Article
Dermatology
Jiao Li, Hui Hou, Ling Zhou, Juanjuan Wang, Jiannan Liang, Junqin Li, Ruixia Hou, Xuping Niu, Guohua Yin, Xinhua Li, Kaiming Zhang
Summary: The study found that psoriatic HDMECs exhibit increased tube formation and cell migration, as well as reduced proliferation and metabolic activity compared to normal HDMECs.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Yu-Hang Liu, Lorenz M. Brunner, Johannes Rebling, Maya Ben-Yehuda Greenwald, Sabine Werner, Michael Detmar, Daniel Razansky
Summary: This study used non-invasive imaging technology to observe and monitor the process of skin repair in mice, and found that overexpression of vascular endothelial growth factor A (VEGF-A) can promote vascularization in the skin, which was further validated by detailed histological staining results.
Article
Biochemistry & Molecular Biology
Chiara Agostinis, Mariagiulia Spazzapan, Roman Vuerich, Andrea Balduit, Chiara Stocco, Alessandro Mangogna, Giuseppe Ricci, Giovanni Papa, Serena Zacchigna, Roberta Bulla
Summary: The loss of skin integrity poses a challenge for clinicians, but acellular dermal matrices (ADMs) have shown promise in repairing skin functionality before skin grafts. Integra(R) and PELNAC(R) demonstrated superior adhesive and angiogenetic properties, with preseeded ADMECs on Integra(R) promoting engraftment, integration, and vascularization of ADMs in animal models.
Article
Neurosciences
Wen Zeng, Qiaoling Lei, Jiao Ma, Shuqiang Gao, Rong Ju
Summary: This study investigated the biological effects of EPC-derived MVs on BMECs, showing that EPC-MVs can enhance BMEC viability, proliferation, migration, and tube formation. These results suggest the proangiogenic effect of EPC-derived MVs on BMECs, which holds potential applications in cell-free therapy for brain injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Emergency Medicine
Hengyu Du, Shenghong Li, Jinqiang Lu, Lingzhi Tang, Xiao Jiang, Xi He, Jiaji Liang, Xuan Liao, Taixing Cui, Yuesheng Huang, Hongwei Liu
Summary: Impaired angiogenesis in diabetic foot ulcers (DFUs) is associated with dysregulated expression of RAB17 in human dermal microvascular endothelial cells (HDMECs). Overexpression of RAB17 enhances angiogenesis and promotes diabetic wound healing, suggesting its potential as a therapeutic target for impaired angiogenesis in DFUs.
Article
Multidisciplinary Sciences
Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi, Hidehito Saito-Takatsuji, Yasuhito Ishigaki, Hideto Yonekura
Summary: This study revealed that EPAC2 affects the morphology and migration of microvascular endothelial cells, and is involved in the termination and proper network formation of vascular tubes.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Shasha Jia, Xueya Wang, Guowei Wang, Xiaojing Wang
Summary: Soft tissue damage stimulates the release of catecholamine hormones which bind to beta-adrenergic receptors on the cell membrane surface, impairing soft tissue wound healing. Beta-blockers inhibit this activation and accelerate wound healing by reducing inflammation, promoting cell migration, and inhibiting bacterial effects. They are being studied for their efficacy in various soft tissue wound repair applications, but further investigation into their mechanisms of action is necessary.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Dermatology
Hui Hou, Jiao Li, Juanjuan Wang, Ling Zhou, Junqin Li, Jiannan Liang, Guohua Yin, Xinhua Li, Yueai Cheng, Kaiming Zhang
Summary: The study found that Integrin subunit alpha 9 (ITGA9) expression levels were decreased in psoriatic human dermal microvascular endothelial cells (HDMECs), while miR-146a-3p expression levels were increased. Overexpression of miR-146a-3p reduced ITGA9 expression and promoted proliferation and migration of HMEC-1. In contrast, overexpression of ITGA9 inhibited proliferation and migration of HMEC-1, and increased the expression levels of related genes.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mostafa Samak, Diana Kaltenborn, Andreas Kues, Ferdinand Le Noble, Rabea Hinkel, Giulia Germena
Summary: This study demonstrates the important role of miR-92a in cardiac microvascular dysfunction and inflammation in diabetes. Through studying mouse and human cardiac microvascular endothelial cells, it was found that upregulation of miR-92a is associated with impaired angiogenesis and increased inflammation. Additionally, the study uncovered the novel miR-92a target ADAM10, which mediates the anti-angiogenic effect.
Article
Biotechnology & Applied Microbiology
Haifeng Liu, Bing Wu, Xin Shi, Yanpeng Cao, Xin Zhao, Daqiang Liang, Qihuang Qin, Xinzhi Liang, Wei Lu, Daping Wang, Jun Liu
Summary: This study demonstrates the potential of aerobic exercise-induced circulating extracellular vesicles (EVs) as a cell-free therapy for activating angiogenesis and promoting diabetic wound healing. The results show that circulating EVs can enhance cell proliferation, migration, and tube formation, as well as improve wound healing in diabetic rats.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Sung-Won Kim, Gwang-Bum Im, Gun-Jae Jeong, Sangyul Baik, Jiyu Hyun, Yu-Jin Kim, Changhyun Pang, Young Charles Jang, Suk Ho Bhang
Summary: Low cell engraftment and viability due to oxygen and nutrient depletion are challenges in tissue engineering. Fibroblast therapy is considered promising, especially with the unique properties of three-dimensional fibroblasts. Strategies for macrophage polarization offer possibilities for wound healing, but efficacy and safety concerns remain.
Article
Biochemistry & Molecular Biology
Rory K. M. Long, Livia Piatti, Francois Korbmacher, Maria Bernabeu
Summary: Three-dimensional engineered blood-brain barrier models offer a better mimicry of the brain microvasculature structure, recapitulate BBB properties, physiology, and function, providing improved control over experimental parameters and compatibility with advanced imaging technologies. These models have the potential to help researchers overcome limitations of traditional research methods and understand parasite interactions with the BBB.
MOLECULAR MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yaqian Wang, Fangfang Chen, Yuan Zhang, Xiangyu Zheng, Shiyan Liu, Meijuan Tang, Ziling Wang, Pan Wang, Yongping Bao, Dan Li
Summary: Sulforaphane (SFN) was found to promote migration and tube formation of HUVECs under hypoxic conditions, while alleviating hypoxia-induced proliferation retardation. Additionally, SFN protected against hypoxia-induced mitochondrial injury and regulated angiogenesis via modulation of Nrf2 and mitochondrial dynamics.
Review
Geriatrics & Gerontology
Yuying Guan, Jia Liu, Yakun Gu, Xunming Ji
Summary: Cerebrovascular microcirculation is crucial for brain function, and angiogenesis plays a significant role in remodeling the microcirculation. Hypoxia is an important regulator of angiogenesis, but it also negatively affects cerebral vascular tissue. Establishing a model that promotes cerebral microvasculogenesis without causing injury is essential.
Article
Multidisciplinary Sciences
Ze Zhang, Chao Wu, Jinrui Yang, Jie Liu, Yi Li, Luojia Liu, Meng Kong, Jiaping Zhang, Xupin Jiang
Summary: This study investigated the effect of hypoxia on the directional migration of human dermal microvascular endothelial cells under electric fields. It was found that hypoxia could enhance cell galvanotaxis and upregulate the expression of VEGF/VEGFR2, promoting migration directionality. Knockdown of VEGFR2 reversed the directivity of cells, suggesting its important role in this process.
Article
Public, Environmental & Occupational Health
James M. Fox, Robert Newton, Marija Bedaj, Ada Keding, Elizabeth Molyneux, Lucy M. Carpenter, Fabiola Martin, Nora Mutalima
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2015)
Article
Cell & Tissue Engineering
Sally James, James Fox, Farinaz Afsari, Jennifer Lee, Sally Clough, Charlotte Knight, James Ashmore, Peter Ashton, Olivier Preham, Martin Hoogduijn, Raquel De Almeida Rocha Ponzoni, Y. Hancock, Mark Coles, Paul Genever
Article
Virology
Lucy B. M. Cook, Anat Melamed, Maria Antonietta Demontis, Daniel J. Laydon, James M. Fox, Jennifer H. C. Tosswill, Declan de Freitas, Ashley D. Price, James F. Medcalf, Fabiola Martin, James M. Neuberger, Charles R. M. Bangham, Graham P. Taylor
Review
Public, Environmental & Occupational Health
James M. Fox, Nora Mutalima, Elizabeth Molyneux, Lucy M. Carpenter, Graham P. Taylor, Martin Bland, Robert Newton, Fabiola Martin
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2016)
Article
Virology
James M. Fox, Silva Hilburn, Maria-Antonietta Demontis, David W. Brighty, Maria Fernanda Rios Grassi, Bernardo Galvao-Castro, Graham P. Taylor, Fabiola Martin
Article
Cell Biology
Katherine M. Wilson, Alistair M. Jagger, Matthew Walker, Estere Seinkmane, James M. Fox, Roland Kroger, Paul Genever, Daniel Ungar
JOURNAL OF CELL SCIENCE
(2018)
Article
Multidisciplinary Sciences
James M. Fox, Fahima Kausar, Amy Day, Michael Osborne, Khansa Hussain, Anja Mueller, Jessica Lin, Tomoko Tsuchiya, Shiro Kanegasaki, James E. Pease
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Charlotte Knight, Sally James, David Kuntin, James Fox, Katherine Newling, Sam Hollings, Rebecca Pennock, Paul Genever
CELLULAR SIGNALLING
(2019)
Article
Infectious Diseases
Samuel J. Simpson, Rebecca Wiggins, James M. Fox, Jabu Mthethwa, Chun Cai, Charles J. N. Lacey
SEXUALLY TRANSMITTED DISEASES
(2019)
Article
Biochemical Research Methods
Carina Peres, Yuetsu Tanaka, Fabiola Martin, James Fox
JOURNAL OF VIROLOGICAL METHODS
(2019)
Letter
Biochemical Research Methods
Fabiola Martin, James Fox
JOURNAL OF VIROLOGICAL METHODS
(2020)
Article
Multidisciplinary Sciences
R. A. Rocha, J. M. Fox, P. G. Genever, Y. Hancock
Summary: This study demonstrates the use of Raman spectroscopy for classifying and stratifying bone-derived mesenchymal stromal cells based on biological function, with quantified assessment of biomolecular stratification and cell heterogeneity achieved through high-precision measurements and statistical sampling. The results show the potential of these methods as label-free assays for cell sub-type classification within complex heterogeneous populations, with implications for therapeutic translation and phenotypic characterisation of various cells.
SCIENTIFIC REPORTS
(2021)
Correction
Biology
James M. Fox, Rebecca C. Wiggins, John W. J. Moore, Christine Brewer, Bill Hunter, Alison C. Andrew, Fabiola Martin
Article
Biology
James M. Fox, Rebecca C. Wiggins, John W. J. Moore, Christine Brewer, Alison C. Andrew, Fabiola Martin