Article
Biochemistry & Molecular Biology
Thomas E. Zapadka, Sarah I. Lindstrom, Julia C. Batoki, Chieh A. Lee, Brooklyn E. Taylor, Scott J. Howell, Patricia R. Taylor
Summary: The study examined the efficacy of an AhR agonist, VAF347, as a potential therapeutic for non-proliferative diabetic retinopathy. It was found that the AhR agonist significantly reduced leukostasis, oxidative stress, and inflammation in the retina of diabetic mice, and ameliorated retinal capillary degeneration. These findings suggest that VAF347 could be a potentially novel therapeutic for non-proliferative diabetic retinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Meixi Wang, Zuqi Zhang, Panpan Ruan, Guangchen Zhang, Chengrong Xiao, Yuguang Wang, Yue Gao
Summary: The study found that the metabolism of emodin to 5-hydroxyemodin by CYP1A plays an important role in the hepatocellular toxicity of emodin. CYP1A1 and AhR can be used to predict and validate liver injury caused by PMT or other herbs containing emodin.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Gang Cao, Hua Miao, Yan-Ni Wang, Dan-Qian Chen, Xia-Qing Wu, Lin Chen, Yan Guo, Liang Zou, Nosratola D. Vaziri, Ping Li, Ying-Yong Zhao
Summary: This study found that the metabolite 1-methoxypyrene (MP) activates the aryl hydrocarbon receptor (AhR) signaling pathway, leading to tubulointerstitial fibrosis (TIF). MP promotes the epithelial-mesenchymal transition and macrophage-myofibroblast transition, which are important for the development of TIF.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Clinical Neurology
Thanos Tsaktanis, Tobias Beyer, Lucy Nirschl, Mathias Linnerbauer, Verena Grummel, Mathias Bussas, Emily Tjon, Mark Muhlau, Thomas Korn, Bernhard Hemmer, Francisco J. Quintana, Veit Rothhammer
Summary: The study found that AHR ligand levels were decreased in RRMS and correlated with disease duration and neurological disability. In SPMS and PPMS, serum AHR agonistic activity was also decreased and correlated with disease severity. Longitudinally, decreased AHR agonistic activity in RRMS patients was linked to progressive CNS atrophy and increased lesion load, suggesting it could serve as a novel biomarker for disability progression in MS.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Review
Immunology
Andreia Barroso, Joao Mahler, Pedro H. Fonseca-Castro, Francisco J. Quintana
Summary: Dendritic cells are crucial for controlling the effector and regulatory components of immune responses. Tolerogenic dendritic cells expand regulatory T cells and suppress immune responses, potentially providing a therapeutic target for autoimmune diseases and allergies, although further research is needed on their population characteristics and activation states.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Yixi Zhou, Kongyang Zhu, Qian Wang, Meng Chen, Chengyong He, Chunyan Yang, Zhenghong Zuo
Summary: This study reveals the potential harmful effects of diuron on reproduction in marine fish, including decreased male reproductive capacity, histological changes in testes, decreased sperm mobility, and abnormal reproductive behaviors. The study also found an increase in the proportion of diuron metabolites in fish, while the proportion of diuron decreased with increasing exposure concentration.
Article
Multidisciplinary Sciences
Yun Seok Kim, Bongsub Ko, Da Jung Kim, Jihoon Tak, Chang Yeob Han, Joo-Youn Cho, Won Kim, Sang Geon Kim
Summary: This study reveals that alcohol consumption induces the activation of aryl hydrocarbon receptor (AhR) in the liver, leading to changes in the content of hepatic phospho-/sphingo-lipids. Elevated levels of kynurenine, an endogenous AhR ligand, are observed in alcohol-fed mice, along with increased hepatic tryptophan metabolic enzymes. Alcohol or kynurenine treatment activates AhR and dysregulates autophagy through AMPK. The transcriptional target Ppp2r2d, regulated by AhR, is identified as the key player in the inhibition of autophagy and mitochondrial dysfunction. Hepatocyte-specific AhR ablation reduces steatosis and restores phospho-/sphingo-lipids content. These findings are supported by patient specimens, suggesting the importance of AhR-dependent metabolism in lipid regulation.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Kulas Jelena, Tucovic Dina, Zeljkovic Milica, Popovic Dusanka, Popov Aleksandrov Aleksandra, Kataranovski Milena, Mirkov Ivana
Summary: Cadmium exposure increased the expression of CYP1B1 and CYP1A1 mRNA, indicating the involvement of AhR in its actions. The AhR antagonist CH-223191 abolished the effects of Cd on cytokine response. AhR signaling is important in the lung leukocyte proinflammatory cytokine response to Cd, providing new insights into Cd immunotoxicity mechanisms.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2021)
Article
Plant Sciences
Cai Zhang, Jin-Quan Zhao, Jia-Xing Sun, Hui-Jun Li
Summary: The study revealed that the hepatotoxicity induced by psoralen and isopsoralen is associated with the expression and activity of CYP1A2, possibly through the mechanism of AhR-mediated transcriptional induction of CYP1A2. These findings are important to alert about the potential risks of combined usage of psoralen or isopsoralen with AhR ligands or CYP1A2 substrates in clinical practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Li Lin, Yongmin Liu, Li Chen, Yue Dai, Yufeng Xia
Summary: Researchers designed and synthesized a compound III11 that can activate AhR, which showed good bioavailability and remarkable therapeutic effects in treating inflammatory diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Van Thi-Hong Tran, Duc-Vinh Pham, Dong-Young Choi, Pil-Hoon Park
Summary: This study reveals a novel mechanism underlying the breast tumor-suppressing effect of raloxifene. Raloxifene inhibits the activation of NLRP3 inflammasomes, leading to the inhibition of breast cancer cell growth.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Pharmacology & Pharmacy
Atsuhito Kubota, Masaru Terasaki, Rie Takai, Masaki Kobayashi, Ryuta Muromoto, Hiroyuki Kojima
Summary: This study found that 5-aminosalicylic acid (5-ASA) acts as a weak agonist of the aryl hydrocarbon receptor (AhR) and induces regulatory T cells (Tregs) in spleen cells. These findings provide insights into the mechanism by which 5-ASA regulates inflammation.
Article
Developmental Biology
Chisato Kunitomi, Miyuki Harada, Akari Kusamoto, Jerilee M. K. Azhary, Emi Nose, Hiroshi Koike, Zixin Xu, Yoko Urata, Nozomi Takahashi, Osamu Wada-Hiraike, Yasushi Hirota, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga
Summary: Recent studies have highlighted the important role of aryl hydrocarbon receptor (AHR) in diseases such as obesity and cancer, beyond its known role as a receptor for endocrine-disrupting chemicals (EDCs). The activation of endoplasmic reticulum (ER) stress in granulosa cells is found to contribute to the pathology of polycystic ovary syndrome (PCOS) by upregulating AHR and its downstream signaling, particularly the AHR target gene cytochrome P450 IBI (CYPIBI). Inhibiting AHR activity with an antagonist shows promise in restoring normal ovarian function in PCOS mice.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Behavioral Sciences
Caitlin A. Madison, Lauren Hillbrick, Jacob Kuempel, Georgia Lee Albrecht, Kerstin K. Landrock, Stephen Safe, Robert S. Chapkin, Shoshana Eitan
Summary: This study suggests that the aryl hydrocarbon receptor (AhR) in the intestine plays a crucial role in depression, anxiety, and spatial learning. AhR-active microbial metabolites can modulate neuronal responses. The antidepressant effects of DIM and DHNA are not dependent on the expression of intestinal AhR.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Chemistry, Medicinal
Kou Nakamura, Masako Yamasaki, Hirofumi Ohashi, Shiki Saito, Koudai Ashikawa, Kanna Sato, Kazane Nishioka, Yuka Suzuki, Yukine Tsurukawa, Kazuki Kanno, Nozomi Mosu, Hironobu Murakami, Masaki Nagane, Maiko Okada, Koichi Watashi, Shinji Kamisuki
Summary: Recent studies have shown that aryl hydrocarbon receptors (AhRs) are involved in both xenobiotic metabolism and the life cycle of viruses and inflammatory reactions. A screening of fungal metabolites led to the discovery of methylsulochrin as a partial agonist of AhR, which was found to inhibit the production of hepatitis C virus (HCV) and suppress pro-inflammatory cytokine production. These findings suggest the potential use of methylsulochrin derivatives as anti-HCV compounds with anti-inflammatory activity.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Sung-Po Hsu, Po-Han Lin, Chih-Ming Chou, Wen-Sen Lee
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Pei-Ching Ting, Woan-Ruoh Lee, Yen-Nien Huo, Sung-Po Hsu, Wen-Sen Lee
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2019)
Article
Cell Biology
Suphannee Chokchaiwong, Yung-Ting Kuo, Sung-Po Hsu, Yi-Ching Hsu, Shih-Hsiang Lin, Wen-Bin Zhong, Yung-Feng Lin, Shu-Huei Kao
Article
Immunology
Chia-Chi Hung, Yi-Hsuan Lee, Yi-Min Kuo, Pei-Chien Hsu, Huey-Jen Tsay, Ying-Ting Hsu, Chih-Chin Lee, Jia-Jun Liang, Feng-Shiun Shie
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Neurosciences
Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee
MOLECULAR NEUROBIOLOGY
(2019)
Article
Immunology
Wan-Ci Chen, Li-Hsin Chang, Shiang-Suo Huang, Yu-Jie Huang, Chun-Lien Chih, Hung-Chih Kuo, Yi-Hsuan Lee, I-Hui Lee
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Endocrinology & Metabolism
Po-Han Lin, Yen-Ting Tung, Hsin-Yuan Chen, Yi-Fen Chiang, Hui-Chih Hong, Ko-Chieh Huang, Sung-Po Hsu, Tsui-Chin Huang, Shih-Min Hsia
JOURNAL OF PINEAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Hong-Yi Lin, Kuo-Hsing Liao, Chiung-Yuan Ko, Guan-Yuan Chen, Sung-Po Hsu, Chia-Yang Hung, Tsung- Hsu
Summary: The study suggests that 17β-estradiol plays a crucial role in the development of drug resistance in glioblastoma multiforme (GBM) by reducing oxidative stress and inducing drug resistance through NRF2 expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
John Tsu-An Hsu, Chih-Feng Tien, Guann-Yi Yu, Santai Shen, Yi-Hsuan Lee, Pei-Chien Hsu, Yun Wang, Po-Kuan Chao, Huey-Jen Tsay, Feng-Shiun Shie
Summary: Elderly individuals with dementia, particularly Alzheimer's disease, may be more susceptible to severe COVID-19 due to increased levels of beta-amyloid (Aβ). Aβ(1-42) specifically binds to viral proteins of SARS-CoV-2, such as the spike protein S1 subunit and ACE2 receptor, potentially enhancing viral entry into cells and increasing inflammation. Further research is needed to explore the mechanisms underlying this interaction and investigate the potential benefits of reducing Aβ(1-42) levels in combating COVID-19 and AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Yu-Ching Fan, Kai-Cheng Hsu, Tony-Eight Lin, Dietmar Zechner, Sung-Po Hsu, Yuan-Chin Tsai
Summary: Prostate and pancreatic cancers are leading causes of cancer death in America. Current treatments face challenges, but a novel MLK1 inhibitor has shown promising anti-tumor effects on both cancers.
Article
Biochemistry & Molecular Biology
Yin-Hsun Feng, Sher-Wei Lim, Hong-Yi Lin, Shao-An Wang, Sung-Po Hsu, Tzu-Jen Kao, Chiung-Yuan Ko, Tsung- Hsu
Summary: Allopregnanolone (allo) has the potential to be a treatment for glioblastoma (GBM). It enhances the inhibitory effect of temozolomide (TMZ) on cell survival and proliferation, inhibits cell migration, and induces apoptosis. Allo also decreases the expression of DPYSL3/S100A11 and induces DNA damage to suppress GBM cell survival.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Chih Wu, Sung-Po Hsu, Meng-Chun Hu, Yu-Ting Lan, Edward T. H. Yeh, Feng-Ming Yang
Summary: In this study, a cell permeable PEP-sNASP peptide was generated to ameliorate acute lung injury by reducing inflammation through binding to TRAF6. The PEP-sNASP peptide showed potential as a protein therapy for pulmonary diseases.
FRONTIERS IN MEDICINE
(2022)
Review
Physiology
Yi-Min Kuo, Yi-Hsuan Lee
Summary: This article reviews the action mechanisms and potential applications of epoxyeicosatrienoic acids (EETs) and their metabolic enzyme soluble epoxide hydrolase (sEH) in the central nervous system. EETs exhibit beneficial effects such as anti-inflammation, anti-apoptosis, and anti-oxidation through multiple signaling pathways, while inhibition of sEH holds potential therapeutic value in cardiovascular disease and cancer treatment.
CHINESE JOURNAL OF PHYSIOLOGY
(2022)
Review
Physiology
Sung-Po Hsu, Wen-Sen Lee
CHINESE JOURNAL OF PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Chih-Cheng Chang, Kuo-How Huang, Sung-Po Hsu, Yuan-Chii G. Lee, Yuh-Mou Sue, Shu-Hui Juan
SCIENTIFIC REPORTS
(2019)