Article
Biochemistry & Molecular Biology
Wen-qing Tian, Si-yu Chen, Feng-ning Chuan, Wen-rui Zhao, Bo Zhou
Summary: TINAGL1 plays an important role in diabetic wound healing and its expression is regulated by high glucose. Administration of exogenous TINAGL1 can promote wound healing in diabetic mice. These findings provide new insights for the treatment of diabetic wounds.
Article
Multidisciplinary Sciences
Mitsunori Miyazaki, Michito Shimozuru, Yu Kitaoka, Kenya Takahashi, Toshio Tsubota
Summary: During hibernation, the skeletal muscles of black bears undergo minimal changes, likely as an adaptive strategy to minimize energy wasting.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina, Antonio D'Amati, Guosu Wang, Thanushiyan Poobalasingam, Maria Fankhaenel, Davide Lucchesi, Rachel Coleby, David Tarussio, Bernard Thorens, Robert J. Hearnden, M. Paula Longhi, Paul Grevitt, Madeeha H. Sheikh, Egle Solito, Susana A. Godinho, Michele Bombardieri, David M. Smith, Dianne Cooper, Asif J. Iqbal, Jeffrey C. Rathmell, Samuel Schaefer, Valle Morales, Katiuscia Bianchi, Giuseppe Danilo Norata, Federica M. Marelli-Berg
Summary: T cell activation requires increased glucose uptake and engagement of the glycolytic pathway. In this study, researchers found that the glucose transporter 2 (Glut2) plays a key role in regulating the development of CD8(+) T cell effector responses in mice. Glut2 expression is influenced by environmental factors and is regulated by molecular interactions. Furthermore, human T cells also rely on Glut2, making it a potential target for therapeutic immunomodulation.
Article
Biochemistry & Molecular Biology
Ching-Chia Wang, Huang-Jen Chen, Ding-Cheng Chan, Chen-Yuan Chiu, Shing-Hwa Liu, Kuo-Cheng Lan
Summary: The study found that acrolein exposure led to increased fasting blood glucose and impaired glucose tolerance in mice. It also showed that acrolein treatment decreased the expression of GLUT4 in both mouse soleus muscles and C2C12 myotubes, as well as suppressed phosphorylation of glucose metabolic signals. Additionally, over-expression of constitutive activation of Akt reversed the inhibitory effects of acrolein on GLUT4 protein expression and glucose uptake in myotubes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Gang Li, Congchun Zhao, Shanhua Fang
Summary: The study showed that upregulated expression of SGLT2 in cardiac fibrosis following MI was regulated by miR-141, and knocking down SGLT2 reduced cardiac fibrosis and improved cardiac function after MI.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Sandra Schorn, Ann-Kristin Dicke, Ute Neugebauer, Rita Schroter, Maren Friedrich, Stefan Reuter, Giuliano Ciarimboli
Summary: The study showed that organic cation transporter 2 (OCT2) is expressed in the pancreas and has a functional relationship with glucose transporter 2 (GLUT2). High glucose was found to stimulate OCT2 expression and activity, while overexpression of GLUT2 decreased OCT2 activity. This suggests a complex regulatory relationship between OCT2, GLUT2, and glucose levels in the pancreas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ara Yoo, Hyeonhee Lee, Jinyoung Jung, Sang Seok Koh, Soojin Lee
Summary: The study identified MCT9 as a novel gene highly downregulated in renal cell cancer, with its overexpression clearly attenuating RCC cell proliferation. Functional analysis of MCT9 may help in deciphering kidney-specific energy metabolism during renal tumor progression.
Article
Plant Sciences
Sheng Huang, Noriyuki Konishi, Naoki Yamaji, Ji Feng Shao, Namiki Mitani-Ueno, Jian Feng Ma
Summary: Boron uptake in rice is mediated by two transporters, OsLsi1 and OsBOR1, with polar localization cooperating for efficient uptake. OsBOR1 undergoes degradation in response to high B, while OsLsi1 remains unaffected. This distinct regulatory mechanism in rice involves clathrin-independent degradation of OsBOR1 in contrast to Arabidopsis thaliana.
Article
Endocrinology & Metabolism
Hui Chen, Xiongze Zhang, Nanying Liao, Yuying Ji, Lan Mi, Yuhong Gan, Yongyue Su, Feng Wen
Summary: This study investigated the expression of GLP-1R, SGLT1, SGLT2, GLUT1, and GLUT2 in DR patients and found that GLP-1R and SGLT2 were significantly decreased in PDR patients. Their decrease was associated with an increased level of expression of TNF-alpha and IFN-gamma, suggesting a potential correlation between defective GLP-1R and SGLT2 signaling and immune response cytokines in PDR patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Kai Aoki, Takuji Suzuki, Fang Hui, Takuro Nakano, Koki Yanazawa, Masato Yonamine, Shinichiro Fujita, Takehito Sugasawa, Yasuko Yoshida, Naomi Omi, Yasushi Kawakami, Kazuhiro Takekoshi
Summary: This study showed that acute low-intensity exercise affects the expression of molecules involved in intestinal carbohydrate digestion and absorption through GLP-2, leading to higher plasma GLP-2 levels and increased expression of GLP-2 receptor, SI, and GLUT2 in the jejunum in mice. These results suggest that exercise may be beneficial for small intestine function in individuals with intestinal frailty.
Article
Agriculture, Dairy & Animal Science
Xuedong Ding, Chenglu Peng, Siting Li, Manman Li, Xinlu Li, Zhi Wang, Yu Li, Xichun Wang, Jinchun Li, Jinjie Wu
Summary: The study investigated the expression of chicken GLUT9 and serum uric acid levels, finding a possible feedback regulation of GLUT9 in the liver and kidney to maintain uric acid balance, highlighting the need for further research on the underlying mechanisms.
Article
Multidisciplinary Sciences
Monira Obaid, S. M. Nashir Udden, Prasanna Alluri, Subhrangsu S. Mandal
Summary: The study demonstrates that during inflammation, HOTAIR plays a key role in regulating Glut1 expression and glucose uptake by activating NF-kB, thereby controlling metabolic programming in immune cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Yongfeng Liu, Cheng-e Tu, Xuxue Guo, Changjie Wu, Chuncai Gu, Qiuhua Lai, Yuxin Fang, Junqi Huang, Zhizhang Wang, Aimin Li, Side Liu
Summary: This study found that EZH2 knockout colorectal cancer cells were more likely to survive under glucose deprivation conditions, and showed a negative correlation with GLS expression. This provides an explanation for the clinical tolerance of cancer cells to EZH2 inhibitors and suggests the potential of combining EZH2 inhibitors with glutamine metabolism inhibitors for cancer treatment.
CELL DEATH & DISEASE
(2021)
Review
Endocrinology & Metabolism
Maria Anna Bantounou, Panagiotis Sardellis, Rosa Thuemmler, Daniel Black Boada, Justyna Kaczmarek, Ribeya Mahmood, Josip Plascevic, Sam Philip
Summary: This study investigated the renal safety profile of sotagliflozin, a new inhibitor of sodium-glucose co-transporter-1 and -2, in patients with type 1 and type 2 diabetes. The results showed that sotagliflozin did not adversely affect renal function and did not change the risk of key renal outcomes, even in patients with pre-existing renal impairment.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, Research & Experimental
Tianqiao Yong, Danling Liang, Chun Xiao, Longhua Huang, Shaodan Chen, Yizhen Xie, Xiong Gao, Qingping Wu, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai
Summary: This paper reports the hypouricemic effect of 2,4-dihydroxybenzoic acid methyl ester (DAE) from Ganoderma applanatum on hyperuricemic mice. DAE inhibits XOD and down-regulates URAT1, showing high similarity and affinity to allopurinol. In vitro, DAE exhibits inhibitory effect against XOD. Importantly, DAE demonstrates remarkable hypouricemic effect on hyperuricemic mice, with no toxicity observed. Mechanistically, DAE inhibits XOD activities and up-regulates OAT1 while down-regulating GLUT9, URAT1, and CNT2.
BIOMEDICINE & PHARMACOTHERAPY
(2022)