Article
Biochemistry & Molecular Biology
Mutaz Amin, Jurg Ott, Rongling Wu, Teodor T. Postolache, Claudia Gragnoli
Summary: Melanocortin receptor genes are associated with the risk of major depressive disorder (MDD) and type 2 diabetes (T2D). This study found that MC2R and MC5R genes are associated with MDD, while MC1R, MC2R, MC3R, and MC4R genes are associated with T2D. These findings provide important insights into the role of melanocortin receptor genes in the comorbidity of MDD and T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Endocrinology & Metabolism
Kanchan Tyagi, Nidhi Bharal Agarwal, Prem Kapur, Sunil Kohli, Rajinder K. Jalali
Summary: The study found that T2DM obese patients may be more prone to developing stress and depression, and adiponectin and cortisol could be potential biomarkers for T2DM, aiding in the early diagnosis of these comorbid conditions.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Octavian Vasiliu
Summary: There are ongoing studies on investigational antidepressant drugs for various types of depression. Despite the majority of current antidepressants being based on the monoaminergic hypothesis, recent data supports the market launch of two non-monoamine-modulating drugs. However, their use is limited by various factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Clinical Neurology
Huan Yu, Ruotong Yang, Junhui Wu, Siyue Wang, Xueying Qin, Tao Wu, Yonghua Hu, Yiqun Wu
Summary: This study suggests that metformin is associated with a lower risk of depression. When compared with other oral hypoglycemic agents, the metformin group had a reduced incidence of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Endocrinology & Metabolism
Nahi Sabih Alruwaili, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Amany E. Ragab, Ahmad Awad Alenazi, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha
Summary: Type 2 diabetes (T2D) is a metabolic disease caused by insulin resistance, insulin deficiency, and hyperglycemia. Depression progression in T2D patients is activated by neurochemical dysregulation due to hyperglycemia. Antidepressant drugs can improve glucose homeostasis and insulin sensitivity, but long-term use may increase the risk of T2D development. The use of antidepressant drugs in T2D is controversial, thus this review aims to clarify their potential effects on T2D, both detrimental and beneficial.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Paula M. Trief, Diane Uschner, Melinda Tung, Marsha D. Marcus, Maria Rayas, Sarah MacLeish, Ryan Farrell, Joyce Keady, Lily Chao, Ruth S. Weinstock
Summary: This study aimed to assess the prevalence of high diabetes distress and associated factors in young adults with youth-onset type 2 diabetes. The findings highlighted the association between high distress and factors such as female sex, high blood sugar levels, anxiety symptoms, and lack of health care coverage. These results are important for informing distress interventions for this medically vulnerable group.
Article
Clinical Neurology
Jay A. Brieler, Joanne Salas, Elizabeth Keegan-Garrett, Jeffrey F. Scherrer
Summary: This study investigated the association between acute phase antidepressant medication treatment and glycemic control in patients with type 2 diabetes. The results showed that acute phase treatment was significantly associated with achieving glycemic control within 36 months, but not beyond 36 months. There was no association between acute vs. less than acute phase treatment and glycemic control.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Olga E. Titova, John A. Baron, Tove Fall, Karl Michaelsson, Susanna C. Larsson
Summary: This study found that current and former smoking are associated with an increased risk of Type 2 diabetes, while the link between snus use and Type 2 diabetes risk is inconclusive. The study also revealed that even after quitting smoking, the risk of Type 2 diabetes remains elevated up to approximately 15 years later. However, compounds other than nicotine may underlie the detrimental association of smoking with the risk of Type 2 diabetes.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Lin Gan, Nanfang Li, Mulalibieke Heizhati, Mei Li, Ling Yao, Jing Hong, Ting Wu, Hui Wang, Miaomiao Liu, Adalaiti Maitituersun
Summary: A study found that diurnal cortisol features are associated with the risk of type 2 diabetes (T2D) in patients with hypertension and obstructive sleep apnea (OSA). Specifically, a steep diurnal cortisol slope (DCS) is associated with lower T2D risk, while higher midnight cortisol levels are associated with higher T2D risk. These findings suggest that diurnal cortisol features may be an important target for early prevention of diabetes in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Agnieszka Kilanowska, Agnieszka Ziolkowska
Summary: Diabetes mellitus is a complex disease with various causes and mechanisms. Hyperglycemia not only leads to serious complications but also triggers beta cell apoptosis. Manipulating the Hippo signaling pathway and enhancing pancreatic protective factors may serve as potential strategies for preserving beta cells and treating diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Haigang Cui, Xin Luo, Mingwei Chen, Jun Lu, Johnson J. J. Liu
Summary: Targeting sodium-dependent glucose transporters (SGLT1 and SGLT2) is a promising approach for the treatment of type 2 diabetes mellitus. Market approvals of SGLT2 inhibitors have opened the doors for the discovery of novel agents, including SGLT1/2 dual inhibitors and selective SGLT1 inhibitors. Understanding the physiology of SGLTs offers the potential for additional benefits in T2DM patients at risk. This review discusses recent investigational compounds and future perspectives in drug discovery.
CURRENT DRUG TARGETS
(2023)
Article
Clinical Neurology
Ju-Wei Hsu, Li-Chi Chen, Kai-Lin Huang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Compared to adolescents with antidepressant-responsive depression, those with antidepressant-resistant depression have a higher risk of developing type 2 diabetes mellitus. Clinicians should closely monitor risk factors related to type 2 diabetes in high-risk populations, especially in adolescents with antidepressant-resistant depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Kristina Almby, Susanne Hetty, Jan W. Eriksson
Summary: Counter-regulatory hormonal responses to glucose variations differ in individuals with type 2 diabetes, prediabetes, and normoglycemia, and may contribute to the progression of the disease by promoting insulin resistance and dysglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Laura del Bosque-Plata, Eduardo Martinez-Martinez, Miguel Angel Espinoza-Camacho, Claudia Gragnoli
Summary: TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and is consistently associated with the disease across diverse populations with different genetic origins. The exact mechanisms by which TCF7L2 affects T2D are still not well understood.
Review
Cell Biology
Laura del Bosque-Plata, Eduardo Pavel Hernandez-Cortes, Claudia Gragnoli
Summary: The TCF7L2 protein is key in the Wnt signaling pathway and has been linked to type 2 diabetes, with research suggesting associations with various diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mutaz Amin, Jurg Ott, Rongling Wu, Teodor T. Postolache, Claudia Gragnoli
Summary: Melanocortin receptor genes are associated with the risk of major depressive disorder (MDD) and type 2 diabetes (T2D). This study found that MC2R and MC5R genes are associated with MDD, while MC1R, MC2R, MC3R, and MC4R genes are associated with T2D. These findings provide important insights into the role of melanocortin receptor genes in the comorbidity of MDD and T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mutaz Amin, Jurg Ott, Derek Gordon, Rongling Wu, Teodor T. Postolache, Michael Vergare, Claudia Gragnoli
Summary: Variants of the CRHR2 gene are associated with the risk of depression and type 2 diabetes. This study identified novel risk variants related to depression and type 2 diabetes in 212 Italian families. The findings suggest that CRHR2 plays a stronger role in the risk of depression than in the risk of type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mutaz Amin, Shumail Syed, Rongling Wu, Teodor Tudorel Postolache, Claudia Gragnoli
Summary: Impairment in the HPA axis and cortisol pathway may contribute to the development of major depressive disorders and type 2 diabetes. Variants in the NR3C1 gene are associated with the risk of T2D-MDD comorbidity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Qian Wang, Ang Dong, Jinshuai Zhao, Chen Wang, Christipher Griffin, Claudia Gragnoli, Fengxia Xue, Rongling Wu
Summary: This study uses functional graph theory, combining allometry scaling law and evolutionary game theory, to reveal the bidirectional, signed, and weighted interactions between microbes in microbial communities, and finds that the role of Lactobacillus in maintaining vaginal microbial symbiosis is enabled by upregulation from other microbes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
L. Del Bosque-plata, M. Amin, R. Wu, T. T. Postolache, C. Gragnoli
Summary: The study investigates the role of TCF7L2 gene in major depressive disorder, type 2 diabetes, and their comorbidity. Several novel linkage signals and genetic associations were found, highlighting the cross-interactivity between these diseases.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
M. Amin, M. Perrelli, R. Wu, C. Gragnoli
Summary: Polycystic ovarian syndrome (PCOS) is a complex disorder with various symptoms and comorbidities. Many genetic risk factors are not yet known, but the mineralocorticoid receptor gene (NR3C2) has been identified as a potential risk gene for PCOS. This study found several novel risk variants in NR3C2 that are associated with the development of PCOS.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
M. Amin, M. Perrelli, R. Wu, C. Gragnoli
Summary: Polycystic ovarian syndrome (PCOS) is a complex heterogeneous disorder characterized by hyperandrogenism, irregular menses, and subfertility and often accompanied by other related comorbid disorders such as insulin resistance, obesity, and type 2 diabetes. We found 18 novel risk variants of the NR3C2 gene significantly linked to and/or associated with the risk of PCOS. However, our findings need to be replicated in other ethnic groups in order to reach more solid conclusions.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
L. D. E. L. Bosque-plata, M. Amin, C. Gragnoli
Summary: This study analyzed the link between PSMD9 rs74421874 (IVS3+nt460-G > A), rs3825172 (IVS3+nt437-C > T), and rs14259 SNPs and the quantitative traits of type 2 diabetes (T2D) and the qualitative phenotypes of irregular menses, couple infertility, and menopausal hot flashes. The results showed that PSMD9 is linked to irregular menses, menopausal hot flashes, T2D age of onset, years of combined oral and insulin therapy, and only insulin therapy.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Meeting Abstract
Psychiatry
M. Amin, J. Ott, R. Wu, T. Postolache, M. Vergare, C. Gragnoli
EUROPEAN PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
M. Perrelli, R. Wu, D. J. Liu, R. G. Lucchini, L. DEL Bosque-plata, M. J. Vergare, M. P. Akhter, J. Ott, C. Gragnoli
Summary: Exposure to heavy metals in modern industrial agricultural processes can have potential subclinical and chronic effects on human health, particularly in the brain, cardiovascular and endocrine-metabolic systems, and reproduction.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
M. Amin, R. Wu, T. T. Postolache, C. Gragnoli
Summary: This study is the first to link and associate DRD2 variants with the comorbidity of T2D and MDD. Three novel variants (rs6276, rs35608204, and rs1800499) were found to be significantly linked to the risk of T2D, and one novel variant (rs112646785) was significantly linked and associated with the comorbidity of T2D and MDD in 212 Italian families.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
M. Amin, R. Wu, T. T. Postolache, C. Gragnoli
Summary: This study identified novel variants in the DRD2 gene that are significantly linked and/or associated with the risk of T2D and the comorbidity of T2D and MDD in Italian families.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Libo Jiang, Xinjuan Liu, Xiaoqing He, Yi Jin, Yige Cao, Xiang Zhan, Christopher H. Griffin, Claudia Gragnoli, Rongling Wu
Summary: Through integrating ecological behavioral theory and genetic mapping theory, researchers have developed a computational approach to explore the genetic mechanisms underlying microbiota-host relationships, shedding light on how microbial networks impact host health.
