期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 234, 期 4, 页码 3661-3674出版社
WILEY
DOI: 10.1002/jcp.27135
关键词
CD276; epidermal hyperplasia; keratinocytes hyperproliferation; microRNA-187 (miR-187); psoriasis
资金
- Medical Scientific Research Foundation of Guangdong Province [A2017277]
- National Natural Science Foundation of China [81302868, 81602748]
- Natural Science Foundation of Guangdong Province [2016A030310291, 2017A030313639]
- China Postdoctoral Science Foundation [2017M612639]
- Specific research fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2015QN03, YN2014ZH08]
Psoriasis is a common chronic skin disease characterized by epidermal hyperplasia and inflammation. However, the pathogenesis of psoriasis is multifactorial and is not fully understood. MicroRNAs (miRNAs) represent a promising class of small, noncoding RNA molecules that have a large impact on cellular functions by regulating gene expression. Here we reported that microRNA-187 (miR-187), which is one of the most dynamic microRNAs identified in the deep screening miRNAs profile, is downregulated in inflammatory cytokines-stimulated keratinocytes and psoriatic skins. By luciferase activity assay and gain-of-function studies, we showed that miR-187 inhibits keratinocytes hyperproliferation by targeting CD276. Moreover, overexpression of miR-187 decreases acanthosis and reduces the disease severity in psoriasis mouse models. Taken together, the results of our study implies miR-187 as a critical factor in psoriasis pathogenesis, which could be a potent target for psoriasis treatment.
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