Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Article
Biochemical Research Methods
Li Zhang, Peng Ma, Zijing Wang, Tianshu Xu, Sin Man Lam, Guanghou Shui, Yuzhen Wang, Jiming Xie, Guifen Qiang
Summary: Using a multiomics approach, this study explored the mechanism of thermogenesis in BAT, revealing a high abundance of glycerophospholipids and sphingolipids in BAT. The study also identified specific lipid biomarkers and gene biomarkers that may serve as potential targets for antiobesity drugs by boosting BAT thermogenesis.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Shengnan Liu, Siyi Shen, Ying Yan, Chao Sun, Zhiqiang Lu, Hua Feng, Yiruo Ma, Zhili Tang, Jing Yu, Yuting Wu, Balazs Gereben, Petra Mohacsik, Csaba Fekete, Xiaoyun Feng, Feixiang Yuan, Feifan Guo, Cheng Hu, Mengle Shao, Xin Gao, Lin Zhao, Yuying Li, Jingjing Jiang, Hao Ying
Summary: The active form of thyroid hormone, T3, promotes the proliferation of adipocyte progenitor cells in brown adipose tissue, leading to increased thermogenic capacity.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Haopeng Xiao, Luiz H. M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L. Mills, Margo P. Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M. Cypess, Andrew P. White, Yuchen He, Rebecca Deng, Heiko Schoder, Joao A. Paulo, Mark P. Jedrychowski, Alexander S. Banks, Yu-Hua Tseng, Paul Cohen, Linus T. Tsai, Evan D. Rosen, Samuel Klein, Maria Chondronikola, Fiona E. McAllister, Nick Van Bruggen, Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Summary: By studying a genetically diverse cohort of mice, researchers have identified the functional architecture of brown adipose tissue (BAT) proteome and discovered key regulators of BAT. They also found proteins that are associated with protection from or sensitivity to metabolic diseases. These findings provide important insights into the conserved mechanisms of BAT regulation over metabolic physiology.
Review
Endocrinology & Metabolism
Rafael C. Gaspar, Jose R. Pauli, Gerald Shulman, Vitor R. Munoz
Summary: This article discusses the thermogenic activity and energy expenditure contribution of BAT, as well as the recently discovered secretory molecules batokines from BAT that may explain the beneficial effects of BAT on glucose and fat metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Food Science & Technology
Mingzhu Yan, Suwei Jin, Zhi Wang, Tianji Xia, Yongguang Liu, Qi Chang
Summary: Limonin, a compound found in citrus fruits, has been found to effectively combat obesity by reducing fat mass and body weight gain, and improving fatty liver and hyperlipidemia caused by a high-fat diet. It also promotes the browning of white adipose tissues and prevents the whitening of brown adipose tissue in mice. These effects are associated with the activation of PGC-1 alpha pathway. Overall, limonin shows great potential for regulating energy balance and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Pei-Chi Chan, Po-Shiuan Hsieh
Summary: This review focuses on the role and regulatory mechanism of BAT in DIT and whether these mechanisms are applicable to human health and diseases. BAT is considered an important organ in the process of counter-regulating energy intake and lipid accumulation through DIT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Subramanian Senthivinayagam, Vlad Serbulea, Clint M. Upchurch, Renata Polanowska-Grabowska, Suresh K. Mendu, Srabani Sahu, Prathiba Jayaguru, Kevin W. Aylor, Mahendra D. Chordia, Limor Steinberg, Nathaniel Oberholtzer, Seichii Uchiyama, Noriko Inada, Ulrike M. Lorenz, Thurl E. Harris, Susanna R. Keller, Akshaya K. Meher, Alexandra Kadl, Bimal N. Desai, Bijoy K. Kundu, Norbert Leitinger
Summary: By studying the activity of Panx1 channels in brown adipocytes, it was discovered that Panx1 channels play a significant role in regulating thermogenesis induced by beta 3AR, with potential therapeutic implications for thermoregulation.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Ching-Fang Chang, Amanda L. Gunawan, Irene Liparulo, Peter-James H. Zushin, Ambre M. Bertholet, Yuriy Kirichok, Andreas Stahl
Summary: Coenzyme Q deficiency affects respiration in brown adipose tissue by regulating UCP1 expression, leading to increased mitochondrial membrane potential and decreased ADP/ATP ratios. This deficiency also enhances cold sensitivity.
Article
Biochemistry & Molecular Biology
Sydney Pence, Zachary LaRussa, Zhijun Shen, Min Liu, Karen T. Coschigano, Haifei Shi, Chunmin C. Lo
Summary: The study found that centrally administered Apolipoprotein A-IV regulates thermogenesis in brown adipose tissue through sympathetic and sensory nerves.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tingting Jiang, Duo Su, Xin Liu, Yan Wang, Linjie Wang
Summary: This study found that FGF11 is enriched in brown adipose tissue of goats and promotes differentiation and thermogenesis in brown adipocytes by promoting UCP1 gene expression through EBF2 binding to the UCP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Kaiqing Liu, Xin Liu, Yaqin Deng, Zesong Li, Aifa Tang
Summary: Adipose tissue is a potential target for the treatment of metabolic illnesses, and understanding the roles of circular RNAs (circRNAs) in brown adipose tissue (BAT) and white adipose tissue (WAT) can provide insights into lipid metabolism. In this study, circRNA expression profiling of mouse BAT and WAT revealed differentially expressed circRNAs that are associated with mitochondria and are involved in thermogenesis and lipid metabolism pathways. Furthermore, a novel circRNA circOgdh was discovered to be highly expressed in BAT and to have regulatory effects on lipolysis and lipid droplet accumulation.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Xin Liu, Yuehua Zhu, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang
Summary: This study provides a detailed landscape of miRNA expression in goat brown adipose tissue (BAT) and white adipose tissue (WAT). It is found that miR-433 acts as a negative regulator in controlling brown adipocyte differentiation and thermogenesis in goats.
Article
Biochemistry & Molecular Biology
Sergio Quesada-Vazquez, Anna Antolin, Marina Colom-Pellicer, Gerard Aragones, Laura Herrero, Josep Maria Del Bas, Antoni Caimari, Xavier Escote
Summary: A specific combination of metabolic cofactors showed promising results in treating obesity in a high-fat diet mouse model. The combination reduced obesity and adiposity, improved glucose and lipid metabolic parameters, increased lipid oxidation, and decreased adipocyte hypertrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Edward Milbank, Nathalia R. V. Dragano, Ismael Gonzalez-Garcia, Marcos Rios Garcia, Veronica Rivas-Limeres, Liliana Perdomo, Gregory Hilairet, Francisco Ruiz-Pino, Patricia Mallegol, Donald A. Morgan, Ramon Iglesias-Rey, Cristina Contreras, Luisa Vergori, Juan Cunarro, Begona Porteiro, Aleix Gavalda-Navarro, Rebecca Oelkrug, Anxo Vidal, Juan Roa, Tomas Sobrino, Francesc Villarroya, Carlos Dieguez, Ruben Nogueiras, Cristina Garcia-Caceres, Manuel Tena-Sempere, Jens Mittag, M. Carmen Martinez, Kamal Rahmouni, Ramaroson Andriantsitohaina, Miguel Lopez
Summary: Milbank et al. demonstrate that targeted delivery of AMPK alpha 1 in SF1 neurons of the VMH using small extracellular vesicles can lead to weight loss through increased brown adipose tissue thermogenesis, independent of feeding.