Pharmaco-metabolomics: An emerging “omics” tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets

Metabolomics and Its Practical Value in Pharmaceutical Industry

(2012) Ru Wei   CURRENT DRUG METABOLISM

Successful Translation of Pharmacogenetics into the Clinic

(2012) Elizabeth Phillips et al.   Molecular Diagnosis & Therapy

Identification of a serum-detectable metabolomic fingerprint potentially correlated with the presence of micrometastatic disease in early breast cancer patients at varying risks of disease relapse by traditional prognostic methods

(2011) C. Oakman et al.   ANNALS OF ONCOLOGY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Pharmacometabonomic Profiling as a Predictor of Toxicity in Patients with Inoperable Colorectal Cancer Treated with Capecitabine

(2011) A. Backshall et al.   CLINICAL CANCER RESEARCH

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

13C High-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns

(2011) Maria T. Grinde et al.   NMR IN BIOMEDICINE

Pharmacogenetics, Pharmacogenomics, and Individualized Medicine

(2011) Q. Ma et al.   PHARMACOLOGICAL REVIEWS

Advances in NMR-based biofluid analysis and metabolite profiling

(2010) Shucha Zhang et al.   ANALYST

Nanostructure-Initiator Mass Spectrometry Metabolite Analysis and Imaging

(2010) Matthew P. Greving et al.   ANALYTICAL CHEMISTRY

Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose

(2010) Jost Klawitter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Sarcosine as a potential prostate cancer biomarker and therapeutic target

(2010) Caitlin E. Baum et al.   CANCER BIOLOGY & THERAPY

Use of Pharmaco-Metabonomics for Early Prediction of Acetaminophen-Induced Hepatotoxicity in Humans

(2010) J H Winnike et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An Integrative Approach for Identifying a Metabolic Phenotype Predictive of Individualized Pharmacokinetics of Tacrolimus

(2010) P B Phapale et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A metabonomic approach to chemosensitivity prediction of cisplatin plus 5-fluorouracil in a human xenograft model of gastric cancer

(2010) Xi Wang et al.   INTERNATIONAL JOURNAL OF CANCER

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

(2010) Olaf Beckonert et al.   Nature Protocols

Practical recommendations for pharmacogenomics-based prescription: 2010 ESF–UB Conference on Pharmacogenetics and Pharmacogenomics

(2010) Laurent Becquemont et al.   PHARMACOGENOMICS

Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy

(2010) E Cecchin et al.   PHARMACOGENOMICS JOURNAL

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

(2009) T. A. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spectroscopic and statistical methods in metabonomics

(2009) Daniel S Waterman et al.   Bioanalysis

Metabolic Phenotyping in Health and Disease

(2008) Elaine Holmes et al.   CELL