Review
Biochemistry & Molecular Biology
Estera Rintz, Grzegorz Wegrzyn, Toshihito Fujii, Shunji Tomatsu
Summary: The process of skeletal development in the body, known as endochondral ossification, is regulated by natriuretic peptides, including C-type natriuretic peptide (CNP), which promotes bone growth through various mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Li Liu, Yaping Feng, Shiyu Hu, Huimin Li, Yanyan Li, Jin Ke, Xing Long
Summary: The study revealed that PDCD4 is highly expressed in cartilage from MIA-induced TMJOA rats, inhibiting autophagy and promoting apoptosis. Furthermore, Akt mediates PDCD4-induced apoptosis and inhibited autophagy.
Article
Agriculture, Dairy & Animal Science
Alison Ramser, Elizabeth Greene, Narayan Rath, Sami Dridi
Summary: Lameness is a significant issue in the poultry industry due to bone diseases and infections in fast-growing broilers. The lack of immortalized chondrocyte cell lines has hindered the study of these disorders. This study successfully isolated and cultured primary chondrocytes from newborn chicks and identified their optimal phenotypes and functionality. The results provide a basis for disease modeling and future research using avian primary chondrocytes.
Review
Endocrinology & Metabolism
Junying Hua, Jianping Huang, Gang Li, Sien Lin, Liao Cui
Summary: Long-term or supra-physiological dose of glucocorticoid application can lead to impaired bone growth and osteoporosis, especially in children. Despite the availability of drugs for treating osteoporosis, there is currently no specific drug to mitigate these severe side effects.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Samantha R. Weaver, Earnest L. Taylor, Elizabeth L. Zars, Katherine M. Arnold, Elizabeth W. Bradley, Jennifer J. Westendorf
Summary: The study demonstrates that deficiency in Phlpp1 affects endochondral ossification by increasing Pth1r expression and signaling, leading to enhanced proliferation of chondrocytes and resulting in shorter long bones in Phlpp1-deficient mice. Injection of PTH (7-34) is able to reverse these abnormal phenotypes, but does not rescue deficits in bone mineral density or trabecular number.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Cell Biology
Firli Rahmah Primula Dewi, Shabierjiang Jiapaer, Akiko Kobayashi, Masaharu Hazawa, Dini Kurnia Ikliptikawati, Hartono, Hemragul Sabit, Mitsutoshi Nakada, Richard W. Wong
Summary: Children with ependymoma face high mortality rates due to resistance to conventional therapy. Targeting the oncogenic role of TPR in regulating HSF1 and MTOR signaling pathways may serve as a potential therapeutic approach for ependymoma treatment. TPR expression levels could potentially act as a biomarker for ependymoma, with pharmacological interventions showing promise in reducing tumor size in vivo.
Article
Environmental Sciences
Yajing Wang, Aoyun Li, Khalid Mehmood, Riaz Hussain, Rao Zahid Abbas, M. Tariq Javed, Yung-Fu Chang, Lianmei Hu, Jiaqiang Pan, Ying Li, Lijun Shi, Zhaoxin Tang, Hui Zhang
Summary: Long-term exposure to excessive fluoride can cause chronic damage to body tissues, leading to skeletal and dental fluorosis. Fluoride accumulation blocks chondrocyte development via apoptosis and autophagy, while not significantly affecting osteoclasts. Apoptosis of tibial bone and autophagy induction were observed in fluoride-exposed ducks, highlighting the role of CytC/Bcl-2/P53 pathways in preventing fluoride-induced chondrocyte injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Endocrinology & Metabolism
Fan Wang, Petri Rummukainen, Matias Pehkonen, Anna-Marja Saamanen, Terhi J. Heino, Riku Kiviranta
Summary: This study reveals that Wnt1 plays an important regulatory role in subchondral bone remodeling, with no effect on the regulation of growth plate or articular cartilage.
Article
Biochemistry & Molecular Biology
Xiaohong Wang, Lianhai Zhang, Francis K. L. Chan, Jiafu Ji, Jun Yu, Jessie Qiaoyi Liang
Summary: GGT7 is frequently downregulated in gastric cancer and its methylation is correlated with patient survival. GGT7 inhibits gastric cancer cell growth and migration by inducing autophagy.
Article
Biochemistry & Molecular Biology
Masanari Kuwahara, Yukio Akasaki, Ichiro Kurakazu, Takuya Sueishi, Masakazu Toya, Taisuke Uchida, Tomoaki Tsutsui, Ryota Hirose, Hidetoshi Tsushima, Takeshi Teramura, Yasuharu Nakashima
Summary: This study found that DEPP is involved in the mitochondrial autophagy function of chondrocytes and plays a protective role in the pathogenesis of osteoarthritis.
Article
Endocrinology & Metabolism
Rui-Jun Bai, Di Liu, Yu-Sheng Li, Jian Tian, Deng-Jie Yu, Heng-Zhen Li, Fang-Jie Zhang
Summary: In this study, it was found that OPN inhibited autophagy in chondrocytes through CD44 and alpha v beta 3 integrin receptors, as well as the ERK MAPK signaling pathway. These findings are important for understanding the pathogenesis of osteoarthritis and developing new treatment approaches.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xuan-Run Wang, Ze-Bo Jiang, Cong Xu, Wei-Yu Meng, Pei Liu, Yi-Zhong Zhang, Chun Xie, Jing-Yi Xu, Ya-Jia Xie, Tu-Liang Liang, Hao-Xin Yan, Xing-Xing Fan, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leung
Summary: Andrographolide (AD) in the treatment of non-small-cell lung cancer (NSCLC) involves regulating autophagy and PD-L1 expression, inhibiting tumour growth by suppressing JAK2/STAT3 signaling and P62-dependent selective autophagy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xiaoming Dai, Cong Jiang, Qiwei Jiang, Lan Fang, Haihong Yu, Jinhe Guo, Peiqiang Yan, Fangtao Chi, Tao Zhang, Hiroyuki Inuzuka, John M. Asara, Ping Wang, Jianping Guo, Wenyi Wei
Summary: mTORC1 senses glucose availability through AMPK-mediated phosphorylation of WDR24, regulating downstream signaling pathways and cell growth.
Article
Biochemistry & Molecular Biology
Wangyuan Yao, Muhammad Fakhar-e-Alam Kulyar, Yanmei Ding, Haitao Du, Jiajia Hong, Kyein San Loon, Shah Nawaz, Jiakui Li
Summary: The interaction between miR-140 and HDAC4 plays a crucial role in bone disorders such as tibial dyschondroplasia. Low miR-140 expression is associated with poor pathological characteristics and low chondrocyte survival. HDAC4 inhibits MEF2C and Runx2 and interacts with Col-II, Col-X, and COMP, leading to uncontrolled chondrocyte proliferation, differentiation, and dysplastic growth. Targeting the miR-140 and HDAC4 feedback loop may provide a promising therapeutic approach for chondrocyte-related bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Nora E. Renthal, Priyanka Nakka, John M. Baronas, Henry M. Kronenberg, Joel N. Hirschhorn
Summary: Human adult height reflects childhood skeletal growth, with growth plate chondrocytes being key determinants. Genes expressed specifically in the round cell layer of the growth plate are linked to skeletal biology regulation and height. These findings suggest that genes identified in GWAS studies and specifically expressed in the round cell layer play a crucial role in skeletal growth regulation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Cell Biology
Qian-Shi Zhang, Gregory J. Eaton, Carol Diallo, Theresa A. Freeman
JOURNAL OF CELLULAR PHYSIOLOGY
(2016)
Article
Physics, Applied
Abraham Lin, Natalie Chernets, Justine Han, Yordano Alicea, Danil Dobrynin, Gregory Fridman, Theresa A. Freeman, Alexander Fridman, Vandana Miller
PLASMA PROCESSES AND POLYMERS
(2015)
Article
Physics, Applied
Natalie Chernets, Deepa S. Kurpad, Vitali Alexeev, Dario B. Rodrigues, Theresa A. Freeman
PLASMA PROCESSES AND POLYMERS
(2015)
Article
Orthopedics
Sai Y. Veruva, Todd H. Lanman, Jorge E. Isaza, Theresa A. Freeman, Steven M. Kurtz, Marla J. Steinbeck
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2017)
Article
Orthopedics
Marla J. Steinbeck, Peter T. Eisenhauer, Mitchell G. Maltenfort, Javad Parvizi, Theresa A. Freeman
JOURNAL OF ARTHROPLASTY
(2016)
Article
Cell & Tissue Engineering
Peter Eisenhauer, Natalie Chernets, You Song, Danil Dobrynin, Nancy Pleshko, Marla J. Steinbeck, Theresa A. Freeman
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2016)
Article
Orthopedics
Jun Zhang, Peter Eisenhauer, Oz An Kaya, Alexander R. Vaccaro, Carol Diallo, Andrzej Fertala, Theresa A. Freeman
INTERNATIONAL ORTHOPAEDICS
(2017)
Article
Medicine, Research & Experimental
George Feldman, Arlene Offemaria, Hind Sawan, Javad Parvizi, Theresa A. Freeman
JOURNAL OF TRANSLATIONAL MEDICINE
(2017)
Article
Engineering, Biomedical
Erik V. Munsell, Deepa S. Kurpad, Theresa A. Freeman, Millicent O. Sullivan
ACTA BIOMATERIALIA
(2018)
Article
Dermatology
Felicia Cooper, Andrew M. Overmiller, Anthony Loder, Donna M. Brennan-Crispi, Kathleen P. McGuinn, Molly R. Marous, Theresa A. Freeman, Natalia A. Riobo-Del Galdo, Linda D. Siracusa, James K. Wahl, My. G. Mahoney
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Review
Biotechnology & Applied Microbiology
Brendan F. Gilmore, Padrig B. Flynn, Seamus O'Brien, Noreen Hickok, Theresa Freeman, Paula Bourke
TRENDS IN BIOTECHNOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Ly Nguyen, Peng Lu, Daniela Boehm, Paula Bourke, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman
BIOLOGICAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Qian-Shi Zhang, Deepa S. Kurpad, My G. Mahoney, Marla J. Steinbeck, Theresa A. Freeman
Article
Engineering, Biomedical
Timothy O. Josephson, Jason P. Moore, Ebrahim Maghami, Theresa A. Freeman, Ahmad R. Najafi
Summary: This study investigates the mechanical behavior of cortical bone and the role of perilacunar zones formed by local remodeling processes. The results show that perilacunar regions can delay or prevent the growth of microcracks.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Endocrinology & Metabolism
Nimish K. Acharya, Xin Qi, Eric L. Goldwaser, George A. Godsey, Hao Wu, Mary C. Kosciuk, Theresa A. Freeman, Colin H. Macphee, Robert L. Wilensky, Venkat Venkataraman, Robert G. Nagele
DIABETES & VASCULAR DISEASE RESEARCH
(2017)