Article
Biochemistry & Molecular Biology
Yuwa Takahashi, Marni E. Cueno, Noriaki Kamio, Toshimitsu Iinuma, Yoshiyuki Hasegawa, Kenichi Imai
Summary: The study demonstrates that Porphyromonas gingivalis Mfa1 protein can interact functionally with human bronchial epithelial cells, inducing an inflammatory response involving IL-8 and IL-6 gene expression and protein levels. Specifically, Mfa1-TLR2 showed a functional interaction, suggesting a potential role in pulmonary disease development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Matthew S. Coates, Eric W. F. W. Alton, Garth W. Rapeport, Jane C. Davies, Kazuhiro Ito
Summary: The study identified the involvement of specific kinases in Pseudomonas aeruginosa-induced inflammation, with inhibition of p38MAPK and Syk kinase showing significant reduction in IL-6 and CXCL8 release. Additionally, a novel narrow spectrum kinase inhibitor (NSKI) demonstrated potential as an effective therapy for Pseudomonas aeruginosa-induced inflammation.
Article
Multidisciplinary Sciences
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D. Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Summary: GzmK and GzmA can activate PAR1 and PAR2, influencing cell signaling cascades and leading to the release of inflammatory cytokines. This suggests that GzmK acts as a pro-inflammatory regulator during immune responses.
Article
Plant Sciences
Jessica Gasparello, Elisabetta D'Aversa, Chiara Papi, Laura Gambari, Brunella Grigolo, Monica Borgatti, Alessia Finotti, Roberto Gambari
Summary: Sulforaphane may modulate the inflammatory response by inhibiting key molecules IL-6 and IL-8 involved in the COVID-19 cytokine storm, potentially controlling the hyperinflammatory state associated with SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Chien-Hung Lin, Chuan Wan, Wen-Sheng Liu, Hsin-Hui Wang
Summary: Exposure to PM2.5 can induce EMT characteristics in HK-2 cells, with the IL-6/STAT3 pathway playing a key role in mediating early renal tubule cell injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Teng Zhao, Mingchao Wang, Xin Zhao, Shuang Weng, Kun Qian, Kejian Shi, Yanfei Gu, Wantao Ying, Xiaohong Qian, Yi Zhang
Summary: YTHDF2 is upregulated in lung adenocarcinoma and inhibits the migration and invasion of lung cancer cells by regulating the FAM83D-TGF beta 1-pSMAD2/3 pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D. Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Summary: Granzyme K (GzmK) and GzmA can activate PAR1 and PAR2, and are involved in inflammatory response and cell signaling cascade. Despite cleaving PAR2 at the same point as trypsin, GzmK activates a distinct signaling pathway instead of the classical Ca2+ flux. In epithelial cells, GzmK induces the release of inflammatory cytokines through the activation of PAR2.
Article
Environmental Sciences
Xin Fu, Wei Hong, Shuyi Li, Zhi Chen, Wenqu Zhou, Jianwei Dai, Xiaoliang Deng, Hongbin Zhou, Bing Li, Pixin Ran
Summary: The study reveals that biofuel PM2.5 can induce significant pyroptosis and inflammation in human bronchial epithelial cells through both classic NLRP3/Caspase-1/IL-1 beta-dependent and novel ATP/P2Y-dependent mechanisms.
Article
Multidisciplinary Sciences
Yasuhiro Kimura, Masahiro Shinoda, Masaharu Shinkai, Takeshi Kaneko
Summary: Solithromycin, a fluoroketolide antibiotic, can attenuate IL-13-induced goblet cell hyperplasia and mucin production by inhibiting CLCA1 and ANO1 mRNA and protein expression, without affecting STAT6 and ERK phosphorylation. However, further research is needed to clarify the molecular mechanisms underlying this inhibition.
Article
Nutrition & Dietetics
Hae Sou Kim, Joo Weon Lim, Hyeyoung Kim
Summary: In this study, it was found that Korean red ginseng extract (RGE) suppresses the expression of IL-8 and alleviates mitochondrial dysfunction in H. pylori-infected cells through the activation of Nrf2, induction of SOD-1 and HO-1, and reduction of ROS.
Article
Multidisciplinary Sciences
Shanshan Wang, Xin You, Xiaoshu Liu, Fengwei Zhang, Hongjuan Zhou, Xuechai Shang, Long Cai
Summary: This study investigates the contribution of histone methyltransferase SMYD3 to sorafenib resistance in hepatocellular carcinoma (HCC). SMYD3 was found to be significantly elevated in sorafenib-resistant tumors and cells. Functional studies demonstrated that SMYD3 promotes the migration, invasion, metastasis, and stemness of sorafenib-resistant HCC cells. Mechanistically, SMYD3 is required for SMAD2/3-mediated epithelial-mesenchymal transition (EMT) in sorafenib-resistant HCC cells by promoting the expression of SOX4, ZEB1, SNAIL1, and MMP9 genes.
Article
Cell Biology
Fara Silvia Yuliani, Jing-Yun Chen, Wen-Hao Cheng, Heng-Ching Wen, Bing-Chang Chen, Chien-Huang Lin
Summary: Thrombin activates the DCLK1/RhoA signaling pathway, promoting YAP activation and translocation to the nucleus from the cytosol, resulting in YAP/p65 formation and binding to the NF-kappa B site, which enhances IL-8/CXCL8 expression. DCLK1 may play an essential role in thrombin-stimulated IL-8/CXCL8 expression in asthmatic lungs and suggests a potential therapeutic strategy for severe asthma treatment.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Cell Biology
Sahoko Imoto, Maho Suzukawa, Kazufumi Takada, Shizuka Watanabe, Sayaka Igarashi, Masashi Kitani, Takahide Nagase, Ken Ohta
Summary: Serum IgA activates human bronchial smooth muscle cells through transferrin receptor, regulating cell proliferation, migration, and the production of inflammatory factors.
CELLULAR IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Shih-Chang Tsai, Wei-Chei Wu, Jai-Sing Yang
Summary: The study demonstrated that tetrandrine can inhibit EMT in IL-6-stimulated HCT116 cells, indicating its potential as a drug for colorectal cancer treatment.
ONCOTARGETS AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Yanbo Wang, Yanling Yu, Wanjing Yu, Xun Bian, Linxia Gong
Summary: IL-35 inhibits cell pyroptosis and reduces asthma injury by suppressing the p38 MAPK pathway.
Review
Food Science & Technology
Yinghan Chan, Venkata Sita Rama Raju Allam, Keshav Raj Paudel, Sachin K. Singh, Monica Gulati, Muralikrishnan Dhanasekaran, Piyush Kumar Gupta, Niraj Kumar Jha, Hari Prasad Devkota, Gaurav Gupta, Philip M. Hansbro, Brian Gregory George Oliver, Dinesh Kumar Chellappan, Kamal Dua
Summary: Nutraceuticals, such as probiotics, vitamins, and phytochemicals, have been found to modulate the pathological mechanisms of inflammatory respiratory diseases, leading to improved therapeutic outcomes and overall health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Rheumatology
Sumel Ashique, Kirti Gupta, Gaurav Gupta, Neeraj Mishra, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Harish Dureja, Flavia Zacconi, Brian G. Oliver, Keshav Raj Paudel, Philip M. Hansbro, Dinesh Kumar Chellappan, Kamal Dua
Summary: This study summarizes the research on the use of vitamin D for COVID-19 treatment and prevention. Vitamin D supplementation is considered an effective option to enhance immune response and prevent the spread of infection. Vitamin D acts as an immunomodulator, treating infected lung tissue by improving immune response and suppressing inflammatory reactions.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Allergy
Ji Wang, Xin Zhang, Li Zhang, Ying Liu, Gang Wang, Hong Ping Zhang, Lei Wang, De Ying Kang, Brian G. Oliver, Hua Jing Wan, Vanessa M. McDonald, Alan Chen-Yu Hsu, Dan Liu, Wei Min Li, Surinder S. Birring, Gang Wang
Summary: This study investigates the clinical characteristics, inflammatory features, phenotypes, and treatment response in elderly asthma patients. The results show that elderly patients have worse airway obstruction, more comorbidities, lower levels of IgE and FeNO, and a higher risk for late-onset and fixed airflow obstruction asthma. Path analysis suggests that age directly contributes to future exacerbations, partially mediated by increased airway IFN-gamma. Furthermore, elderly patients with asthma exhibit a reduced treatment response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Respiratory System
Senani N. H. Rathnayake, Benedikt Ditz, Jos van Nijnatten, Tayyaba Sadaf, Philip M. Hansbro, Corry A. Brandsma, Wim Timens, Annemarie van Schadewijk, Peter S. Hiemstra, Nick H. T. ten Hacken, Brian Oliver, Huib A. M. Kerstjens, Maarten van den Berge, Alen Faiz
Summary: This study uses scRNA-seq to analyze the effects of smoking on the cellular composition and gene expression of the bronchial-mucus-barrier. It found that smoking alters the cell composition, increases mucus production, and leads to gene expression changes in the bronchial-mucus-barrier. However, these effects can be partially reversed within a year of smoking cessation. The CD methodology can predict goblet cell percentages from RNA-seq.
Editorial Material
Biochemistry & Molecular Biology
Richard Y. Kim, Brian Oliver
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Michael Chhor, Esra Tulpar, Tara Nguyen, Charles G. Cranfield, Catherine A. Gorrie, Yik Lung Chan, Hui Chen, Brian G. Oliver, Lana McClements, Kristine C. McGrath
Summary: Cardiovascular disease (CVD) is a leading cause of death globally, with smoking being a major risk factor. Quitting smoking is challenging due to nicotine addiction and withdrawal symptoms. Electronic cigarettes (e-Cigs) have emerged as an alternative, but their cardiovascular effects are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Gabriele De Rubis, Keshav Raj Paudel, Bikash Manandhar, Sachin Kumar Singh, Gaurav Gupta, Raniya Malik, Jessie Shen, Aniss Chami, Ronan MacLoughlin, Dinesh Kumar Chellappan, Brian Gregory George Oliver, Philip Michael Hansbro, Kamal Dua
Summary: Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease caused by chronic cigarette smoke exposure. Traditional treatments focus on reducing symptoms, but fail to regulate oxidative stress and inflammation, resulting in lung damage. This study explores the potential of agarwood essential oil nanoemulsion (agarwood-NE) as a promising treatment option for COPD by demonstrating its antioxidant and anti-inflammatory effects. The findings show that agarwood-NE successfully counters the pro-inflammatory effects of cigarette smoke extract by reducing the expression of pro-inflammatory cytokines and inducing the expression of anti-inflammatory mediators and antioxidant genes.
Review
Biochemistry & Molecular Biology
Karosham Diren Reddy, Brian Gregory George Oliver
Summary: Sex differences are common in various diseases, particularly in respiratory diseases. While asthma exhibits an age-dependent pattern of sexual dimorphism, substantial differences between males and females also exist in other common conditions like COPD and lung cancer. Sex hormones, such as estrogen and testosterone, are considered primary factors contributing to sexual dimorphism in disease. However, the role of sex chromosomes in this dimorphism is not well-defined. Recent studies have identified key genes on the sex chromosomes that regulate important cell processes and may contribute to disease mechanisms. This review summarizes the patterns of sex differences in asthma, COPD, and lung cancer, highlighting the physiological mechanisms and potential involvement of sex hormones and candidate genes on the sex chromosomes.
CELL AND BIOSCIENCE
(2023)
Editorial Material
Neurosciences
Natasha N. Kumar, Yik Lung Chan, Hui Chen, Brian G. Oliver
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Psychiatry
Hui Chen, Yang Yang, Diana Odisho, Siqi Wu, Chenju Yi, Brian G. Oliver
Summary: Currently, the diagnosis of ADHD relies on behavioral tests. However, this review aims to identify potential biomarkers for ADHD which can provide more objective and accurate diagnosis and evaluation of treatment efficacy.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Min Feng, Xu Bai, Andrew E. Thorpe, Long The Nguyen, Meng Wang, Brian G. Oliver, Angela S. Y. Chou, Carol A. Pollock, Sonia Saad, Hui Chen
Summary: High-fat diet and tobacco smoking are risk factors for chronic kidney disease. E-cigarettes, especially those containing nicotine, increase susceptibility to kidney disease when combined with a high-fat diet. Nicotine-free e-vapour and high-fat diet consumption suppress the production of mitochondrial OXPHOS complexes and extracellular matrix protein deposition, leading to structural instability that can disrupt normal kidney function in the future.
Article
Medicine, General & Internal
Akash Gupta, Janette K. Burgess, Dirk-Jan Slebos, Simon D. Pouwels
Summary: In this study, a cellulose matrix was used as an absorptive probe for bronchial epithelial lining fluid (bELF) sampling. The absorption and elution capacity of the matrix were validated, and the design of the sampling device was optimized. The bELF probe detected higher concentrations of inflammatory proteins compared to bronchial wash samples, indicating its effectiveness for high-precision bELF sampling.
FRONTIERS IN MEDICINE
(2023)
Article
Environmental Sciences
Andrew E. Thorpe, Chantal Donovan, Richard Y. Kim, Howard J. Vindin, Razia Zakarya, Hanna Miyai, Yik L. Chan, David van Reyk, Hui Chen, Brian G. Oliver
Summary: The usage of e-cigarettes has increased in recent years, but there is limited information on the effects of third-hand exposure to e-cigarette vapor. A study found that mice exposed to third-hand e-vapour with nicotine experienced negative effects on lung health, including alveolar enlargement, reduced bronchial responsiveness, and increased epithelial thickening.
Article
Integrative & Complementary Medicine
Li Han, Xiaomin Huang, Haiyang Cai, George Herok, Jing He, Yixun Su, Weihong Li, Chenju Yi, Brian Oliver, Hui Chen
Summary: This study explores the association between kidney Yang deficiency (KYD) and metabolic disorders, suggesting that impaired mitochondrial function in thermogenesis and metabolic tissues may contribute to this vulnerability. The rat model used in the study confirmed the human relevance of KYD and demonstrated that treatment targeting mitochondria function could reverse this phenotype.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Gang Liu, Tatt Jhong Haw, Malcolm R. Starkey, Ashleigh M. Philp, Stelios Pavlidis, Christina Nalkurthi, Prema M. Nair, Henry M. Gomez, Irwan Hanish, Alan CY. Hsu, Elinor Hortle, Sophie Pickles, Joselyn Rojas-Quintero, Raul San Jose Estepar, Jacqueline E. Marshall, Richard Y. Kim, Adam M. Collison, Joerg Mattes, Sobia Idrees, Alen Faiz, Nicole G. Hansbro, Ryutaro Fukui, Yusuke Murakami, Hong Sheng Cheng, Nguan Soon Tan, Sanjay H. Chotirmall, Jay C. Horvat, Paul S. Foster, Brian GG. Oliver, Francesca Polverino, Antonio Ieni, Francesco Monaco, Gaetano Caramori, Sukhwinder S. Sohal, Ken R. Bracke, Peter A. Wark, Ian M. Adcock, Kensuke Miyake, Don D. Sin, Philip M. Hansbro
Summary: TLR7 plays a crucial role in the development of emphysema and COPD through the modulation of mast cell activity. This finding highlights TLR7 as a potential therapeutic target for human lung inflammation.
NATURE COMMUNICATIONS
(2023)