Article
Biochemistry & Molecular Biology
Nicolai Bjodstrup Palstrom, Rune Matthiesen, Lars Melholt Rasmussen, Hans Christian Beck
Summary: The human plasma proteome reflects the physiological state of the cardiovascular system and has been used to analyze plasma biomarkers for cardiovascular diseases for decades. However, current plasma biomarkers only address a limited subset of cardiovascular diseases, and there is an urgent need for biomarkers for diseases with increasing incidence like heart failure and abdominal aortic aneurysm. Recent advancements in technologies for analyzing the human plasma proteome are addressing the complexity and facilitating the discovery of novel biomarkers for cardiovascular diseases.
Article
Automation & Control Systems
Carlos E. H. Ventura, Frederico C. Magalhaes, Alexandre M. Abrao, Berend Denkena, Bernd Breidenstein
Summary: This study investigates the impact of geometric parameters on cutting tool performance when turning hardened steel, finding that parameters such as hone radius projection, form factor, and perimeter ratio have significant effects on cutting force and temperature. The experimental and numerical results provide insights into the relationship between edge preparation and cutting forces, as well as chip temperature trends.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2021)
Review
Neurosciences
Benjamin J. Ryan, Nisha Charkoudian, Michael J. Joyner
Summary: In recent years, there have been many new approaches to improve physical performance for athletes, the military, and other applications. The goal of this discussion is to review and quantify the potential impact of these approaches using physiological insights. The evaluation ranges from transformative to ineffective or undetermined. For example, an increase of arterial oxygen partial pressure by 10% may not have a significant impact on healthy individuals at sea level, but it could be beneficial at high altitude or for certain patient populations. The importance of quantitative evaluation and the role of integrative physiologists in appraising these approaches are highlighted.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Environmental Sciences
Menglei Ye, Zhongquan Jiang, Zhongyang Wang, Yanyan Wang, Shu Fang, Yutong Sun, Huize Guan, Danqing Sun, Xuening Ma, Chunhua Zhang, Ying Ge
Summary: In combined treatments of As(V) and Pb(II) in Chlamydomonas reinhardtii, lead could alleviate arsenic stress at lower concentrations, but enhance it at higher concentrations. Proteomic results showed 71 differently expressed proteins (DEPs) in the low concentration treatment and 167 DEPs in the high concentration treatment, involving energy metabolism, photosynthetic carbon fixation, reactive oxygen scavenging, defense, and amino acid synthesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Habibpourmehraban, Yunqi Wu, Jemma X. Wu, Sara Hamzelou, Farhad Masoomi-Aladizgeh, Karthik Shantharam Kamath, Ardeshir Amirkhani, Brian J. Atwell, Paul A. Haynes
Summary: Rice crops are affected by multiple abiotic stresses, with different genotypes exhibiting varied physiological and proteomic responses. Under combined drought, salt, and extreme temperature stress, rice stomata close, ABA levels increase, and proteins like heat shock proteins show consistent responsiveness in two rice genotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Dhruv R. Seshadri, Ethan R. Harlow, Mitchell L. Thom, Michael S. Emery, Dermot M. Phelan, Jeffrey J. Hsu, Peter Dueking, Kristof De Mey, Joseph Sheehan, Benjamin Geletka, Robert Flannery, Jacob G. Calcei, Michael Karns, Michael J. Salata, Tim J. Gabbett, James E. Voos
Summary: The COVID-19 pandemic has led to the use of digital health platforms for self-monitoring and diagnosis, and it has also impacted athletes' ability to train and compete. This paper addresses the gap in literature on how wearable technology can assist athletes infected with COVID-19 in returning to sport. It provides recommendations for team physicians and athletic trainers, highlighting the physiological changes in infected athletes and the potential role of wearable technology in the return-to-play process. This paper contributes to a greater understanding of the implementation of wearable technology in rehabilitation and opens opportunities for innovation in wearables, digital health, and sports medicine.
Article
Psychology, Multidisciplinary
Menglin Fang, Elena Gorozhanina, Larisa Mamedova
Summary: The paper investigates the motivational drivers and engagement of preschoolers to learn in a friendly environment on the basis of the conducted research. Using cutting-edge technology and an interactive environment, the study found that preschoolers had a stronger motivation to learn compared to a conventional setting.
CURRENT PSYCHOLOGY
(2022)
Review
Nutrition & Dietetics
Jeronimo Aragon-Vela, Olivia Gonzalez-Acevedo, Julio Plaza-Diaz, Rafael A. Casuso, Jesus R. Huertas
Summary: This systematic review evaluates the efficacy of seawater consumption in long-duration sport events. The results indicate that consuming seawater can accelerate the recovery of aerobic capacity and muscle capacity, while reducing lactate production after running exercise.
Review
Neurosciences
John A. Hawley, Michael J. Joyner, Daniel J. Green
Summary: Over the past decade, there has been growing interest in identifying bioactive oral compounds that mimic the effects of exercise, but these compounds have typically only targeted skeletal muscle and fail to impart the broad health benefits seen in other tissues and organs. The challenges of designing a pill that can mimic the extensive range of exercise benefits are discussed, including the limitations of the current myocentric paradigm and the potential application of low dose cardiovascular polypills in mimicking cardiovascular exercise effects. Calls for an exercise pill stem from perceived failures of expert advice and public health approaches, and possible strategies to address the global rise in inactivity are explored.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Chemistry, Analytical
Xingyu Chen, Carolin Sailer, Kai Michael Kammer, Julius Fursch, Markus R. Eisele, Eri Sakata, Riccardo Pellarin, Florian Stengel
Summary: This article presents a mono-and intralink filter that can be applied to any type of cross-linking data and workflow, effectively reducing the number of false-positive identifications for inter-protein links in XL-MS data.
ANALYTICAL CHEMISTRY
(2022)
Review
Sport Sciences
Kellsey N. Smith, Tracy Baynard, Peter S. Fischbach, Jane S. Hankins, Lewis L. Hsu, Peggy M. Murphy, Kiri K. Ness, Shlomit Radom-Aizik, Amy Tang, Robert Liem
Summary: In total, 24 studies met inclusion/exclusion criteria. Adverse events were reported in 3.8% of 939 participants with SCD undergoing maximal CPET, with most related to transient ischaemic changes on ECG monitoring or oxygen desaturation during testing. Only 0.43% experienced pain events related to maximal CPET.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Sport Sciences
J. O. R. E. N. BUEKERS, P. A. T. R. I. C. K. DE BOEVER, J. A. N. THEUNIS, S. A. R. A. H. HOUBEN-WILKE, A. N. O. U. K. W. VAES, F. R. I. T. S. M. E. FRANSSEN, E. M. I. E. L. F. M. WOUTERS, S. A. M. I. O. SIMONS, JEAN-MARIE AERTS, M. A. R. T. I. J. N. A. SPRUIT
Summary: The effects of pulmonary rehabilitation on physiological exercise responses in COPD patients vary between responders and nonresponders. Responders showed significant improvements in endurance time and breathing patterns after PR, while nonresponders did not exhibit similar improvements. These physiological changes are associated with the variable improvements in physical performance seen in COPD patients after PR.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Review
Plant Sciences
Roberto Marceddu, Alessandra Carrubba, Mauro Sarno
Summary: In recent years, the cultivation of hops has expanded in the Mediterranean, particularly in the semi-arid regions of Spain and Italy. Research has shown that understanding the response of hops to abiotic stresses is crucial for assessing their adaptive capacity to new growing conditions. Lack of knowledge on the effects of abiotic stress could result in economic risks over multiple years.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Sport Sciences
Felipe Miguel Marticorena, Arthur Carvalho, Luana Farias de Oliveira, Eimear Dolan, Bruno Gualano, Paul Swinton, Bryan Saunders
Summary: This study found a very small but potentially important placebo effect in nutritional supplement studies, with the placebo effect equivalent to 25% to 59% of the total intervention effect. Further research should consider the proportion of placebo effects in intervention studies to avoid underestimating the overall benefits provided by the intervention.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Education & Educational Research
Weijia Wan
Summary: This paper investigates the development of creative mindset in the training of music education professionals. The research examines the level of creativity of students before and after the training program, which focuses on developing creative thinking using cutting-edge technology. The study uses the Torrance Tests of Creative Thinking (TTCT) to measure students' creativity. Conducted at the School of Music, Soochow University, the experiment involves 95 students. The findings highlight the importance of fostering creative thinking skills in music training programs at universities.
INTERACTIVE LEARNING ENVIRONMENTS
(2023)
Article
Neurosciences
L. Pavelka, A. Rauschenberger, Z. Landoulsi, S. Pachchek, P. May, E. Glaab, R. Krueger
Summary: The study found that age significantly affects motor and non-motor symptoms in Parkinson's disease (PD) patients, with only the associations of age at assessment with burden of motor symptoms and cognitive impairment significantly different between PD and healthy controls. Furthermore, a significant inverse correlation of age at onset and polygenic risk score was identified in PD.
NPJ PARKINSONS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Eliane Santana Fernandes Alves, Bruno de Paula Oliveira de Santos, Leticia Valvassori Rodrigues, Carlos Daniel Pereira Freitas, Lucianna Helene Silva dos Santos, Simoni Campos Dias, Octavio Luiz Franco, Luciano Morais Liao, Mariana Torquato Quezado de Magalhaes
Summary: Synoeca-MP, a 14-residue peptide, exhibits antibacterial and antifungal activity. This study investigated the peptide's behavior and structure in membrane-like environments using CD spectroscopy, hydrogen-deuterium exchange, and molecular dynamics simulations. The peptide was found to adopt a partially α-helical conformation when bound to SDS micelles. These findings improve our understanding of the peptide's mode of action and provide insights for future clinical applications.
Review
Biochemistry & Molecular Biology
Cristiane dos Santos, Octavio Luiz Franco
Summary: Plants can synthesize peptides with antimicrobial properties, making them potential biofactories for antimicrobial peptides (AMPs). However, obtaining large-scale, diverse AMPs derived from plants is a significant challenge. This review summarizes the main findings from the past 5 years on plants used as biofactories for AMPs and provides insights into the prospects of using plant-based systems for recombinant AMP production for drug development and the availability of products in the market.
Article
Neurosciences
Lukas Pavelka, Armin Rauschenberger, Zied Landoulsi, Sinthuja Pachchek, Taina Marques, Clarissa P. C. Gomes, Enrico Glaab, Patrick May, Rejko Krueger
Summary: This study identified a specific subtype of PD that is characterized by RBD, predominant autonomic dysfunction, hallucinations, and depression, supporting the concept of a distinctive body-first subtype of PD. The study did not find a significant association between APOE epsilon 4 and pRBD, suggesting that both factors have an independent effect on cognitive decline in iPD.
JOURNAL OF PARKINSONS DISEASE
(2022)
Review
Geriatrics & Gerontology
Jade Ormondes de Farias, Taia Maria Berto Rezende
Summary: Dental pulp and apical papilla play important roles in defense processes and regeneration. However, aging and stressful situations can lead to cellular senescence, which affects the efficiency of these tissues and clinical treatments. This review provides an overview of the causes and consequences of senescence in dental pulp and stem cells from apical papilla, as well as potential prevention methods.
Review
Biochemical Research Methods
Samilla B. Rezende, Lucas R. Lima, Maria L. R. Macedo, Octavio L. Franco, Marlon H. Cardoso
Summary: Peptides and proteins play crucial roles in biological processes. Determining their three-dimensional structures using experimental and computational methods has greatly advanced structure prediction. Machine learning and deep learning approaches have further improved the accuracy of structure prediction. These methods have greatly assisted in answering key biological questions.
CURRENT BIOINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Ramar Perumal Samy, Stephen P. P. Mackessy, Alagarmalai Jeyasankar, Mano Ranjana Ponraj, Octavio Luiz Franco, Matthew A. A. Cooper, Matheswaran Kandasamy, Tapan Kumar Mohanta, Jebasingh Bhagavathsingh, Sakthivel Vaiyapuri
Summary: PaTx-II, an active component from the venom of the Mulga Snake, showed potent antimicrobial activity and promoted wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thuany Alencar-Silva, Ruben D. Diaz-Martin, Alessandra Zonari, Daniel Foyt, Mylieneth Guiang, Robert Pogue, Felipe Saldanha-Araujo, Simoni Campos Dias, Octavio Luiz Franco, Juliana Lott Carvalho
Summary: In this study, the IDR-1018 peptide was found to attenuate the cytotoxicity of synoeca-MP and promote skin cell proliferation and wound repair. The combination of these peptides exhibited good antimicrobial and pro-regenerative activity, suggesting the potential for new strategies in the treatment of skin lesions.
Review
Plant Sciences
Cristiane dos Santos, Octavio Luiz Franco
Summary: Throughout evolution, plants have developed a complex defense system against phytopathogens, which involves constitutive and induced factors combined as defense mechanisms. Plant defense relies on a signaling network connecting structural and biochemical defense and includes the accumulation of antimicrobial and pathogenesis-related (PR) proteins. These PR proteins play a key role in early defense events, reducing damage and mortality caused by pathogens. This review discusses defense response proteins, specifically PR proteins with enzymatic action, and the technological advancements in studying these enzymes for plant defense against phytopathogens.
Article
Plant Sciences
Daiane Gonzaga Ribeiro, Ana Carolina Mendes Bezerra, Ivonaldo Reis Santos, Priscila Grynberg, Wagner Fontes, Mariana de Souza Castro, Marcelo Valle de Sousa, Maria Eugenia Lisei-de-Sa, Maria Fatima Grossi-de-Sa, Octavio Luiz Franco, Angela Mehta
Summary: The co-occurrence of biotic and abiotic stresses severely affects crop performance and productivity in agricultural areas. The present study aimed to identify proteins involved in the resistance of cowpea to nematode and drought stresses. Proteomic analysis revealed key processes, such as hormonal signaling regulation, pathogenesis-related proteins production, and downregulation of photosynthetic activity.
Article
Chemistry, Multidisciplinary
Hadar Cohen, Naiem Ahmad Wani, Daniel Ben Hur, Ludovico Migliolo, Marlon H. Cardoso, Ziv Porat, Eyal Shimoni, Octavio Luiz Franco, Yechiel Shai
Summary: Antibiotic-resistant bacterial infections have increased sepsis and septic shock mortality worldwide and are now a global concern. Antimicrobial peptides (AMPs) show great potential for developing new antimicrobial agents and therapies for host response modulation. A new series of AMPs derived from pexiganan (MSI-78) have been synthesized, with positively charged amino acids at the ends and a hydrophobic core surrounded by positive charges simulating lipopolysaccharide (LPS). These peptides have been investigated for their antimicrobial activity and inhibition of LPS-induced cytokine release using various biochemical and biophysical methods. Two new AMPs, MSI-Seg-F2F and MSI-N7K, have shown promising results with neutralizing endotoxin activity while reducing toxicity and hemolytic activity. These designed peptides have the potential to eradicate bacterial infection and detoxify LPS, making them potentially useful for sepsis treatment.
Article
Chemistry, Medicinal
Ellynes Amancio Correia Nunes, Maria Claudia da Silva, Marlon Henrique Cardoso, Sergio Leandro Espindola Preza, Lucas Silva de Oliveira, Breno Emanuel Farias Frihling, Sebastien Olivier Charneau, Philippe Grellier, Octavio Luiz Franco, Ludovico Migliolo
Summary: This study found that synthetic polyalanine peptides Pa-MAP1.9 and Pa-MAP2 derived from polar fish can inhibit the growth of sleeping sickness pathogens, suggesting their potential as a treatment for sleeping sickness.
Article
Plant Sciences
Lucas Jose de Sousa, Ana Carolina Mendes Bezerra, Mariana Rocha Maximiano, Fabiano T. P. K. Tavora, Natalia Faustino Cury, Osmundo Brilhante de Oliveira Neto, Laurence Veronique Bindschedler, Octavio Luiz Franco, Luiz Eduardo Bassay Blum, Angela Mehta
Summary: This study compares the behavior of S-genes during the interaction of tomato with Xanthomonas euvesicatoria pv. perforans (Xep). It reveals that several putative host S-genes are positively modulated during bacterial infection. Additionally, using ASOs targeting the SlTFIIA γ gene significantly improves plant resistance against bacterial attack.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2023)
Review
Infectious Diseases
Ana Laura Pereira Lourenco, Thuanny Borba Rios, Allan Pires da Silva, Octavio Luiz Franco, Marcelo Henrique Soller Ramada
Summary: Antimicrobial peptides (AMPs) are a promising therapeutic approach against multi-drug resistant microorganisms, but their proteolytic susceptibility limits their market competitiveness. All-hydrocarbon stapling is an effective helix stabilization technique, but its toxicity poses limitations. This review explores recent studies on stapled AMPs for antimicrobial usage.
Review
Agriculture, Multidisciplinary
Mariana Rocha Maximiano, Octavio Luiz Franco
Summary: Modern agriculture faces challenges due to increasing food demand, climate change, and dietary pattern changes. Biotechnological advances, especially the CRISPR/Cas technology, have significant applications in editing the genomes of plant crops. This technology offers an alternative approach to developing plants resistant to biotic and abiotic stresses, contributing to more sustainable agricultural production.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2022)