Article
Biochemistry & Molecular Biology
Xinyu Wang, Tingting Zhang, Jianlong Zhai, Zhongli Wang, Yan Wang, Lili He, Sai Ma, Hanying Xing, Yifang Guo
Summary: This study found that miR-21 attenuated FAS-mediated cardiomyocyte apoptosis by regulating the expression of HIPK3. This finding has important clinical implications for the treatment of patients with acute myocardial infarction.
BIOSCIENCE REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Haipeng Tan, Ya'nan Song, Jing Chen, Ning Zhang, Qiaozi Wang, Qiyu Li, Jinfeng Gao, Hongbo Yang, Zheng Dong, Xueyi Weng, Zhengmin Wang, Dili Sun, Wusiman Yakufu, Zhiqing Pang, Zheyong Huang, Junbo Ge
Summary: A platelet-like fusogenic liposome (PLPs) was developed to deliver mesoporous silica nanospheres loaded with anti-inflammatory agent miR-21 to the inflammatory monocytes in MI/R induced mice, achieving reparative reprogramming of inflamed macrophages and preserving cardiac function effectively. This nano-platform shows promise as a minimally invasive and biologically safe approach for immunotherapy.
Article
Dermatology
Min Zhou, Hao Zhang, Hairen Chen, Baiwen Qi
Summary: This study reveals that adiponectin protects skeletal muscle from ischemia-reperfusion injury through the miR-21/PI3K/Akt signaling pathway by inhibiting inflammatory response, apoptosis, and autophagy.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Min Zeng, Xin Wei, Yang-Li He, Ji-Xiong Chen, Wen-Ting Lin
Summary: In this study, the researchers investigated the role of TFAP2C in cell autophagy during myocardial ischemia/reperfusion (MI/R) injury. They found that TFAP2C inhibited autophagy and improved cell injury caused by MI/R by mediating the miR-23a-5p/SFRP5/Wnt5a axis. These findings suggest that TFAP2C could be a potential therapeutic target for treating MI/R injury.
Article
Medicine, Research & Experimental
Lingyan Wang, Jin Liu, Zhuoran Wang, Xi Qian, Yu Zhao, Quan Wang, Na Dai, Yuhan Xie, Weijun Zeng, Wei Yang, Xiangfeng Bai, Yuqiao Yang, Jinqiao Qian
Summary: This study aimed to explore the mechanisms of Dex in regulating myocardial pyroptosis against MIRI. The effects of Dex on MIRI were assessed in rat models through hemodynamic parameters, infarction sizes, and histopathological changes. Functional experiments on H9c2 cell H/R models were conducted to investigate the mechanisms, including cell viability, apoptosis, and the expressions of related proteins. The findings showed that Dex attenuated hemodynamic derangements, infarct size, and histopathological damage in rats undergoing MIRI. Dex also increased cell viability, suppressed apoptosis, and inhibited pyroptosis-related proteins in H9c2 cells. MiR-665/MEF2D/Nrf2 axis was found to be involved in the mechanism of Dex.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Xinxin Liu, Wenqiang Tang, Kemin Chen, Yuxia Wang, Jie Qin, Fengrui Yang
Summary: This study reveals the cardioprotective role of circ_0002612 against myocardial ischemia/reperfusion injury (MI/RI), and identifies its mechanistic actions. circ_0002612 competitively binds to miR-30a-5p to release the expression of its target gene Ppargc1a, promoting cardiomyocyte viability and suppressing apoptosis. Furthermore, circ_0002612 inhibits the expression of NLRP3, leading to enhanced cardiomyocyte proliferation and reduced apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Gaiqin Pei, Li Chen, Yang Wang, Chengqi He, Chenying Fu, Quan Wei
Summary: In recent decades, the treatment of cardiovascular and cerebrovascular diseases has advanced greatly, leading to more effective prevention of cardiovascular and cerebrovascular events. However, cardiac and cerebral atherothrombotic complications still cause significant morbidity and mortality worldwide. This article discusses the role of miR-182 in regulating various factors related to atherosclerosis, coronary artery disease, myocardial infarction, ischemia/reperfusion injury, organ transplant, cardiac hypertrophy, hypertension, heart failure, congenital heart disease, and cardiotoxicity. Additionally, it summarizes the current progress of miR-182 therapeutics in clinical development and highlights challenges that need to be addressed for clinical application in patients with cardiac disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Peng Guo, Han Yi, Mingming Han, Xinxin Liu, Kemin Chen, Jie Qing, Fengrui Yang
Summary: Dexmedetomidine protects myocardium from ischemia/reperfusion (I/R) injury by suppressing miR-34b-3p to activate Jagged1-mediated Notch signaling pathway. Our findings reveal a novel mechanism underlying the effects of Dex on myocardial I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng
Summary: Baicalin exhibits positive effects on myocardial ischemia diseases, achieved by regulating key pathological indicators and various signaling pathways. In animal models of myocardial ischemia, reperfusion injury, and myocardial infarction, baicalin can reduce myocardial infarction size, improve cardiac pathological condition, and enhance heart function indicators.
Article
Medicine, Research & Experimental
Masoumeh Asgari, Iraj Salehi, Kamal Ranjbar, Maryam Khosravi, Ebrahim Zarrinkalam
Summary: This study evaluated the effects of exercise training and Crataegus persica extract on myocardial ischemia-reperfusion-induced kidney injury in diabetic rats. The results showed that interval training and Crataegus persica treatment decreased renal damage, improved insulin sensitivity and renal function in these rats.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xia Li, Yalei Jin
Summary: This study revealed the important regulatory role of miR-182-5p in ischemia-reperfusion injury, by targeting STK17A to regulate myocardial cell apoptosis and oxidative stress response, thereby protecting the myocardium from I/R injury.
Article
Biotechnology & Applied Microbiology
Pengjie Yang, Kun Liang, Weisong Wang, Dehua Zhou, Yuan Chen, Xueyan Jiang, Rong Fu, Benben Zhu, Xuefeng Lin
Summary: This study demonstrated for the first time that the long noncoding RNA SOX2-OT plays an important role in myocardial ischemia/reperfusion (MI/R) injury through regulating the miR-186-5p/YY1 axis. Inhibition of SOX2-OT attenuated cardiomyocyte dysregulation induced by oxygen-glucose deprivation/reoxygenation (OGD/R), with effects on relieving inflammation, promoting proliferation, and reducing apoptosis.
Article
Cell & Tissue Engineering
Changliang Lu, Guoyong Jiang, Xiaoyan Zhao
Summary: The study found that overexpression of miR-21 can promote the proliferation of BMSCs, inhibit apoptosis, and accelerate the recovery of damaged myocardium.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2022)
