Article
Biology
Miriam Jacome-Sosa, Zhi-Feng Miao, Vivek S. Peche, Edward F. Morris, Ramkumar Narendran, Kathryn M. Pietka, Dmitri Samovski, Hei-Yong G. Lo, Terri Pietka, Andrea Varro, Latisha Love-Gregory, James R. Goldenring, Ondrej Kuda, Eric R. Gamazon, Jason C. Mills, Nada A. Abumrad
Summary: Research on the gastric function of CD36 suggests that its absence leads to altered gland organization, increased fibronectin, and inflammatory signaling in gastric tissues in mice. Defective epithelial cell renewal and progenitor cell differentiation impairs mucosal repair, possibly due to altered lipid metabolism and fatty acid delivery. Low CD36 expression is associated with gastric diseases in humans, highlighting the importance of CD36 in gastric tissue repair.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Geng Tian, Shubin Wang, Jianhui Wu, Yanxia Wang, Xiutang Wang, Shuwei Liu, Dejun Han, Guangmin Xia, Mengcheng Wang
Summary: In this study, a drought tolerant gene TaWD40-4B.1 was identified in wheat through a genome-wide association study. The full-length allele TaWD40-4B.1(C) enhances drought tolerance and grain yield of wheat under drought, while the truncated allele TaWD40-4B.1(T) does not. TaWD40-4B.1(C) interacts with catalases, promotes their activities, and reduces H2O2 levels under drought.
NATURE COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Yanyan Shi, Jing Ning, Kelsang Norbu, Xingzi Hou, Huiling Zheng, Hejun Zhang, Wei Yu, Feng Zhou, Yuan Li, Shigang Ding, Qingying Zhang
Summary: ZZDX has been proven to have therapeutic effects on H. pylori-induced gastric mucosa inflammation.
Article
Plant Sciences
Aoi Narutaki, Prihardi Kahar, Shunji Shimadzu, Shota Maeda, Tomoyuki Furuya, Kimitsune Ishizaki, Hidehiro Fukaki, Chiaki Ogino, Yuki Kondo
Summary: In this study, the effects of sugars on vascular cell differentiation were examined using a vascular cell induction system. Sucrose was found to have the strongest inhibitory effect on xylem differentiation. Transcriptome analysis revealed that sucrose suppresses xylem and phloem differentiation in cambial cells. The central regulator BRI1-EMS-SUPPRESSOR1 transcription factor was suggested to be involved in the sucrose-mediated regulation of vascular cell differentiation.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Neurosciences
Sean K. Ryan, Matija Zelic, Yingnan Han, Erin Teeple, Luoman Chen, Mahdiar Sadeghi, Srinivas Shankara, Lilu Guo, Cong Li, Fabrizio Pontarelli, Elizabeth H. Jensen, Ashley L. Comer, Dinesh Kumar, Mindy Zhang, Joseph Gans, Bailin Zhang, Jonathan D. Proto, Jacqueline Saleh, James C. Dodge, Virginia Savova, Deepak Rajpal, Dimitry Ofengeim, Timothy R. Hammond
Summary: Iron dysregulation is associated with multiple neurodegenerative diseases, including Parkinson's disease. In this study, it is found that iron-loaded microglia are responsive to iron and susceptible to ferroptosis, a form of cell death that is dependent on iron. Iron overload also induces a shift in the microglial transcriptional state that is similar to the transcriptomic signature found in postmortem brain microglia of Parkinson's disease. The removal of microglia delays iron-induced neurotoxicity, suggesting the contribution of microglial response to neurodegeneration.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Ziyang Sun, Hang Liu, Yuehao Hu, Gang Luo, Zhengqiang Yuan, Weixuan Liu, Bing Tu, Hongjiang Ruan, Juehong Li, Cunyi Fan
Summary: Trauma-induced heterotopic ossification (HO) is a complex disorder characterized by abnormal bone formation after musculoskeletal injury. Recent studies have found that dysregulated osteogenic differentiation plays a critical role in this process. In this study, we investigated the roles of Krupel-like factor 2 (KLF2) and peroxisome proliferator-activated receptor gamma (PPARγ) in HO formation. We found that elevated KLF2 and reduced PPARγ levels were present in tendon stem/progenitor cells (TSPCs) during trauma-induced HO formation. Inhibition of KLF2 and promotion of PPARγ reduced HO formation, while overexpression of KLF2 abolished the effects of PPARγ promotion. Additionally, we observed mitochondrial dysfunction and increased reactive oxygen species (ROS) production after burn/tenotomy, and improving mitochondrial function could alleviate HO formation. However, this effect was abolished by KLF2 activation and PPARγ suppression. In vitro experiments showed that increased KLF2 and decreased PPARγ levels were present in osteogenically induced TSPCs, and inhibition of KLF2 and promotion of PPARγ relieved osteogenesis by improving mitochondrial function and redox balance. The findings suggest that the KLF2/PPARγ axis regulates trauma-induced HO formation through modulation of mitochondrial dysfunction and ROS production via redox balance. Targeting this axis and mitochondrial dysfunction may provide new therapeutic strategies for trauma-induced HO.
CELL PROLIFERATION
(2023)
Article
Immunology
Xuyang Zhao, Yuhang Liu, Jiayuan Xie, Lei Zhang, Qingsong Zhu, Lian Su, Cheng Guo, Heng Li, Guangxin Wang, Wanting Zhang, Yingyin Cheng, Nan Wu, Xiao-Qin Xia
Summary: Although there are currently no dedicated procedures for isolating immune cells from zebrafish intestines, a speedy and simple approach has been devised to better understand intestinal cellular immunity in zebrafish. This new technique involves separating the mucosal villi from the muscle layer and has shown higher expression of immune genes compared to traditional methods. The resulting immune cell suspension is enriched in immune-related genes and pathways and can aid in the study of intestinal illness at the cellular level.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Respiratory System
Yuqing Mo, Ling Ye, Hui Cai, Guiping Zhu, Jian Wang, Mengchan Zhu, Xixi Song, Chengyu Yang, Meiling Jin
Summary: The study revealed that SERPINB10 plays a crucial role in the survival of Th2 cells in allergic asthma by inhibiting apoptosis, contributing to allergic inflammation and the Th2 response.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pao-Huan Chen, Cheng-Chih Chung, Yuan-Feng Lin, Yu-Hsun Kao, Yi-Jen Chen
Summary: The study showed that therapeutic trough levels of lithium can reduce the migration and collagen synthesis abilities of human cardiac fibroblasts by inhibiting SOCE and Orai1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yanhong Xing, Xiangqing Wei, Meng-Meng Wang, Yucheng Liu, Zhongheng Sui, Xinyan Wang, Yang Zhang, Yuan-Hui Fei, Yi Jiang, Chen Lu, Peng Zhang, Rong Chen, Nan Liu, Mengmei Wu, Lin Ding, Yuqing Wang, Feng Guo, Jun-Li Cao, Jiansong Qi, Wuyang Wang
Summary: TRPM7 activation inhibits autophagy by releasing Zn2+, disrupting fusion between autophagosomes and lysosomes, ultimately arresting autophagy process. TRPM7-mediated autophagy inhibition triggers cell death and restricts tumor growth.
Article
Cardiac & Cardiovascular Systems
Hideaki Inazumi, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takuro Numaga-Tomita, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Miku Oya, Miki Nonaka, Masami Sugihara, Hideyuki Kinoshita, Kenji Moriuchi, Hiromu Yanagisawa, Toshio Nishikimi, Hirohiko Motoki, Mitsuhiko Yamada, Sachio Morimoto, Kinya Otsu, Richard M. Mortensen, Kazuwa Nakao, Takeshi Kimura
Summary: NRSF is a transcriptional repressor that suppresses the reactivation of fetal cardiac gene program and maintains cardiac integrity. This study reveals that NRSF regulates ventricular function by controlling the expression of G alpha(o) gene, and excessive expression of G alpha(o) leads to cardiac dysfunction. Additionally, G alpha(o) plays a critical role in cardiac Ca2+ homeostasis and systolic function.
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Tadashi Takeuchi, Tetsuya Kubota, Yumiko Nakanishi, Hiroshi Tsugawa, Wataru Suda, Andrew Tae-Jun Kwon, Junshi Yazaki, Kazutaka Ikeda, Shino Nemoto, Yoshiki Mochizuki, Toshimori Kitami, Katsuyuki Yugi, Yoshiko Mizuno, Nobutake Yamamichi, Tsutomu Yamazaki, Iseki Takamoto, Naoto Kubota, Takashi Kadowaki, Erik Arner, Piero Carninci, Osamu Ohara, Makoto Arita, Masahira Hattori, Shigeo Koyasu, Hiroshi Ohno
Summary: Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes. Carbohydrate metabolism by gut microbiota plays a crucial role in insulin resistance, and an increase in host-accessible monosaccharides is associated with insulin resistance and host inflammation.
Article
Biochemistry & Molecular Biology
Chuang Wang, Yunhe Gao, Wenquan Liang, Yixun Lu, KeCheng Zhang, Di Wu, ZiWei Zhuang, Kai Li, Zhi Qiao, Hongqing Xi, Lin Chen
Summary: This study identifies the role of Rspondin-1 in the progression and stemness of gastric cancer through LGR5.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Zibo Wei, Shuangyan Ye, Haipeng Feng, Chong Zeng, Xinhuai Dong, Xiaokang Zeng, Liming Zeng, Xu Lin, Qiuzhen Liu, Jie Yao
Summary: Metabolic reprogramming is a hallmark of malignant tumors. This study demonstrates that Silybin, a nontoxic flavonoid, exhibits notable anti-tumor effects on human ovarian cancer cells. Silybin targets and inhibits IDH1 in ovarian cancer cells, leading to reduced reactive oxygen species generation.
Article
Medicine, Research & Experimental
Ting Zhao, Zhenyu Wang, Yehong Chi, Chunmei Ni, Xudan Zheng
Summary: The study found that TFEC was overexpressed in the hearts of mice with cardiac hypertrophy, and silencing TFEC may improve AngII-induced cardiac hypertrophy and dysfunction by activating AMPK/mTOR signaling.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Microbiology
Hyeri Seok, Ji-Young Choi, Michidmaral Ganbold, Jong Hyun Shin, Jooyun Kim, Won Suk Choi, Dae Won Park, Kwan Soo Ko
Summary: Recently, there has been an increase in the number of reported infections caused by non-diphtheriae Corynebacterium spp. in patients, as well as the discovery of novel species of Corynebacterium isolated from humans. We report two cases of human infections caused by Corynebacterium haemomassiliense-like organisms, which were initially unidentified by MALDI-TOF MS analysis. Further analysis using three housekeeping genes and phenotypic features revealed their close relation to the recently described species C. haemomassiliense. These strains were found to be multidrug-resistant but susceptible to vancomycin, meropenem, and linezolid. Our report suggests that these recently described Corynebacterium species may not be limited to a specific region, highlighting the difficulty in classifying the genus Corynebacterium.
CURRENT MICROBIOLOGY
(2023)
Article
Microbiology
Won-Suk Choi, Sol Oh, Khristine Joy C. Antigua, Ju Hwan Jeong, Beom Kyu Kim, Yu Soo Yun, Da Hyeon Kang, Seong Cheol Min, Byung-Kwan Lim, Won Seop Kim, Ji-Hyuk Lee, Eung-Gook Kim, Young Ki Choi, Yun Hee Baek, Min-Suk Song
Summary: Due to the broad spread, incidence, and genetic divergence of enteroviruses (EVs), it has been challenging to deal with this virus that causes severe human diseases. Therefore, an efficient and universal cloning system for the reverse genetics of highly divergent EVs contributes to an understanding of the viral pathology and molecular mechanisms of evolution.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Jooyun Kim, Hyeri Seok, Ji Hoon Jeon, Won Suk Choi, Gi Hyeon Seo, Dae Won Park
Summary: This study used large population-based cohort data from South Korea to investigate the association between scrub typhus and dementia. The results showed that a history of scrub typhus infection in old age is significantly associated with an increased risk of dementia, especially Alzheimer's disease. Therefore, prevention and appropriate treatment of scrub typhus should be emphasized as a measure for dementia prevention.
BMC INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Sungho Bea, Ahhyung Choi, Jae Hyeon Kim, Young Min Cho, Won Suk Choi, Jaehun Jung, Ju-Young Shin
Summary: This study aimed to explore the risk of breakthrough infection among patients with type 2 diabetes and the risk of severe clinical outcomes after SARS-CoV-2 infection according to vaccination status. The results showed that patients with type 2 diabetes were more likely to experience breakthrough infections, but fully vaccinated patients had a lower risk of adverse clinical outcomes after SARS-CoV-2 infection.
DIABETES OBESITY & METABOLISM
(2023)
Meeting Abstract
Infectious Diseases
J. Y. Song, W. S. Choi, H. J. Cheong, H. Kim
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Geriatrics & Gerontology
Michael Woodward, Venkatasubramanian Ramasubramanian, Adeeba Kamarulzaman, Terapong Tantawichien, Minggui Wang, Joon Young Song, Won Suk Choi, Samsuridjal Djauzi, Rontgene Solante, Wen-Sen Lee, Kazuhiko Tateda, HongXing Pan, Ning-Chi Wang, Tikki Pang
Summary: The impact of vaccinating the older population against vaccine-preventable diseases in terms of health, social and economic benefits has been increasingly recognised. However, there is a gap in the utilisation of vaccines worldwide. The population is ageing at an unprecedented pace in the Asia-Pacific (APAC) region, with the number of persons older than 65 years set to double by 2050 to around 1.3 billion. This review provides an overview of the challenges to adult vaccination in APAC, drivers to increase vaccination coverage, vaccination insights gained through the COVID-19 pandemic, and potential measures to increase the uptake of adult vaccines in the region.
CLINICAL INTERVENTIONS IN AGING
(2023)
Article
Microbiology
Beom Kyu Kim, Won-Suk Choi, Ju Hwan Jeong, Sol Oh, Ji-Hyun Park, Yu Soo Yun, Seong Cheol Min, Da Hyeon Kang, Eung-Gook Kim, Hojin Ryu, Hye Kwon Kim, Yun Hee Baek, Young Ki Choi, Min-Suk Song
Summary: The emergence of SARS-CoV-2 variants in late 2020 has raised global public health concerns. In this study, a method using circular polymerase extension cloning (CPEC) is demonstrated to efficiently generate full-length clones of SARS-CoV-2 variants. This method is valuable for studying the molecular characteristics of emerging variants and for the development and testing of vaccines and antivirals.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Jin Gu Yoon, Young-Eun Kim, Min Joo Choi, Won Suk Choi, Yu Bin Seo, Jaehun Jung, Hak-Jun Hyun, Hye Seong, Eliel Nham, Ji Yun Noh, Joon Young Song, Woo Joo Kim, Dong Wook Kim, Hee Jin Cheong
Summary: Our study found that COVID-19 mRNA vaccination may increase the risk of herpes zoster reactivation, emphasizing the need for close monitoring of individuals who have been vaccinated.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Hyeri Seok, Jooyun Kim, Won Suk Choi, Dae Won Park
Summary: A prospective cohort study found that severe vitamin D deficiency significantly increased mortality in sepsis patients. Evaluating vitamin D levels in sepsis patients may become necessary in an aging society.
Article
Public, Environmental & Occupational Health
Sungho Bea, Hyesung Lee, Won Suk Choi, Kyungmin Huh, Jaehun Jung, Ju-Young Shin
Summary: This study aimed to measure healthcare delay and its association with clinical outcomes among tuberculosis (TB) patients from 2013 to 2018. The results showed that the mean healthcare delay was 42.3 days, and it was associated with increased risk of all-cause mortality, pneumonia, and mechanical ventilation use. The findings suggest the need for attention from authorities and healthcare professionals to timely treatment in order to reduce the preventable burden caused by TB.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Joon Young Song, Won Suk Choi, Jung Yeon Heo, Eun Jin Kim, Jin Soo Lee, Dong Sik Jung, Shin -Woo Kim, Kyung-Hwa Park, Joong Sik Eom, Su Jin Jeong, Jacob Lee, Ki Tae Kwon, Hee Jung Choi, Jang Wook Sohn, Young Keun Kim, Byung Wook Yoo, In-Jin Jang, Maria Z. Capeding, Francois Roman, Thomas Breuer, Piotr Wysocki, Lauren Carter, Sushant Sahastrabuddhe, Manki Song, Naveena D'Cor, Hun Kim, Ji Hwa Ryu, Su Jeen Lee, Yong Wook Park, Hee Jin Cheng
Summary: This study reports the interim immunogenicity results of the GBP510/AS03 vaccine compared to the ChAdOx1-S vaccine in healthy adults. The GBP510/AS03 vaccine demonstrated superiority in generating neutralizing antibodies and non-inferiority in seroconversion rate, and showed a clinically acceptable safety profile.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Shenggang Dong, Navneet Sharma, Sensen Li, Michael Chen, Xiaohan Zhang, Yaolong Hu, Jiantong Li, Yong Su, Xinguang Xu, Vitali Loseu, Eunyoung Seok, Taiyun Chi, Won-Suk Choi, Gary Xu
Summary: This article presents a 140GHz 4-element RF beamforming phased-array receiver (RX) implemented in 22nm FDSOI CMOS. The receiver utilizes a single-side-band architecture and achieves image rejection ratios of >25dB and >20dB across 4GHz and 8GHz channel bandwidth centered at 7GHz intermediate frequency (IF). The RX consumes 480mW DC power, has a noise figure of <10dB from 135 to 147 GHz, and achieves data rates of up to 32Gb/s and 24Gb/s in probe and over-the-air tests.
2023 IEEE RADIO FREQUENCY INTEGRATED CIRCUITS SYMPOSIUM, RFIC
(2023)
Article
Infectious Diseases
Jing Chen, Ju-Young Shin, Sumitra Shantakumar, Sungho Bea, Byong Duk Ye, Dong-Gun Lee, Hyungwoo Kim, Won Suk Choi, Iain Kaan
Summary: The incidence rate of herpes zoster (HZ) is higher in individuals with immunocompromised conditions and autoimmune diseases (IC/AID) in the Republic of Korea (ROK), especially in women, those aged 50 years and above, and those who have undergone transplants and hemato-oncology treatment. HZ in IC/AID patients leads to higher medical costs.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Medicine, General & Internal
Hakjun Hyun, A-Yeung Jang, Jin Woong Suh, In-Gyu Bae, Won Suk Choi, Yu Bin Seo, Jacob Lee, Jin Gu Yoon, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Min Ja Kim, Joon Young Song
Summary: The serotype distribution of pneumococcus in South Korea is evolving, which hinders vaccine rollout. Despite vaccination efforts, serotypes 3 and 19A remain the most common in pneumococcal pneumonia cases in South Korea.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Infectious Diseases
Won Suk Choi
Summary: This paper examines the characteristics of adult immunization, policies implemented in Korea, and considerations for adult vaccination.
INFECTION AND CHEMOTHERAPY
(2023)
