
Article
Surgery
Han-Jin Lai, Ya-Qing Zhan, Yu-Xin Qiu, Yi-Hong Ling, Xu-Yu Zhang, Ze-Nan Chang, Yi-Nan Zhang, Zi-Meng Liu, Shi-Hong Wen
Summary: The study revealed that high-mobility group box-1 played a key role in renal damage following intestinal ischemia/reperfusion by regulating endoplasmic reticulum stress. Neutralization or inhibition of high-mobility group box-1 with antibodies or drugs effectively attenuated renal injury caused by intestinal ischemia/reperfusion.
Review
Pharmacology & Pharmacy
Zhizhun Mo, Zhongyi Zeng, Yuxiang Liu, Linsheng Zeng, Jiansong Fang, Yinzhong Ma
Summary: Stroke is a leading cause of death and survivors often suffer from severe neurological and motor deficits. The Wnt signaling pathway has been found to play a key role in the pathogenesis of stroke and reactivating this pathway can have significant therapeutic effects. A comprehensive understanding of the role of Wnt signaling in different cell types can help evaluate its potential value for stroke treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Yunong Li, Jiaolin Zheng, Yanmei Zhu, Youyang Qu, Rui Suo, Yulan Zhu
Summary: Methylcobalamin demonstrates neuroprotective effects on cerebral ischemic injury by increasing cell viability and autophagy, reducing inflammation and apoptosis, and activating the ERK1/2 pathway. Its potential as a novel neuroprotective therapy for ischemic stroke is promising.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Tao Yang, Haiqiong Liu, Chaobo Yang, Huaqiang Mo, Xianbao Wang, Xudong Song, Luping Jiang, Ping Deng, Ran Chen, Pengcui Wu, Aihua Chen, Jing Yan
Summary: This study aimed to investigate the pharmacological effects of Gal on myocardial ischemic reperfusion injury (MIRI). The results showed that Gal alleviates myocardial injury, enhances cardiac function, and reduces cell death by targeting the Nrf2/Gpx4 signaling pathway to prevent iron overload and lipid peroxidation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Summary: Berberine exerts neuroprotective effects against ischemic stroke by inhibiting neuronal apoptosis induced by CIRI through downregulating the CNPY2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marie Piollet, Adrian Sturza, Stephanie Chadet, Claudie Gabillard-Lefort, Lauriane Benoist, Danina-Mirela Muntean, Oana-Maria Aburel, Denis Angoulvant, Fabrice Ivanes
Summary: The study demonstrated that activation of P2Y11 receptor may protect blood vessels from injury induced by HR and AngII, suggesting that modulating the P2Y11R signaling pathway could improve vascular dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Abdelrahman Y. Fouda, Wael Eldahshan, Zhimin Xu, Tahira Lemtalsi, Esraa Shosha, Syed A. H. Zaidi, Ammar A. Abdelrahman, Paul Ning-Man Cheng, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Summary: The study demonstrates that systemic administration of PEG-A1 provides neuroprotection and offers an excellent route to deliver the drug to the retina and brain after acute injury.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Chemistry, Physical
Wei Liu, Haowei Lu, Xiaoyong Rao, Xiang Li, Hongdan Lu, Feifei Li, Yan He, Riyue Yu, Rongsheng Zhong, Yao Zhang, Xiaojian Luo, Hongliang Xin
Summary: Inflammation is the main pathological mechanism of cerebral ischemia-reperfusion injury (CIRI), and neutrophils play a role in facilitating drug delivery to the ischemic penumbra through chemotaxis. Puerarin, a neuroprotective isoflavone derivative, is hindered by the blood-brain barrier in treating CIRI. Using neutrophils as carriers can enhance the BBB penetration of puerarin, improving its concentration in the brain parenchyma and enhancing neuroprotection at the ischemic penumbra in response to inflammatory conditions associated with brain injury.
Article
Biochemistry & Molecular Biology
Michael A. Fawzy, Sherif A. Maher, Sally M. Bakkar, Mahmoud A. El-Rehany, Moustafa Fathy
Summary: This study demonstrated the protective effect of pantoprazole on renal ischemia/reperfusion injury in rats for the first time, by suppressing apoptosis, reducing pro-inflammatory cytokines levels, and impacting intracellular signaling pathways. Moreover, multiple doses of pantoprazole showed a greater therapeutic effect than a single dose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Parth M. Patel, Margaret R. Connolly, Taylor M. Coe, Anthony Calhoun, Franziska Pollok, James F. Markmann, Lars Burdorf, Agnes Azimzadeh, Joren C. Madsen, Richard N. Pierson
Summary: Recent advances in minimizing ischemia have shown promising results in reducing initial xenograft dysfunction in pig-to-non-human primate heart transplantation, indicating the significant role of ischemia reperfusion injury (IRI) in cardiac xenotransplantation. Understanding the molecular, cellular, and immune mechanisms of IRI and primary graft dysfunction in allotransplantation can help develop genetic modifications and technical strategies to minimize IRI and improve clinical xenotransplantation outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Wenjie Hu, Xiangyi Kong, Yu Cui, Hui Wang, Jingchen Gao, Xiyuran Wang, Shujun Chen, Xiaohua Li, Shifang Li, Fengyuan Che, Qi Wan
Summary: This study reveals the critical role of SURF4 in cerebral ischemia/reperfusion injury and its potential as a molecular target for therapeutic strategies in acute ischemic stroke. Transcranial direct-current stimulation exerts a neuroprotective effect through SURF4-dependent signaling.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Haiyun Guo, Ze Fan, Shiquan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zhengwu Peng, Wenming Liu, Wugang Hou, Yanhui Cai
Summary: The mobilization of astrocytic glycogen inhibits A1-like astrocytes and enhances A2-like astrocytes during reperfusion, leading to reduced reactive oxygen species levels and increased production of NADPH and glutathione. This neuroprotection is mediated through ROS-mediated NF-kappa B inhibition and STAT3 activation, presenting a promising metabolic target for brain reperfusion injury in ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Clinical Neurology
Yanling Wang, Yazeed Haddad, Radhika Patel, Xiaokun Geng, Huishan Du, Yuchuan Ding
Summary: The onset of cardiogenic cerebral embolism is sudden and dangerous, with factors such as severity of neurological impairment, types and severity of combined heart diseases, establishment of cerebral collateral circulation, treatments, components of emboli causing cardiogenic cerebral embolism, existence and control of other system complications, distribution and expression of inflammatory immune cells and molecules, and epigenetic changes related to disease prognosis all influencing patient outcomes. Emphasis should be placed on clinical settings, emboli pathological profile, and epigenetic changes in the prevention and treatment of cardiogenic cerebral embolism to improve outcomes and reduce recurrence.
NEUROLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Haiyue Zhang, Jingwei Guan, Hangil Lee, Chuanjie Wu, Kai Dong, Zongjian Liu, Lili Cui, Haiqing Song, Yuchuan Ding, Ran Meng
Summary: This study investigated the changes in immune cell composition in the peripheral blood of patients with acute ischemic stroke (AIS) based on their age groups. The results showed that the proportions of certain immune cells differed among the age groups, with a decrease in certain cells as age increased. These differences may have implications for clinical outcomes and suggest the need for customized treatment for AIS in different age groups.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hao Sun, Jonathan Warren, James Yip, Yu Ji, Shaolong Hao, Wei Han, Yuchuan Ding
Summary: Gallstone disease is a common digestive system pathology with a 10-20% incidence rate among adults. Cholecystectomy is the main treatment, but it can cause physical pain and greatly impact a patient's quality of life. Clinical research suggests that cholelithiasis is closely related to age, gender, body mass index, and other physical characteristics, as well as obesity, diabetes, non-alcoholic fatty liver, and other diseases.
Article
Neurosciences
Mengqi Wang, Xiaoqin Wu, Duo Lan, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: This study aimed to compare the similarities and differences between acquired stenosis and anatomical slenderness of the internal jugular vein (IJV). Imaging features, along with clinical symptoms, can be used to differentiate between the two conditions.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Jiali Xu, Gary B. Rajah, Houdi Zhang, Cong Han, Xuxuan Shen, Bin Li, Zhengxing Zou, Wenbo Zhao, Changhong Ren, Guiyou Liu, Yuchuan Ding, Qi Yang, Sijie Li, Xunming Ji
Summary: This study used high-resolution magnetic resonance imaging to investigate the characteristics of patients with moyamoya disease and anterior intracerebral hemorrhage. The results showed that the length of lenticulostriate arteries was shorter and the lumen area of the terminal internal carotid artery was larger in the hemorrhagic group compared to the ischemic group and asymptomatic group. Multivariate analysis revealed that these features were significantly associated with anterior intracerebral hemorrhage. Additionally, the coexistence of reduced lenticulostriate arteries and relatively preserved lumen area of the terminal internal carotid artery may serve as a potential predictor of anterior intracerebral hemorrhage in moyamoya disease patients.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biochemical Research Methods
Di Wu, Jian Chen, Longfei Wu, Hangil Lee, Jingfei Shi, Mo Zhang, Yanhui Ma, Xiaoduo He, Zixin Zhu, Feng Yan, Chuanjie Wu, Yunxia Duan, Yongjuan Fu, Sijie Li, Xinglong Zhi, Xuxiang Zhang, Shengli Li, Yuchuan Ding, Xunming Ji
Summary: The article describes a protocol for developing a stroke model in rhesus monkeys and highlights the advantages of using this model in simulating patients with ischemic stroke.
Article
Rheumatology
Baozhen Huang, Xinning Wang, Yanlin Niu, Yuchuan Ding, Xiaolei Wang, Qingqing Tan, Yucong Li, Yuan Liu, Ying Chi, Yuan Wang, Zhixuan Zhou, Jianguo Li
Summary: This study evaluated the use of JAKi in treating JDM and found it to be a relatively safe and effective alternative. Cytokine profiles were able to reflect the inflammatory status of JDM patients.
Article
Clinical Neurology
Honglian Duan, Zhe Cheng, Ho Jun Yun, Lipeng Cai, Yanna Tong, Zhenzhen Han, Xiaokun Geng, Yuchuan Ding
Summary: This study investigates the relationship between serum bilirubin, stroke severity, and prognosis in patients with acute ischemic stroke (AIS). The results suggest that serum bilirubin levels are independently associated with stroke severity and prognosis.
NEUROLOGICAL RESEARCH
(2023)
Review
Neurosciences
Shuling Wan, Chaitu Dandu, Guangyu Han, Yibing Guo, Yuchuan Ding, Haiqing Song, Ran Meng
Summary: Cerebral small vessel disease (CSVD) is a group of pathological processes affecting small arteries, arterioles, capillaries, and small veins of the brain. Inflammation plays an important role in the pathophysiology of CSVD. MRI is the main diagnostic method for CSVD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
Fengwu Li, Xiaokun Geng, Roxanne Ilagan, Shangying Bai, Yuhua Chen, Yuchuan Ding
Summary: This study explored the effect of post-stroke exercise conditioning on brain injury and gluconeogenesis regulation. The results showed that exercise reduced brain infarct volumes, cell death, and neurological deficits after stroke. This neuroprotection was associated with the activation of the PI3K/AKT/FoxO1 signaling pathway and inhibition of gluconeogenesis.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Zhongao Wang, Chaitu Dandu, Yibing Guo, Meini Gao, Zixiang Wang, Duo Lan, Liqun Pan, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: This study aimed to explore the characteristics of high jugular bulb (JB) in patients with non-thrombotic internal jugular venous stenosis (IJVS) and/or transverse sinus stenosis (TSS) in order to investigate the pathogenesis of high JB formation. The results showed that IJVS and asymmetric transverse sinus were independently and positively associated with high JB, especially dominant-side IJVS with dominant-side high JB.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Bin Jiang, Xiaojie Wang, Jianping Ma, Aminah Fayyaz, Li Wang, Pei Qin, Yuchuan Ding, Xunming Ji, Sijie Li
Summary: Stroke is a major global health concern, and remote ischemic conditioning (RIC) has emerged as a convenient, simple, non-intrusive, and effective method for treating stroke. RIC improves brain tolerance to ischemia, increases cerebral blood perfusion, and reduces the risk of brain tissue damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Shuyu Lv, Xiaokun Geng, Ho Jun Yun, Yuchuan Ding
Summary: The study demonstrates that the combined treatment of phenothiazines can reduce autophagy levels, decrease apoptosis, and increase neuroprotection by inhibiting ER stress-mediated pathways. Phenothiazines exert their beneficial effects through the PERK-eIF2 alpha pathway, potentially paving the way for more targeted and effective treatments for stroke patients.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Hangil Lee, Enoch Kim, Martin Mccandless, Reid Johnson, Rohin Singh, Yuchuan Ding
Summary: The COVID-19 pandemic has had significant consequences for patients with cerebrovascular disorders requiring interventions. The study found an increase in cerebrovascular accidents, a decrease in elective carotid endarterectomies, and an increase in carotid stenting during the pandemic. Patients from ethnic and racial minorities were disproportionately affected, and delayed care and prolonged operative times resulted in worse outcomes.
WORLD NEUROSURGERY
(2023)
Review
Geriatrics & Gerontology
Sichao Guo, Ruchi Mangal, Chaitu Dandu, Xiaokun Geng, Yuchuan Ding
Summary: Stroke is a prevalent cause of death worldwide, leading to severe cellular dysfunction and long-term disability. FoxO1 plays a role in regulating cellular processes like gluconeogenesis and glycogenolysis. During stroke, FoxO1 modifications are linked to various functions such as inducing cell death and inflammation, affecting BBB, and regulating hepatic gluconeogenesis.