Article
Environmental Sciences
Kaori Shimizu, Masanori Horie, Yosuke Tabei, Shosaku Kashiwada
Summary: The cellular effects of Pb nanoparticles varied among different cell types, primarily by inducing interleukin-8 expression and heme oxygenase-1 gene expression. Pb nanoparticles induced a stronger cellular response compared to Pb nitrate, primarily through cytokine production and in a cell type-dependent manner.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
Guoliang Chai, Emmanuelle Szenker-Ravi, Changuk Chung, Zhen Li, Lu Wang, Muznah Khatoo, Trevor Marshall, Nan Jiang, Xiaoxu Yang, Jennifer McEvoy-Venneri, Valentina Stanley, Paula Anzenberg, Nhi Lang, Vanessa Wazny, Jia Yu, David M. Virshup, Rie Nygaard, Filippo Mancia, Rijad Merdzanic, Maria B. P. Toralles, Paula M. L. Pitanga, Ratna D. Puri, Rebecca Hernan, Wendy K. Chung, Aida M. Bertoli-Avella, Nouriya Al-Sannaa, Maha S. Zaki, Karl Willert, Bruno Reversade, Joseph G. Gleeson
Summary: This study identified homozygous mutations in WLS in patients with syndromic structural birth defects, affecting Wnt protein secretion and signaling. Mouse models showed potential for pharmacologic intervention to prevent Zaki syndrome.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Rosa M. Coco-Martin, Cristina Andres-Iglesias, Girish K. Srivastava, Javier Lagos-Rodriguez, Miguel Ruiz-Tevah, Mario R. Diaz-Cardenas, Ivan Fernandez-Bueno, Juan Garcia-Serna, Maria T. Garcia-Gutierrez, Alfredo Garcia-Layana, J. Carlos Pastor
Summary: The study reported cases of acute intraocular toxicity caused by MEROCTANE commercialized by a Turkish company, highlighting the cytotoxic effects and presence of highly toxic contaminants. While perfluorocarbon liquids are useful tools for intraocular surgery, measures must be implemented to ensure product safety based on both chemical and cytotoxicity analysis for every batch, and medical staff should report suspected cases to the respective National Agencies.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sei-Yong Jun, Dae-Seong Kim, Yong-Sung Kim
Summary: Based on an anti-EGFR monobody, this study developed a new strategy for immunotoxins that can distinguish between cells with EGFR overexpression in tumors and normal tissues, providing a new approach for targeting antigens overexpressed in tumors in broad normal tissues with immunotoxins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ozge Erol Fenercioglu, Merve Cin, Ediz Beyhan, Rahime Sahin, Tevfik Fikret Cermik
Summary: Most patients treated with epidermal growth factor receptor inhibitors develop skin rashes, which are associated with good treatment response and prognosis. We presented two cases of increased uptake of F-18-FDG in skin rashes after treatment with these inhibitors in patients with metastatic colorectal cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lu Feng, Chen Li, Lin-Wen Zeng, Deng Gao, Yu-Hao Sun, Li Zhong, Heng Lin, Hong-Bing Shu, Shu Li
Summary: This study reveals that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling. MARCH3 is associated with IL-3R alpha, promoting its degradation and inhibiting IL-3-induced physiological functions and inflammatory diseases. MARCH3 deficiency aggravates IL-3-amplified expression of inflammatory cytokines, organ damage, and inflammatory death in sepsis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Environmental Sciences
Monica Torres-Ruiz, Mercedes de Alba Gonzalez, Monica Morales, Raquel Martin-Folgar, M. Carmen Gonzalez, Ana I. Canas-Portilla, Antonio De la Vieja
Summary: This study evaluated the neurotoxic effects of nanoplastics on zebrafish embryos and found that nanoplastics accumulated in eyes, neuromasts, brain, and digestive system organs. It inhibited acetylcholinesterase activity and altered endocrine-related gene expression, leading to abnormal behaviors such as increased activity, increased anxiety, and lethargy. These findings provide new understanding into the toxic effects of nanoplastics and their potential health risks to human populations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Medicine, General & Internal
Robert J. Unwin
Summary: Toxic nephropathy, a growing concern, is often caused by new drugs and polypharmacy. Patients' lack of knowledge about their medications and the prevalence of unapproved drugs contribute to the problem. Early detection, drug withdrawal, and supportive care are crucial for effective treatment.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Liyu Jiang, Yan Zeng, Leilei Ai, Hao Yan, Xiaochun Yang, Peihua Luo, Bo Yang, Zhifei Xu, Qiaojun He
Summary: The application of lapatinib, a dual inhibitor, is limited by its cutaneous toxicity. This study revealed that lapatinib-induced cutaneous toxicity is associated with mitochondrial dysfunction, DNA damage, apoptosis of keratinocytes, aberrant immune response, and release of inflammatory factors. Downregulated expression of the DNA repair protein HMGB1 played a critical role in these toxic reactions. Restoring HMGB1 expression might be an effective remedy for lapatinib-induced cutaneous toxicity. Additionally, saikosaponin A could rescue reduced HMGB1 transcription and alleviate lapatinib-induced DNA damage, keratinocyte apoptosis, and toxicity in mice.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pediatrics
Jing Liu, Yuese Lin, Xuandi Li, Hongjun Ba, Xiufang He, Huimin Peng, Shujuan Li, Ling Zhu
Summary: A 3-year-and-6-month-old child presented with recurrent high fever, generalized lymph node enlargement, and elevated inflammatory markers. Whole exome sequencing revealed haploinsufficiency of A20 (HA20) as the cause. After immunosuppressive therapy, the child's symptoms improved significantly and the inflammatory markers returned to normal levels. Due to its unique characteristics, HA20 is often underdiagnosed and misdiagnosed in clinical practice. By reporting this case, we aim to increase awareness of HA20 in the clinic.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biology
Leying Chen, Qing You, Min Liu, Shuaihu Li, Zhaoyu Wu, Jiajun Hu, Yurui Ma, Liangyong Xia, Ying Zhou, Nan Xu, Shiyi Zhang
Summary: This study found that the atrophy of dermal white adipose tissue (dWAT) is associated with the occurrence and exacerbation of rash in a murine model of EGFR inhibitor-induced rash. Activation of PPAR gamma can improve the severity of rash without affecting the antitumor effects.
Article
Biochemistry & Molecular Biology
Plamena R. Angelova, Isabella Myers, Andrey Y. Abramov
Summary: A study found that carbon monoxide (CO) poisoning is a major cause of toxic mortality and morbidity. Reactive oxygen species were found to be generated in response to toxic doses of CO exposure, leading to lipid peroxidation and a decrease in GSH. Inhibition of different phases of reactive oxygen species generation protected cells against CO-induced oxidative stress and cell death, with the most significant effect observed during NADPH oxidase inhibition.
Article
Engineering, Environmental
Jin Chen, Shuangyong Su, Chunqi Wang, Qiang Li, Huiling Wang, Wenjian Xu, Xiaolan Li, Hongpeng Jia
Summary: Electromagnetic induction heating promotes the highly selective reduction of CO2 into CO. Incorporating Ru into the catalyst improves catalytic performance, and the EMIH-driven RWGS reaction takes place at milder conditions and requires lower reaction temperature compared to traditional heating-driven RWGS. On the electron-rich surface of the catalyst, the RWGS reaction follows the HCOOH-intermediated mechanism.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Lina Sun, Ya'nan Han, Ying Yang, Fengfan Wang, Xin Hou, Xiaoxia Ren, Ying Fang
Summary: This study reports a Chinese child with early-onset haploinsufficiency of A20 (HA20) and explores the genetic etiology of TNFAIP3 variant. The patient exhibited symptoms such as fever, arthritis, gastrointestinal symptoms, and colonic ulcers. A heterozygous de novo variant in the TNFAIP3 gene was identified as the genetic cause. The novel variant resulted in loss-of-function of TNFAIP3, leading to elevated inflammatory indicators. Treatment with corticosteroids, TNF-α inhibitors, and thalidomide alleviated symptoms and improved the patient's condition.
CELLULAR IMMUNOLOGY
(2023)
Article
Oncology
Florence Atrafi, Ruben A. G. van Eerden, Stijn L. W. Koolen, Peter de Bruijn, Cristianne J. F. Rijcken, Rob Hanssen, Ferry A. L. M. Eskens, Martijn P. Lolkema, Esther Oomen-de Hoop, Jeffrey Damman, Ron H. J. Mathijssen
Summary: CPC634, a nanoparticle entrapping docetaxel, and conventional docetaxel both result in skin toxicity through anti-mitotic effects such as micronucleation, which can lead to inflammatory reactions. The total docetaxel concentration in the skin was significantly higher after CPC634 administration compared to conventional docetaxel, while the released docetaxel concentrations were not statistically different.Histopathological examination revealed increased apoptosis, mitotic cells with nuclear atypia, and micronucleation with an enhanced Ki-67 index for both compounds.
