Article
Urology & Nephrology
Ju-Tao Yu, Xiao-Wei Hu, Qin Yang, Run-Run Shan, Yao Zhang, Ze-Hui Dong, Hai-Di Li, Jia-Nan Wang, Chao Li, Shuai-Shuai Xie, Yu-Hang Dong, Wei-Jian Ni, Ling Jiang, Xue-Qi Liu, Biao Wei, Jia-Gen Wen, Ming-Ming Liu, Qi Chen, Ya-Ru Yang, Gui-Yang Zhang, Hong-Mei Zang, Juan Jin, Yong-Gui Wu, Xiang Zhong, Jun Li, Wei Wang, Xiao-Ming Meng
Summary: IGFBP7 is a novel biomarker that plays a key regulatory role in acute kidney injury. It improves kidney function by inhibiting tubular injury and inflammation mediated by RNF4/PARP1.
KIDNEY INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Xinyue Zhang, Ruling Yang, Mengjie Ma, Siyu Chen, Kaiyin Guo, Li Zhang, Yingnan You, Hailin Jia, Bo Han
Summary: This study investigated the plasma exosome miRNA profile in pediatric fulminant myocarditis (FM) using small RNA microarray. Differential expression of 266 miRNAs was observed, including 197 upregulated and 69 downregulated candidate genes. Through analysis, FM-specific target genes related to inflammation and/or the immune system were identified. CeRNA networks between cardiomyocytes and peripheral blood mononuclear cells were established, and specific miRNAs were validated as potential biomarkers for FM diagnosis.
Article
Environmental Sciences
Qing Li, Tianyi Wang, Ximin Wang, Xin-Yu Ge, Tao Yang, Guang Bai, Wei Wang
Summary: This study found that circular RNAs (circRNAs) are associated with the regulation of sepsis-induced acute kidney injury (AKI), but the specific function of circITCH in the development of sepsis-induced AKI is still unclear. The levels of circITCH, miR-579-3p, and ZEB2 were examined, and the roles of circITCH in cell viability, apoptosis, and inflammation were evaluated in LPS-treated HK-2 cells. CircITCH overexpression restored cell viability, inhibited apoptosis and inflammatory cytokine production in LPS-treated HK-2 cells by negatively regulating miR-579-3p and upregulating ZEB2 expression. This study provides a theoretical basis for AKI therapy by demonstrating the protective role of circITCH in LPS-induced HK-2 cell injury.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Jingni Wu, Xiaoling Fang, Hongyan Huang, Wei Huang, Lei Wang, Xiaomeng Xia
Summary: Novel biomarkers for the diagnosis and treatment of endometriosis were identified through RNA sequencing and construction of a ceRNA network. Twelve potential exosomal RNA-based biomarkers were discovered, providing insight into the molecular pathways of endometriosis.
Review
Medicine, Research & Experimental
Dongli Wang, Rong Li, Jiajia Jiang, Hui Qian, Wenrong Xu
Summary: Despite the lack of effective biomarkers and therapeutic targets, exosomal circRNAs show great potential as cancer biomarkers and anti-tumor tools for gastrointestinal tumors. This article introduces the characteristics and functions of circRNAs and exosomes, and systematically discusses the biological roles and mechanisms of exosomal circRNAs in gastrointestinal tumors. It also summarizes the detection methodology of exosomal circRNAs and discusses their clinical significance as biomarkers and targets for gastrointestinal tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medical Laboratory Technology
Lu Hong, Liu Xu, Lufei Jin, Kaiwei Xu, Weiwei Tang, Yuchao Zhu, Xuedan Qiu, Jianhua Wang
Summary: This study found that the high expression of exosomal hsa_circ_0001666 and hsa_circ_0006220 may serve as new biomarkers for the diagnosis and treatment of pancreatic cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medical Laboratory Technology
Yinfeng Chen, Chengtao Lou, Xinyi Ma, Chengwei Zhou, Xiaodong Zhao, Nan Li, Haihua Tian, Xiaodan Meng
Summary: This study found that the levels of hsa_circ_0069313 in serum and serum exosomes were significantly elevated in patients with non-small cell lung cancer (NSCLC). The study also confirmed that the higher levels of serum exosomal hsa_circ_0069313 were associated with aggressive pathological features of NSCLC, such as tumor stage, lymph node metastasis, and distant metastasis.
CLINICAL BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Ningxia Sun, Shiting Qin, Lu Zhang, Shiguo Liu
Summary: Preeclampsia (PE) is a disease occurring during pregnancy with unclear pathogenesis, posing serious risks to maternal and infant safety. Current treatments are limited, with termination of pregnancy being the only way to eliminate clinical symptoms. Noncoding RNAs play important roles in the pathogenesis of PE and may serve as biomarkers for its diagnosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Oncology
Yunjing Zhang, Ying Wang, Xinwan Su, Ping Wang, Weiqiang Lin
Summary: Liquid biopsy is a novel approach for non-invasive analysis of circulating tumor-derived substances, showing great potential in human cancers. The focus is on the stability and high specificity of circular RNA as a liquid biomarker, along with the challenges of translating it into clinical practices in the future.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhijian Zhang, Hanzhi Chen, Leting Zhou, Cheng Li, Guoyuan Lu, Liang Wang
Summary: This study investigated the mechanism of tubule injury in acute kidney injury (AKI). In an AKI mouse model, tubular injury was observed and linked to macrophage infiltration. Blocking exosome production improved tubular injury, and it was found that exosomal miR-155 mediated communication between activated macrophages and injured tubules, leading to AKI progression. This study provides insights into the pathophysiology of AKI and offers a potential therapeutic strategy for kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Urology & Nephrology
Qin Yang, Li Gao, Xiao-wei Hu, Jia-nan Wang, Yao Zhang, Yu-hang Dong, Hui Yao Lan, Xiao-ming Meng
Summary: This study investigated the role of Smad3 in cisplatin-induced acute kidney injury, showing that disruption of Smad3 attenuated kidney injury, inflammation, and oxidative stress. Smad3-targeted therapy protected against loss of renal function, apoptosis, necroptosis, inflammation, and oxidative stress in cisplatin nephropathy, suggesting Smad3 as a potential therapeutic target for acute kidney injury.
Article
Oncology
Jinshi Zhang, Wenfang He, Danna Zheng, Qiang He, Mingming Tan, Juan Jin
Summary: miR-1184 expression is downregulated in AKI, and exosomal-miR-1184 derived from MSCs significantly reverses cisplatin-induced cell growth inhibition by inhibiting apoptosis. FOXO4 is a direct target of miR-1184, and exosomes expressing miR-1184 notably inhibit cisplatin-induced inflammatory responses in HK-2 cells via the mediation of IL-1 beta and TNF-alpha.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Pediatrics
Yu Wang, Xuan Wang, Qiushi Xu, Jiao Yin, Huaiyan Wang, Lin Zhang
Summary: This study detected the expression profiles of circRNAs, lncRNAs, and mRNAs in umbilical cord blood-derived exosomes of infants with BPD and identified differentially expressed circRNAs and lncRNAs. The results suggested that these exosomal RNAs may play important roles in the development of BPD.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Lais Reis-das-Merces, Tatiana Vinasco-Sandoval, Rafael Pompeu, Aline Cruz Ramos, Ana K. M. Anaissi, Samia Demachki, Paulo Pimentel de Assumpcao, Amanda F. Vidal, Andrea Ribeiro-dos-Santos, Leandro Magalhaes
Summary: This study investigates the expression profiles of circular RNAs (circRNAs) and their potential as minimally invasive biomarkers for gastric cancer (GC). Results show that certain circRNAs have consistent expression profiles across different methods and types of samples, and functional enrichment analysis reveals important signaling pathways related to GC. These findings suggest that circRNAs could serve as promising biomarkers for the diagnosis and clinical management of GC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Article
Plant Sciences
Wei-Feng Wu, Jia-Nan Wang, Zeng Li, Biao Wei, Juan Jin, Li Gan, Hai-Di Li, Jun Li, Hai-Yong Chen, Xiao-Ming Meng
Review
Pharmacology & Pharmacy
Hong Zhou, Yan Fang, Tao Xu, Wei-Jian Ni, Ai-Zong Shen, Xiao-Ming Meng
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Review
Cell Biology
Juan Jin, Haolu Sun, Chao Shi, Hui Yang, Yiwan Wu, Wanhai Li, Yu-hang Dong, Liang Cai, Xiao-ming Meng
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Jia-Nan Wang, Qin Yang, Chen Yang, Yu-Ting Cai, Tian Xing, Li Gao, Fang Wang, Xin Chen, Xue-Qi Liu, Xiao-Yan He, Biao Wei, Ling Jiang, Chao Li, Juan Jin, Jia-Gen Wen, Tao-Tao Ma, Hai-Yong Chen, Jun Li, Xiao-Ming Meng
Article
Pharmacology & Pharmacy
Xue-qi Liu, Juan Jin, Zeng Li, Ling Jiang, Yu-hang Dong, Yu-ting Cai, Ming-fei Wu, Jia-nan Wang, Tao-tao Ma, Jia-gen Wen, Ming-ming Liu, Jun Li, Yong-gui Wu, Xiao-ming Meng
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Ju-Tao Yu, Xiao-Wei Hu, Hai-Yong Chen, Qin Yang, Hai-Di Li, Yu-Hang Dong, Yao Zhang, Jia-Nan Wang, Juan Jin, Yong-Gui Wu, Jun Li, Jin-Fang Ge, Xiao-Ming Meng
Summary: Alcohol consumption increases the risk of kidney injury by activating NLRP3 inflammasomes and NF-κB signaling, leading to inflammation. FTO epigenetically modifies PPAR-α through demethylation, resulting in renal inflammation.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Hong Zhou, Wei-Jian Ni, Xiao-Ming Meng, Li-Qin Tang
Summary: miRNAs play pivotal roles in the inflammatory and immune processes of DN, affecting the progression of the disease by modulating various aspects of immune and inflammatory responses. Understanding the mechanisms and signaling pathways of miRNAs can lead to the identification of new therapeutic targets and strategies for the treatment of DN.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Qin Yang, Hong-mei Zang, Tian Xing, Shao-fei Zhang, Chao Li, Yao Zhang, Yu-hang Dong, Xiao-wei Hu, Ju-tao Yu, Jia-gen Wen, Juan Jin, Jun Li, Ren Zhao, Tao-tao Ma, Xiao-ming Meng
Summary: Gyp XLIX exerts significant renal protective effects in AKI by inhibiting renal dysfunction and alleviating inflammation and cell death. Mechanistically, Gyp XLIX mediates its effects by suppressing IGFBP7 levels and activating downstream signaling through the IGF1R kinase. These findings provide new insights for the potential clinical application of Gyp XLIX in AKI treatment.
Article
Urology & Nephrology
Qin Yang, Li Gao, Xiao-wei Hu, Jia-nan Wang, Yao Zhang, Yu-hang Dong, Hui Yao Lan, Xiao-ming Meng
Summary: This study investigated the role of Smad3 in cisplatin-induced acute kidney injury, showing that disruption of Smad3 attenuated kidney injury, inflammation, and oxidative stress. Smad3-targeted therapy protected against loss of renal function, apoptosis, necroptosis, inflammation, and oxidative stress in cisplatin nephropathy, suggesting Smad3 as a potential therapeutic target for acute kidney injury.
Article
Chemistry, Multidisciplinary
Fang Wang, Jia-nan Wang, Xiao-yan He, Xiao-guo Suo, Chao Li, Wei-jian Ni, Yu-ting Cai, Yuan He, Xin-yun Fang, Yu-hang Dong, Tian Xing, Ya-ru Yang, Feng Zhang, Xiang Zhong, Hong-mei Zang, Ming-ming Liu, Jun Li, Xiao-ming Meng, Juan Jin
Summary: The study demonstrates that SFN enhances programmed cell death and inflammation caused by cisplatin or I/R via interacting with RIPK3, suggesting it may serve as a promising therapeutic target for AKI treatment.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biotechnology & Applied Microbiology
Ling Jiang, Xueqi Liu, Xueru Hu, Li Gao, Hanxu Zeng, Xian Wang, Yuebo Huang, Wei Zhu, Jianan Wang, Jiagen Wen, Xiaoming Meng, Yonggui Wu
Summary: Epigenetic changes, specifically the N-6-methyladenosine (m6A) modification, play a crucial role in diabetic nephropathy (DN). This study demonstrates that METTL3-mediated m6A modification is an important mechanism in podocyte injury in DN. Elevated METTL3 levels lead to increased inflammation and apoptosis, while METTL3 knockout alleviates these responses. Silencing METTL3 shows therapeutic potential in mitigating kidney injury and albuminuria in diabetic mice. METTL3 modulates Notch signaling through m6A modification of TIMP2, exerting pro-inflammatory and pro-apoptotic effects.
Article
Chemistry, Medicinal
Xiaohui Chen, Qixia Liu, Jing Yang, Min Kan, Rui Jin, Tian Pu, Yaru Yang, Tian Xing, Xiaoming Meng, Hongmei Zang
Summary: The study suggests that eleutheroside B may be a potential drug to protect against renal fibrosis, and PLGA-eleutheroside B NPs could facilitate specific targeted therapy for renal fibrosis.
PHYTOTHERAPY RESEARCH
(2021)
Review
Chemistry, Multidisciplinary
Juan Jin, Tao-jie Zhou, Gui-ling Ren, Liang Cai, Xiao-ming Meng
Summary: NLRs, a major subfamily of pattern recognition receptors, have gained considerable attention due to their involvement in mediating the immune response and inflammatory pathways. This review summarises recent progress on the functions and mechanisms of NLRs in different types of renal diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Jia-Nan Wang, Fang Wang, Jing Ke, Zeng Li, Chuan-Hui Xu, Qin Yang, Xin Chen, Xiao-Yan He, Yuan He, Xiao-Guo Suo, Chao Li, Ju-Tao Yu, Ling Jiang, Wei-Jian Ni, Juan Jin, Ming-Ming Liu, Wei Shao, Chen Yang, Qian Gong, Hai-Yong Chen, Jun Li, Yong-Gui Wu, Xiao-Ming Meng
Summary: The role of N-6-methyladenosine (m6A) modifications in renal diseases, particularly acute kidney injury (AKI), is still largely unknown. In this study, the researchers investigated the role of N-6-adenosine-methyltransferase-like 3 (METTL3) in AKI and found that its expression is elevated in renal tubules. They discovered that silencing METTL3 alleviated renal inflammation and programmed cell death in tubular epithelial cells (TECs) in response to stimulation, while overexpression of METTL3 had the opposite effects. Conditional knockout of METTL3 in mice also attenuated renal dysfunction, injury, and inflammation induced by AKI. Furthermore, the researchers identified TAB3 as a target of METTL3 and explored its proinflammatory effects. They also investigated the therapeutic potential of inhibiting METTL3 using an inhibitor called Cpd-564. Overall, they concluded that the METTL3/TAB3 axis may be a potential target for the treatment of AKI.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Li Gao, Xiang Zhong, Juan Jin, Jun Li, Xiao-ming Meng
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)