Article
Multidisciplinary Sciences
Jekaterina Truskina, Jingyi Han, Elina Chrysanthou, Carlos S. Galvan-Ampudia, Stephanie Laine, Geraldine Brunoud, Julien Mace, Simon Bellows, Jonathan Legrand, Anne-Maarit Bagman, Margot E. Smit, Ondrej Smetana, Arnaud Stigliani, Silvana Porco, Malcolm J. Bennett, Ari Pekka Mahonen, Francois Parcy, Etienne Farcot, Francois Roudier, Siobhan M. Brady, Anthony Bishopp, Teva Vernoux
Summary: Genes encoding the class A auxin-response factor group of plant transcriptional activators reside in constitutively open chromatin, enabling their continual regulation by transcriptional repressors to modulate auxin signalling throughout development.
Article
Physiology
Dan Zhou, Jin Xue, Yukiko Miyamoto, Orit Poulsen, Lars Eckmann, Gabriel G. Haddad
Summary: The microbiota plays a critical role in regulating the host transcriptional response to intermittent hypoxia and hypercapnia in the mouse heart, as shown by distinct transcriptional changes in conventionally reared and germ-free mice exposed to these conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Fisheries
Pei-Pei Wu, Rui-Hao Shu, Xin-Xin Gao, Miao-Miao Li, Ji-Hong Zhang, Huan Zhang, Qi-Lian Qin, Zhen Zou, Qian Meng
Summary: This study revealed that immulectin-2 (IML2) in Thitarodes xiaojinensis larvae is induced after infection by Cordyceps militaris or Beauveria bassiana but maintained at a low level after infection by Ophiocordyceps sinensis or Ringer's buffer. Recombinant IML2 (rIML2) can promote melanization, encapsulation, phagocytosis, and hemocyte aggregation. RNA interference with IML2 reduces the transcript levels of various antimicrobial peptides. Importantly, the abundance of O. sinensis blastospores coated with rIML2 dramatically decreases in the host hemolymph.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Cell Biology
Lorena Pizarro, Daniela Munoz, Iftah Marash, Rupali Gupta, Gautam Anand, Meirav Leibman-Markus, Maya Bar
Summary: This study investigated the effects of the plant hormone cytokinins on cellular trafficking and the actin cytoskeleton, revealing that CK influences the distribution of the actin cytoskeleton and endomembrane compartments, as well as affecting the cellular response in defense signaling. CK plays a fundamental role in regulating cellular integrity and trafficking in plant cells, amplifying signals and enhancing responses to external stimuli.
Article
Immunology
Abdulsalam Adegoke, Jose M. C. Ribeiro, Sidney Brown, Ryan C. Smith, Shahid Karim
Summary: This study identified five distinct phagocytic and non-phagocytic hemocyte populations in ticks and showed that phagocytic hemocytes play a crucial role in eliminating bacterial infection. The research also revealed that an intracellular tick-borne pathogen modifies tick cellular immune responses by infecting phagocytic hemocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Marine Z. C. Hatit, Melissa P. Lokugamage, Curtis N. Dobrowolski, Kalina Paunovska, Huanzhen Ni, Kun Zhao, Daryll Vanover, Jared Beyersdorf, Hannah E. Peck, David Loughreyl, Manaka Sato, Ana Cristianl, Philip J. Santangelo, James E. Dahlman
Summary: This study compared the delivery of mRNA by lipid nanoparticles in different species using DNA barcoding technology and identified species-dependent responses. These findings contribute to the acceleration of RNA therapy development.
NATURE NANOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dongheng Zhou, Huanhuan Yan, Shuying Yang, Yuhong Zhang, Xiaoyan Xu, Xufeng Cen, Kai Lei, Hongguang Xia
Summary: The study demonstrates that SC75741 exerts neuroprotective effects on ALS through multiple mechanisms such as inhibiting NF-κB, enhancing TFEB nuclear translocation, and promoting TDP25 degradation. Additionally, the dual-targeted inhibition of c-Abl and NF-κB by SC75741 may be a potential therapeutic approach for TDP43 proteinopathies and ALS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Philippe Nicolas, Richard J. Pattison, Yi Zheng, Taly Lapidot-Cohen, Yariv Brotman, Sonia Osorio, Alisdair R. Fernie, Zhangjun Fei, Carmen Catala
Summary: Tomato fruits with disrupted starch biosynthesis undergo significant transcriptional and metabolic remodeling, affecting central carbohydrate and lipid metabolism and impacting stress responses. The lack of carbon flow into starch leads to increased levels of soluble sugars, readjustment of metabolism, and activation of growth and stress protection pathways. These findings provide insights into the effects of carbohydrate metabolism perturbations on tomato fruit development and potential implications for enhancing protective mechanisms against abiotic stress in fleshy fruit.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Immunology
Aleksei Parshenkov, Thierry Hennet
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hafsa Munir, James O. Jones, Tobias Janowitz, Markus Hoffmann, Maximilien Euler, Carla P. Martins, Sarah J. Welsh, Jacqueline D. Shields
Summary: The study reveals that cancer-associated fibroblasts (CAF) induce the formation of neutrophil extracellular traps (NET) within tumors and systemically in the blood and bone marrow. These tumor-induced NETs are driven by a ROS-mediated pathway dependent on CAF-derived Amyloid beta peptide. Inhibition of NETosis skews neutrophils to an anti-tumor phenotype, while t-NETs enhance CAF activation.
NATURE COMMUNICATIONS
(2021)
Review
Neurosciences
Adrian Gonzalez-Martin, Tomas Moyano, Daniela A. Gutierrez, Franciso J. Carvajal, Waldo Cerpa, Jonathan G. Hanley, Rodrigo A. Gutierrez, Alejandra R. Alvarez
Summary: Studies have shown that c-Abl kinase deficiency in the brain of mice can improve learning acquisition and memory consolidation, and also affect gene expression patterns in the mouse hippocampus. Trained c-Abl KO mice exhibit upregulation of genes involved in synaptic plasticity and actin cytoskeleton dynamics, and have larger and more densely distributed dendritic spines.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Juliano Morimoto
Summary: Intraspecific competition in larval stage of holometabolous insects affects their development, and the metabolism of uric acid plays a role in this process along with larval crowding, diet, and urea concentration. Larvae with disrupted uric acid metabolism develop faster in sugar-rich diets, but pupate at lower heights in protein-and sugar-rich diets in crowded conditions and show slower development in protein-rich mixed-genotype environments. The disrupted uric acid metabolism does not affect female oviposition or larval pupation success.
Article
Biochemistry & Molecular Biology
Marina Yu. Kopaeva, Asya M. Azieva, Anton B. Cherepov, Irina Yu. Zarayskaya
Summary: This study investigates the ability of lactoferrin to regulate gene expression involved in long-term neuroplasticity, and its effect on neuronal processes. The findings show that exogenous lactoferrin can enter the nuclei of neuronal cells and colocalize with the transcription factor c-Fos, leading to increased expression of c-Fos. These results suggest that lactoferrin may function as a modulator of neuronal processes and provide new insights into its regulatory effects on cell function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Jinchen Chen, Tianze Song, Sha Long, Kevin J. Zhu, Spyros G. Pavlostathis
Summary: This study assessed the effects of peracetic acid (PAA) and hydrogen peroxide (H2O2) solutions on nitrification kinetics, cellular responses, and gene expression in a nitrifying culture. The results showed that PAA mainly inhibited nitrification through enzyme inhibition, while H2O2 had minimal impact. The study provides important insights for the design and operation of biological nitrogen removal systems for PAA-bearing wastewater.
Article
Biochemistry & Molecular Biology
Trisiani Affandi, Angela M. Ohm, Dany Gaillard, Ami Haas, Mary E. Reyland
Summary: The study demonstrates that tyrosine kinase inhibitors (TKIs) provide radioprotection to salivary gland tissues by enhancing DNA repair mechanisms. TKIs increase the repair of DNA double-stranded breaks, regulate pathways involved in DNA repair, and prime cells for more efficient repair post-irradiation, suggesting a potential clinical application in head and neck cancer patients receiving radiation therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Estefanie Dufey, Jose Manuel Bravo-San Pedro, Cristian Eggers, Matias Gonzalez-Quiroz, Hery Urra, Alfredo Sagredo, Denisse Sepulveda, Philippe Pihan, Amado Carreras-Sureda, Younis Hazari, Eduardo A. Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M. Domingos, Remy Pedeux, Eric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walter, Alvaro Glavic, Guido Kroemer, Claudio Hetz
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Pedro Jara-Guajardo, Pablo Cabrera, Freddy Celis, Monica Soler, Isadora Berlanga, Nicole Parra-Munoz, Gerardo Acosta, Fernando Albericio, Fanny Guzman, Marcelo Campos, Alejandra Alvarez, Francisco Morales-Zavala, Marcelo J. Kogan
Article
Materials Science, Biomaterials
M. Cisternas, H. Bhuyan, M. J. Retamal, N. Casanova-Morales, M. Favre, U. G. Volkmann, P. Saikia, D. E. Diaz-Droguett, S. Maendl, D. Manova, N. Moraga, A. Chandia-Cristi, A. Alvarez, F. Guzman
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Review
Biochemistry & Molecular Biology
M. J. Yanez, T. Marin, E. Balboa, A. D. Klein, A. R. Alvarez, S. Zanlungo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Cell Biology
Pol Picon-Pages, Daniela A. Gutierrez, Alejandro Barranco-Almohalla, Giulia Crepin, Marta Tajes, Gerard Ill-Raga, Francesc X. Guix, Silvia Menendez, Montserrat Arumi-Uria, Ruben Vicente, Alejandra R. Alvarez, Francisco J. Munoz
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Fabian Montecino, Natalia Gonzalez, Natasha Blanco, Manuel J. Ramirez, Adrian Gonzalez-Martin, Alejandra R. Alvarez, Hugo Olguin
Summary: The study reveals the role of c-Abl in regulating myogenic progression in satellite cells (SCs) by controlling Pax7 function and expression, affecting the activity and muscle regeneration of SCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
M. J. Yanez, F. Campos, T. Marin, A. D. Klein, A. H. Futerman, A. R. Alvarez, S. Zanlungo
Summary: This study reveals that c-Abl tyrosine kinase participates upstream of RIPK3 in Gaucher disease, with its inhibition showing potential therapeutic benefits. The interaction and phosphorylation of RIPK3 by c-Abl was reduced with pharmacological intervention, highlighting c-Abl signaling as a novel pathway for potential GD treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Elisa Balboa, Tamara Marin, Juan Esteban Oyarzun, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Summary: This study identified potential therapeutic targets for the treatment of liver damage in NPCD by analyzing the pathophysiology of liver damage caused by NPCD and finding significant changes in expression levels of proteins related to liver damage, lipid metabolism, and inflammation. Lysosomal and mitochondrial proteins were found to play important roles in liver fibrosis, damage, and steatosis, validating the dataset.
Review
Neurosciences
Adrian Gonzalez-Martin, Tomas Moyano, Daniela A. Gutierrez, Franciso J. Carvajal, Waldo Cerpa, Jonathan G. Hanley, Rodrigo A. Gutierrez, Alejandra R. Alvarez
Summary: Studies have shown that c-Abl kinase deficiency in the brain of mice can improve learning acquisition and memory consolidation, and also affect gene expression patterns in the mouse hippocampus. Trained c-Abl KO mice exhibit upregulation of genes involved in synaptic plasticity and actin cytoskeleton dynamics, and have larger and more densely distributed dendritic spines.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Pablo Cabrera, Pedro Jara-Guajardo, Maria Paz Oyarzun, Nicole Parra-Munoz, Aldo Campos, Monica Soler, Alejandra Alvarez, Francisco Morales-Zavala, Eyleen Araya, Alicia N. Minniti, Rebeca Aldunate, Marcelo J. Kogan
Summary: This study demonstrates an improved detection of A beta aggregates in C. elegans and mouse models of AD by co-administering functionalized gold nanorods with fluorescent probes, suggesting the potential of using plasmonic gold nanoparticles to enhance the detection of A beta in vivo.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Tamara Marin, Andres E. Dulcey, Fabian Campos, Catalina de la Fuente, Mariana Acuna, Juan Castro, Claudio Pinto, Maria Jose Yanez, Cristian Cortez, David W. McGrath, Pablo J. Saez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugan, Alejandra R. Alvarez, Silvana Zanlungo
Summary: Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder. Recent studies have shown that c-Abl tyrosine kinase activity plays a role in neuronal damage and death in NPA disease. There is potential for the use of c-Abl inhibitors in the clinical treatment of NPA patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Nohela B. Arevalo, Cristian M. Lamaizon, Viviana A. Cavieres, Patricia V. Burgos, Alejandra R. alvarez, Maria J. Yanez, Silvana Zanlungo
Summary: Gaucher disease (GD) is a genetic disorder caused by mutations in the GBA1 gene, leading to GluCer accumulation in lysosomes. Previous studies have focused on lysosomal dysfunction, but recent evidence suggests alterations in other organelles such as the endoplasmic reticulum (ER) and mitochondria. This review collects evidence of organelle dysfunction beyond lysosomes in neuronopathic Gaucher disease (nGD).
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pol Picon-Pages, Hugo Fanlo-Ucar, Victor Herrera-Fernandez, Sira Auselle-Bosch, Lorena Galera-Lopez, Daniela A. Gutierrez, Andres Ozaita, Alejandra R. Alvarez, Baldomero Oliva, Francisco J. Munoz
Summary: Alzheimer's disease (AD) is characterized by the presence of extracellular amyloid plaques in the brain, which are composed of aggregated amyloid beta-peptide (Aβ). It has been found that Aβ oligomers (oAβ) induce the production of reactive oxygen species (ROS), resulting in the oxidation of CaMKII alpha. This oxidized form of CaMKII alpha is present in brain samples from AD patients and is activated independently of calcium/calmodulin binding. The oxidation of CaMKII alpha promotes the phosphorylation of CREB and its translocation to the nucleus, leading to the transcription of ARC and BDNF in AD transgenic mice and primary cultures of murine hippocampal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
America Chandia-Cristi, Nicolas Stuardo, Cristian Trejos, Nancy Leal, Daniela Urrutia, Francisca C. Bronfman, Alejandra Alvarez Rojas
Summary: Brain-derived neurotrophic factor (BDNF) activates TrkB receptor and downstream pathways, promoting neuronal survival, growth, and plasticity. The role of c-Abl, a non-receptor tyrosine kinase, in BDNF-induced dendritic arborization was examined using various strategies. Surprisingly, BDNF promoted c-Abl activation and interaction with TrkB receptors. Inhibition or genetic ablation of c-Abl abolished BDNF-induced dendritic arborization without affecting classic TrkB downstream pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Daniela A. Gutierrez, America Chandia-Cristi, Maria Jose Yanez, Silvana Zanlungo, Alejandra R. Alvarez
Summary: This review focuses on the role of the non-receptor tyrosine kinase c-Abl in synaptic and neuronal functions. It has been found that the activation of c-Abl can be detrimental to neurons and may promote the development of neurodegenerative diseases. However, c-Abl activity plays a pivotal role in healthy synaptic plasticity, dendritic spine remodeling, and gene expression regulation after cognitive training.
NEURAL REGENERATION RESEARCH
(2023)