Article
Cell Biology
Yang Li, Shuting Yang, Ling Qin, Shuying Yang
Summary: Chondrogenesis is regulated by the transcriptional coactivator TAZ, whose expression increases during chondrogenic differentiation. TAZ deletion impairs skeletal development, joint maintenance, and fracture healing by affecting chondrocyte proliferation and differentiation, and interacting with Sox5.
Article
Biology
Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E. Wheelock, Sasha A. Singh, Masanori Aikawa, Lois E. Smith, Richard L. Proia, Timothy Hla
Summary: This study reveals the crucial role of endothelial sphingolipid biosynthesis in regulating vascular development, maintaining circulatory and peripheral organ sphingolipid levels, and contributing to lipid raft formation and efficient signaling. The deletion of SPTLC1 in endothelial cells leads to impaired proliferation, differentiation, and delayed retinal vascular development. Furthermore, EC-derived sphingolipid metabolites are in constant flux between the vasculature, circulation, and non-CNS organs, and play a role in hepatocyte response to stress.
Article
Genetics & Heredity
Tianpeng Gu, Dapeng Hao, Junsung Woo, Teng-Wei Huang, Lei Guo, Xueqiu Lin, Anna G. Guzman, Ayala Tovy, Carina Rosas, Mira Jeong, Yubin Zhou, Benjamin Deneen, Yun Huang, Wei Li, Margaret A. Goodell
Summary: This study reveals the essential role of the long isoform (DNMT3A1) of DNA methyltransferase 3a (DNMT3A) in mouse postnatal development. DNMT3A1 specifically regulates bivalent neurodevelopmental genes in the brain. The N terminus of DNMT3A1 is shown to be necessary for normal development and DNA methylation at DNMT3A1-enriched regions, possibly through binding to mono-ubiquitinated histone H2AK119. These findings provide insights into the isoform-specific functions and regulatory mechanisms of DNMT3A in development.
Article
Multidisciplinary Sciences
Jing Gao, Aonan Li, Shinsuke Fujii, Fei Huang, Chihiro Nakatomi, Ichiro Nakamura, Hiroaki Honda, Tamotsu Kiyoshima, Eijiro Jimi
Summary: Salivary glands develop through epithelial-mesenchymal interactions and are formed through repeated branching. p130Cas protein acts as an adapter, forming complexes with various proteins through integrin and growth factor signaling, regulating essential cellular processes. This study found that p130Cas is expressed in ductal epithelial cells of the submandibular gland (SMG), and its deficiency leads to immature development of granular convoluted tubules (GCT) and downregulated AR signaling.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Khushwant S. Bhullar, Nan Shang, Evan Kerek, Kaiyu Wu, Jianping Wu
Summary: MOTS-c can promote mitochondrial biogenesis and fusion, but many unknown factors still exist in its mechanism of action. The study revealed a pathway in which MOTS-c promotes GLUT4 translocation by regulating mitochondrial fusion GTPases.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Diana C. Rotaru, Ilse Wallaard, Maud de Vries, Julia van der Bie, Ype Elgersma
Summary: Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by loss of functional UBE3A. This study investigated the role of UBE3A in striatal maturation and found that reinstatement of UBE3A expression in early postnatal stages can fully restore neuronal excitability but only partially restore synaptic transmission and behavioral phenotypes. These findings highlight the importance of UBE3A in striatal maturation and the need for early intervention in AS.
Article
Biochemistry & Molecular Biology
Mathie Tenenbaum, Valerie Plaisance, Raphael Boutry, Valerie Pawlowski, Cecile Jacovetti, Clara Sanchez-Parra, Helene Ezanno, Julien Bourry, Nicole Beeler, Gianni Pasquetti, Valery Gmyr, Stephane Dalle, Julie Kerr-Conte, Francois Pattou, Syu-ichi Hirai, Romano Regazzi, Amelie Bonnefond, Philippe Froguel, Amar Abderrahmani
Summary: The study revealed that activation of Jnk3 signaling by Dlk could be a key mechanism for adapting islet beta-cell mass during postnatal development and weight gain.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biology
Sayumi Fujimori, Izumi Ohigashi, Hayato Abe, Yosuke Matsushita, Toyomasa Katagiri, Makoto M. Taketo, Yousuke Takahama, Shinji Takada
Summary: The thymic epithelium plays a crucial role in supporting the development of T cells. This study found that enhanced expression of beta-catenin in thymic epithelial cells leads to thymic dysplasia and T cell deficiency in the embryonic period, while loss of beta-catenin function only slightly reduces cortical thymic epithelial cells and thymocytes in postnatal development.
Article
Cell Biology
Younghoon Jang, Young-Kwon Park, Ji-Eun Lee, Danyang Wan, Nhien Tran, Oksana Gavrilova, Kai Ge
Summary: Our study reveals that MED1 is not generally required for transcription during adipogenesis, but plays a crucial role in postnatal adipose expansion and induction of lipid synthesis genes after diet switch.
GENES & DEVELOPMENT
(2021)
Article
Cell Biology
Bozena Samborska, Dominic G. Roy, Janane F. Rahbani, Mohammed F. Hussain, Eric H. Ma, Russell G. Jones, Lawrence Kazak
Summary: This study reveals the intrinsic role of creatine transport and creatine transphosphorylation in supporting CD8(+) T cell homeostasis and effector function, independent of their effects on global cellular energy charge.
Article
Endocrinology & Metabolism
Stephanie A. Campbell, Jocelyn Begin, Cassandra L. McDonald, Ben Vanderkruk, Tabea L. Stephan, Brad G. Hoffman
Summary: H3K4 trimethylation plays a crucial role in the differentiation and functional maturation of pancreatic islet endocrine cells, with its loss potentially leading to impaired islet function and affected blood glucose regulation.
Article
Biochemistry & Molecular Biology
Shuo Liu, Meishan Chen, Xi Liu, Kang Zheng, Baohua Liu, Weiwei Wu, Qiuxiang Pang
Summary: The study reveals the crucial roles of DjApi5 and its interacting molecule DjAcinus in planarian homeostasis and regeneration, which may be correlated with their specific localization in neoblasts and anti-apoptotic functions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Karin Hori, Satoshi Yamazaki, Chiaki Ohtaka-Maruyama, Tomio Ono, Tomohiro Iguchi, Hisao Masai
Summary: By using Nestin-Cre, we generated mice with Cdc7 knockout in neural stem cells, which displayed severe growth retardation and impaired postnatal brain development. Cerebral cortical layer formation was impaired, while cell numbers remained unchanged. In the hypoplastic cerebellum, granule cell numbers were reduced, indicating that Cdc7 is necessary for DNA replication and cell proliferation of granule cells during mid embryonic stage. These findings demonstrate differential roles of Cdc7 in brain DNA replication/cell proliferation and suggest a potential additional role in cell migration during neural development.
Article
Biochemistry & Molecular Biology
Roni Rahimi, Israel Malek, Tali Lerrer-Goldshtein, Yoav Elkis, Irit Shoval, Avi Jacob, Sally Shpungin, Uri Nir
Summary: The study investigates the regulatory role of TMF1 in GLUT4-mediated glucose uptake and insulin-directed functioning, showing that TMF1 is essential for the formation of insulin responsive, GLUT4-containing vesicles. Absence of TMF1 leads to impaired glucose uptake, resulting in hyperglycemia and decreased body weight in mice, indicating a novel effector in insulin-regulated glucose homeostasis.
Article
Biochemistry & Molecular Biology
Cristina Sanchez-de-Diego, Leonardo Pedrazza, Carolina Pimenta-Lopes, Arturo Martinez-Martinez, Norma Dahdah, Jose Antonio Valer, Pablo Garcia-Roves, Jose Luis Rosa, Francesc Ventura
Summary: The study unveils that increased NRF2 activity during osteocytogenesis leads to elevated ROS levels, promoting the expression of osteocyte-specific genes. Ablation of Nfe2l2 can result in osteopenia and mitigate bone loss induced by ovariectomy.
Article
Endocrinology & Metabolism
Paola Manduca, Alessia Castagnino, Domenico Lombardini, Stefania Marchisio, Stefano Soldano, Valentina Ulivi, Stefano Zanotti, Corrado Garbi, Nicoletta Ferrari, Daniela Palmieri
Article
Endocrinology & Metabolism
Stefano Zanotti, Ernesto Canalis
Review
Endocrinology & Metabolism
Stefano Zanotti, Ernesto Canalis
CALCIFIED TISSUE INTERNATIONAL
(2012)
Article
Biochemistry & Molecular Biology
Stefano Zanotti, Anna Smerdel-Ramoya, Lisa Stadmeyer, Ernesto Canalis
JOURNAL OF CELLULAR BIOCHEMISTRY
(2008)
Article
Biochemistry & Molecular Biology
Stefano Zanotti, Ernesto Canalis
JOURNAL OF CELLULAR BIOCHEMISTRY
(2012)