Article
Biochemistry & Molecular Biology
Shaoying Chen, Yanchun Zhou, Pei Peng, Liqun Xu, Quandong Tang, Weibin Chen, Wei Gu
Summary: This study reveals a novel function of lncRNA SNHG15 in mediating breast cancer cell invasion through regulating the local translation of CDH2 mRNA. SNHG15 forms a complex with nucleolin and transports it to the cell protrusions, stabilizing local CDH2 mRNA and promoting cell invasive potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Emanuela Teveroni, Fiorella Di Nicuolo, Edoardo Vergani, Giada Bianchetti, Carmine Bruno, Giuseppe Maulucci, Marco De Spirito, Tonia Cenci, Francesco Pierconti, Gaetano Gulino, Pierfrancesco Bassi, Alfredo Pontecorvi, Domenico Milardi, Francesca Mancini
Summary: This study investigated the role of PTTG1 in the EMT process in seminoma. The results showed that PTTG1 transcriptionally represses E-Cadherin through its cooperation with the transcriptional repressor ZEB1. It also demonstrated that PTTG1 and ZEB1 strongly localize together in the periphery of the tumors. These findings suggest that PTTG1 is a prognostic factor in seminoma clinical management.
Article
Biotechnology & Applied Microbiology
Yanni Hong, Xiaofeng Li, Jinfeng Zhu
Summary: The study demonstrates that LSD1 promotes proliferation, migration, and invasion of NSCLC cells by demethylating the SEPT6 promoter and suppressing apoptosis. Additionally, LSD1-mediated SEPT6 accelerates NSCLC metastasis in vivo through the TGF-beta 1/Smad pathway.
CANCER GENE THERAPY
(2022)
Article
Multidisciplinary Sciences
Ines Malenica, Julien Adam, Stephanie Corgnac, Laura Mezquita, Edouard Auclin, Isabelle Damei, Laetitia Grynszpan, Gwendoline Gros, Vincent de Montpreville, David Planchard, Nathalie Theret, Benjamin Besse, Fathia Mami-Chouaib
Summary: The study indicates that lower expression of alpha(V) in cancer cells is associated with better immunotherapy outcomes, affecting CD8 T cell recruitment and differentiation, and leading to improved progression-free survival for patients.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Chunjie Meng, Jun Zhan, Delin Chen, Genze Shao, Hongquan Zhang, Wei Gu, Jianyuan Luo
Summary: USP11 plays a critical role in stabilizing NRF2 through deubiquitination, thereby promoting cell proliferation and resistance to stress-induced cell death. Experimental evidence supports the high expression of USP11 in non-small cell lung cancer and its positive correlation with NRF2 expression.
Article
Cell Biology
Megan M. Nelson, J. Damon Hoff, Mya L. Zeese, Gabriel Corfas
Summary: PARP1 plays a novel role in brain development by regulating Cajal-Retzius (CR) cells, neuronal density, and cell adhesion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yarui Sun, Lei Wang, Bo Wang, Yanli Meng, Weiming Wang
Summary: This study investigated the therapeutic effect of Genistein on postmenopausal senile vaginitis and its mechanism of action. The results showed that Genistein improved vaginal health, increased vaginal index, and promoted the expression of EGF and E-cadherin. It also increased the levels of glycogen and Lactobacillus in the vagina, and thickened the vaginal epithelial layers. However, it had no effect on hormone levels in rats.
Article
Immunology
Li Chen, Jun-Ying Xu, Hong-Bao Tan
Summary: The study revealed that lncRNA TUG1 alleviated I/R-induced AKI by targeting miR-494-3p/E-cadherin. Overexpression of TUG1 or transfection with miR-494-3p inhibitor significantly reduced cell apoptosis.
JOURNAL OF INFLAMMATION-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Olga Tsaplina, Ekaterina Lomert, Yuliya Berson
Summary: Bacteria use cell surface proteins to interact with host cells, and E-cadherin plays a crucial role in bacterial invasion. Full-length E-cadherin is involved in S. proteamaculans invasion, while both full-length and truncated E-cadherin can promote S. grimesii invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Meng Luo, Jinfan Li, Qi Yang, Song Xu, Kun Zhang, Jing Chen, Suzhan Zhang, Shu Zheng, Jiaojiao Zhou
Summary: This study identifies N4BP3 as a new regulator that promotes breast cancer metastasis by regulating the ubiquitination and degradation of E-cadherin. It uncovers an unprecedented role for N4BP3 in breast cancer metastasis and elucidates the underlying molecular mechanisms.
Article
Multidisciplinary Sciences
Nabila Founounou, Reza Farhadifar, Giovanna M. Collu, Ursula Weber, Michael J. Shelley, Marek Mlodzik
Summary: The study highlights the critical role of the Nemo molecule in regulating the transition from solid to viscoelastic tissues in the process of cell migration, emphasizing the importance of junctional remodeling regulation for tissue fluidity.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Seon-Young Kim, Song-Yi Park, Hwan-Seok Jang, Yong-Doo Park, Sun-Ho Kee
Summary: Yes-associated protein (YAP) regulates cell migration by influencing ZO-1, potentially through the NF-kappa B signaling pathway. The association of YAP with ZO-1 via angiomotin (AMOT) at TJs at high expression levels helps maintain TJ integrity.
Article
Biotechnology & Applied Microbiology
Feng-Lian Yang, Yu-Xia Wei, Bi-Yun Liao, Gui-Jiang Wei, Hai-Mei Qin, Xiao-Xia Pang, Jun-Li Wang
Summary: The study revealed that HOTAIR and EZH2 are highly expressed in NPC, while E-cadherin is lowly expressed. By regulating trimethylation of H3K27, HOTAIR inhibits E-cadherin expression, promoting NPC cell progression and tumor growth.
Article
Oncology
Yang Zhao, Jia Li, Ka Ka Ting, Jinbiao Chen, Paul Coleman, Ken Liu, Li Wan, Thorleif Moller, Mathew A. Vadas, Jennifer R. Gamble
Summary: The stabilization of VE-Cadherin through CD5-2 treatment selectively regulates leukocyte transmigration, promoting the penetration of CD8(+) T cells while reducing the infiltration of neutrophils. This effect is mediated in part through the upregulation of chemokines like CCL2 and CXCL10, which facilitate immune cell transmigration, and involves the activation of the AKT/GSK3 beta/beta-catenin/TCF4 signaling pathway. Additionally, CD5-2 treatment induces cytoskeletal reorganization and promotes the transcellular migration of CD8(+) T cells by stabilizing the endothelial barrier.
Article
Oncology
Hydari Masuma Begum, Chelsea Mariano, Hao Zhou, Keyue Shen
Summary: The study demonstrated the role of E-cadherin in negatively regulating the mitochondrial membrane potential of cancer cells in the context of biophysical cues in the tumor microenvironment.
Review
Food Science & Technology
Lvting Fan, Qin Ye, Wenjing Lu, Di Chen, Cen Zhang, Lihan Xiao, Xianghe Meng, Yi-Chieh Lee, Hui-Min David Wang, Chaogeng Xiao
Summary: This article provides an overview of the structural characteristics, physiological functions, and applications of slow digestion starch (SDS) and resistant starch (RS) in the food industry. It also compares the preparation methods of functional starch from different plant sources. The lack of standardization in experimental methods has led to significant differences in research results, hindering the development of starch processing technology.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Infectious Diseases
Kuralayanapalya Puttahonnappa Suresh, Uma Bharathi Indrabalan, Bhargav Shreevatsa, Chandan Dharmashekar, Pranav Singh, Sharanagouda S. Patil, Asad Syed, Abdallah M. Elgorban, Rajalakshmanan Eswaramoorthy, Raghavendra G. Amachawadi, Chandan Shivamallu, Shiva Prasad Kollur
Summary: Japanese encephalitis (JE) is a common mosquito-borne disease, accounting for about 30% of fatalities. This study used bioinformatics tools to investigate the codon usage bias, evolutionary inference, and selection pressure analysis of the JE virus. The results showed that the virus had biased codon usage, natural selection played a major role, and it had a rapid evolutionary rate.
INFECTION GENETICS AND EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Priyanka Kannan, Hadeefa A. Begum, Madhana N. Priya, Thirumal D. Kumar, Gnansambandan Ramanathan, Rajalakshmanan Eswaramoorthy, Magesh Ramasamy
Summary: Pycnodysostosis is a rare inherited disorder caused by a deficit of the enzyme Cathepsin K, leading to abnormal collagen degradation and accumulation of toxic fibers in bone cells. This study aims to identify the most significant variant through computational analysis.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Materials Science, Ceramics
Abdallah M. M. Elgorban, D. Sivaganesh, Muthuraj Arunpandian, Ali H. H. Bahkali, Rajalakshmanan Eswaramoorthy, Nouf S. S. Zaghloul, Meenakshi Verma, Asad Syed
Summary: In this study, ZnO@CuO nanocomposites were synthesized and successfully achieved the visible light degradation of the organic dye methyl orange and the drug ciprofloxacin. The structural characterization of the materials was analyzed by powder X-ray diffraction and the Rietveld refinement technique, and the surface morphology was measured by scanning electron microscope characterization. The luminescence performance of the materials was studied by photoluminescence characterization. The results showed that the ZnO@CuO composite is an effective candidate for degrading ciprofloxacin and methyl orange under stimulated sunlight, with an efficiency of above 95%. Optimization parameters were analyzed to improve the degradation process. This affordable photocatalyst provides a new starting point for further research. Additionally, electron density distribution analysis of the synthesized materials was studied.
JOURNAL OF ELECTROCERAMICS
(2023)
Article
Multidisciplinary Sciences
M. R. Suhasini, K. M. Rajeshwari, S. Bindya, A. B. Hemavathi, Prashant M. Vishwanath, Asad Syed, Rajalakshmanan Eswaramoorthy, Raghavendra G. Amachawadi, Chandan Shivamallu, Vijay Kumar Chattu, Sanjay S. Majani, Shiva Prasad Kollur
Summary: There is a growing demand for replacing non-renewable materials with eco-friendly renewable materials in various applications. This study focused on substituting synthetic polymer-based films used in food packaging with films made from renewable materials derived from waste. The inclusion of MgO nanoparticles in the polymer matrix improved the mechanical strength and thermal stability of the films. The results showed that the films containing MgO nanoparticles had better ductility and modulus, making them suitable as environmentally friendly food packaging materials.
Article
Biochemistry & Molecular Biology
Chiu-Fang Chen, Szu-Hsien Chen, Rong-Fu Chen, Keng-Fan Liu, Yur-Ren Kuo, Chih-Kuang Wang, Tzer-Min Lee, Yan-Hsiung Wang
Summary: This study aimed to prepare a high-absorption polyurethane foam dressing modified by polyethylene glycol (PEG) and triethoxysilane (APTES) for promoting wound healing. The PEG/APTES-modified dressing showed better physicochemical properties, anti-adhesion properties, absorption capacity, and promoted wound healing by shortening the inflammatory phase and enhancing collagen deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Po-Sung Fu, Ting-Hsun Lan, Pei-Ling Lai, Cheng-Hwei Chen, Jen-Hao Chen, Jen-Chyan Wang, Chih-Te Liu, Wen-Cheng Chen, Chun-Cheng Hung
Summary: This study investigated the impact of age, gender, bone density, implant length, and diameter on implant stability, as well as the influence of these factors on marginal bone loss. Ninety patients received implant therapy, and the results showed that implant diameter had a stronger effect on implant stability compared to length. Bone density also played a significant role in determining implant stability. Additionally, both bone density and implant torque had a greater impact on marginal bone loss compared to implant stability quotient (ISQ).
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Po-Sung Fu, Fei-Chi Tseng, Ting-Hsun Lan, Pei -Ling Lai, Cheng-Hwei Chen, Jen-Hao Chen, Chih-Te Liu, Wen-Cheng Chen, Chun-Cheng Hung
Summary: The aim of this study was to compare the effects of immediate implant placement with and without immediate provisionalization on implant stability, marginal bone loss, survival rates, and patient satisfaction. The results showed that immediate implant placement with immediate provisionalization had significantly higher implant stability and patient satisfaction compared to immediate implant placement without immediate provisionalization, but there were no significant differences between the two groups in terms of marginal bone loss and survival.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Materials Science, Biomaterials
Ssu-Meng Huang, Wen-Cheng Chen, Cheng-Chen Wu, Shih-Ming Liu, Chia-Ling Ko, Jian-Chih Chen, Chi-Jen Shih
Summary: This study aimed to release gentamicin sulfate to reduce tissue inflammation and prevent infection, and to release ferulic acid to accelerate the overall bone repair. Different particle properties of micro-nano hybrid mesoporous bioactive glass (MBG) were explored to generate different dose releases in MBG/CPC composite bone cement. The developed MBG/CPC composite bone cement can achieve the synergistic sustained release of antibacterial and osteoconductive activities.
BIOMATERIALS ADVANCES
(2023)
Review
Cell Biology
Howida M. Nail, Chien-Chih Chiu, Chung-Hang Leung, Mahmoud M. M. Ahmed, Hui-Min David Wang
Summary: Extracellular communication plays a crucial role in an organism's survival, and one method of communication is through extracellular vesicles called exosomes. These vesicles contain important molecules such as lipids, proteins, DNA, mRNA, and microRNAs, and are secreted by all types of cells, including immune cells and tumor cells. The tumor microenvironment is a complex network that supports tumor growth and includes various components, including exosomes and cytokines. This review focuses on the latest discoveries regarding the communication of the immune system and other cell types, specifically examining the role of exosomal microRNAs in macrophages, dendritic cells, B lymphocytes, and T lymphocytes, as well as their impact on the tumor microenvironment and immunomodulation.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Mathematical & Computational Biology
Giri Senthil, Sahana Selvaganesh, Thiyaneswaran Nessapan, Vishnu Priya Veeraragavan, Rajalakshmanan Eswaramoorthy
Summary: Implantology is an important method for rehabilitating edentulous patients, but neglect after extraction can lead to severe bone loss. Grafting procedures are complex and consider factors such as graft material, surgical site, surgeon's skill, and patient compliance. A study of 20 patients showed that pre-operative stress levels were significantly higher than post-operative stress levels. Female patients and those in the age group of 41-50 also experienced increased stress levels.
Article
Mathematical & Computational Biology
Sundaram Surendran, Subhashree Rohinikumar, Abhinav Rajendra Prabhu, Thiyaneswaran Nesappan, Vishnu Priya Veeraraghavan, Rajalakshmanan Eswaramoorthy
Summary: This study retrospectively analyzed cone beam computed tomographic radiographs of 42 patients who received dental implant therapy at Saveetha Dental College Hospitals in India. The results showed that the mean angular deviation was 3.17° in the anterior region, 1.6° in the premolar region, and 0.81° in the molar region. The data suggests that free hand placement of dental implants can be achieved with minimal deviation by using the opposing dentition as a guide.
Article
Mathematical & Computational Biology
Sundaram Surendran, Sahana Selvaganesh, Thiyaneswaran Nesappan, Vishnu Priya Veeraraghavan, Rajalakshmanan Eswaramoorthy
Summary: This study assessed the effectiveness of two drug regimens for managing pain and swelling in 40 dental implant surgery patients. Visual analogue scale readings were taken at different time points. The data shows that the combination of acetaminophen and aceclofenac with trypsin-chymotrypsin was more effective than acetaminophen alone.
Article
Chemistry, Medicinal
Pin-Keng Shih, Pei-Yuan Lee, Hui Min David Wang, Chung Yi Chen
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Article
Chemistry, Applied
Cam Thi Hong Tran, Hui-Min David Wang, Le Thi Hong Anh, Chitsan Lin, Chun-Yung Huang, Chia-Hung Kuo
Summary: This study evaluates the impact of beta-cyclodextrin on the properties of bitter gourd extract under different heating conditions. It is found that beta-cyclodextrin mitigates the effect of heat treatment on the bitter gourd extract, improving its thermal stability and creating opportunities for its incorporation into heat-processed products.