Article
Multidisciplinary Sciences
Ettore Vanni, Karina Lindner, Anne-Claude Gavin, Christophe Montessuit
Summary: The formation of lipid droplets (LD) is associated with glucose uptake, while the inhibition of diacylglycerol acyltransferases (DGAT) affects glucose uptake under metabolic stress stimulation. This regulation is mediated through the diacylglycerol/triacylglycerol ratio.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Suting Li, Zhi Wang, Mao Chen, Ya Xiao, Jie Min, Ming Hu, Jianming Tang, Li Hong
Summary: In this study, ArfGAP3 was found to be expressed during skeletal muscle injury and myoblast differentiation, and positively correlated with COPI-related genes. In vitro experiments showed that ArfGAP3 regulates COPI-associated vesicle and GLUT4 transport, impacting myoblast proliferation and differentiation by influencing glucose uptake. These findings provide insight into the repair process after skeletal muscle injury.
CELLULAR SIGNALLING
(2023)
Article
Endocrinology & Metabolism
Rafael C. Gaspar, Kun Lyu, Brandon T. Hubbard, Brooks P. Leitner, Panu K. Luukkonen, Sandro M. Hirabara, Ikki Sakuma, Ali Nasiri, Dongyan Zhang, Mario Kahn, Gary W. Cline, Jose Rodrigo Pauli, Rachel J. Perry, Kitt F. Petersen, Gerald I. Shulman
Summary: This study found that regular aerobic exercise can prevent the increase of muscle fat content, as well as reduce the content of sn-1,2-diacylglycerols (DAGs) in the cell membrane and the activation of protein kinase C (PKC), thus maintaining muscle insulin sensitivity.
Article
Cell Biology
Giulia Pozzi, Valentina Presta, Elena Masselli, Giancarlo Condello, Samuele Cortellazzi, Maria Luisa Arcari, Cristina Micheloni, Marco Vitale, Giuliana Gobbi, Prisco Mirandola, Cecilia Carubbi
Summary: Reactive oxygen species (ROS) are key players in physiological processes and can affect myogenic differentiation. Protein kinase C epsilon (PKCe) is involved in muscle stem cell differentiation and skeletal muscle regeneration. PKCs have a role in redox biology and may regulate ROS production. Our study suggests that PKCe is a molecular link between redox homeostasis and myogenic differentiation. We found that PKCe interacts with Nrf2 to activate antioxidant signaling, preventing ROS accumulation and promoting myogenic differentiation.
Article
Endocrinology & Metabolism
Erik A. Richter
Summary: Exercise in humans greatly increases muscle glucose uptake, but the translocation of GLUT4 to the cell membrane only doubles, indicating a significant disparity. This could be due to underestimated measurements or an increase in GLUT4 intrinsic activity during exercise.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Physiology
Arkady Uryash, Alfredo Mijares, Carlos E. Lopez, Jose A. Adams, Jose R. Lopez
Summary: Chronic elevated muscle Ca2+ levels may decrease insulin-stimulated glucose uptake, leading to hyperglycemia. By reducing muscle Ca2+ levels, muscle glucose uptake can be improved, alleviating hyperglycemia. This phenomenon may be related to the expression and subcellular fractionation of GLUT4.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Han Wang, Moran Hu, Zhaoxue Ding, Xiaolong Zhou, Songbai Yang, Zhonghao Shen, Feifei Yan, Ayong Zhao
Summary: PHGDH accelerates chicken muscle cell proliferation by increasing FoxM1 expression.
Article
Biochemistry & Molecular Biology
Chih-Hsuan Chou, Elisabeth R. Barton
Summary: Glucose is a vital energy source for active skeletal muscles, and AMPK plays a crucial role in glucose uptake during muscle contraction. The study aimed to investigate the impact of increased muscle IGF-I on AMPK α phosphorylation and activity. The results demonstrated that high muscle IGF-I enhances glucose uptake under resting conditions but does not inhibit AMPK activity during muscle contraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Nicole Baker, Steven Wade, Matthew Triolo, John Girgis, Damian Chwastek, Sarah Larrigan, Peter Feige, Ryo Fujita, Colin Crist, Michael A. Rudnicki, Yan Burelle, Mireille Khacho
Summary: Physiological changes in mitochondrial shape play a crucial role in regulating the quiescent state and activation potential of adult stem cells. Mitochondrial fragmentation promotes the exit from deep quiescence, while loss of the mitochondrial fusion protein OPA1 leads to premature activation and depletion of stem cells.
Article
Endocrinology & Metabolism
Pablo Panico, Myrian Velasco, Ana Maria Salazar, Patricia Ostrosky-Wegman, Marcia Hiriart
Summary: This study evaluated the effects of sucrose and arsenic exposure on the pathways involved in insulin-stimulated GLUT4 translocation in muscle. The results showed that sucrose and arsenic exposure induced systemic insulin resistance, with defects in GLUT4 retention and docking in the quadriceps muscle, and impacts on the Akt pathway and proteolytic pathway in the gastrocnemius muscle.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Alex B. Addinsall, Nicola Cacciani, Anders Backeus, Yvette Hedstrom, Ganna Shevchenko, Jonas Bergquist, Lars Larsson
Summary: This study found that chronic supramaximal electrical stimulation (ES) can alleviate the symptoms of critical illness myopathy (CIM) and maintain muscle glucose homeostasis by increasing the AMPK-TBC1D4 signaling pathway, reducing muscle protein degradation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Mirko Magnone, Sonia Spinelli, Giulia Begani, Lucrezia Guida, Laura Sturla, Laura Emionite, Elena Zocchi
Summary: This study demonstrates that the plant hormone ABA can improve glycemic control and enhance muscle insulin sensitivity and glucose uptake in a murine model of T1D.
Article
Environmental Sciences
Lan Ma, Chengmei Zhang, Yu Gui, Tingling Zou, Shuhua Xi, Xiaoying Guo
Summary: Excess intake of fluoride leads to fluorosis, which causes muscle damage. In this study, C2C12 cells were used to investigate the impact of fluoride on muscle development and the role of FGF21/ERK signaling pathway. Fluoride inhibited myogenic development and increased muscle atrophy-related markers. Pre-treatment with FGF21 reversed these effects and alleviated muscle atrophy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Anna E. D'Amico, Alexander C. Wong, Cheryl M. Zajd, Xuexin Zhang, Ananya Murali, Mohamed Trebak, Michelle R. Lennartz
Summary: The research revealed the essential role of PKC-ε in IgG-mediated phagocytosis, showing that its regulatory domain drives vesicles from the Golgi to the phagosome, while catalytic activity is required for their fusion. This study represents one of the first examples of a PKC requirement for vesicular trafficking and describes a novel function for a PKC regulatory domain.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biology
Binglin Yue, Haiyan Yang, Jiyao Wu, Jian Wang, Wenxiu Ru, Jie Cheng, Yongzheng Huang, Xianyong Lan, Chuzhao Lei, Hong Chen
Summary: Circular RNA circSVIL promotes bovine myoblast proliferation and inhibits apoptosis, by interacting with STAT1 to inhibit its phosphorylation and affect downstream signaling cascade.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Physiology
Fernando F. Anhe, Soumaya Zlitni, Nicole G. Barra, Kevin P. Foley, Mats Nilsson, Joshua P. Nederveen, Lauren G. Koch, Steven L. Britton, Mark A. Tarnopolsky, Jonathan D. Schertzer
Summary: Exercise training and host genetics have similar effects on the gut microbiome in different rodent species during aging, suggesting that they can mitigate gut dysbiosis and functional decline.
PHYSIOLOGICAL REPORTS
(2022)
Article
Endocrinology & Metabolism
Lindsay A. Broadfield, Amna Saigal, Jake C. Szamosi, Joanne A. Hammill, Ksenia Bezverbnaya, Dongdong Wang, Jaya Gautam, Evangelia E. Tsakiridis, Fiorella Di Pastena, Jamie McNicol, Jianhan Wu, Saad Syed, James S. V. Lally, Amogelang R. Raphenya, Marie-Jose Blouin, Michael Pollak, Andrea Sacconi, Giovanni Blandino, Andrew G. McArthur, Jonathan D. Schertzer, Michael G. Surette, Stephen M. Collins, Jonathan L. Bramson, Paola Muti, Theodoros Tsakiridis, Gregory R. Steinberg
Summary: This study demonstrates that in obese mice fed a high-fat diet, metformin reduces tumor burden through changes in the gut microbiome. Fecal microbiome transfer or in vitro treatment with fecal filtrates from high-fat diet-fed animals partially recapitulates the acceleration of tumor growth. Oral administration of metformin suppresses tumor growth and increases the expression of short-chain fatty acid-producing microbes. Transplanting the gut microbiome from mice treated orally with metformin to drug naive obese mice reduces tumor proliferation and affects the expression of tumor-related genes.
MOLECULAR METABOLISM
(2022)
Editorial Material
Cell Biology
Han Fang, Fernando F. Anhe, Jonathan D. Schertzer
Summary: This study demonstrates that dietary sugar can disrupt the balance of intestinal microbiota, lower protective immunity, and exacerbate metabolic diseases.
Article
Gastroenterology & Hepatology
Fernando F. Anhe, Soumaya Zlitni, Song-Yang Zhang, Beatrice So-Yun Choi, Cassandra Y. Chen, Kevin P. Foley, Nicole G. Barra, Michael G. Surette, Laurent Biertho, Denis Richard, Andre Tchernof, Tony K. T. Lam, Andre Marette, Jonathan Schertzer
Summary: Exposure of rodents to human gut microbiota after restrictive or malabsorptive bariatric surgery improves glycaemic control independently from changes in obesity, insulin or insulin resistance. Higher Parabacteroides and lower Blautia coincided with improvements in blood glucose control after colonisation with human bacteria post-BPD-DS and LSG.
Review
Endocrinology & Metabolism
Brittany M. Duggan, Daniel M. Marko, Raveen Muzaffar, Darryl Y. Chan, Jonathan D. Schertzer
Summary: Small molecule kinase inhibitors (SMKIs) are therapeutic drugs that can target protein kinases and have effects on cell metabolism and endocrine control of organismal metabolism. They have been shown to improve blood glucose levels in diabetic cancer patients and reduce the dependence on insulin or diabetic medication.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Heather L. Petrick, Leslie M. Ogilvie, Henver S. Brunetta, Avery Robinson, Aleah J. Kirsh, Pierre-Andre Barbeau, Rachel M. Handy, Bridget Coyle-Asbil, Connor Gianetto-Hill, Kaitlyn M. J. H. Dennis, Luc J. C. van Loon, Adrian Chabowski, Jonathan D. Schertzer, Emma Allen-Vercoe, Jeremy A. Simpson, Graham P. Holloway
Summary: Impaired heart function in diabetes patients can be caused by factors other than hypertension, such as gut dysbiosis. Dietary nitrate and fecal microbial transplantation have been found to prevent high-fat diet-induced cardiac abnormalities by mitigating gut dysbiosis.
Editorial Material
Gastroenterology & Hepatology
Han Fang, Rodrigo R. e-Lacerda, Jonathan D. Schertzer
Article
Pediatrics
Eileen D. Hutton, Julia C. Simioni, Lehana G. Thabane, Katherine Morrison, Alison C. Holloway, Helen McDonald, Elyanne M. Ratcliffe, Jonathan D. Schertzer, Jennifer C. Stearns, Mike G. Surette
Summary: This prospective study found that exposure to intrapartum antibiotics can affect infant outcomes related to growth, atopic disease, gastrointestinal symptoms, and sleep. In addition, intrapartum and early neonatal antibiotic exposure are associated with an increased risk of fungal infection. Therefore, the use of intrapartum and early neonatal antibiotics should be carefully considered, weighing the risks and benefits.
PEDIATRIC RESEARCH
(2023)
Correction
Pediatrics
Eileen D. Hutton, Julia C. Simioni, Lehana G. Thabane, Katherine Morrison
PEDIATRIC RESEARCH
(2023)
Meeting Abstract
Physiology
Arshpreet Bhatwa, Gabriel Anhe, Fernando Anhe, Jonathan Schertzer
Meeting Abstract
Physiology
Nazli Robin, Nicole Barra, Danish Patoli, Kevin Watt, Khang Nguyen, Kevin Foley, Yujin Li, Akhilesh Tamrakar, Irena Rebalka, Michael Huang, Rhianna Davis, Darryl Chan, Brittany Duggan, Brandyn Henriksbo, Paul Gregorevic, Gary Sweeney, Thomas Hawke, Benedicte Py, Jonathan Schertzer
Meeting Abstract
Physiology
Daniel Marko, Breanne McAlpin, Brittany Duggan, Joseph Cavallari, Jonathan Schertzer
Correction
Multidisciplinary Sciences
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Alba Santiago, Amber Hann, Marco Constante, Sara Rahmani, Josie Libertucci, Kyle Jackson, Gaston Rueda, Laura Rossi, Ramachandran Rithwick, Wolfram Ruf, Jon Schertzer, Alberto Caminero, Premysl Bercik, Heather Jean Galipeau, Elena Francisca Verdu
Summary: Emerging evidence suggests that microbial proteolytic activity is implicated in ulcerative colitis (UC), but its role in Crohn's disease (CD) remains unclear. This study investigated the effects of colonizing germ-free mice with CD microbiota and healthy control microbiota. It was found that CD proteolytic microbiota increased colitis severity through a PAR2 pathway. These findings highlight the proinflammatory nature of CD proteolytic microbiota and its role in exacerbating colitis.
Article
Multidisciplinary Sciences
Tatiane A. Ribeiro, Jessica A. Breznik, Katherine M. A. Kennedy, Erica S. Yeo, Brianna K. E. J. Kennelly, Patrycja A. F. Jazwiec, Violet S. D. Patterson, Christian J. Bellissimo, Fernando F. M. Anhe, Jonathan D. Schertzer, Dawn M. E. Bowdish, Deborah M. Sloboda
Summary: This study found that pregnancy and diet have an impact on maternal intestinal structure and barrier function, as well as peripheral immunophenotype. High-fat diet can worsen the effects of pregnancy on the gut and immune system. Excess maternal adiposity can negatively influence both maternal and child health.