Review
Biochemistry & Molecular Biology
Hossein Khanahmad, Seyedeh Mahnaz Mirbod, Farzaneh Karimi, Ebrahim Kharazinejad, Maryam Owjfard, Malihe Najaflu, Mehrsa Tavangar
Summary: Renal ischemia-reperfusion injury triggers signaling reactions involving TRPM2 channels, which play a crucial role in regulating kidney damage.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Multidisciplinary Sciences
Adam Bartok, Laszlo Csanady
Summary: TRPM2 is a heat-sensing cation channel protein that is activated by Ca2+ and ADP ribose. It is highly dependent on agonist concentrations for channel gating and shows sensitivity to temperature fluctuations around 37 degrees C. The channel's response to heat is amplified by positive feedback from Ca2+ entering through its pore, allowing it to autonomously respond to tiny temperature changes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Mi Bao, Weiyi Huang, Yang Zhao, Xinzhe Fang, Yanmei Zhang, Fenfei Gao, Danmei Huang, Bin Wang, Ganggang Shi
Summary: The study demonstrated that verapamil reduces myocardial I/R-induced oxidative stress through modulation of SIRT1 signaling, resulting in decreased ROS and MDA levels, and subsequently protecting against cardiac dysfunction and myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyun Seok Hwang, Aida Rahimi Kahmini, Julia Prascak, Alexis Cejas-Carbonell, Isela C. Valera, Samantha Champion, Mikayla Corrigan, Florence Mumbi, Michelle S. Parvatiyar
Summary: This study investigated the role of sarcospan (SSPN) in the cardiac response to acute ischemia-reperfusion (IR) injury. The findings suggested that SSPN deficiency in mice leads to increased infarct size and arrhythmia susceptibility post-IR injury. Additionally, SSPN depletion resulted in decreased Ca2+ handling capacity and increased oxidative stress pathways in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Hyeonbin Shin, Seungwon Jeong, Yeongjong Lee, Chanhee Jeon, Gayoung Kwon, Sooyeon Kim, Dongwon Lee
Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marlize Ferreira-Cravo, Daniel C. Moreira, Marcelo Hermes-Lima
Summary: The upregulation of endogenous antioxidants is a common response in animals that tolerate hypoxia/anoxia for extended periods. This study investigated the role of glutathione (GSH) in controlling redox homeostasis under the stress of anoxia and reoxygenation in Helix aspersa. The depletion of total GSH (tGSH) using BSO revealed that GSH is required to withstand the oxidative challenge induced by hypoxia and reoxygenation in land snails.
Article
Biochemistry & Molecular Biology
Jin Yu, Hong Zhu, Mark S. Kindy, Saeid Taheri
Summary: This study demonstrates that suppression of CYP2E1 can alleviate I/R injury and protect BBB integrity by reducing oxidative stress and inflammation. CYP2E1 KO mice showed lower lesion volume and neurological deficits after I/R, with decreased oxidative stress and inflammatory responses.
Article
Biochemistry & Molecular Biology
Piotr Frydrychowski, Marcin Michalek, Iwona Bil-Lula, Elzbieta Chelmecka, Alina Kafel, Agnieszka Noszczyk-Nowak, Dominika Stygar
Summary: The study evaluated the cardioprotective effect of intracoronary administered aspirin on myocardial ischemia-reperfusion injury using an experimental animal model. The results showed that aspirin reduced oxidative stress levels in heart tissue and serum compared to the control group.
Review
Biochemistry & Molecular Biology
Jose Lillo-Moya, Catalina Rojas-Sole, Diego Munoz-Salamanca, Emiliano Panieri, Luciano Saso, Ramon Rodrigo
Summary: Ischemic heart disease is a major cause of death globally, and reoxygenation is the primary treatment to restore blood flow, although it can also induce tissue injury. Iron-induced ferroptosis plays a critical role in heart damage, and efforts to inhibit it may improve clinical outcomes for patients.
Review
Endocrinology & Metabolism
Niloofar Dehdari Ebrahimi, Sara Shojaei-Zarghani, Ehsan Taherifard, Sanaz Dastghaib, Shima Parsa, Nasim Mohammadi, Fatemeh Sabet Sarvestani, Zahra Moayedfard, Nima Hosseini, Heidar Safarpour, Alireza Sadeghi, Negar Azarpira, Ali Reza Safarpour
Summary: This study evaluates the protective effects of melatonin therapy on testicular tissue damage caused by physical, heat, and ischemic factors in animal models. The results show that melatonin therapy improves histopathological characteristics of testicular tissue and enhances sperm quality and tissue markers of oxidative stress. However, there are limitations and bias risks in the included studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Rajesh Kumar Goit, Andrew W. Taylor, Amy C. Y. Lo
Summary: Retinal ischemia/reperfusion (I/R) injury is a common cause of vision loss, particularly in diabetic retinopathy. Inflammation plays a major role in the pathogenesis of I/R injury. This study found that alpha-MSH, an anti-inflammatory peptide hormone, has protective effects against I/R-induced retinal damage in hyperglycemic conditions. Treatment with alpha-MSH improved retinal function, prevented histological alterations and retinal swelling, attenuated loss of retinal ganglion cells and oxidative stress, and increased the level of interleukin 10, which is linked to anti-inflammatory response. These findings suggest that alpha-MSH may have therapeutic potential for treating retinal I/R injury in diabetic patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ersen Eraslan, Ayhan Tanyeli, Elif Polat, Zeliha Yetim
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Medicine, Research & Experimental
Omer Topdagi, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Mustafa Can Guler, Selim Comakli
Article
Pharmacology & Pharmacy
Ersen Eraslan, Ayhan Tanyeli, Mustafa Can Guler, Nezahat Kurt, Zeliha Yetim
PHARMACOLOGICAL REPORTS
(2020)
Article
Pharmacology & Pharmacy
Ramazan Bal, Gurkan Ozturk, Ebru Onalan Etem, Ersen Eraslan, Seda Ozaydin
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Agriculture, Multidisciplinary
E. P. Topdagi Yilmaz, A. Tanyeli, F. N. Ekinci Akdemir, M. C. Gueler, E. Eraslan
JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
(2020)
Article
Veterinary Sciences
Mustafa Can Guler, Ayhan Tanyeli, Ersen Eraslan, Fazile Nur Ekinci Akdemir, Tuncer Nacar, Omer Topdagi
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2020)
Article
Veterinary Sciences
Ayhan Tanyeli, Ersen Eraslan, Mustafa Can Guler, Nezahat Kurt, Nurhan Akaras
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
(2020)
Meeting Abstract
Physiology
Ayhan Tanyeli, Emsal Pinar Topdagi Yilmaz, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Mustafa Can Guler
Meeting Abstract
Physiology
Ayhan Tanyeli, Emsal Pinar Topdagi Yilmaz, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Mustafa Can Guler
Article
Biochemistry & Molecular Biology
Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Mustafa Can Guler, Tuncer Nacar
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2019)
Meeting Abstract
Physiology
Ayhan Tanyeli, Ersen Eraslan, Mustafa Can Guler, Nezahat Kurt, Zeliha Yetim
Meeting Abstract
Physiology
Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Mustafa Can Guler, Omer Topdagi
Meeting Abstract
Physiology
Omer Topdagi, Ersen Eraslan, Ayhan Tanyeli, Mustafa Can Guler, Engin Sebin, Saime Ozbek Sebin, Elif Polat
Meeting Abstract
Physiology
Mustafa Can Guler, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Mustafa Can Guler, Omer Topdagi
