Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Hao Li, George C. Tsokos
Summary: Inflammatory rheumatic disorders involve the immune system attacking connective tissues and internal organs. Advances in understanding the cellular and molecular mechanisms have led to targeting the IL-23/IL-17 axis therapeutically, resulting in clinical benefits. The complicated interrelationship between IL-23 and IL-17 may be uncoupled in certain disease settings.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Review
Immunology
Angela Ceribelli, Francesca Motta, Matteo Vecellio, Natasa Isailovic, Francesco Ciccia, Carlo Selmi
Summary: Spondyloarthritis (SpA) is a group of inflammatory musculoskeletal diseases with common genetic backgrounds, and IL-17 and IL-23 have been identified as key cytokines in its pathogenesis. Treatment options for axial SpA differ significantly from peripheral arthritis, with new therapies targeting these cytokines showing promising results for both axial psoriatic arthritis and ankylosing spondylitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yanpeng Li, Zhilei Li, Kutty Selva Nandakumar, Rikard Holmdahl
Summary: A recent study found that a single nucleotide variant (NCF1(R90H)) on the NCF1 gene was associated with low production of reactive oxygen species (ROS) and causative for several autoimmune diseases. The study induced psoriasis in the skin and psoriatic arthritis using mannan and evaluated the effects. It was found that the NCF1(90H) variant promoted psoriasis and psoriatic arthritis by hyperactivating macrophages, expanding keratinocytes, and increasing numbers of γδT17 cells.
Article
Dermatology
L. Mastorino, S. Susca, C. Cariti, N. Sliquini, A. Verrone, E. Stroppiana, M. Ortoncelli, P. Dapavo, S. Ribero, P. Quaglino
Summary: Many European national guidelines recommend initial treatment with anti-TNF-alpha adalimumab for psoriasis and psoriatic arthritis due to economic reasons. This study evaluated the efficacy and safety of IL-17 and IL-23 inhibitors for patients who had previously received adalimumab treatment compared to adalimumab-naive patients. The findings suggested that there were no significant differences in efficacy between IL-17 and IL-23 inhibitors for both adalimumab-experienced and adalimumab-naive patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Keisuke Kobayashi, Sakiko Chikazawa, Yue Chen, So Suzuki, Nao Ichimasu, Kazumoto Katagiri
Summary: Sex hormones, particularly estrogen, have dual effects on the pathogenesis of psoriasis. Estrogen can suppress inflammation by enhancing IL-10 production, but can also enhance inflammation by inducing IL-22 and IL-23 expression.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Christian F. Krebs, Jan-Eric Turner, Jan-Hendrik Riedel, Ulf Panzer
Summary: Immune-mediated kidney diseases are a major cause of end-stage renal disease. The immunopathogenesis of these diseases is not fully understood, leading to a lack of specific therapies. However, research has shown that cytokines related to T cell response play a crucial role in renal autoimmunity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diksha Jawale, Shweta Khandibharad, Shailza Singh
Summary: IL-6, IL-17, IL-23, and IL-1 beta are important cytokines in controlling inflammation and immune response during L. major infection. The CD4+ Th17 subset plays a crucial role in lesion formation by stimulating infected macrophages and producing pro-inflammatory cytokines. The study suggests that targeting SATB1 may modulate the secretion of pro-inflammatory cytokines and abnormal immune functioning, potentially leading to the elimination of the intracellular parasite. The use of systems immunological methods helps in understanding crucial components and developing therapeutic interventions for L. major infection.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Review
Immunology
Mohamed Mandour, Sijia Chen, Marleen G. H. van de Sande
Summary: Spondyloarthritis (SpA) is a chronic inflammatory joint disease where the IL-23/IL-17 pathway and TNF-α cytokine play important roles in its pathogenesis. Animal models have provided new insights into molecular mechanisms at different stages of SpA, aiding in understanding disease initiation and potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I'tishom, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: The development of Helicobacter pylori-related diseases is closely linked to chronic inflammation, which is significantly impacted by immune responses. Key cytokines such as IL-17, IL-21, and IL-23 play crucial roles in antimicrobial activity and pathogenic immune response, maintaining Th17 cells and accommodating humoral immune cells in the gut environment.
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kahena R. Soldati, Felipe A. Toledo, Sabrina G. Aquino, Carlos Rossa Jr, Dongmei Deng, Daniela L. Zandim-Barcelos
Summary: Smoking is associated with reduced levels of LL-37 and HNP 1-3 in the gingival crevicular fluid of patients with periodontitis. LL-37 and HNP 1-3 have different expression patterns and correlations with inflammatory mediators in diseased and healthy sites of the periodontium.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Thamiris Cirelli, Rafael Nepomuceno, Silvana R. P. Orrico, Carlos Rossa, Joni A. Cirelli, Kari E. North, Mariaelisa Graff, Silvana P. Barros, Raquel M. Scarel-Caminaga
Summary: Genetic markers of susceptibility to periodontitis were validated in a Brazilian population, with SNPs in the NPY, IL37, and NCR2 genes associated with moderate or severe periodontitis, and the TLR9 marker associated with lower risk of severe periodontitis in men. Sex- and smoking-specific effects were observed for these SNPs, highlighting the genetic predisposition to periodontitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Oncology
Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Juliete Aparecida Francisco da Silva, Guilherme Rossi Assis-Mendonca, Cristiane Okuda Torello, Rodrigo Nato Shiraishi, Fernando Viera Pericole, Karla Priscila Ferro, Adriana Santos Silva Duarte, Eduardo Magalhaes Rego, Sara Teresinha Olalla Saad
Summary: MDS and AML are hematological disorders with high relapse risk and poor survival. This study investigated the effects of a novel HCK inhibitor, iHCK-37, in combination with 5-Azacytidine or Cytarabine on leukemia cells. The combination treatment showed additive effects and reduced oncogenic pathway activation. In addition, iHCK-37 selectively reduced the number of MDS and AML cells without affecting normal cells. These findings suggest that iHCK-37 may have potential as a targeted therapy for leukemia.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Pamela L. Brito, Alisson F. Dos Santos, Hanan Chweih, Maria E. Favero, Erica M. F. Gotardo, Juliete A. F. Silva, Flavia C. Leonardo, Carla F. Franco-Penteado, Mariana G. de Oliveira, Wilson A. Ferreira Jr, Bruna C. Zaidan, Athanase Billis, Giorgio Baldanzi, Denise A. Mashima, Edson Antunes, Sara T. Olalla Saad, Fernando F. Costa, Nicola Conran
Summary: This study investigated the association between blood pressure and renin-angiotensin system components in sickle cell disease (SCD) patients and mice, as well as the effects of angiotensin converting enzyme (ACE) inhibitor on blood pressure and renin-angiotensin system in SCD mice. The results showed that SCD patients and mice had lower diastolic and systolic blood pressure compared to controls, and the reduced blood pressure was associated with increased renin and markers of kidney damage in SCD. ACE concentrations and ACE enzyme activity were significantly decreased in SCD. The administration of enalapril, an ACE inhibitor, lowered blood pressure, plasma angiotensin II, and organ ACE activity in control mice, but had no additional effect on SCD mice. However, plasma angiotensin II and renin levels were significantly higher in enalapril-treated SCD mice than in treated control mice.
Article
Cell Biology
Vinicius de Paiva Goncalves, Joao Paulo Steffens, Carlos Rossa Junior, Luis Carlos Spolidorio
Summary: This study aimed to evaluate the effects of testosterone depletion and supraphysiological testosterone supplementation on early phase wound healing in animals. The results showed that supraphysiological testosterone supplementation improved wound healing by enhancing angiogenesis and reducing wound contraction.
INFLAMMATION RESEARCH
(2022)
Article
Oncology
Marcell Costa de Medeiros, Min Liu, Rajat Banerjee, Emily Bellile, Nisha J. D'Silva, Carlos Rossa Jr
Summary: The study found that galanin secreted by head and neck squamous cell carcinoma (HNSCC) cells exhibits immune-suppressive and pro-tumoral effects. Galanin decreases cell proliferation and expression of pro-inflammatory cytokines, while increasing apoptosis and expression of pro-tumoral cytokines/growth factors. It also suppresses T cell activation and anti-tumoral phenotypes. High expression of galanin is associated with reduced overall survival in HNSCC patients.
Article
Pharmacology & Pharmacy
Cindy Grace Perez-Pacheco, Natalie Aparecida Rodrigues Fernandes, Angelo Constantino Camilli, Danilo Paschoal Ferrarezi, Amanda Favoreto Silva, Mayara Cristina Zunareli, Camila Fernanda Amantino, Fernando Lucas Primo, Morgana Rodrigues Guimaraes-Stabilli, Carlos Rossa Junior
Summary: The aim of this study was to assess the influence of local application of curcumin-loaded nanoparticles on periodontal repair. The results demonstrate that local administration of curcumin-loaded nanoparticles enhanced tissue repair in an experimental model of periodontal repair, promoting bone repair and increasing collagen content.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Meeting Abstract
Hematology
Fernanda Marconi Roversi, Maura Lima Pereira Bueno, Audrey Basso, Adriana Silva Santos Duarte, Juliete A. F. Silva, Sara T. Olalla Saad
Article
Biochemistry & Molecular Biology
Laura Andrea Gonzalez Maldonado, Camyla Rodrigues Nascimento, Natalie Aparecida Rodrigues Fernandes, Ana Lidia Pinheiro Silva, Nisha J. D'Silva, Carlos Rossa Jr
Summary: In oral squamous cell carcinoma, macrophages in the tumor microenvironment play a significant role in prognosis and disease survival. This study focuses on the effects of tumor cell-secreted TGF-beta on macrophage phenotype and macrophage-facilitated tumor invasion. The results show that blocking the effects of TGF-beta can affect macrophage phenotype and impact tumor cell invasion and chemotaxis differently.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Oncology
Mauricio Rocha Dourado, Amr Elseragy, Bruno Cesar da Costa, Fabio Haach Teo, Gustavo Narvaes Guimaraes, Renato Assis Machado, Maija Risteli, Wafa Wahbi, Clarissa Araujo Gurgel Rocha, Livia Maris Ribeiro Paranaiba, Wilfredo Alejandro Gonzalez-Arriagada, Sabrina Daniela da Silva, Ana Lucia Carrinho Ayroza Rangel, Marcelo Rocha Marques, Carlos Rossa Junior, Tuula Salo, Ricardo D. Coletta
Summary: In this study, the expression and impact of stress induced phosphoprotein 1 (STIP1) in oral squamous cell carcinoma (OSCC) were investigated. It was found that STIP1 was highly expressed in OSCC, and its overexpression was associated with shorter survival and higher risk of recurrence. Knockdown of STIP1 reduced proliferation, migration, and invasion of tumor cells, and decreased the number of metastases in a zebrafish model. Furthermore, STIP1 was inversely expressed with miR-218-5p, and transfection of miR-218-5p mimics decreased STIP1 levels and inhibited tumor cell proliferation, migration, and invasion.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Aileen C. Johnson, Juliete A. F. Silva, Steven C. Kim, Christian P. Larsen
Summary: The development of systems biology has led to significant advancements in translational research and personalized medicine. By combining multidisciplinary approaches and novel techniques, it is now possible to extract and analyze vast amounts of data from human samples, even when they are limited in volume and source. These advancements have made the application of a multi-omics approach more accessible outside of specialized centers. In this review, the focus is on biological techniques that are improving our understanding of the immune system and its interactions, with specific emphasis on their potential applications in transplant immunology. The review covers advancements in techniques, initial applications, and future developments in the field.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Camyla Rodrigues Nascimento, Natalie Ap Rodrigues Fernandes, Laura Andrea Gonzalez Maldonado, Carlos Rossa Junior
Summary: Understanding macrophage biology is important for understanding various biological processes and developing new immunomodulatory strategies. This study compared the response of macrophages derived from THP-1 and U937 cells to different polarizing conditions, and found that they have different tendencies towards M1 and M2 phenotypes, with THP-1-derived macrophages being more responsive to M1 stimuli.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Iolanda Augusta Fernandes de Matos, Natalie Aparecida Rodrigues Fernandes, Giovani Cirelli, Mariely Araujo de Godoi, Leticia Ribeiro de Assis, Luis Octavio Regasini, Carlos Rossa Junior, Morgana Rodrigues Guimaraes-Stabili
Summary: In this in vitro study, a newly synthesized chalcone T4 was found to inhibit osteoclast differentiation and activity and stimulate osteogenesis, indicating a promising therapeutic potential in osteolytic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elisandra Marcia Rodrigues, Kennia Scapin Viola, Laura Gonzalez Maldonado, Carlos Rossa-Junior, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho
Summary: Modified formulations of calcium silicate repair materials with additives have been developed to enhance handling, consistency, biocompatibility, and bioactivity. In this study, the effects of these modified materials on human osteoblastic cells were evaluated. The results showed that the modified cements did not have cytotoxic effects and promoted cell viability, gene expression, and mineralization processes.
BRAZILIAN ORAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Juliete A. F. Silva, Xiaoping Qi, Maria B. Grant, Michael E. Boulton
Summary: The study demonstrates that VEGF induces rapid translocation of VEGFRs to the nucleus, with distinct characteristics between VEGFR1 and VEGFR2 in different cell types and a key role of the endosomal pathway in this process.
SCIENTIFIC REPORTS
(2021)