The p53 tumor suppressor protein regulates hematopoietic stem cell fate

Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose  -irradiation

(2010) H. Yu et al.   BLOOD

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation

(2010) L. Shao et al.   BLOOD

Blockade of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase and Murine Double Minute Synergistically Induces Apoptosis in Acute Myeloid Leukemia via BH3-Only Proteins Puma and Bim

(2010) W. Zhang et al.   CANCER RESEARCH

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

(2010) Katerina I. Leonova et al.   CELL CYCLE

p53-Mediated Hematopoietic Stem and Progenitor Cell Competition

(2010) Tanya Bondar et al.   Cell Stem Cell

Cell Competition: Pirates on the Tangled Bank

(2010) Douglas R. Green   Cell Stem Cell

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Irradiation Selects for p53-Deficient Hematopoietic Progenitors

(2010) Andriy Marusyk et al.   PLOS BIOLOGY

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle

(2009) A. J. Tipping et al.   BLOOD

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT

Pharmacological activation of the p53 pathway in haematological malignancies

(2009) M. N Saha et al.   JOURNAL OF CLINICAL PATHOLOGY

ELF4/MEF Activates MDM2 Expression and Blocks Oncogene-Induced p16 Activation To Promote Transformation

(2009) G. Sashida et al.   MOLECULAR AND CELLULAR BIOLOGY

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

(2009) Jochen Utikal et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q– syndrome

(2009) Jillian L Barlow et al.   NATURE MEDICINE

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

(2008) K. Kojima et al.   BLOOD

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Pbx1 Regulates Self-Renewal of Long-Term Hematopoietic Stem Cells by Maintaining Their Quiescence

(2008) Francesca Ficara et al.   Cell Stem Cell

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

(2008) Heather E. Fleming et al.   Cell Stem Cell

Targeting the MDM2-p53 Interaction for Cancer Therapy

(2008) S. Shangary et al.   CLINICAL CANCER RESEARCH

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

(2008) Jichun Chen et al.   EXPERIMENTAL HEMATOLOGY

Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis

(2008) J. M. Perry et al.   GENES & DEVELOPMENT

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

(2008) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype

(2008) C Haferlach et al.   LEUKEMIA

Chromosomal aberrations in 17p predict in vitro drug resistance and short overall survival in acute myeloid leukemia

(2008) Hareth Nahi et al.   LEUKEMIA & LYMPHOMA

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

(2008) Omobolaji O. Akala et al.   NATURE

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal

(2008) Leonard I. Zon   NATURE

Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid

(2008) M. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA