期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 224, 期 2, 页码 289-299出版社
WILEY
DOI: 10.1002/jcp.22150
关键词
-
资金
- National Institutes of Health [2 R01 CM045916, 2 R01 CA055035, 1 R01 CM067777, 2 R01 GM061909]
The chromogenome is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post-translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication-independent manner, and for which three-dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome-free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function. J. Cell. Physiol. 224: 289-299, 2010. (C) 2010 Wiley-Liss, Inc.
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