Article
Immunology
Qianxue Mou, Ke Yao, Meng Ye, Bowen Zhao, Yuanyuan Hu, Xiaotong Lou, Huixia Li, Hong Zhang, Yin Zhao
Summary: This study reveals the potential role of the SIRT1-mTORC1 pathway in regulating microglia after optic nerve injury, highlighting the importance of microglia in neurodegeneration.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Neurosciences
Xiaohuan Zhao, Mengqiao Xu, Zhenzhen Zhao, Yimin Wang, Yang Liu, Ting Zhang, Xiaoling Wan, Mei Jiang, Xueting Luo, Yao Shen, Lei Chen, Minwen Zhou, Feng Wang, Xiaodong Sun
Summary: This study found that the probiotic Bifidobacterium can promote the survival of retinal ganglion cells and optic nerve regeneration. This effect is achieved by inhibiting microglia activation and promoting Muller cell activation, leading to a reduction in the risk of optic nerve injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Jacky M. K. Kwong, Joseph Caprioli, Joanne C. Y. Lee, Yifan Song, Feng-Juan Yu, Jingfang Bian, Ying-Hon Sze, King-Kit Li, Chi-Wai Do, Chi-Ho To, Thomas Chuen Lam
Summary: This study investigated the proteomic changes in the retina after optic nerve transection in rats. Using high-resolution mass spectrometry, they identified several differentially expressed proteins related to retinal ganglion cell damage, such as ALDH1A1 and SNCG.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yuan Liu, Rossana Cheng He, Gustavo C. Munguba, Richard K. Lee
Summary: Glaucoma is one of the main causes of irreversible visual field loss and blindness worldwide. This study found that the expression level of PVALB decreases with RGC degeneration, indicating that PVALB is a reliable RGC molecular marker.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Dekel Rosenfeld, Hannah Field, Ye Ji Kim, Karen Ka Lam Pang, Keisuke Nagao, Florian Koehler, Polina Anikeeva
Summary: Nerve injuries are common and current treatment methods have limitations. Researchers have discovered that thermal activation of a heat sensitive ion channel TRPV1 can promote axonal growth without invasive surgeries. This finding may become a minimally invasive approach to accelerate nerve regeneration in the future.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Jacky M. K. Kwong, Joseph Caprioli, Ying H. Sze, Feng J. Yu, King K. Li, Chi H. To, Thomas C. Lam
Summary: Retinal proteins associated with primary and secondary RGC degeneration were investigated using SWATH label-free and target-based mass spectrometry. Different proteomic profiles were found in response to localized optic nerve injury, indicating potential roles in RGC loss and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Jing Zhao, Graydon B. Gonsalvez, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Summary: In this study, the absence of S1R within optic nerve head astrocytes was found to have a negative effect on the growth and survival of retinal ganglion cells. The data suggest that S1R may enhance ganglion cell survival via glia-mediated mechanisms.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Xi Chen, Shanshan Li, Xiaoli Liu, Jingjie Zhao, Lanting Wu, Ran You, Yanling Wang
Summary: This study investigates the role of endogenous c-kit(+) cells in retinal degeneration. Stimulation of these cells by stem cell factor (SCF) provides protection against retinal degeneration. SCF administration improves visual function and prevents the loss of retinal ganglion cells. Transcriptome analysis reveals that SCF-induced changes are closely correlated with eye development-related pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiahui Tang, Zhe Liu, Jiaxu Han, Jingfei Xue, Liyan Liu, Jicheng Lin, Caiqing Wu, Qi Zhang, Siting Wu, Canying Liu, Haishun Huang, Yuanyuan Fu, Min Li, Yehong Zhuo, Yiqing Li
Summary: Retinal ganglion cell (RGC) loss is a critical mechanism of glaucoma, and zinc ion plays a key role in this process. This study identified that increased levels of zinc ion upregulate the expression and activity of mitochondrial zinc metallopeptidase OMA1, which leads to the activation of cytosolic eIF2α kinase PKR and triggers the integrated stress response (ISR) in RGCs.
Review
Biochemistry & Molecular Biology
Jess Rhee, Kendrick Co Shih
Summary: The review of gene-based therapy for RGC neuroprotection showed promising results utilizing AAV vectors encoding specific genes. However, challenges still exist, such as the acute nature of injury models in studies and the regulation of gene expression.
Article
Multidisciplinary Sciences
Ling-Ping Cen, Tsz Kin Ng, Jia-Jian Liang, Ciyan Xu, Xi Zhuang, Yu-Fen Liu, Shao-Lang Chen, Yanxuan Xu, Qichen Yang, Xiang-Ling Yuan, Yong Jie Qin, Sun On Chan, Haoyu Chen, Mingzhi Zhang, Andrew V. Schally, Chi Pui Pang
Summary: The study demonstrated that both agonists and antagonists of GHRH could promote the survival of RGCs through increasing Akt phosphorylation and regulating the expression of inflammation-related genes. GHRH analogs not only have a protective effect on RGCs after optic nerve injury, but also enhance the activation of macrophages.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Yali Wu, Qing Cun, Yijin Tao, Wenyan Yang, Jia Wei, Daoqing Fan, Ying Zhang, Qin Chen, Hua Zhong
Summary: The study showed that estimated retinal ganglion cells play a significant role in the diagnosis and staging of glaucoma, with the estimates gradually decreasing as glaucoma progresses.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ahmara G. Ross, Devin S. McDougald, Reas S. Khan, Thu T. Duong, Kimberly E. Dine, Puya Aravand, Jean Bennett, Venkata Ramana Murthy Chavali, Kenneth S. Shindler
Summary: This study investigates the neuroprotective potential of RGC-selective SIRT1 gene therapy in models of optic neuropathy, showing that overexpression of SIRT1 can effectively preserve RGC survival and visual function. The study suggests a targeted therapy for optic neuropathies through RGC-selective expression of SIRT1, expanding our understanding of SIRT1-mediated neuroprotection in optic neuropathy models and highlighting its therapeutic potential.
Article
Biochemistry & Molecular Biology
Hyoung Won Bae, Wungrak Choi, Ah Reum Hwang, Sang Yeop Lee, Gong Je Seong, Chan Yun Kim
Summary: The study found that hypoxic preconditioning significantly increased the survival rate of primary retinal ganglion cells, with VEGF playing an important regulatory role in this process. Over-inhibition of VEGF negatively impacted the survival of RGCs mediated by hypoxic preconditioning.
Article
Neurosciences
Andrew M. Boal, Nolan R. McGrady, Michael L. Risner, David J. Calkins
Summary: This article investigates how intrinsic properties shape the excitability and action potential generation in two different types of retinal ganglion cells (RGCs). The study demonstrates the impact of extracellular potassium concentration on the differences in intrinsic excitability among RGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)